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Protein

G-protein coupled receptor 98

Gene

Gpr98

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that may have an important role in the development of the central nervous system.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB
  • myosin binding Source: MGI

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • cellular response to calcium ion Source: MGI
  • detection of mechanical stimulus involved in sensory perception of sound Source: MGI
  • establishment of protein localization Source: MGI
  • inner ear development Source: MGI
  • inner ear receptor stereocilium organization Source: MGI
  • maintenance of organ identity Source: MGI
  • nervous system development Source: UniProtKB
  • neurological system process Source: MGI
  • photoreceptor cell maintenance Source: MGI
  • positive regulation of protein kinase A signaling Source: MGI
  • sensory perception of light stimulus Source: MGI
  • sensory perception of sound Source: MGI
  • single organismal cell-cell adhesion Source: UniProtKB
  • visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 98
Alternative name(s):
Monogenic audiogenic seizure susceptibility protein 1
Neurepin
Very large G-protein coupled receptor 1
Gene namesi
Name:Gpr98
Synonyms:Kiaa0686, Mass1, Vlgr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1274784. Gpr98.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 59015873ExtracellularSequence analysisAdd
BLAST
Transmembranei5902 – 592221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini5923 – 593210CytoplasmicSequence analysis
Transmembranei5933 – 595321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini5954 – 597320ExtracellularSequence analysisAdd
BLAST
Transmembranei5974 – 599421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini5995 – 60039CytoplasmicSequence analysis
Transmembranei6004 – 602421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini6025 – 605228ExtracellularSequence analysisAdd
BLAST
Transmembranei6053 – 607321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini6074 – 609724CytoplasmicSequence analysisAdd
BLAST
Transmembranei6098 – 611821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini6119 – 61268ExtracellularSequence analysis
Transmembranei6127 – 614721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini6148 – 6298151CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • periciliary membrane compartment Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • photoreceptor connecting cilium Source: MGI
  • plasma membrane Source: MGI
  • receptor complex Source: MGI
  • stereocilia ankle link Source: MGI
  • stereocilia ankle link complex Source: MGI
  • USH2 complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice display audiogenic epilepsy. Audiogenic epilepsy syndrome is an autosomal recessive mutation, characterized by generalized self-sustained convulsive seizures in which acoustics stimulations evoke wild running, tonic flexion and extesion pigmentosa with sensorineural deafness. They are induced by exposing animals to a loud noise during the early stages of their development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 62986270G-protein coupled receptor 98PRO_0000232736Add
BLAST

Proteomic databases

MaxQBiQ8VHN7.
PaxDbiQ8VHN7.
PRIDEiQ8VHN7.

PTM databases

iPTMnetiQ8VHN7.
PhosphoSiteiQ8VHN7.

Expressioni

Developmental stagei

High level expression restricted to the developing central nervous system and eye. At mid-gestation expression is prominent in the ventricular zone and in the eye. At late gestation expression declines.1 Publication

Gene expression databases

BgeeiENSMUSG00000069170.
CleanExiMM_GPR98.
ExpressionAtlasiQ8VHN7. baseline and differential.

Interactioni

Subunit structurei

Interacts with WHRN. Interacts with PDZD7 (By similarity).By similarity

GO - Molecular functioni

  • myosin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093245.

