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Q8VHN2

- NMD3B_RAT

UniProt

Q8VHN2 - NMD3B_RAT

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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene
Grin3b
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

GO - Molecular functioni

  1. cation channel activity Source: RGD
  2. extracellular-glutamate-gated ion channel activity Source: RefGenome
  3. glycine binding Source: RGD
  4. neurotransmitter binding Source: RGD
  5. neurotransmitter receptor activity Source: RGD
  6. N-methyl-D-aspartate selective glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. cation transport Source: GOC
  2. ionotropic glutamate receptor signaling pathway Source: RGD
  3. ion transmembrane transport Source: GOC
  4. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name:
NMDAR3B
Short name:
NR3B
Gene namesi
Name:Grin3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621705. Grin3b.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity
Note: Requires the presence of GRIN1 to be targeted at the plasma membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 564540Extracellular Reviewed predictionAdd
BLAST
Transmembranei565 – 58521Helical; Reviewed predictionAdd
BLAST
Topological domaini586 – 64863Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei649 – 66921Helical; Reviewed predictionAdd
BLAST
Topological domaini670 – 826157Extracellular Reviewed predictionAdd
BLAST
Transmembranei827 – 84721Helical; Reviewed predictionAdd
BLAST
Topological domaini848 – 1002155Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. N-methyl-D-aspartate selective glutamate receptor complex Source: RGD
  4. postsynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 1002978Glutamate receptor ionotropic, NMDA 3BPRO_0000011572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi212 – 2121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi451 – 4511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi786 – 7861N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VHN2.
PRIDEiQ8VHN2.

Expressioni

Tissue specificityi

Expressed in the hippocampus, the corpus callosum, in the facial and trigeminal nuclei of the brainstem and the ventral horn of the spinal cord.2 Publications

Gene expression databases

GenevestigatoriQ8VHN2.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017064.

Structurei

Secondary structure

1
1002
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi416 – 4216
Turni425 – 4273
Beta strandi428 – 4325
Beta strandi440 – 4467
Helixi453 – 46513
Helixi470 – 4723
Beta strandi473 – 4786
Helixi479 – 49113
Beta strandi494 – 4996
Helixi515 – 5217
Beta strandi526 – 5283
Helixi536 – 5394
Beta strandi542 – 5443
Beta strandi548 – 55811
Helixi683 – 6864
Helixi701 – 7099
Helixi711 – 7177
Beta strandi722 – 7243
Helixi725 – 7339
Beta strandi734 – 7363
Beta strandi740 – 7456
Helixi746 – 75510
Beta strandi761 – 77313
Beta strandi776 – 7783
Helixi784 – 79613
Helixi799 – 8079

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RCAX-ray1.58A/B413-560[»]
A/B676-815[»]
2RCBX-ray1.62A/B413-560[»]
A/B676-815[»]
ProteinModelPortaliQ8VHN2.
SMRiQ8VHN2. Positions 414-808.

Miscellaneous databases

EvolutionaryTraceiQ8VHN2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni951 – 98434Involved in the trafficking and surface expression of NMDARs By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili944 – 98542 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi914 – 99380Arg-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320645.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
KOiK05214.
PhylomeDBiQ8VHN2.

Family and domain databases

InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHN2-1 [UniParc]FASTAAdd to Basket

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MESVRTLWLS VALALAVGSR VVRGHPQPCR VPTRAGASVR LAALLPRAPA     50
ARARVLAALA TPAPRLPHNL SLELVAVASP TRDPASLARG LCQVLAPPGV 100
VASIAFPEAR PELRLLQFLA AATETPVVSV LRREVRTALG APTPFHLQLD 150
WASPLETILD VLVSLVRAHA WEDIALVLCR VRDPGSLVTL WTNHASQAPK 200
FVLDLSRLDS RNDSLRAGLA LLGALEGGGT PVPAAVLLGC STARAHEVLE 250
AAPPGPQWLL GTPLPAEALP TTGLPPGVLA LGETEQHSLE AVVHDMVELV 300
AQALSSMALV HPERALLPAV VNCDDLKTGG SEATGRTLAR FLGNTSFQGR 350
TGAVWVTGSS QVHVSRHFKV WSLRRDPLGA PAWATVGSWQ DGQLDFQPGA 400
AALRVPSPSG TQARPKLRVV TLVEHPFVFT RESDEDGQCP AGQLCLDPGT 450
NDSARLDALF AALVNGSVPR TLRRCCYGYC IDLLERLAED LAFDFELYIV 500
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS 550
TSLGIMVRTR DTASPIGAFM WPLHWSMWVG VFAALHLTAL FLTLYEWRSP 600
YGLTPRGRNR GTVFSYSSAL NLCYAILFGR TVSSKTPKCP TGRFLMNLWA 650
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPSQ GFRFGTVWES 700
SAEAYIKASF PEMHAHMRRH SAPTTPHGVA MLTSDPPKLN AFIMDKSLLD 750
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI 800
DLLHDKWYKM VPCGKRVFAV TETLQMGVYH FSGLFVLLCL GLGSALLTSL 850
GEHVFYRLVL PRIRRGNKLQ YWLHTSQKIH RALNTGPPEG QQERAEQERS 900
GPKDELPATD GAGRWRRVRR AVERERRVRF LLEPGEAGGD RPWLCSNGPG 950
LQAELRELEL RIEAARERLR SALLRRGELR ALLGDGTRLR PLRLLHAAPA 1000
ES 1002
Length:1,002
Mass (Da):109,158
Last modified:June 1, 2002 - v2
Checksum:i4AC840EF97E0AB83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF440691 mRNA. Translation: AAL69893.2.
RefSeqiNP_579842.2. NM_133308.2.
UniGeneiRn.162906.

Genome annotation databases

GeneIDi170796.
KEGGirno:170796.
UCSCiRGD:621705. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF440691 mRNA. Translation: AAL69893.2 .
RefSeqi NP_579842.2. NM_133308.2.
UniGenei Rn.162906.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RCA X-ray 1.58 A/B 413-560 [» ]
A/B 676-815 [» ]
2RCB X-ray 1.62 A/B 413-560 [» ]
A/B 676-815 [» ]
ProteinModelPortali Q8VHN2.
SMRi Q8VHN2. Positions 414-808.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000017064.

Chemistry

BindingDBi Q8VHN2.
ChEMBLi CHEMBL2096669.
GuidetoPHARMACOLOGYi 461.

Proteomic databases

PaxDbi Q8VHN2.
PRIDEi Q8VHN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 170796.
KEGGi rno:170796.
UCSCi RGD:621705. rat.

Organism-specific databases

CTDi 116444.
RGDi 621705. Grin3b.

Phylogenomic databases

eggNOGi NOG320645.
HOGENOMi HOG000231528.
HOVERGENi HBG052634.
KOi K05214.
PhylomeDBi Q8VHN2.

Miscellaneous databases

EvolutionaryTracei Q8VHN2.
NextBioi 621215.
PROi Q8VHN2.

Gene expression databases

Genevestigatori Q8VHN2.

Family and domain databases

InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. Chatterton J.E., Awobuluyi M., Cui J., Sevarino K.K.A., Lipton S.A., Zhang D.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
    Andersson O., Stenqvist A., Attersand A., von Euler G.
    Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNMD3B_RAT
AccessioniPrimary (citable) accession number: Q8VHN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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