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Protein

Protocadherin 18

Gene

Pcdh18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin 18
Gene namesi
Name:Pcdh18
Synonyms:Kiaa1562
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1920423. Pcdh18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 699ExtracellularSequence analysisAdd BLAST672
Transmembranei700 – 720HelicalSequence analysisAdd BLAST21
Topological domaini721 – 1134CytoplasmicSequence analysisAdd BLAST414

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500006132528 – 1134Protocadherin 18Add BLAST1107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi559N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VHR0.
PRIDEiQ8VHR0.

PTM databases

iPTMnetiQ8VHR0.
PhosphoSitePlusiQ8VHR0.

Expressioni

Tissue specificityi

Predominantly expressed in kidney and lung.1 Publication

Developmental stagei

Expressed at high levels throughout the developing embryo, except in the heart and liver. In the developing brain, expressed at high levels in the ventricular zone (vz) in the forebrain and midbrain. Expression in the developing brain is maximal around birth and gradually decreases until it is completely absent from the adult brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000037892.
ExpressionAtlasiQ8VHR0. baseline and differential.
GenevisibleiQ8VHR0. MM.

Interactioni

Subunit structurei

Interacts with DAB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dab1P973182EBI-399910,EBI-81680

Protein-protein interaction databases

BioGridi215816. 1 interactor.
IntActiQ8VHR0. 2 interactors.
STRINGi10090.ENSMUSP00000039245.

Structurei

3D structure databases

ProteinModelPortaliQ8VHR0.
SMRiQ8VHR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 137Cadherin 1PROSITE-ProRule annotationAdd BLAST110
Domaini138 – 246Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini247 – 354Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini361 – 465Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini466 – 576Cadherin 5PROSITE-ProRule annotationAdd BLAST111
Domaini582 – 688Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni892 – 1134Interaction with DAB11 PublicationAdd BLAST243

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ8VHR0.
KOiK16499.
OMAiMDSVPYT.
OrthoDBiEOG091G00QD.
PhylomeDBiQ8VHR0.
TreeFamiTF352008.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030714. Protocadherin-18.
[Graphical view]
PANTHERiPTHR24028:SF9. PTHR24028:SF9. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQMNTKMHF RFALALLMAF FSHDVLAKNL KYRIYEEQRV GSVIARLSED
60 70 80 90 100
VADVLLKLPN PSAVRFRAMP RGNSPLLVVN ENTGEISIGA KIDREQLCQK
110 120 130 140 150
NLNCSIEFDV LTLPTEHLQL FHIEVDVLDI NDNSPQFSRP VIPIEISESA
160 170 180 190 200
AVGTRIPLDS AFDPDVGENS LHTYSLSAND YFNIEVRTRT DGAKYAELIV
210 220 230 240 250
VKELDRELKA SYELQLTASD MGVPQRSGSS ILKISISDSN DNSPAFEQPS
260 270 280 290 300
YTIQLLENSP VGTLLLDLNA TDPDEGANGR IVYSFSSHVS PKIIETFKID
310 320 330 340 350
SEKGHLTLFK PVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN
360 370 380 390 400
KPEISINLMS PGKEEVSYVF EGDPIDTFVA IVRVQDKDSG LNGEIICKLH
410 420 430 440 450
GHGHFKLQKT YENNYLILTN ATLDREKRSE YSLTVIAEDK GTPSLSSVRH
460 470 480 490 500
FTVQINDIND NPPRFQRSRY EFVISENNSP GAYITTVTAT DPDLGENGHV
510 520 530 540 550
TYTILESFVL GSSITTYVTI DPSNGAIYAL RIFDHEEVSQ ITFVVEARDG
560 570 580 590 600
GSQKQLSSNT TVVLTIIDEN DNVPVVIGPA MHNNTAEISI PKGAESGFHV
610 620 630 640 650
TRIRVVDRDS GANAEFSCSI VSGNEENIFI MDPRSCDIHT NVSMESIPSA
660 670 680 690 700
EWALSVIIQD KGSPPLHTKV LLRCMVFDYA ESVTSTAMTS VSRASLDVSM
710 720 730 740 750
IIIISLGAIC AVLLVIMVLF ATRCNREKKD TRSYNCRVAE STYQHHPKRP
760 770 780 790 800
SRQIHKGDIT LVPTINGTLP IRSHHRSSPS SSPTLERGQM GSRQSHNSHQ
810 820 830 840 850
SLNSLVTISS NHVPENFSLE LTHATPAVEV SQLLSMLHQG QYQPRPSFRG
860 870 880 890 900
NKYSRSYRYA LQDMDKFSLK DSGRGDSEAG DSDYDLGRDS PIDRLLGEGF
910 920 930 940 950
SDLFLTDGRI PAAMRLCTEE CRVLGHSDQC WMPPLPSPSS DYRSNMFIPG
960 970 980 990 1000
EEFPAQPQQQ HSHQGLDDDS QPAENGEKKK SFSTFGKDSP SDEDSGDSST
1010 1020 1030 1040 1050
SSLLSEMSSV FQRLLPASLD TFSECNEGDR SNSLERRKGP AQGKTGGYPQ
1060 1070 1080 1090 1100
GVAAWAASTH FQNPTSSSGT PLGTHSSVQP SSKWLPAMEE IPENYEEDDF
1110 1120 1130
DNVLNHLSDG KHELMDASEL VAEINKLLQD VRQS
Length:1,134
Mass (Da):125,420
Last modified:October 14, 2008 - v2
Checksum:i6C99B12BCA420353
GO

Sequence cautioni

The sequence BAD32482 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti650A → T in AAL47095 (PubMed:11716507).Curated1
Sequence conflicti650A → T in BAD32482 (PubMed:15368895).Curated1
Sequence conflicti650A → T in AAH52198 (PubMed:15489334).Curated1
Sequence conflicti1066S → N in BAD32482 (PubMed:15368895).Curated1
Sequence conflicti1066S → N in AAH52198 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416735 mRNA. Translation: AAL47095.1.
AK173204 mRNA. Translation: BAD32482.1. Different initiation.
AK036560 mRNA. Translation: BAC29477.1.
BC052198 mRNA. Translation: AAH52198.1.
CCDSiCCDS17334.1.
RefSeqiNP_569715.3. NM_130448.3.
UniGeneiMm.87246.

Genome annotation databases

EnsembliENSMUST00000035931; ENSMUSP00000039245; ENSMUSG00000037892.
GeneIDi73173.
KEGGimmu:73173.
UCSCiuc008pdg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416735 mRNA. Translation: AAL47095.1.
AK173204 mRNA. Translation: BAD32482.1. Different initiation.
AK036560 mRNA. Translation: BAC29477.1.
BC052198 mRNA. Translation: AAH52198.1.
CCDSiCCDS17334.1.
RefSeqiNP_569715.3. NM_130448.3.
UniGeneiMm.87246.

3D structure databases

ProteinModelPortaliQ8VHR0.
SMRiQ8VHR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215816. 1 interactor.
IntActiQ8VHR0. 2 interactors.
STRINGi10090.ENSMUSP00000039245.

PTM databases

iPTMnetiQ8VHR0.
PhosphoSitePlusiQ8VHR0.

Proteomic databases

PaxDbiQ8VHR0.
PRIDEiQ8VHR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035931; ENSMUSP00000039245; ENSMUSG00000037892.
GeneIDi73173.
KEGGimmu:73173.
UCSCiuc008pdg.2. mouse.

Organism-specific databases

CTDi54510.
MGIiMGI:1920423. Pcdh18.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ8VHR0.
KOiK16499.
OMAiMDSVPYT.
OrthoDBiEOG091G00QD.
PhylomeDBiQ8VHR0.
TreeFamiTF352008.

Miscellaneous databases

PROiQ8VHR0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037892.
ExpressionAtlasiQ8VHR0. baseline and differential.
GenevisibleiQ8VHR0. MM.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030714. Protocadherin-18.
[Graphical view]
PANTHERiPTHR24028:SF9. PTHR24028:SF9. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCD18_MOUSE
AccessioniPrimary (citable) accession number: Q8VHR0
Secondary accession number(s): Q69ZG2, Q80VY4, Q8CB88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.