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Protein

Acyl-coenzyme A thioesterase 11

Gene

Acot11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831Coenzyme ABy similarity

GO - Molecular functioni

  • acyl-CoA hydrolase activity Source: UniProtKB
  • carboxylic ester hydrolase activity Source: UniProtKB-KW
  • lipid binding Source: InterPro

GO - Biological processi

  • fatty acid metabolic process Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • response to cold Source: BHF-UCL
  • response to temperature stimulus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-MMU-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 11 (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase 11
Alternative name(s):
Acyl-CoA thioester hydrolase 11
Adipose-associated thioesterase
Brown fat-inducible thioesterase
Short name:
BFIT
Gene namesi
Name:Acot11
Synonyms:Bfit, Thea
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913736. Acot11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Acyl-coenzyme A thioesterase 11PRO_0000053814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei25 – 251PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VHQ9.
MaxQBiQ8VHQ9.
PaxDbiQ8VHQ9.
PRIDEiQ8VHQ9.

PTM databases

iPTMnetiQ8VHQ9.
PhosphoSiteiQ8VHQ9.

Expressioni

Inductioni

By cold exposure and repressed by heat exposure.

Gene expression databases

BgeeiQ8VHQ9.
CleanExiMM_ACOT11.
ExpressionAtlasiQ8VHQ9. baseline and differential.
GenevisibleiQ8VHQ9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VHQ9. 2 interactions.
MINTiMINT-4137645.
STRINGi10090.ENSMUSP00000099823.

Structurei

3D structure databases

ProteinModelPortaliQ8VHQ9.
SMRiQ8VHQ9. Positions 48-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 157113HotDog ACOT-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini217 – 330114HotDog ACOT-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini370 – 582213STARTPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 953Coenzyme A bindingBy similarity
Regioni122 – 1243Coenzyme A bindingBy similarity
Regioni272 – 2743Coenzyme A bindingBy similarity

Sequence similaritiesi

Contains 2 HotDog ACOT-type domains.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2763. Eukaryota.
COG1607. LUCA.
GeneTreeiENSGT00760000119297.
HOGENOMiHOG000232032.
HOVERGENiHBG023847.
InParanoidiQ8VHQ9.
KOiK12417.
OrthoDBiEOG70CR6C.
PhylomeDBiQ8VHQ9.
TreeFamiTF328368.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
3.30.530.20. 1 hit.
InterProiIPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
IPR006683. Thioestr_dom.
[Graphical view]
PfamiPF03061. 4HBT. 2 hits.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 2 hits.
PROSITEiPS51770. HOTDOG_ACOT. 2 hits.
PS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQNVGNHLR RGFASMFSNR TSRKSISHPE SGDPPTMAEG EGYRNPTEVQ
60 70 80 90 100
MSQLVLPCHT NHRGELSIGQ LLKWIDTTAC LSAERHAGCP CVTASMDDIY
110 120 130 140 150
FDHTISVGQV VNIKAKVNRA FNSSMEVGIQ VVSEDLCSEK QWSVCKALAT
160 170 180 190 200
FVAHRELSKV KLKQVIPLTE EEKTEHGVAA ERRRMRLVYA DTIKDLLTHC
210 220 230 240 250
VIQDDLDKDC SNMVPAEKTR VESVELVLPP HANHQGNTFG GQIMAWMENV
260 270 280 290 300
ATIAASRLCH AHPTLKAIEM FHFRGPSQVG DRLVLKAIVN NAFKHSMEVG
310 320 330 340 350
VCVEAYRQEA ETQRRHINSA FMTFVVLDKD DQPQKLPWIR PQPGEGERRY
360 370 380 390 400
REASARKKIR LDRKYLVSCK QAEVALSVPW DPSNQVYLSY YNVSSLKTLM
410 420 430 440 450
AKDNWVLSVE ISEVRLYILE EDFLSFHLEM VVNVDAAQVF QLLSDLRRRP
460 470 480 490 500
EWDKHYRSVE LVQQVDEDDA IYHVISPALS GNTKPQDFVI LASRRKPCDN
510 520 530 540 550
GDPYVIALRS VTLPTHHETP EYQRGETLCS GFCLWREGDQ MTKVSYYNQA
560 570 580 590
TPGFLNYVTT NVSGLSSEFY NTFKACESFL LDNRNDLAPS LQTL
Length:594
Mass (Da):67,355
Last modified:March 1, 2002 - v1
Checksum:i9A51D3BCF38870C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416923 mRNA. Translation: AAL40939.1.
BC042492 mRNA. Translation: AAH42492.1.
CCDSiCCDS18426.1.
RefSeqiNP_079866.2. NM_025590.4.
UniGeneiMm.222956.

Genome annotation databases

EnsembliENSMUST00000102762; ENSMUSP00000099823; ENSMUSG00000034853.
GeneIDi329910.
KEGGimmu:329910.
UCSCiuc008tyv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416923 mRNA. Translation: AAL40939.1.
BC042492 mRNA. Translation: AAH42492.1.
CCDSiCCDS18426.1.
RefSeqiNP_079866.2. NM_025590.4.
UniGeneiMm.222956.

3D structure databases

ProteinModelPortaliQ8VHQ9.
SMRiQ8VHQ9. Positions 48-584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VHQ9. 2 interactions.
MINTiMINT-4137645.
STRINGi10090.ENSMUSP00000099823.

PTM databases

iPTMnetiQ8VHQ9.
PhosphoSiteiQ8VHQ9.

Proteomic databases

EPDiQ8VHQ9.
MaxQBiQ8VHQ9.
PaxDbiQ8VHQ9.
PRIDEiQ8VHQ9.

Protocols and materials databases

DNASUi329910.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102762; ENSMUSP00000099823; ENSMUSG00000034853.
GeneIDi329910.
KEGGimmu:329910.
UCSCiuc008tyv.2. mouse.

Organism-specific databases

CTDi26027.
MGIiMGI:1913736. Acot11.

Phylogenomic databases

eggNOGiKOG2763. Eukaryota.
COG1607. LUCA.
GeneTreeiENSGT00760000119297.
HOGENOMiHOG000232032.
HOVERGENiHBG023847.
InParanoidiQ8VHQ9.
KOiK12417.
OrthoDBiEOG70CR6C.
PhylomeDBiQ8VHQ9.
TreeFamiTF328368.

Enzyme and pathway databases

ReactomeiR-MMU-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

PROiQ8VHQ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHQ9.
CleanExiMM_ACOT11.
ExpressionAtlasiQ8VHQ9. baseline and differential.
GenevisibleiQ8VHQ9. MM.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
3.30.530.20. 1 hit.
InterProiIPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
IPR006683. Thioestr_dom.
[Graphical view]
PfamiPF03061. 4HBT. 2 hits.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 2 hits.
PROSITEiPS51770. HOTDOG_ACOT. 2 hits.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity."
    Adams S.H., Chui C., Schilbach S.L., Yu X.X., Goddard A.D., Grimaldi J.C., Lee J., Dowd P., Colman S., Lewin D.A.
    Biochem. J. 360:135-142(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney and Lung.

Entry informationi

Entry nameiACO11_MOUSE
AccessioniPrimary (citable) accession number: Q8VHQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.