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Protein
Submitted name:

Cytokine receptor gamma chain

Gene

Il2rg

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cytokine binding Source: RGD
  2. cytokine receptor activity Source: RGD
  3. interleukin-2 binding Source: RGD
  4. interleukin-7 binding Source: RGD

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. immune response Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Cytokine receptor gamma chainImported
Gene namesi
Name:Il2rgImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621466. Il2rg.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: RGD
  2. integral component of membrane Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8VHR8.

Structurei

3D structure databases

ProteinModelPortaliQ8VHR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG052111.
PhylomeDBiQ8VHR8.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8VHR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
WSSKVLMSSG NEDTKSDLLL TSMDLKHLSV PTLPLPEVQC FVFNVEYMNC
60 70 80 90 100
TWNSSSEPQP TNLTMHYRYK GSDNNTFQEC SHYLFSKEIT SGCQIQKEDI
110 120 130 140 150
QLYQTFVVQL QDPQKPQRRA EQKLNLQNLV IPWAPENLTL YNLSESQVEL
160 170 180 190 200
RWKSRYIERC LQYLVQYRSN RDRSWTEQIV DHEPRFSLPS VDEQKLYPFR
210 220 230 240 250
VRSRFNPICG STQQWSKWSQ PIHWGSHTAE ENPSLFALEA VLIPVGTMGL
260 270
IITLIFVYCW LERMPXIPXI KNLEIWLL
Length:278
Mass (Da):32,722
Last modified:March 1, 2002 - v1
Checksum:i4011F8F774804CDD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei278 – 2781Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410926 mRNA. Translation: AAL61621.1.
UniGeneiRn.14508.

Genome annotation databases

UCSCiRGD:621466. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410926 mRNA. Translation: AAL61621.1.
UniGeneiRn.14508.

3D structure databases

ProteinModelPortaliQ8VHR8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621466. rat.

Organism-specific databases

RGDi621466. Il2rg.

Phylogenomic databases

HOVERGENiHBG052111.
PhylomeDBiQ8VHR8.

Gene expression databases

GenevestigatoriQ8VHR8.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain."
    Olosz F., Malek T.R.
    J. Biol. Chem. 277:12047-12052(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ8VHR8_RAT
AccessioniPrimary (citable) accession number: Q8VHR8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.