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Protein

Suppressor of cytokine signaling 7

Gene

Socs7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • cerebral cortex radially oriented cell migration Source: MGI
  • cytokine-mediated signaling pathway Source: GO_Central
  • fat cell differentiation Source: MGI
  • insulin receptor signaling pathway Source: MGI
  • intracellular signal transduction Source: InterPro
  • layer formation in cerebral cortex Source: MGI
  • negative regulation of JAK-STAT cascade Source: GO_Central
  • negative regulation of protein kinase activity Source: GO_Central
  • protein ubiquitination Source: MGI
  • radial glia guided migration of Purkinje cell Source: MGI
  • regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 7
Short name:
SOCS-7
Gene namesi
Name:Socs7
Synonyms:Cish7, Nap4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2651588. Socs7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are smaller and half of them develop fatal hydrocephalus between 3 to 15 weeks of age. They display subtle alterations in glucose homeostasis with an enhanced response to insulin which causes hypoglycemia. Pancreatic islets become progressively larger.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Suppressor of cytokine signaling 7PRO_0000181254Add
BLAST

Proteomic databases

MaxQBiQ8VHQ2.
PaxDbiQ8VHQ2.
PeptideAtlasiQ8VHQ2.
PRIDEiQ8VHQ2.

PTM databases

iPTMnetiQ8VHQ2.
PhosphoSiteiQ8VHQ2.

Expressioni

Tissue specificityi

Widely expressed with higher expression in brain and testis where it is expressed by spermatocytes and early spermatids. Also significantly expressed in spleen, skeletal muscle and kidney.3 Publications

Developmental stagei

Ubiquitously expressed at low level in 12.5 dpc and 15.5 dpc embryos. More significantly expressed in the nervous system at 12.5 dpc and the cortical plate at 15.5 dpc. Expressed in the brain postnatally in particular in the hippocampal formation and the medial habenular nuclei at P7. Low-level expression in other brain areas was present at P7 and was reduced to very low levels at P14 and P21. The hippocampal granule cell layer and the cerebellar granular layer maintained moderate expression levels at P7, P14, and P21.1 Publication

Gene expression databases

BgeeiQ8VHQ2.
CleanExiMM_SOCS7.
GenevisibleiQ8VHQ2. MM.

Interactioni

Subunit structurei

Interacts with phosphorylated IRS4 and PIK3R1. Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin and phosphorylated STAT3 and STAT5 (By similarity). Interacts with SEPT6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi228649. 4 interactions.
IntActiQ8VHQ2. 1 interaction.
MINTiMINT-2577282.
STRINGi10090.ENSMUSP00000040896.

Structurei

3D structure databases

ProteinModelPortaliQ8VHQ2.
SMRiQ8VHQ2. Positions 383-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 507110SH2PROSITE-ProRule annotationAdd
BLAST
Domaini502 – 55251SOCS boxPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 492369Mediates interaction with SORBS3By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi82 – 202121Pro-richAdd
BLAST
Compositional biasi84 – 9714Poly-ProAdd
BLAST
Compositional biasi141 – 1499Poly-Gly
Compositional biasi181 – 1855Poly-Gln
Compositional biasi186 – 19510Poly-Pro
Compositional biasi301 – 38181Pro-richAdd
BLAST
Compositional biasi301 – 31010Poly-Pro
Compositional biasi341 – 3488Poly-Pro

Domaini

The SOCS box domain is required for IRS1 ubiquitination and subsequent proteasomal degradation.By similarity
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000035093.
HOVERGENiHBG079201.
InParanoidiQ8VHQ2.
KOiK04699.
OMAiFPMQDLV.
OrthoDBiEOG7SXW3G.
PhylomeDBiQ8VHQ2.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028423. SOCS7.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF82. PTHR24369:SF82. 3 hits.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFRNVGRPP EEEDAEAARE PGPSELLCPR HRCALDPKAL PPGLALERTW
60 70 80 90 100
GPVAGLEAQL AALGLGQPAG PGIKTAGGGC CPCPCPPQPP PPQPPPPAAA
110 120 130 140 150
PQAGEDPTET SDALLVLEGL ESEAESLETN SCSEEELSSP GRGGGGVGGR
160 170 180 190 200
LLLQPPGPEL PPVPFPLQDL VPPGRLSRGE QQQQQPPPPP PPPGPLRPLA
210 220 230 240 250
GPSRKGSFKI RLSRLFRTKS CNGGSGGGDG TGKRPSGDLA ASAASLTDMG
260 270 280 290 300
GSAVRELDTG RKPRLTRTQS AFSPVSFSPL FTGETVSLVD VDISQRGLTS
310 320 330 340 350
PHPPTPPPPP RRSLSLLDDI SGTLPTSVLV APMGSSLQSF PLPPPPPPHA
360 370 380 390 400
PDAFPRIAPI RASESLHSQP PQHLQCPLYR PDSSSFAASL RELEKCGWYW
410 420 430 440 450
GPMNWEDAEM KLKGKPDGSF LVRDSSDPRY ILSLSFRSQG ITHHTRMEHY
460 470 480 490 500
RGTFSLWCHP KFEDRCQSVV EFIKRAIMHS KNGKFLYFLR SRVPGLPPTP
510 520 530 540 550
VQLLYPVSRF SNVKSLQHLC RFRIRQLVRI DHIPDLPLPK PLISYIRKFY
560 570
YYDPQEEVYL SLKEAQLISK QKQEVEPST
Length:579
Mass (Da):62,784
Last modified:March 1, 2002 - v1
Checksum:iFAB66BF2A0BE685A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424814 mRNA. Translation: AAL60516.1.
AK147580 mRNA. Translation: BAE28006.1.
AK147650 mRNA. Translation: BAE28049.1.
AL596088 Genomic DNA. Translation: CAM15701.1.
CCDSiCCDS25319.1.
RefSeqiNP_619598.1. NM_138657.3.
UniGeneiMm.34339.

Genome annotation databases

EnsembliENSMUST00000045540; ENSMUSP00000040896; ENSMUSG00000038485.
GeneIDi192157.
KEGGimmu:192157.
UCSCiuc007lea.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424814 mRNA. Translation: AAL60516.1.
AK147580 mRNA. Translation: BAE28006.1.
AK147650 mRNA. Translation: BAE28049.1.
AL596088 Genomic DNA. Translation: CAM15701.1.
CCDSiCCDS25319.1.
RefSeqiNP_619598.1. NM_138657.3.
UniGeneiMm.34339.

3D structure databases

ProteinModelPortaliQ8VHQ2.
SMRiQ8VHQ2. Positions 383-551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228649. 4 interactions.
IntActiQ8VHQ2. 1 interaction.
MINTiMINT-2577282.
STRINGi10090.ENSMUSP00000040896.

PTM databases

iPTMnetiQ8VHQ2.
PhosphoSiteiQ8VHQ2.

Proteomic databases

MaxQBiQ8VHQ2.
PaxDbiQ8VHQ2.
PeptideAtlasiQ8VHQ2.
PRIDEiQ8VHQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045540; ENSMUSP00000040896; ENSMUSG00000038485.
GeneIDi192157.
KEGGimmu:192157.
UCSCiuc007lea.1. mouse.

Organism-specific databases

CTDi30837.
MGIiMGI:2651588. Socs7.

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000035093.
HOVERGENiHBG079201.
InParanoidiQ8VHQ2.
KOiK04699.
OMAiFPMQDLV.
OrthoDBiEOG7SXW3G.
PhylomeDBiQ8VHQ2.
TreeFamiTF321368.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiSocs7. mouse.
PROiQ8VHQ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHQ2.
CleanExiMM_SOCS7.
GenevisibleiQ8VHQ2. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028423. SOCS7.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF82. PTHR24369:SF82. 3 hits.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hilton D.J., Viney E.M., Alexander W.S., Willson T.A., Nicola N.A.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Cited for: INTERACTION WITH IRS4 AND PIK3R1, TISSUE SPECIFICITY.
  5. "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin."
    Martens N., Wery M., Wang P., Braet F., Gertler A., Hooghe R., Vandenhaute J., Hooghe-Peters E.L.
    Exp. Cell Res. 298:239-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  7. "Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans."
    Banks A.S., Li J., McKeag L., Hribal M.L., Kashiwada M., Accili D., Rothman P.B.
    J. Clin. Invest. 115:2462-2471(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSOCS7_MOUSE
AccessioniPrimary (citable) accession number: Q8VHQ2
Secondary accession number(s): B1AQY1, Q3UH08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.