Structurei

3D structure databases

ProteinModelPortaliQ8VHN7.
SMRiQ8VHN7. Positions 34-258, 260-488, 1025-1185, 1622-2307, 2491-2781, 2871-3145, 3579-3723, 3824-4002, 4196-4505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11688Calx-beta 1Sequence analysisAdd
BLAST
Domaini132 – 236105Calx-beta 2Sequence analysisAdd
BLAST
Domaini251 – 362112Calx-beta 3Sequence analysisAdd
BLAST
Domaini389 – 489101Calx-beta 4CuratedAdd
BLAST
Domaini646 – 746101Calx-beta 5CuratedAdd
BLAST
Domaini764 – 86299Calx-beta 6Sequence analysisAdd
BLAST
Domaini877 – 980104Calx-beta 7Sequence analysisAdd
BLAST
Domaini994 – 1094101Calx-beta 8Sequence analysisAdd
BLAST
Domaini1108 – 1208101Calx-beta 9CuratedAdd
BLAST
Domaini1440 – 1540101Calx-beta 10CuratedAdd
BLAST
Domaini1562 – 1662101Calx-beta 11CuratedAdd
BLAST
Domaini1706 – 1805100Calx-beta 12Sequence analysisAdd
BLAST
Domaini1846 – 1948103Calx-beta 13Sequence analysisAdd
BLAST
Domaini1962 – 2075114Calx-beta 14Sequence analysisAdd
BLAST
Domaini2103 – 2202100Calx-beta 15Sequence analysisAdd
BLAST
Domaini2218 – 2320103Calx-beta 16Sequence analysisAdd
BLAST
Domaini2437 – 2537101Calx-beta 17CuratedAdd
BLAST
Domaini2576 – 267297Calx-beta 18Sequence analysisAdd
BLAST
Domaini2687 – 2786100Calx-beta 19Sequence analysisAdd
BLAST
Domaini2810 – 2921112Calx-beta 20Sequence analysisAdd
BLAST
Domaini2945 – 3044100Calx-beta 21Sequence analysisAdd
BLAST
Domaini3067 – 3167101Calx-beta 22CuratedAdd
BLAST
Repeati3185 – 323753EAR 1Add
BLAST
Repeati3292 – 334150EAR 2Add
BLAST
Repeati3343 – 338947EAR 3Add
BLAST
Repeati3390 – 343546EAR 4Add
BLAST
Repeati3436 – 348449EAR 5Add
BLAST
Repeati3487 – 353044EAR 6Add
BLAST
Domaini3581 – 362242Calx-beta 23Sequence analysisAdd
BLAST
Domaini3636 – 3736101Calx-beta 24CuratedAdd
BLAST
Domaini3772 – 3872101Calx-beta 25CuratedAdd
BLAST
Domaini3919 – 400385Calx-beta 26Sequence analysisAdd
BLAST
Domaini4017 – 4120104Calx-beta 27Sequence analysisAdd
BLAST
Domaini4135 – 4235101Calx-beta 28CuratedAdd
BLAST
Domaini4251 – 4351101Calx-beta 29Sequence analysisAdd
BLAST
Domaini4384 – 4484101Calx-beta 30Sequence analysisAdd
BLAST
Domaini4507 – 4607101Calx-beta 31CuratedAdd
BLAST
Domaini4628 – 4728101Calx-beta 32CuratedAdd
BLAST
Domaini4989 – 5089101Calx-beta 33Sequence analysisAdd
BLAST
Domaini5281 – 532545Calx-beta 34Sequence analysisAdd
BLAST
Domaini5361 – 5461101Calx-beta 35CuratedAdd
BLAST
Domaini5846 – 589550GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 35 Calx-beta domains.Curated
Contains 6 EAR repeats.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDV8. Eukaryota.
ENOG410XT0U. LUCA.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000088618.
HOVERGENiHBG081572.
InParanoidiQ8VHN7.
PhylomeDBiQ8VHN7.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR003644. Calx_beta.
