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Protein

Ras-related protein Rab-40C

Gene

Rab40c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288GTPBy similarity
Nucleotide bindingi69 – 735GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-40C
Alternative name(s):
SOCS box-containing protein RAR3
Gene namesi
Name:Rab40c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2183454. Rab40c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Ras-related protein Rab-40CPRO_0000121262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi273 – 2731S-palmitoyl cysteineSequence analysis
Lipidationi278 – 2781S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate, Prenylation

Proteomic databases

MaxQBiQ8VHQ4.
PaxDbiQ8VHQ4.
PRIDEiQ8VHQ4.

PTM databases

iPTMnetiQ8VHQ4.
PhosphoSiteiQ8VHQ4.

Expressioni

Gene expression databases

BgeeiQ8VHQ4.
CleanExiMM_RAB40C.
ExpressionAtlasiQ8VHQ4. baseline and differential.
GenevisibleiQ8VHQ4. MM.

Interactioni

Subunit structurei

Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, TCEB1 and TCEB2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi230291. 1 interaction.
IntActiQ8VHQ4. 17 interactions.
STRINGi10090.ENSMUSP00000026826.

Structurei

3D structure databases

ProteinModelPortaliQ8VHQ4.
SMRiQ8VHQ4. Positions 9-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 22854SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
GeneTreeiENSGT00840000129698.
HOGENOMiHOG000233967.
HOVERGENiHBG009351.
InParanoidiQ8VHQ4.
KOiK07928.
OMAiFCSGNDC.
PhylomeDBiQ8VHQ4.
TreeFamiTF323230.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID
60 70 80 90 100
YKTTTILLDG RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW
110 120 130 140 150
SFDGIDRWIK EIDEHAPGVP RILVGNRLHL AFKRQVPTEQ ARAYAEKNCM
160 170 180 190 200
TFFEVSPLCN FNVIESFTEL SRIVLMRHGM EKIWRPNRVF SLQDLCCRAI
210 220 230 240 250
VSCTPVHLID KLPLPVTIKS HLKSFSMANG MNAVMMHGRS YSLASGAGGS
260 270 280
GSKGNSLKRS KSIRPPQSPP QNCSRSNCKI S
Length:281
Mass (Da):31,348
Last modified:March 1, 2002 - v1
Checksum:i3625546777BA90A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF422144 mRNA. Translation: AAL60515.1.
BC027008 mRNA. Translation: AAH27008.1.
CCDSiCCDS28537.1.
RefSeqiNP_631893.1. NM_139154.2.
UniGeneiMm.328872.

Genome annotation databases

EnsembliENSMUST00000026826; ENSMUSP00000026826; ENSMUSG00000025730.
ENSMUST00000167626; ENSMUSP00000127546; ENSMUSG00000025730.
ENSMUST00000179998; ENSMUSP00000136612; ENSMUSG00000025730.
GeneIDi224624.
KEGGimmu:224624.
UCSCiuc008bco.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF422144 mRNA. Translation: AAL60515.1.
BC027008 mRNA. Translation: AAH27008.1.
CCDSiCCDS28537.1.
RefSeqiNP_631893.1. NM_139154.2.
UniGeneiMm.328872.

3D structure databases

ProteinModelPortaliQ8VHQ4.
SMRiQ8VHQ4. Positions 9-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230291. 1 interaction.
IntActiQ8VHQ4. 17 interactions.
STRINGi10090.ENSMUSP00000026826.

PTM databases

iPTMnetiQ8VHQ4.
PhosphoSiteiQ8VHQ4.

Proteomic databases

MaxQBiQ8VHQ4.
PaxDbiQ8VHQ4.
PRIDEiQ8VHQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026826; ENSMUSP00000026826; ENSMUSG00000025730.
ENSMUST00000167626; ENSMUSP00000127546; ENSMUSG00000025730.
ENSMUST00000179998; ENSMUSP00000136612; ENSMUSG00000025730.
GeneIDi224624.
KEGGimmu:224624.
UCSCiuc008bco.2. mouse.

Organism-specific databases

CTDi57799.
MGIiMGI:2183454. Rab40c.

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
GeneTreeiENSGT00840000129698.
HOGENOMiHOG000233967.
HOVERGENiHBG009351.
InParanoidiQ8VHQ4.
KOiK07928.
OMAiFCSGNDC.
PhylomeDBiQ8VHQ4.
TreeFamiTF323230.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiRab40c. mouse.
PROiQ8VHQ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHQ4.
CleanExiMM_RAB40C.
ExpressionAtlasiQ8VHQ4. baseline and differential.
GenevisibleiQ8VHQ4. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kile B.T., Hilton D.J., Nicola N.A.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiRB40C_MOUSE
AccessioniPrimary (citable) accession number: Q8VHQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.