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Q8VHN2 (NMD3B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate receptor ionotropic, NMDA 3B

Short name=GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name=NMDAR3B
Short name=NR3B
Gene names
Name:Grin3b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1002 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

Subunit structure

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Note: Requires the presence of GRIN1 to be targeted at the plasma membrane By similarity.

Tissue specificity

Expressed in the hippocampus, the corpus callosum, in the facial and trigeminal nuclei of the brainstem and the ventral horn of the spinal cord. Ref.1 Ref.3

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   DomainCoiled coil
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Magnesium
   Molecular functionIon channel
Ligand-gated ion channel
Receptor
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcation transport

Inferred from direct assay Ref.1. Source: GOC

ion transmembrane transport

Inferred from Biological aspect of Ancestor. Source: GOC

ionotropic glutamate receptor signaling pathway

Inferred from direct assay Ref.1. Source: RGD

synaptic transmission, glutamatergic

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentN-methyl-D-aspartate selective glutamate receptor complex

Inferred from direct assay Ref.1. Source: RGD

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

dendrite

Inferred from Biological aspect of Ancestor. Source: RefGenome

postsynaptic membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionN-methyl-D-aspartate selective glutamate receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

cation channel activity

Inferred from direct assay Ref.1. Source: RGD

extracellular-glutamate-gated ion channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

glycine binding

Inferred from direct assay Ref.1. Source: RGD

neurotransmitter binding

Inferred from direct assay Ref.1. Source: RGD

neurotransmitter receptor activity

Inferred from direct assay Ref.1. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 1002978Glutamate receptor ionotropic, NMDA 3B
PRO_0000011572

Regions

Topological domain25 – 564540Extracellular Potential
Transmembrane565 – 58521Helical; Potential
Topological domain586 – 64863Cytoplasmic Potential
Transmembrane649 – 66921Helical; Potential
Topological domain670 – 826157Extracellular Potential
Transmembrane827 – 84721Helical; Potential
Topological domain848 – 1002155Cytoplasmic Potential
Region951 – 98434Involved in the trafficking and surface expression of NMDARs By similarity
Coiled coil944 – 98542 Potential
Compositional bias914 – 99380Arg-rich

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation3441N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential
Glycosylation4651N-linked (GlcNAc...) Potential
Glycosylation7861N-linked (GlcNAc...) Potential

Secondary structure

............................................... 1002
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8VHN2 [UniParc].

Last modified June 1, 2002. Version 2.
Checksum: 4AC840EF97E0AB83

FASTA1,002109,158
        10         20         30         40         50         60 
MESVRTLWLS VALALAVGSR VVRGHPQPCR VPTRAGASVR LAALLPRAPA ARARVLAALA 

        70         80         90        100        110        120 
TPAPRLPHNL SLELVAVASP TRDPASLARG LCQVLAPPGV VASIAFPEAR PELRLLQFLA 

       130        140        150        160        170        180 
AATETPVVSV LRREVRTALG APTPFHLQLD WASPLETILD VLVSLVRAHA WEDIALVLCR 

       190        200        210        220        230        240 
VRDPGSLVTL WTNHASQAPK FVLDLSRLDS RNDSLRAGLA LLGALEGGGT PVPAAVLLGC 

       250        260        270        280        290        300 
STARAHEVLE AAPPGPQWLL GTPLPAEALP TTGLPPGVLA LGETEQHSLE AVVHDMVELV 

       310        320        330        340        350        360 
AQALSSMALV HPERALLPAV VNCDDLKTGG SEATGRTLAR FLGNTSFQGR TGAVWVTGSS 

       370        380        390        400        410        420 
QVHVSRHFKV WSLRRDPLGA PAWATVGSWQ DGQLDFQPGA AALRVPSPSG TQARPKLRVV 

       430        440        450        460        470        480 
TLVEHPFVFT RESDEDGQCP AGQLCLDPGT NDSARLDALF AALVNGSVPR TLRRCCYGYC 

       490        500        510        520        530        540 
IDLLERLAED LAFDFELYIV GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ 

       550        560        570        580        590        600 
VVDFTSPFFS TSLGIMVRTR DTASPIGAFM WPLHWSMWVG VFAALHLTAL FLTLYEWRSP 

       610        620        630        640        650        660 
YGLTPRGRNR GTVFSYSSAL NLCYAILFGR TVSSKTPKCP TGRFLMNLWA IFCLLVLSSY 

       670        680        690        700        710        720 
TANLAAVMVG DKTFEELSGI HDPKLHHPSQ GFRFGTVWES SAEAYIKASF PEMHAHMRRH 

       730        740        750        760        770        780 
SAPTTPHGVA MLTSDPPKLN AFIMDKSLLD YEVSIDADCK LLTVGKPFAI EGYGIGLPQN 

       790        800        810        820        830        840 
SPLTSNLSEF ISRYKSSGFI DLLHDKWYKM VPCGKRVFAV TETLQMGVYH FSGLFVLLCL 

       850        860        870        880        890        900 
GLGSALLTSL GEHVFYRLVL PRIRRGNKLQ YWLHTSQKIH RALNTGPPEG QQERAEQERS 

       910        920        930        940        950        960 
GPKDELPATD GAGRWRRVRR AVERERRVRF LLEPGEAGGD RPWLCSNGPG LQAELRELEL 

       970        980        990       1000 
RIEAARERLR SALLRRGELR ALLGDGTRLR PLRLLHAAPA ES 

« Hide

References

[1]"Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits."
Chatterton J.E., Awobuluyi M., Premkumar L.S., Takahashi H., Talantova M., Shin Y., Cui J., Tu S., Sevarino K.K.A., Nakanishi N., Tong G., Lipton S.A., Zhang D.
Nature 415:793-798(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]Chatterton J.E., Awobuluyi M., Cui J., Sevarino K.K.A., Lipton S.A., Zhang D.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
Andersson O., Stenqvist A., Attersand A., von Euler G.
Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF440691 mRNA. Translation: AAL69893.2.
RefSeqNP_579842.2. NM_133308.2.
UniGeneRn.162906.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RCAX-ray1.58A/B413-560[»]
A/B676-815[»]
2RCBX-ray1.62A/B413-560[»]
A/B676-815[»]
ProteinModelPortalQ8VHN2.
SMRQ8VHN2. Positions 414-808.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000017064.

Chemistry

BindingDBQ8VHN2.
ChEMBLCHEMBL2096669.
GuidetoPHARMACOLOGY461.

Proteomic databases

PaxDbQ8VHN2.
PRIDEQ8VHN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID170796.
KEGGrno:170796.
UCSCRGD:621705. rat.

Organism-specific databases

CTD116444.
RGD621705. Grin3b.

Phylogenomic databases

eggNOGNOG320645.
HOGENOMHOG000231528.
HOVERGENHBG052634.
KOK05214.
PhylomeDBQ8VHN2.

Gene expression databases

GenevestigatorQ8VHN2.

Family and domain databases

InterProIPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamPF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSPR00177. NMDARECEPTOR.
SMARTSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8VHN2.
NextBio621215.
PROQ8VHN2.

Entry information

Entry nameNMD3B_RAT
AccessionPrimary (citable) accession number: Q8VHN2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references