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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

Grin3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

GO - Molecular functioni

  • cation channel activity Source: RGD
  • extracellular-glutamate-gated ion channel activity Source: InterPro
  • glycine binding Source: RGD
  • neurotransmitter binding Source: RGD
  • neurotransmitter receptor activity Source: RGD
  • NMDA glutamate receptor activity Source: GO_Central

GO - Biological processi

  • ionotropic glutamate receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name:
NMDAR3B
Short name:
NR3B
Gene namesi
Name:Grin3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621705. Grin3b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 564ExtracellularSequence analysisAdd BLAST540
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 648CytoplasmicSequence analysisAdd BLAST63
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 826ExtracellularSequence analysisAdd BLAST157
Transmembranei827 – 847HelicalSequence analysisAdd BLAST21
Topological domaini848 – 1002CytoplasmicSequence analysisAdd BLAST155

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • NMDA selective glutamate receptor complex Source: RGD
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1907608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001157225 – 1002Glutamate receptor ionotropic, NMDA 3BAdd BLAST978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi451N-linked (GlcNAc...)Sequence analysis1
Glycosylationi465N-linked (GlcNAc...)Sequence analysis1
Glycosylationi786N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VHN2.
PRIDEiQ8VHN2.

Expressioni

Tissue specificityi

Expressed in the hippocampus, the corpus callosum, in the facial and trigeminal nuclei of the brainstem and the ventral horn of the spinal cord.2 Publications

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017064.

Structurei

Secondary structure

11002
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi416 – 421Combined sources6
Turni425 – 427Combined sources3
Beta strandi428 – 432Combined sources5
Beta strandi440 – 446Combined sources7
Helixi453 – 465Combined sources13
Helixi470 – 472Combined sources3
Beta strandi473 – 478Combined sources6
Helixi479 – 491Combined sources13
Beta strandi494 – 499Combined sources6
Helixi515 – 521Combined sources7
Beta strandi526 – 528Combined sources3
Helixi536 – 539Combined sources4
Beta strandi542 – 544Combined sources3
Beta strandi548 – 558Combined sources11
Helixi683 – 686Combined sources4
Helixi701 – 709Combined sources9
Helixi711 – 717Combined sources7
Beta strandi722 – 724Combined sources3
Helixi725 – 733Combined sources9
Beta strandi734 – 736Combined sources3
Beta strandi740 – 745Combined sources6
Helixi746 – 755Combined sources10
Beta strandi761 – 773Combined sources13
Beta strandi776 – 778Combined sources3
Helixi784 – 796Combined sources13
Helixi799 – 807Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RCAX-ray1.58A/B413-560[»]
A/B676-815[»]
2RCBX-ray1.62A/B413-560[»]
A/B676-815[»]
ProteinModelPortaliQ8VHN2.
SMRiQ8VHN2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VHN2.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni951 – 984Involved in the trafficking and surface expression of NMDARsBy similarityAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili944 – 985Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi914 – 993Arg-richAdd BLAST80

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiQ8VHN2.
KOiK05214.
PhylomeDBiQ8VHN2.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVRTLWLS VALALAVGSR VVRGHPQPCR VPTRAGASVR LAALLPRAPA
60 70 80 90 100
ARARVLAALA TPAPRLPHNL SLELVAVASP TRDPASLARG LCQVLAPPGV
110 120 130 140 150
VASIAFPEAR PELRLLQFLA AATETPVVSV LRREVRTALG APTPFHLQLD
160 170 180 190 200
WASPLETILD VLVSLVRAHA WEDIALVLCR VRDPGSLVTL WTNHASQAPK
210 220 230 240 250
FVLDLSRLDS RNDSLRAGLA LLGALEGGGT PVPAAVLLGC STARAHEVLE
260 270 280 290 300
AAPPGPQWLL GTPLPAEALP TTGLPPGVLA LGETEQHSLE AVVHDMVELV
310 320 330 340 350
AQALSSMALV HPERALLPAV VNCDDLKTGG SEATGRTLAR FLGNTSFQGR
360 370 380 390 400
TGAVWVTGSS QVHVSRHFKV WSLRRDPLGA PAWATVGSWQ DGQLDFQPGA
410 420 430 440 450
AALRVPSPSG TQARPKLRVV TLVEHPFVFT RESDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSARLDALF AALVNGSVPR TLRRCCYGYC IDLLERLAED LAFDFELYIV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRTR DTASPIGAFM WPLHWSMWVG VFAALHLTAL FLTLYEWRSP
610 620 630 640 650
YGLTPRGRNR GTVFSYSSAL NLCYAILFGR TVSSKTPKCP TGRFLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPSQ GFRFGTVWES
710 720 730 740 750
SAEAYIKASF PEMHAHMRRH SAPTTPHGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI
810 820 830 840 850
DLLHDKWYKM VPCGKRVFAV TETLQMGVYH FSGLFVLLCL GLGSALLTSL
860 870 880 890 900
GEHVFYRLVL PRIRRGNKLQ YWLHTSQKIH RALNTGPPEG QQERAEQERS
910 920 930 940 950
GPKDELPATD GAGRWRRVRR AVERERRVRF LLEPGEAGGD RPWLCSNGPG
960 970 980 990 1000
LQAELRELEL RIEAARERLR SALLRRGELR ALLGDGTRLR PLRLLHAAPA

ES
Length:1,002
Mass (Da):109,158
Last modified:June 1, 2002 - v2
Checksum:i4AC840EF97E0AB83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF440691 mRNA. Translation: AAL69893.2.
RefSeqiNP_579842.2. NM_133308.2.
UniGeneiRn.162906.

Genome annotation databases

GeneIDi170796.
KEGGirno:170796.
UCSCiRGD:621705. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF440691 mRNA. Translation: AAL69893.2.
RefSeqiNP_579842.2. NM_133308.2.
UniGeneiRn.162906.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RCAX-ray1.58A/B413-560[»]
A/B676-815[»]
2RCBX-ray1.62A/B413-560[»]
A/B676-815[»]
ProteinModelPortaliQ8VHN2.
SMRiQ8VHN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017064.

Chemistry databases

ChEMBLiCHEMBL1907608.

Proteomic databases

PaxDbiQ8VHN2.
PRIDEiQ8VHN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170796.
KEGGirno:170796.
UCSCiRGD:621705. rat.

Organism-specific databases

CTDi116444.
RGDi621705. Grin3b.

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiQ8VHN2.
KOiK05214.
PhylomeDBiQ8VHN2.

Miscellaneous databases

EvolutionaryTraceiQ8VHN2.
PROiQ8VHN2.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNMD3B_RAT
AccessioniPrimary (citable) accession number: Q8VHN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.