IPR013320. ConA-like_dom.
IPR009039. EAR.
IPR005492. EPTP.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR026919. GPR98.
IPR000203. GPS.
IPR006558. LamG-like.
[Graphical view]
PANTHERiPTHR11878:SF20. PTHR11878:SF20. 8 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF03160. Calx-beta. 37 hits.
PF03736. EPTP. 1 hit.
[Graphical view]
SMARTiSM00237. Calx_beta. 20 hits.
SM00560. LamGL. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50912. EAR. 6 hits.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VHN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSVTSEPGMI SSFLLVYLST LFISFVFGEA EIRFTGQTEF FVNETSTTVI
60 70 80 90 100
RLVIERIGEP ANVTAIVSLS GEDTGDFFDT YAAAFIPARG TNRTVYIAVC
110 120 130 140 150
DDDLPEPDET FTFHLTLQKP SANVKLGWPR AASVTILSND NAFGIISFST
160 170 180 190 200
PSSISVIEPR SRNASVPLTL IREKGTYGMV TVTFDVSGGP NPPEEDLNPV
210 220 230 240 250
RGNITFPPGR ATVIYNVTVL DDEVPENDEL FLIQLRSVEG GAEINASRSS
260 270 280 290 300
VEIIVKKNDS PVNFMQSVYV VPEDDHVLTI PVLRGKDSDG NLIGSDETQV
310 320 330 340 350
SIRYKVMTWD STAHAQQNVD FIDLQPDTTL VFPPFVHESH LKFQIIDDLI
360 370 380 390 400
PEIAESFHIM LLKNTLQGDA VLMGPSTVQV TIKPNDKPYG VLSFNSILFE
410 420 430 440 450
RPVIIDEDTA SSSRFEEIAV VRNGGTHGNV SVSWVLTRNS SDPSPVTADI
460 470 480 490 500
TPASGTLQFA QGQMLAPISL VVFDDDLPEE AEAYLLTILP HTIQGGAEVS
510 520 530 540 550
EPAQLLFYIQ DSDNVYGEIA FFPGESQKIE SSPSERSLSL SLARRGGSKG
560 570 580 590 600
DVRVIYSALY IPAGAMDPLR AKDGILNTSR RSSLLFPEQN QQVSIKLPIR
610 620 630 640 650
NDAFLQNGAH FLVQLEAVVL VNIFPPIPPV SPRFGEIRNI SLLVTPAIAN
660 670 680 690 700
GEIGFLSNLP IILHEPKDSS AEVVSIPLHR DGTDGQATVY WSLRPSGFNS
710 720 730 740 750
KAVTLDDAGP FNGSVVFLSG QNETSINITV KGDDIPELNE TVTLSLDRVS
760 770 780 790 800
VDSDVLKSGY TSRDLIILEN DDPGGIFEFS YDSRGPYVIK EGDAVELRIT
810 820 830 840 850
RSRGSLVKQF LRFHVEPRES NEFYGNMGVL EFTPGEREVV ITLLTRLDGT
860 870 880 890 900
PELDEHFWVI LSSHGERESK LGRATLVNIT ILKNDYPHGI IEFVSDGLSA
910 920 930 940 950
SIKESKGEDI YHAVYGVIRT RGNFGAVNVS WMVSPDFTQD VFPVQGTVCF
960 970 980 990 1000
GDQEFFKNIT VYSLVDEIPE EMEEFTIILL NATGGAQTGI RTTASLRILR
1010 1020 1030 1040 1050
NDDPVYFAEP CVLRVQEGET ANFTVLRNGS VDGACTVQYA TVDGKASGEE
1060 1070 1080 1090 1100
GDFAPVEKGE TLVFEVGSRE QSISVHVKDD GIPETDEPFY IVLFNSTGDT
1110 1120 1130 1140 1150
VVYEYGVATV IIEANDDPNG VFSLEPIDKA VEEGKTNAFW ILRHRGHFGN
1160 1170 1180 1190 1200
VSVAWQLFQN ASLQPGQEFY ETSGTVNFTD GEETKPVILR AFPDRIPEFN
1210 1220 1230 1240 1250
EFYILRLVNI SGPGGQLAET NFQVTVMIPF NDDPFGIFIL DPECLEREVA
1260 1270 1280 1290 1300
EDVLSEDDMS YITSFTILRQ QGVFGDVRVG WEVLSREFTA GLPPMIDFIL
1310 1320 1330 1340 1350
LGSFPSTVPL QPHMRRHHSG TDVLYFSGLE GAFGTVDPKY QPFRNNTIAN
1360 1370 1380 1390 1400
FTFSAWVMPN ANTNGFLIAK DDSHGSIYYG VKIQTNETHV TLSLHYKTFG
1410 1420 1430 1440 1450
SNVTYIAKST VMKYLEEGVW LHVLIILDDG IIEFYLDGKA MPRGIKSLKG
1460 1470 1480 1490 1500
EAITDGPGIL RIGAGMDGGA RFTGWMQDVR TYERKLTPEE IYELHAVPAR
1510 1520 1530 1540 1550
TDLHPISGYL EFRQGESNKS FIVAARDDSE EEGEELFLLK LVSVDGGAQI
1560 1570 1580 1590 1600
SKENTTARLR IQKSDNANGL FGFTGACIPE MTEEGSTVSC VVERTRGALG
1610 1620 1630 1640 1650
YVHVFYTISQ IESEGINYLV DDFANASGTI TFLPWQRSEV LNLYVLDEDM
1660 1670 1680 1690 1700
PELNEYFRVT LVSAVPGDGK LGSTPISGAS IDPEKETTGI TVKASDHPYG
1710 1720 1730 1740 1750
LMQFSTGLPP QPEDSMSLPA SSVPHITVQE EDGEIRLLVI RAQGLLGRVT
1760 1770 1780 1790 1800
VGFRTVSLTA FSPEDYQSTA GTLEFQSGER YKYIFVNITD NSIPELEKSF
1810 1820 1830 1840 1850
KVELLNLDGG VSDLFRVDGS GSGEADTDFF LPPVLPHASL GVASQILVTI
1860 1870 1880 1890 1900
AASDHAHGVF EFSPESLFVS GTEPEDGYST VVLNVTRTRG ALSAVTLQWK
1910 1920 1930 1940 1950
VDSDLDGDLA ITSGNITFET GQRIASITVE ILSDEEPELD KALTVSILNV
1960 1970 1980 1990 2000
SSGSLGVLTN ATLTILASDD PYGVFIFPNK TRPLSVEEAT QNVALSIIRL
2010 2020 2030 2040 2050
KGLMGEVAVS YATIDDMEKP PYFPPNLARA TQGGDYISAS GLALFRVNQT
2060 2070 2080 2090 2100
EATITISILD DAEPERSESV FIELFNSSLV DKVQNRPIPH SPRLGPKVET
2110 2120 2130 2140 2150
VAHLVIVAND DAFGTVQLSA TSVHVAENHV GPIINVTRTG GTFADVSVKF
2160 2170 2180 2190 2200
KAVPITAAAG EDYSIASSDV VLLEGETTKA VPIYIINDIY PELEETFLVQ
2210 2220 2230 2240 2250
LLNETTGGAT LGPLREAVIT IEASDDPYGL FGFQNTKFIV EEPEFNSVRV
2260 2270 2280 2290 2300
NVPIIRNSGT LGNVTVQWVA IINGQFATGD LRVVSGNVTF APGETIQTLL
2310 2320 2330 2340 2350
LEVLADDVPE IEEVVQVQLA AASGGGTIGL DRVANIVIPA NDNPYGSVAF
2360 2370 2380 2390 2400
VQSVFRVQEP LERSSYANIT VRRSGGHFGR LLLCYGTSDI DVVARAVEEG
2410 2420 2430 2440 2450
EDVLSYYESP TQGVPDPLWR TWVNVSAVEE TQYTCATLCL KERACSAFSV
2460 2470 2480 2490 2500
VSGAEGPRCF WMTSWVSGTV NSSDFQTYKK NMTRVASLFS GQAVAGSDYE
2510 2520 2530 2540 2550
PVTRQWAVIL EGDEFANLTV SVLPDDAPEM DESFLISLLE VHLMNISDSF
2560 2570 2580 2590 2600
KNQPTIGHPN TSAVVIGLNG DAFGVFIIYS VSPNTSEDGL CVEVQEQPQT
2610 2620 2630 2640 2650
SVELVIYRTG GSLGQVMVEW RVVGGTATEG LDFMGAGDIL TFAEGETKKM
2660 2670 2680 2690 2700
AILTILDDSE PEDNESILVR LGATEGGSRI LPSSDTVTVN ILANDNVAGI
2710 2720 2730 2740 2750
VSFQTASRSV IGHEGEMLQF HVVRTPPGRG NVTVNWKVVG QNLEVNFANF
2760 2770 2780 2790 2800
TGQLFFSEGT LNKTIFVHLL DDNIPEEKEV YQVVLYDVKT QGVSPAGVAL
2810 2820 2830 2840 2850
LDAQGYAAVL TVEASDEPHG VLNFALSSRF VVLQEANVTI QLFVNREFGS
2860 2870 2880 2890 2900
LGAINVTYAT VPGIVSLKNN TEGNLAEPES DFIPVVGSLV LEEGETTAAI
2910 2920 2930 2940 2950
SITVLEDDIP ELKEYFLVNL THVDLIMAPL TSSPPRLDSE GLTAQIVIDA
2960 2970 2980 2990 3000
NDGAQGMIEW QRNRFEVNET DGVVTLVAQR SRAALGQVSL FMYAQNLEAQ
3010 3020 3030 3040 3050
AGLDYMRTPQ ILHFTDGERF KHVDVMILDD DMPEGDERFQ LLLTNPSPGL
3060 3070 3080 3090 3100
ELGKNTIALI TVLANDDGPG VLSFNNSGHI FLREPTSLYV QESVAVLVIV
3110 3120 3130 3140 3150
