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Protein

Cadherin-related family member 1

Gene

Cdhr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells.

GO - Molecular functioni

GO - Biological processi

  • cellular process Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • photoreceptor cell maintenance Source: MGI
  • photoreceptor cell morphogenesis Source: MGI
  • photoreceptor cell outer segment organization Source: MGI

Keywordsi

Molecular functionReceptor
Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-related family member 1
Alternative name(s):
Photoreceptor cadherin
Short name:
prCAD
Protocadherin-21
Gene namesi
Name:Cdhr1
Synonyms:Kiaa1775, Pcdh21, Prcad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2157782 Cdhr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 701ExtracellularSequence analysisAdd BLAST680
Transmembranei702 – 722HelicalSequence analysisAdd BLAST21
Topological domaini723 – 859CytoplasmicSequence analysisAdd BLAST137

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice have no obvious phenotype but show photoreceptor cell death as early as 1 month of age shortly after completion of retinal development. Its absence severely compromises the structure of OS which are disorganized and fragmented, but the consequences on photoreceptor electrical signaling are very mild. Proteolytic cleavage is partially inhibited in the absence of orderly OS assembly in mouse retinas lacking RDS/peripherin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031849922 – 859Cadherin-related family member 1Add BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Undergoes proteolytic cleavage; produces a soluble 95 kDa N-terminal fragment and a 25 kDa cell-associated C-terminal fragment.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VHP6
PRIDEiQ8VHP6

PTM databases

iPTMnetiQ8VHP6
PhosphoSitePlusiQ8VHP6

Expressioni

Tissue specificityi

Expressed in cone and rod photoreceptor cells (at protein level). Expressed in photoreceptor cells of the outer nuclear layer of the retina. Expressed in mitral and tufted cells in the olfactory bulb.3 Publications

Gene expression databases

BgeeiENSMUSG00000021803
CleanExiMM_PCDH21
GenevisibleiQ8VHP6 MM

Interactioni

Subunit structurei

Interacts with PROM1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PROM1O434903EBI-4395045,EBI-3447549From Homo sapiens.

Protein-protein interaction databases

IntActiQ8VHP6 1 interactor.
STRINGi10090.ENSMUSP00000022337

Structurei

3D structure databases

ProteinModelPortaliQ8VHP6
SMRiQ8VHP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 135Cadherin 1PROSITE-ProRule annotationAdd BLAST100
Domaini136 – 247Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini248 – 354Cadherin 3PROSITE-ProRule annotationAdd BLAST107
Domaini360 – 473Cadherin 4PROSITE-ProRule annotationAdd BLAST114
Domaini474 – 577Cadherin 5PROSITE-ProRule annotationAdd BLAST104
Domaini569 – 691Cadherin 6PROSITE-ProRule annotationAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi789 – 829Pro-richAdd BLAST41

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144087
HOGENOMiHOG000082675
HOVERGENiHBG101964
InParanoidiQ8VHP6
KOiK16501
OMAiYELHVQV
OrthoDBiEOG091G02DT
PhylomeDBiQ8VHP6
TreeFamiTF332908

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGPRVALV LGLLRIYLAQ ANFAPHFFDN GVGSTNGNMA LFSLPEDTPV
60 70 80 90 100
GSHVYTLNGT DPEGDPISYH ISFDPSTRSV FSVDPNFGNI TLVEELDRER
110 120 130 140 150
EDEIEAIISI SDGLNLVAEK VVILVTDAND EAPRFIQEPY IIRVPENIPA
160 170 180 190 200
GSSIFKVQAE DKDTGSGGSV TYSLQNLHSS KFSMDRHSGV LRLQAGATLD
210 220 230 240 250
YEKSRAHYIT VIAKDGGGRL RGADMVFSAT TTVTINVEDV QDTAPIFVGT
260 270 280 290 300
PYYGYVYEDT LPGSEVLTVV AIDGDRGKPN HILYRLLNES DGIFEINETS
310 320 330 340 350
GAISVLQSPA LLRREVYELH VQVTEVNSPG SPAAQATVPV TIRIVDLNNH
360 370 380 390 400
PPTFYGESGP QNKFELSMFE HPPQGEILRG LKITVNDSDQ GANAKFNLRL
410 420 430 440 450
VGPGGIFRVV PQTVLNEAQV TIIVENSAAI DFEKSKLLTF KLLAIEVNTP
460 470 480 490 500
EKFSSTADIV IQLLDTNDNV PKFTSHYYIA RIPENAPGGS NVVAVTAVDP
510 520 530 540 550
DTGPWGKVHY SIYGTGSDLF LIHPSTGLIY TQPWASLDAE GTSRYNFYVK
560 570 580 590 600
AEDMDGRYSL AEVFVTLLDV NDHYPQFVQS VQEKTMVLGT PLKIEATDQD
610 620 630 640 650
AEEPNNLVDY SITRAEPVNV FDIDAHTGEI RLKNSIRSLE ALHNITPSGD
660 670 680 690 700
YSWSLQVQAK DRGSPSFSTT ALLKIDITDT ERLSRGSMAA FLIQTKDNPM
710 720 730 740 750
KAVGVLAGVM AIVVAITVLI STATFWRNKK SNKVLPVRRV LRRRPSPAPH
760 770 780 790 800
TVRIEWLKFR RAKAATKFIL KEDSPNENCN NSRVGVMVPP RAPALPPPPK
810 820 830 840 850
MASSMVAQQT VPTVSGSLTP QPSPQLPTPK TLGGPVQSSL VSELKQKFEK

KSLDNKAYI
Length:859
Mass (Da):94,028
Last modified:March 1, 2002 - v1
Checksum:i6D2BFFD9613325E9
GO

Sequence cautioni

The sequence BAC41482 differs from that shown. Partially unspliced pre-RNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti578 – 579Missing in BAC41482 (Ref. 3) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426393 mRNA Translation: AAL65140.1
BC042454 mRNA Translation: AAH42454.2
BC058270 mRNA Translation: AAH58270.1
AB093300 Transcribed RNA Translation: BAC41482.1 Sequence problems.
CCDSiCCDS26952.1
RefSeqiNP_570948.1, NM_130878.2
UniGeneiMm.156506

Genome annotation databases

EnsembliENSMUST00000022337; ENSMUSP00000022337; ENSMUSG00000021803
GeneIDi170677
KEGGimmu:170677
UCSCiuc007tbu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCDHR1_MOUSE
AccessioniPrimary (citable) accession number: Q8VHP6
Secondary accession number(s): Q8CFQ4, Q8CH99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome