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Protein

Protocadherin 18

Gene

Pcdh18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin 18
Gene namesi
Name:Pcdh18
Synonyms:Kiaa1562
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1920423. Pcdh18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 699672ExtracellularSequence analysisAdd
BLAST
Transmembranei700 – 72021HelicalSequence analysisAdd
BLAST
Topological domaini721 – 1134414CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 11341107Protocadherin 18PRO_5000061325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VHR0.
PRIDEiQ8VHR0.

PTM databases

PhosphoSiteiQ8VHR0.

Expressioni

Tissue specificityi

Predominantly expressed in kidney and lung.1 Publication

Developmental stagei

Expressed at high levels throughout the developing embryo, except in the heart and liver. In the developing brain, expressed at high levels in the ventricular zone (vz) in the forebrain and midbrain. Expression in the developing brain is maximal around birth and gradually decreases until it is completely absent from the adult brain.1 Publication

Gene expression databases

BgeeiQ8VHR0.
ExpressionAtlasiQ8VHR0. baseline and differential.
GenevisibleiQ8VHR0. MM.

Interactioni

Subunit structurei

Interacts with DAB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dab1P973182EBI-399910,EBI-81680

Protein-protein interaction databases

BioGridi215816. 1 interaction.
IntActiQ8VHR0. 2 interactions.
STRINGi10090.ENSMUSP00000039245.

Structurei

3D structure databases

ProteinModelPortaliQ8VHR0.
SMRiQ8VHR0. Positions 30-678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 137110Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 246109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 354108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini361 – 465105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini466 – 576111Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini582 – 688107Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni892 – 1134243Interaction with DAB1Add
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ8VHR0.
KOiK16499.
OMAiCGPPLGT.
OrthoDBiEOG7J445X.
PhylomeDBiQ8VHR0.
TreeFamiTF352008.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030714. Protocadherin-18.
[Graphical view]
PANTHERiPTHR24028:SF9. PTHR24028:SF9. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQMNTKMHF RFALALLMAF FSHDVLAKNL KYRIYEEQRV GSVIARLSED
60 70 80 90 100
VADVLLKLPN PSAVRFRAMP RGNSPLLVVN ENTGEISIGA KIDREQLCQK
110 120 130 140 150
NLNCSIEFDV LTLPTEHLQL FHIEVDVLDI NDNSPQFSRP VIPIEISESA
160 170 180 190 200
AVGTRIPLDS AFDPDVGENS LHTYSLSAND YFNIEVRTRT DGAKYAELIV
210 220 230 240 250
VKELDRELKA SYELQLTASD MGVPQRSGSS ILKISISDSN DNSPAFEQPS
260 270 280 290 300
YTIQLLENSP VGTLLLDLNA TDPDEGANGR IVYSFSSHVS PKIIETFKID
310 320 330 340 350
SEKGHLTLFK PVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN
360 370 380 390 400
KPEISINLMS PGKEEVSYVF EGDPIDTFVA IVRVQDKDSG LNGEIICKLH
410 420 430 440 450
GHGHFKLQKT YENNYLILTN ATLDREKRSE YSLTVIAEDK GTPSLSSVRH
460 470 480 490 500
FTVQINDIND NPPRFQRSRY EFVISENNSP GAYITTVTAT DPDLGENGHV
510 520 530 540 550
TYTILESFVL GSSITTYVTI DPSNGAIYAL RIFDHEEVSQ ITFVVEARDG
560 570 580 590 600
GSQKQLSSNT TVVLTIIDEN DNVPVVIGPA MHNNTAEISI PKGAESGFHV
610 620 630 640 650
TRIRVVDRDS GANAEFSCSI VSGNEENIFI MDPRSCDIHT NVSMESIPSA
660 670 680 690 700
EWALSVIIQD KGSPPLHTKV LLRCMVFDYA ESVTSTAMTS VSRASLDVSM
710 720 730 740 750
IIIISLGAIC AVLLVIMVLF ATRCNREKKD TRSYNCRVAE STYQHHPKRP
760 770 780 790 800
SRQIHKGDIT LVPTINGTLP IRSHHRSSPS SSPTLERGQM GSRQSHNSHQ
810 820 830 840 850
SLNSLVTISS NHVPENFSLE LTHATPAVEV SQLLSMLHQG QYQPRPSFRG
860 870 880 890 900
NKYSRSYRYA LQDMDKFSLK DSGRGDSEAG DSDYDLGRDS PIDRLLGEGF
910 920 930 940 950
SDLFLTDGRI PAAMRLCTEE CRVLGHSDQC WMPPLPSPSS DYRSNMFIPG
960 970 980 990 1000
EEFPAQPQQQ HSHQGLDDDS QPAENGEKKK SFSTFGKDSP SDEDSGDSST
1010 1020 1030 1040 1050
SSLLSEMSSV FQRLLPASLD TFSECNEGDR SNSLERRKGP AQGKTGGYPQ
1060 1070 1080 1090 1100
GVAAWAASTH FQNPTSSSGT PLGTHSSVQP SSKWLPAMEE IPENYEEDDF
1110 1120 1130
DNVLNHLSDG KHELMDASEL VAEINKLLQD VRQS
Length:1,134
Mass (Da):125,420
Last modified:October 14, 2008 - v2
Checksum:i6C99B12BCA420353
GO

Sequence cautioni

The sequence BAD32482.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti650 – 6501A → T in AAL47095 (PubMed:11716507).Curated
Sequence conflicti650 – 6501A → T in BAD32482 (PubMed:15368895).Curated
Sequence conflicti650 – 6501A → T in AAH52198 (PubMed:15489334).Curated
Sequence conflicti1066 – 10661S → N in BAD32482 (PubMed:15368895).Curated
Sequence conflicti1066 – 10661S → N in AAH52198 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416735 mRNA. Translation: AAL47095.1.
AK173204 mRNA. Translation: BAD32482.1. Different initiation.
AK036560 mRNA. Translation: BAC29477.1.
BC052198 mRNA. Translation: AAH52198.1.
CCDSiCCDS17334.1.
RefSeqiNP_569715.3. NM_130448.3.
UniGeneiMm.87246.

Genome annotation databases

EnsembliENSMUST00000035931; ENSMUSP00000039245; ENSMUSG00000037892.
GeneIDi73173.
KEGGimmu:73173.
UCSCiuc008pdg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416735 mRNA. Translation: AAL47095.1.
AK173204 mRNA. Translation: BAD32482.1. Different initiation.
AK036560 mRNA. Translation: BAC29477.1.
BC052198 mRNA. Translation: AAH52198.1.
CCDSiCCDS17334.1.
RefSeqiNP_569715.3. NM_130448.3.
UniGeneiMm.87246.

3D structure databases

ProteinModelPortaliQ8VHR0.
SMRiQ8VHR0. Positions 30-678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215816. 1 interaction.
IntActiQ8VHR0. 2 interactions.
STRINGi10090.ENSMUSP00000039245.

PTM databases

PhosphoSiteiQ8VHR0.

Proteomic databases

PaxDbiQ8VHR0.
PRIDEiQ8VHR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035931; ENSMUSP00000039245; ENSMUSG00000037892.
GeneIDi73173.
KEGGimmu:73173.
UCSCiuc008pdg.2. mouse.

Organism-specific databases

CTDi54510.
MGIiMGI:1920423. Pcdh18.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ8VHR0.
KOiK16499.
OMAiCGPPLGT.
OrthoDBiEOG7J445X.
PhylomeDBiQ8VHR0.
TreeFamiTF352008.

Miscellaneous databases

NextBioi337605.
PROiQ8VHR0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHR0.
ExpressionAtlasiQ8VHR0. baseline and differential.
GenevisibleiQ8VHR0. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030714. Protocadherin-18.
[Graphical view]
PANTHERiPTHR24028:SF9. PTHR24028:SF9. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Disabled-1 interacts with a novel developmentally regulated protocadherin."
    Homayouni R., Rice D.S., Curran T.
    Biochem. Biophys. Res. Commun. 289:539-547(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH DAB1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Head.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiPCD18_MOUSE
AccessioniPrimary (citable) accession number: Q8VHR0
Secondary accession number(s): Q69ZG2, Q80VY4, Q8CB88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: May 11, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.