REPAQGLFGT VAVQFVVTEV NSSTESKDLS PSKGFIVLEE GVRSKTLRIS
3160 3170 3180 3190 3200
AILDTEPEMD EHFVCTLFNP TGGARLGAHV QTLITIFQNQ APLGLFSISA
3210 3220 3230 3240 3250
VENSATSIDV EESNRSVYLN VSRTNGLDLT ASVQWETVSE TAFGMRGMDV
3260 3270 3280 3290 3300
VFSIFQSFFD KTALDWCFFT VEGSVYGVML RKSSLVVYRW QGTFVPVEDL
3310 3320 3330 3340 3350
KVESPKTCEA FNIGVSPYLV ITHGERSGEK PSINSVYMLT AGFRLVLIQT
3360 3370 3380 3390 3400
IIISGSCQVR HFTSDSQDYF IIASRRNDSE LTQVFRWNGN NFAWHQTLPV
3410 3420 3430 3440 3450
RGVLGMALFS RGGSVFLAIS QANIRQTSLL FTWSGTQFIN FQELPISGIT
3460 3470 3480 3490 3500
QVEALSSGDD VYLCFAKNTF LGNQNAIDIF VWEMGHSSLR YFQSLDFAAV
3510 3520 3530 3540 3550
KRIRSFTPAS GIVHILLTAQ DGSALYCWNS ELNAFSFVLE APAAHDAAFV
3560 3570 3580 3590 3600
TVKSLNSSKT LIALVGATDS HLYELTYVSS QSDFIPSLGE LIFEPGDKEA
3610 3620 3630 3640 3650
IIAVNVLDDT VPEKEESFRV QLKSPRGGAE IGINSSVRVT VLANDGAYGV
3660 3670 3680 3690 3700
VAFAQNSLHK QLEELERDSL VTLNVERLRG THGRITVAWE AAGSVSDVFP
3710 3720 3730 3740 3750
TSGVISFTED QAMSMITLTV LADDLPELSE AVVVTLTQIV TEGVEDPLKG
3760 3770 3780 3790 3800
ATIDQSRSRS VLTILPSDSP YGAVRWHTES LFNRVPEPTE NITVVQLHIV
3810 3820 3830 3840 3850
RDKGLFGDIS IHLIAKPNFL LHINNQATED EDFVLQDSVI IMKENIKETH
3860 3870 3880 3890 3900
AEVAILPDEV PELDEGLIVT IAAVNLVNPN FPAEQPRVQR PRMESAEILI
3910 3920 3930 3940 3950
EENDDPRGIF NFHVVRDVGG VIIAHEGPPP LNVLQVPVVR MAGTFETVNV
3960 3970 3980 3990 4000
YWKATPDSAG LEDFQPSHGM LQFADGQVIA PILVTIIDDS EFELLETFTI
4010 4020 4030 4040 4050
SLVSVTGGGR LGDDVSVNVV IAPNDSPFGI FGFEKKTVMV DGPLLSDDPD
4060 4070 4080 4090 4100
SYVTLTVVRS PGGKGAVRLH WAIEEKAKDD LSPLNGTLYF DETESQKSVI
4110 4120 4130 4140 4150
LHTLKDGMVG EDRRFIIELT AADEVEISPV KGSASVIIRG DKSISEVGIA
4160 4170 4180 4190 4200
SSSRHIIIGE PSATYNGTAI IDLVRGPGVS GEITVNWKIL PPSRGEFVET
4210 4220 4230 4240 4250
SGQLTMLDGQ TAATVVIQVL NDDIPEEKCH YEFQLTEISE GRMLHEASVS
4260 4270 4280 4290 4300
ARITMVASDA PYGRFSFSHE QLHVSKAAQR VNVTVVRSGG SFGRARVLYE
4310 4320 4330 4340 4350
TGSRTAEAGW DFVPASGELL FEAREKMKSL YIDILDDDLP EGPEEFVLAI
4360 4370 4380 4390 4400
TRVDLQGRGY DFTIQENGLQ IDQPPEIGNI SIVRIIIMKN DNAEGIIEFD
4410 4420 4430 4440 4450
PKYTDISVEE DAGVITLPVL RLHGTYGHVS ADFSSRGFSA VPGGYVLRGS
4460 4470 4480 4490 4500
SVTFQHGQNL SFINVSIIDD NGSEFEKQFE ILLIGATGGA ILGRHLVSKI
4510 4520 4530 4540 4550
TIAKSDSPFG IIRFLNQSKI SLPNPSSTMA LHLVLERTGG LLGEIQVSWE
4560 4570 4580 4590 4600
VVGPDAEEPL PPHNGDFADP VSGTVSFGDG EGGVRSIILR VCPHEETEAE
4610 4620 4630 4640 4650
ETFIVQLKPL REAKLDPRAK AVTLTIQKFG DPNGVIHFAP ESLSKRRFSE
4660 4670 4680 4690 4700
PPPSDGPLLV SFLVTRSKGT SGDIKVHWEL SSEFDITRDF LSTRGFFTIA
4710 4720 4730 4740 4750
DGESDANFDV HLLPDDVPEI EEEYAVQLVS VEGGAELDLG KCTARFSVSA
4760 4770 4780 4790 4800
NDDPHGVFAL YSDRQSVLIG QNLDRSIQIN ITRLAGAFGA VAVRVQILSD
4810 4820 4830 4840 4850
NKEDPVATEN EERQLVITDG ARYKVGLVPL KNQVFLSLGS NFTLQLVSVR
4860 4870 4880 4890 4900
LLSGPFYGIP TILQEAKNAI LSVPEEAANS QVGFESAAFQ LMDIKAGTSQ
4910 4920 4930 4940 4950
VMVSRKGTYG RLSVAWTTGY APGSEIPEPI VIGNMTPTLG SLSFVHGEER
4960 4970 4980 4990 5000
KGVLLWTFPS PGRPEAFVLH LSGLRSSAAG GAQLRSGFTT AEIEPMGVFQ
5010 5020 5030 5040 5050
FSPSSRNITV SEDAQTIRIC VQRLFGFHGD LIKVSYETTA GSAKPPEDFE
5060 5070 5080 5090 5100
AVQKGEVFFQ RFQPEIDFEI TIINDQLPEI EETYYINLTS VETRGLGKGG
5110 5120 5130 5140 5150
VNWRPRLNPD LSVAVVTIVD NDDLTGAAVS VPVTAGTVAV DSTLLAMETG
5160 5170 5180 5190 5200
STTHPNKSKI TTIPYTTEVF APVTETVTVS AIPEKLATAH SVISVKPDVV
5210 5220 5230 5240 5250
PGTVVASVYG TLSIGPPIVY VSEEMKNGTL STADILIQRM GGFAGNVTIT
5260 5270 5280 5290 5300
VKTFGGRCAQ KEPSVWPFQD VYGVGNLTTW AVEEEDFEEQ LLTLTFLYGE
5310 5320 5330 5340 5350
RERKIAVQIL DDDDAEGQEF FYVFLTDPQG GAEIVRGKDS TGFSAFAVII
5360 5370 5380 5390 5400
ISGSDLHNGI IGFSEESQRG LELREGADKN SQRLVVTRQP NRAFEEVQIF
5410 5420 5430 5440 5450
WRVTLNQTVT ILQEKGANLT DELRFVAGVT TCTGGQTRCF IHLELNPKKV
5460 5470 5480 5490 5500
HQVEMPFFVE LYDVTAGAAI NNSARFAPIK LSKSGAPQSL VSFSVGSRLA
5510 5520 5530 5540 5550
VAHKKSTLIS LQVARDSGTG IMMSVNFITQ ELRSAETVGR VLISPAVSGK
5560 5570 5580 5590 5600
DFVRTEGTLV FEPGQKSAVL DVVLTPEAGS LNKFPKRFQI VLFDPKGGAR
5610 5620 5630 5640 5650
IDKVYGTANI TLISDADSQA VWGLEDLLHR PLHEDILNRV LHNLNLRVAT
5660 5670 5680 5690 5700
ESTDEQLSAV MLIMEKITME GRNQAFSIKS RTLLYELLCV LINPKRKDTR
5710 5720 5730 5740 5750
GFSHFVEVAE HFAFSLLTDV TCGSPGEKSK TILDSCPYLS ILALHWNPQQ
5760 5770 5780 5790 5800
INGHKFEGKE GDYIQIPERL LDVPEAEMLD GKNACTLVQF VEYSSQQWFI
5810 5820 5830 5840 5850
AGDNLPALKD KVLSLNVKGQ SAQPLPNNNE VLYRIHAAEP RVVPHTSRCL
5860 5870 5880 5890 5900
LWNQAAASWL SDSQFCKVVE DASDYVECAC SHMSVYAVYA QTDNSSSYNE
5910 5920 5930 5940 5950
AFFSAGLICI SGLCLAVVSH MFCARHSMFA AKLLTHMMVA SLGTQILFLA
5960 5970 5980 5990 6000
SAYASPHLSE ESCSAVAAVA HYLYLCQFSW MLIQSVNFWY VLVVSDEHTE
6010 6020 6030 6040 6050
RRCLLFCLLS WGLPSFVVIL LILILRGIYH RSMPQIYGLI HGDLCFIPNI
6060 6070 6080 6090 6100
YAALFTAALV PLMCLVVVFV VFIHAYQLKP QWKGYDDVFR GRTNAAEIPL
6110 6120 6130 6140 6150
ILYLFALISM TWLWGGLHMA YGHFWMLVLF VIFNSLQGLY VFVVYFILHN
6160 6170 6180 6190 6200
QTCCPMKASY TVEMNGHPGP STAFFTPGSG IPPAGEINKS TQNLINAMEE
6210 6220 6230 6240 6250
VPSDWERSSF QQTSQASPDL KTSPQNGASF PSSGGYGPGS LIADEESQEF
6260 6270 6280 6290
DDLIFALKTG AGLSVSDNES GQGSQEGGTL TDSQIVELRR IPIADTHL
Length:6,298
Mass (Da):687,458
Last modified:March 1, 2002 - v1
Checksum:iF99E731B0ADBD66D
GO
Isoform 2 (identifier: Q8VHN7-2) [UniParc]FASTAAdd to basket
Also known as: Mass1.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-720: Missing.
     721-748: QNETSINITVKGDDIPELNETVTLSLDR → MCLPSLCPSHCSFCVDRVETERFVVYFG
     2938-2958: DSEGLTAQIVIDANDGAQGMI → GMGLSFMNLLTNCESQRTSLF
     2959-6298: Missing.

Show »
Length:2,238
Mass (Da):244,000
Checksum:i63490CC1D4459E60
GO
Isoform 3 (identifier: Q8VHN7-3) [UniParc]FASTAAdd to basket
Also known as: Mass1.3

The sequence of this isoform differs from the canonical sequence as follows:
     1-1804: Missing.
     1805-1810: LNLDGG → MCVACE
     2938-2958: DSEGLTAQIVIDANDGAQGMI → GMGLSFMNLLTNCESQRTSLF
     2959-6298: Missing.

Show »
Length:1,154
Mass (Da):123,797
Checksum:iF590FB279848E001
GO
Isoform 4 (identifier: Q8VHN7-4) [UniParc]FASTAAdd to basket
Also known as: Neurepin-2, Vlgr1e

The sequence of this isoform differs from the canonical sequence as follows:
     1213-1218: PGGQLA → TNLSHL
     1219-6298: Missing.

Note: Secreted.
Show »
Length:1,218
Mass (Da):133,698
Checksum:i4624468023BE9CA7
GO
Isoform 5 (identifier: Q8VHN7-5) [UniParc]FASTAAdd to basket
Also known as: Neurepin-1, Vlgr1d

The sequence of this isoform differs from the canonical sequence as follows:
     615-616: LE → VL
     617-6298: Missing.

