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Protein

Acyl-coenzyme A thioesterase 11

Gene

Acot11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183Coenzyme ABy similarity1

GO - Molecular functioni

  • acyl-CoA hydrolase activity Source: UniProtKB
  • carboxylic ester hydrolase activity Source: UniProtKB-KW
  • lipid binding Source: InterPro

GO - Biological processi

  • acyl-CoA metabolic process Source: GO_Central
  • fatty acid metabolic process Source: GO_Central
  • intracellular signal transduction Source: UniProtKB
  • response to cold Source: BHF-UCL
  • response to temperature stimulus Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 11 (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase 11
Alternative name(s):
Acyl-CoA thioester hydrolase 11
Adipose-associated thioesterase
Brown fat-inducible thioesterase
Short name:
BFIT
Gene namesi
Name:Acot11
Synonyms:Bfit, Thea
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913736 Acot11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538141 – 594Acyl-coenzyme A thioesterase 11Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VHQ9
MaxQBiQ8VHQ9
PaxDbiQ8VHQ9
PRIDEiQ8VHQ9

PTM databases

iPTMnetiQ8VHQ9
PhosphoSitePlusiQ8VHQ9

Expressioni

Inductioni

By cold exposure and repressed by heat exposure.

Gene expression databases

BgeeiENSMUSG00000034853
CleanExiMM_ACOT11
ExpressionAtlasiQ8VHQ9 baseline and differential
GenevisibleiQ8VHQ9 MM

Interactioni

Protein-protein interaction databases

IntActiQ8VHQ9 2 interactors.
MINTiQ8VHQ9

Structurei

3D structure databases

ProteinModelPortaliQ8VHQ9
SMRiQ8VHQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 157HotDog ACOT-type 1PROSITE-ProRule annotationAdd BLAST113
Domaini217 – 330HotDog ACOT-type 2PROSITE-ProRule annotationAdd BLAST114
Domaini370 – 582STARTPROSITE-ProRule annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 95Coenzyme A bindingBy similarity3
Regioni122 – 124Coenzyme A bindingBy similarity3
Regioni272 – 274Coenzyme A bindingBy similarity3

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2763 Eukaryota
COG1607 LUCA
GeneTreeiENSGT00760000119297
HOGENOMiHOG000232032
HOVERGENiHBG023847
InParanoidiQ8VHQ9
KOiK12417
PhylomeDBiQ8VHQ9
TreeFamiTF328368

Family and domain databases

Gene3Di3.30.530.201 hit
InterProiView protein in InterPro
IPR033120 HOTDOG_ACOT
IPR029069 HotDog_dom_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
IPR006683 Thioestr_dom
PfamiView protein in Pfam
PF03061 4HBT, 2 hits
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00234 START, 1 hit
SUPFAMiSSF54637 SSF54637, 2 hits
PROSITEiView protein in PROSITE
PS51770 HOTDOG_ACOT, 2 hits
PS50848 START, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VHQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQNVGNHLR RGFASMFSNR TSRKSISHPE SGDPPTMAEG EGYRNPTEVQ
60 70 80 90 100
MSQLVLPCHT NHRGELSIGQ LLKWIDTTAC LSAERHAGCP CVTASMDDIY
110 120 130 140 150
FDHTISVGQV VNIKAKVNRA FNSSMEVGIQ VVSEDLCSEK QWSVCKALAT
160 170 180 190 200
FVAHRELSKV KLKQVIPLTE EEKTEHGVAA ERRRMRLVYA DTIKDLLTHC
210 220 230 240 250
VIQDDLDKDC SNMVPAEKTR VESVELVLPP HANHQGNTFG GQIMAWMENV
260 270 280 290 300
ATIAASRLCH AHPTLKAIEM FHFRGPSQVG DRLVLKAIVN NAFKHSMEVG
310 320 330 340 350
VCVEAYRQEA ETQRRHINSA FMTFVVLDKD DQPQKLPWIR PQPGEGERRY
360 370 380 390 400
REASARKKIR LDRKYLVSCK QAEVALSVPW DPSNQVYLSY YNVSSLKTLM
410 420 430 440 450
AKDNWVLSVE ISEVRLYILE EDFLSFHLEM VVNVDAAQVF QLLSDLRRRP
460 470 480 490 500
EWDKHYRSVE LVQQVDEDDA IYHVISPALS GNTKPQDFVI LASRRKPCDN
510 520 530 540 550
GDPYVIALRS VTLPTHHETP EYQRGETLCS GFCLWREGDQ MTKVSYYNQA
560 570 580 590
TPGFLNYVTT NVSGLSSEFY NTFKACESFL LDNRNDLAPS LQTL
Length:594
Mass (Da):67,355
Last modified:March 1, 2002 - v1
Checksum:i9A51D3BCF38870C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416923 mRNA Translation: AAL40939.1
BC042492 mRNA Translation: AAH42492.1
CCDSiCCDS18426.1
RefSeqiNP_079866.2, NM_025590.4
UniGeneiMm.222956

Genome annotation databases

EnsembliENSMUST00000102762; ENSMUSP00000099823; ENSMUSG00000034853
GeneIDi329910
KEGGimmu:329910
UCSCiuc008tyv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiACO11_MOUSE
AccessioniPrimary (citable) accession number: Q8VHQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome