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Protein

Cadherin-related family member 1

Gene

Cdhr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells.

GO - Molecular functioni

GO - Biological processi

  • cellular process Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • photoreceptor cell maintenance Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-related family member 1
Alternative name(s):
Photoreceptor cadherin
Short name:
prCAD
Protocadherin-21
Gene namesi
Name:Cdhr1
Synonyms:Kiaa1775, Pcdh21, Prcad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2157782. Cdhr1.

Subcellular locationi

  • Cell membrane Curated; Single-pass membrane protein Curated

  • Note: Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 701680ExtracellularSequence analysisAdd
BLAST
Transmembranei702 – 72221HelicalSequence analysisAdd
BLAST
Topological domaini723 – 859137CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • photoreceptor outer segment membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice have no obvious phenotype but show photoreceptor cell death as early as 1 month of age shortly after completion of retinal development. Its absence severely compromises the structure of OS which are disorganized and fragmented, but the consequences on photoreceptor electrical signaling are very mild. Proteolytic cleavage is partially inhibited in the absence of orderly OS assembly in mouse retinas lacking RDS/peripherin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 859838Cadherin-related family member 1PRO_0000318499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Undergoes proteolytic cleavage; produces a soluble 95 kDa N-terminal fragment and a 25 kDa cell-associated C-terminal fragment.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8VHP6.
PaxDbiQ8VHP6.
PRIDEiQ8VHP6.

PTM databases

PhosphoSiteiQ8VHP6.

Expressioni

Tissue specificityi

Expressed in cone and rod photoreceptor cells (at protein level). Expressed in photoreceptor cells of the outer nuclear layer of the retina. Expressed in mitral and tufted cells in the olfactory bulb.3 Publications

Gene expression databases

BgeeiQ8VHP6.
CleanExiMM_PCDH21.
GenevisibleiQ8VHP6. MM.

Interactioni

Subunit structurei

Interacts with PROM1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PROM1O434903EBI-4395045,EBI-3447549From a different organism.

Protein-protein interaction databases

IntActiQ8VHP6. 1 interaction.
STRINGi10090.ENSMUSP00000022337.

Structurei

3D structure databases

ProteinModelPortaliQ8VHP6.
SMRiQ8VHP6. Positions 23-679.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 135100Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 247112Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini248 – 354107Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini360 – 473114Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini474 – 577104Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini569 – 691123Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi789 – 82941Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129706.
HOGENOMiHOG000082675.
HOVERGENiHBG101964.
InParanoidiQ8VHP6.
KOiK16501.
OMAiYELHVQV.
OrthoDBiEOG7QRQT4.
PhylomeDBiQ8VHP6.
TreeFamiTF332908.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGPRVALV LGLLRIYLAQ ANFAPHFFDN GVGSTNGNMA LFSLPEDTPV
60 70 80 90 100
GSHVYTLNGT DPEGDPISYH ISFDPSTRSV FSVDPNFGNI TLVEELDRER
110 120 130 140 150
EDEIEAIISI SDGLNLVAEK VVILVTDAND EAPRFIQEPY IIRVPENIPA
160 170 180 190 200
GSSIFKVQAE DKDTGSGGSV TYSLQNLHSS KFSMDRHSGV LRLQAGATLD
210 220 230 240 250
YEKSRAHYIT VIAKDGGGRL RGADMVFSAT TTVTINVEDV QDTAPIFVGT
260 270 280 290 300
PYYGYVYEDT LPGSEVLTVV AIDGDRGKPN HILYRLLNES DGIFEINETS
310 320 330 340 350
GAISVLQSPA LLRREVYELH VQVTEVNSPG SPAAQATVPV TIRIVDLNNH
360 370 380 390 400
PPTFYGESGP QNKFELSMFE HPPQGEILRG LKITVNDSDQ GANAKFNLRL
410 420 430 440 450
VGPGGIFRVV PQTVLNEAQV TIIVENSAAI DFEKSKLLTF KLLAIEVNTP
460 470 480 490 500
EKFSSTADIV IQLLDTNDNV PKFTSHYYIA RIPENAPGGS NVVAVTAVDP
510 520 530 540 550
DTGPWGKVHY SIYGTGSDLF LIHPSTGLIY TQPWASLDAE GTSRYNFYVK
560 570 580 590 600
AEDMDGRYSL AEVFVTLLDV NDHYPQFVQS VQEKTMVLGT PLKIEATDQD
610 620 630 640 650
AEEPNNLVDY SITRAEPVNV FDIDAHTGEI RLKNSIRSLE ALHNITPSGD
660 670 680 690 700
YSWSLQVQAK DRGSPSFSTT ALLKIDITDT ERLSRGSMAA FLIQTKDNPM
710 720 730 740 750
KAVGVLAGVM AIVVAITVLI STATFWRNKK SNKVLPVRRV LRRRPSPAPH
760 770 780 790 800
TVRIEWLKFR RAKAATKFIL KEDSPNENCN NSRVGVMVPP RAPALPPPPK
810 820 830 840 850
MASSMVAQQT VPTVSGSLTP QPSPQLPTPK TLGGPVQSSL VSELKQKFEK

KSLDNKAYI
Length:859
Mass (Da):94,028
Last modified:March 1, 2002 - v1
Checksum:i6D2BFFD9613325E9
GO

Sequence cautioni

The sequence BAC41482.1 differs from that shown.Partially unspliced pre-RNA.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti578 – 5792Missing in BAC41482 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426393 mRNA. Translation: AAL65140.1.
BC042454 mRNA. Translation: AAH42454.2.
BC058270 mRNA. Translation: AAH58270.1.
AB093300 Transcribed RNA. Translation: BAC41482.1. Sequence problems.
CCDSiCCDS26952.1.
RefSeqiNP_570948.1. NM_130878.2.
UniGeneiMm.156506.

Genome annotation databases

EnsembliENSMUST00000022337; ENSMUSP00000022337; ENSMUSG00000021803.
GeneIDi170677.
KEGGimmu:170677.
UCSCiuc007tbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426393 mRNA. Translation: AAL65140.1.
BC042454 mRNA. Translation: AAH42454.2.
BC058270 mRNA. Translation: AAH58270.1.
AB093300 Transcribed RNA. Translation: BAC41482.1. Sequence problems.
CCDSiCCDS26952.1.
RefSeqiNP_570948.1. NM_130878.2.
UniGeneiMm.156506.

3D structure databases

ProteinModelPortaliQ8VHP6.
SMRiQ8VHP6. Positions 23-679.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VHP6. 1 interaction.
STRINGi10090.ENSMUSP00000022337.

PTM databases

PhosphoSiteiQ8VHP6.

Proteomic databases

MaxQBiQ8VHP6.
PaxDbiQ8VHP6.
PRIDEiQ8VHP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022337; ENSMUSP00000022337; ENSMUSG00000021803.
GeneIDi170677.
KEGGimmu:170677.
UCSCiuc007tbu.1. mouse.

Organism-specific databases

CTDi92211.
MGIiMGI:2157782. Cdhr1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129706.
HOGENOMiHOG000082675.
HOVERGENiHBG101964.
InParanoidiQ8VHP6.
KOiK16501.
OMAiYELHVQV.
OrthoDBiEOG7QRQT4.
PhylomeDBiQ8VHP6.
TreeFamiTF332908.

Miscellaneous databases

ChiTaRSiCdhr1. mouse.
NextBioi370204.
PROiQ8VHP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHP6.
CleanExiMM_PCDH21.
GenevisibleiQ8VHP6. MM.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival."
    Rattner A., Smallwood P.M., Williams J., Cooke C., Savchenko A., Lyubarsky A., Pugh E.N., Nathans J.
    Neuron 32:775-786(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: 129.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-859.
    Tissue: Brain.
  4. "Proteolytic shedding of the extracellular domain of photoreceptor cadherin. Implications for outer segment assembly."
    Rattner A., Chen J., Nathans J.
    J. Biol. Chem. 279:42202-42210(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Transgenic expression of Cre recombinase in mitral/tufted cells of the olfactory bulb."
    Nagai Y., Sano H., Yokoi M.
    Genesis 43:12-16(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCDHR1_MOUSE
AccessioniPrimary (citable) accession number: Q8VHP6
Secondary accession number(s): Q8CFQ4, Q8CH99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.