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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

Grin3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

GO - Molecular functioni

  • cation channel activity Source: RGD
  • extracellularly glutamate-gated ion channel activity Source: InterPro
  • glycine binding Source: RGD
  • ionotropic glutamate receptor activity Source: InterPro
  • neurotransmitter binding Source: RGD
  • neurotransmitter receptor activity Source: RGD

GO - Biological processi

  • ionotropic glutamate receptor signaling pathway Source: RGD

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name:
NMDAR3B
Short name:
NR3B
Gene namesi
Name:Grin3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621705 Grin3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 564ExtracellularSequence analysisAdd BLAST540
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 648CytoplasmicSequence analysisAdd BLAST63
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 826ExtracellularSequence analysisAdd BLAST157
Transmembranei827 – 847HelicalSequence analysisAdd BLAST21
Topological domaini848 – 1002CytoplasmicSequence analysisAdd BLAST155

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1907608

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001157225 – 1002Glutamate receptor ionotropic, NMDA 3BAdd BLAST978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi786N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VHN2
PRIDEiQ8VHN2

Expressioni

Tissue specificityi

Expressed in the hippocampus, the corpus callosum, in the facial and trigeminal nuclei of the brainstem and the ventral horn of the spinal cord.2 Publications

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017064

Chemistry databases

BindingDBiQ8VHN2

Structurei

Secondary structure

11002
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi416 – 421Combined sources6
Turni425 – 427Combined sources3
Beta strandi428 – 432Combined sources5
Beta strandi440 – 446Combined sources7
Helixi453 – 465Combined sources13
Helixi470 – 472Combined sources3
Beta strandi473 – 478Combined sources6
Helixi479 – 491Combined sources13
Beta strandi494 – 499Combined sources6
Helixi515 – 521Combined sources7
Beta strandi526 – 528Combined sources3
Helixi536 – 539Combined sources4
Beta strandi542 – 544Combined sources3
Beta strandi548 – 558Combined sources11
Helixi683 – 686Combined sources4
Helixi701 – 709Combined sources9
Helixi711 – 717Combined sources7
Beta strandi722 – 724Combined sources3
Helixi725 – 733Combined sources9
Beta strandi734 – 736Combined sources3
Beta strandi740 – 745Combined sources6
Helixi746 – 755Combined sources10
Beta strandi761 – 773Combined sources13
Beta strandi776 – 778Combined sources3
Helixi784 – 796Combined sources13
Helixi799 – 807Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RCAX-ray1.58A/B413-560[»]
A/B676-815[»]
2RCBX-ray1.62A/B413-560[»]
A/B676-815[»]
ProteinModelPortaliQ8VHN2
SMRiQ8VHN2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VHN2

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni951 – 984Involved in the trafficking and surface expression of NMDARsBy similarityAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili944 – 985Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi914 – 993Arg-richAdd BLAST80

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiQ8VHN2
KOiK05214
PhylomeDBiQ8VHN2

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVRTLWLS VALALAVGSR VVRGHPQPCR VPTRAGASVR LAALLPRAPA
60 70 80 90 100
ARARVLAALA TPAPRLPHNL SLELVAVASP TRDPASLARG LCQVLAPPGV
110 120 130 140 150
VASIAFPEAR PELRLLQFLA AATETPVVSV LRREVRTALG APTPFHLQLD
160 170 180 190 200
WASPLETILD VLVSLVRAHA WEDIALVLCR VRDPGSLVTL WTNHASQAPK
210 220 230 240 250
FVLDLSRLDS RNDSLRAGLA LLGALEGGGT PVPAAVLLGC STARAHEVLE
260 270 280 290 300
AAPPGPQWLL GTPLPAEALP TTGLPPGVLA LGETEQHSLE AVVHDMVELV
310 320 330 340 350
AQALSSMALV HPERALLPAV VNCDDLKTGG SEATGRTLAR FLGNTSFQGR
360 370 380 390 400
TGAVWVTGSS QVHVSRHFKV WSLRRDPLGA PAWATVGSWQ DGQLDFQPGA
410 420 430 440 450
AALRVPSPSG TQARPKLRVV TLVEHPFVFT RESDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSARLDALF AALVNGSVPR TLRRCCYGYC IDLLERLAED LAFDFELYIV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRTR DTASPIGAFM WPLHWSMWVG VFAALHLTAL FLTLYEWRSP
610 620 630 640 650
YGLTPRGRNR GTVFSYSSAL NLCYAILFGR TVSSKTPKCP TGRFLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPSQ GFRFGTVWES
710 720 730 740 750
SAEAYIKASF PEMHAHMRRH SAPTTPHGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI
810 820 830 840 850
DLLHDKWYKM VPCGKRVFAV TETLQMGVYH FSGLFVLLCL GLGSALLTSL
860 870 880 890 900
GEHVFYRLVL PRIRRGNKLQ YWLHTSQKIH RALNTGPPEG QQERAEQERS
910 920 930 940 950
GPKDELPATD GAGRWRRVRR AVERERRVRF LLEPGEAGGD RPWLCSNGPG
960 970 980 990 1000
LQAELRELEL RIEAARERLR SALLRRGELR ALLGDGTRLR PLRLLHAAPA

ES
Length:1,002
Mass (Da):109,158
Last modified:June 1, 2002 - v2
Checksum:i4AC840EF97E0AB83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF440691 mRNA Translation: AAL69893.2
RefSeqiNP_579842.2, NM_133308.2
UniGeneiRn.162906

Genome annotation databases

GeneIDi170796
KEGGirno:170796
UCSCiRGD:621705 rat

Similar proteinsi

Entry informationi

Entry nameiNMD3B_RAT
AccessioniPrimary (citable) accession number: Q8VHN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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