Note: Secreted.
Show »
Length:616
Mass (Da):67,330
Checksum:iAB4CF545CE1A5923
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti412 – 4165SSRFE → RYNLL (PubMed:15606908).Curated
Sequence conflicti520 – 5201A → S in BAC66506 (PubMed:15606908).Curated
Sequence conflicti859 – 8591V → A (PubMed:11545713).Curated
Sequence conflicti873 – 8731R → C in BAC66506 (PubMed:15606908).Curated
Sequence conflicti963 – 9631S → T in BAC66506 (PubMed:15606908).Curated
Sequence conflicti1282 – 12821E → K (PubMed:11545713).Curated
Sequence conflicti1508 – 15081G → E (PubMed:11545713).Curated
Sequence conflicti1933 – 19331S → P (PubMed:11545713).Curated
Sequence conflicti1955 – 19551L → M (PubMed:11545713).Curated
Sequence conflicti1994 – 19941A → T (PubMed:11545713).Curated
Sequence conflicti2047 – 20471V → A (PubMed:11545713).Curated
Sequence conflicti2251 – 22522NV → SA (PubMed:11545713).Curated
Sequence conflicti2672 – 26721G → V (PubMed:11545713).Curated
Sequence conflicti4816 – 483217VITDG…VPLKN → PLIGCPCSSGWCSTMHI (PubMed:14621295).CuratedAdd
BLAST
Sequence conflicti5084 – 50841Y → F (PubMed:14621295).Curated
Sequence conflicti5127 – 51271A → V (PubMed:14621295).Curated
Sequence conflicti5205 – 52051V → L (PubMed:14621295).Curated
Sequence conflicti5282 – 52821V → F (PubMed:14621295).Curated
Sequence conflicti5314 – 53152DA → EP (PubMed:14621295).Curated
Sequence conflicti5417 – 54171A → L (PubMed:14621295).Curated
Sequence conflicti5578 – 55781A → T (PubMed:14621295).Curated
Sequence conflicti5630 – 56301R → Q (PubMed:14621295).Curated
Sequence conflicti6122 – 61221G → R (PubMed:14621295).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 18041804Missing in isoform 3. 1 PublicationVSP_017951Add
BLAST
Alternative sequencei1 – 720720Missing in isoform 2. 1 PublicationVSP_017952Add
BLAST
Alternative sequencei615 – 6162LE → VL in isoform 5. 1 PublicationVSP_017953
Alternative sequencei617 – 62985682Missing in isoform 5. 1 PublicationVSP_017954Add
BLAST
Alternative sequencei721 – 74828QNETS…LSLDR → MCLPSLCPSHCSFCVDRVET ERFVVYFG in isoform 2. 1 PublicationVSP_017955Add
BLAST
Alternative sequencei1213 – 12186PGGQLA → TNLSHL in isoform 4. 1 PublicationVSP_017956
Alternative sequencei1219 – 62985080Missing in isoform 4. 1 PublicationVSP_017957Add
BLAST
Alternative sequencei1805 – 18106LNLDGG → MCVACE in isoform 3. 1 PublicationVSP_017958
Alternative sequencei2938 – 295821DSEGL…AQGMI → GMGLSFMNLLTNCESQRTSL F in isoform 2 and isoform 3. 1 PublicationVSP_017959Add
BLAST
Alternative sequencei2959 – 62983340Missing in isoform 2 and isoform 3. 1 PublicationVSP_017960Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF405693 mRNA. Translation: AAL06013.1.
AF405694 mRNA. Translation: AAL06014.1.
AF435926 mRNA. Translation: AAL30812.1.
AB086166 mRNA. Translation: BAC66505.2.
AB086167 mRNA. Translation: BAC66506.1.
AK129190 mRNA. Translation: BAC98000.3.
CCDSiCCDS36737.1. [Q8VHN7-1]
UniGeneiMm.288694.

Genome annotation databases

EnsembliENSMUST00000128585; ENSMUSP00000121899; ENSMUSG00000069170. [Q8VHN7-5]
UCSCiuc007rht.1. mouse. [Q8VHN7-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF405693 mRNA. Translation: AAL06013.1.
AF405694 mRNA. Translation: AAL06014.1.
AF435926 mRNA. Translation: AAL30812.1.
AB086166 mRNA. Translation: BAC66505.2.
AB086167 mRNA. Translation: BAC66506.1.
AK129190 mRNA. Translation: BAC98000.3.
CCDSiCCDS36737.1. [Q8VHN7-1]
UniGeneiMm.288694.

3D structure databases

ProteinModelPortaliQ8VHN7.
SMRiQ8VHN7. Positions 34-258, 260-488, 1025-1185, 1622-2307, 2491-2781, 2871-3145, 3579-3723, 3824-4002, 4196-4505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093245.

PTM databases

iPTMnetiQ8VHN7.
PhosphoSiteiQ8VHN7.

Proteomic databases

MaxQBiQ8VHN7.
PaxDbiQ8VHN7.
PRIDEiQ8VHN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128585; ENSMUSP00000121899; ENSMUSG00000069170. [Q8VHN7-5]
UCSCiuc007rht.1. mouse. [Q8VHN7-5]

Organism-specific databases

MGIiMGI:1274784. Gpr98.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410KDV8. Eukaryota.
ENOG410XT0U. LUCA.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000088618.
HOVERGENiHBG081572.
InParanoidiQ8VHN7.
PhylomeDBiQ8VHN7.

Miscellaneous databases

PROiQ8VHN7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069170.
CleanExiMM_GPR98.
ExpressionAtlasiQ8VHN7. baseline and differential.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR003644. Calx_beta.
IPR013320. ConA-like_dom.
IPR009039. EAR.
IPR005492. EPTP.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR026919. GPR98.
IPR000203. GPS.
IPR006558. LamG-like.
[Graphical view]
PANTHERiPTHR11878:SF20. PTHR11878:SF20. 8 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF03160. Calx-beta. 37 hits.
PF03736. EPTP. 1 hit.
[Graphical view]
SMARTiSM00237. Calx_beta. 20 hits.
SM00560. LamGL. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50912. EAR. 6 hits.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR98_MOUSE
AccessioniPrimary (citable) accession number: Q8VHN7
Secondary accession number(s): Q6ZQ69
, Q810D2, Q810D3, Q91ZS0, Q91ZS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.