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Q8VHN2

- NMD3B_RAT

UniProt

Q8VHN2 - NMD3B_RAT

Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

Grin3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

    GO - Molecular functioni

    1. cation channel activity Source: RGD
    2. extracellular-glutamate-gated ion channel activity Source: RefGenome
    3. glycine binding Source: RGD
    4. neurotransmitter binding Source: RGD
    5. neurotransmitter receptor activity Source: RGD
    6. N-methyl-D-aspartate selective glutamate receptor activity Source: RefGenome

    GO - Biological processi

    1. cation transport Source: GOC
    2. ionotropic glutamate receptor signaling pathway Source: RGD
    3. ion transmembrane transport Source: GOC
    4. synaptic transmission, glutamatergic Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calcium, Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, NMDA 3B
    Short name:
    GluN3B
    Alternative name(s):
    N-methyl-D-aspartate receptor subtype 3B
    Short name:
    NMDAR3B
    Short name:
    NR3B
    Gene namesi
    Name:Grin3b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621705. Grin3b.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity
    Note: Requires the presence of GRIN1 to be targeted at the plasma membrane.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: RefGenome
    3. N-methyl-D-aspartate selective glutamate receptor complex Source: RGD
    4. postsynaptic membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 1002978Glutamate receptor ionotropic, NMDA 3BPRO_0000011572Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi786 – 7861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8VHN2.
    PRIDEiQ8VHN2.

    Expressioni

    Tissue specificityi

    Expressed in the hippocampus, the corpus callosum, in the facial and trigeminal nuclei of the brainstem and the ventral horn of the spinal cord.2 Publications

    Gene expression databases

    GenevestigatoriQ8VHN2.

    Interactioni

    Subunit structurei

    Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000017064.

    Structurei

    Secondary structure

    1
    1002
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi416 – 4216
    Turni425 – 4273
    Beta strandi428 – 4325
    Beta strandi440 – 4467
    Helixi453 – 46513
    Helixi470 – 4723
    Beta strandi473 – 4786
    Helixi479 – 49113
    Beta strandi494 – 4996
    Helixi515 – 5217
    Beta strandi526 – 5283
    Helixi536 – 5394
    Beta strandi542 – 5443
    Beta strandi548 – 55811
    Helixi683 – 6864
    Helixi701 – 7099
    Helixi711 – 7177
    Beta strandi722 – 7243
    Helixi725 – 7339
    Beta strandi734 – 7363
    Beta strandi740 – 7456
    Helixi746 – 75510
    Beta strandi761 – 77313
    Beta strandi776 – 7783
    Helixi784 – 79613
    Helixi799 – 8079

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2RCAX-ray1.58A/B413-560[»]
    A/B676-815[»]
    2RCBX-ray1.62A/B413-560[»]
    A/B676-815[»]
    ProteinModelPortaliQ8VHN2.
    SMRiQ8VHN2. Positions 414-808.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8VHN2.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 564540ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini586 – 64863CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini670 – 826157ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini848 – 1002155CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei565 – 58521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei649 – 66921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei827 – 84721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni951 – 98434Involved in the trafficking and surface expression of NMDARsBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili944 – 98542Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi914 – 99380Arg-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320645.
    HOGENOMiHOG000231528.
    HOVERGENiHBG052634.
    KOiK05214.
    PhylomeDBiQ8VHN2.

    Family and domain databases

    InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view]
    PfamiPF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VHN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESVRTLWLS VALALAVGSR VVRGHPQPCR VPTRAGASVR LAALLPRAPA     50
    ARARVLAALA TPAPRLPHNL SLELVAVASP TRDPASLARG LCQVLAPPGV 100
    VASIAFPEAR PELRLLQFLA AATETPVVSV LRREVRTALG APTPFHLQLD 150
    WASPLETILD VLVSLVRAHA WEDIALVLCR VRDPGSLVTL WTNHASQAPK 200
    FVLDLSRLDS RNDSLRAGLA LLGALEGGGT PVPAAVLLGC STARAHEVLE 250
    AAPPGPQWLL GTPLPAEALP TTGLPPGVLA LGETEQHSLE AVVHDMVELV 300
    AQALSSMALV HPERALLPAV VNCDDLKTGG SEATGRTLAR FLGNTSFQGR 350
    TGAVWVTGSS QVHVSRHFKV WSLRRDPLGA PAWATVGSWQ DGQLDFQPGA 400
    AALRVPSPSG TQARPKLRVV TLVEHPFVFT RESDEDGQCP AGQLCLDPGT 450
    NDSARLDALF AALVNGSVPR TLRRCCYGYC IDLLERLAED LAFDFELYIV 500
    GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS 550
    TSLGIMVRTR DTASPIGAFM WPLHWSMWVG VFAALHLTAL FLTLYEWRSP 600
    YGLTPRGRNR GTVFSYSSAL NLCYAILFGR TVSSKTPKCP TGRFLMNLWA 650
    IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPSQ GFRFGTVWES 700
    SAEAYIKASF PEMHAHMRRH SAPTTPHGVA MLTSDPPKLN AFIMDKSLLD 750
    YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI 800
    DLLHDKWYKM VPCGKRVFAV TETLQMGVYH FSGLFVLLCL GLGSALLTSL 850
    GEHVFYRLVL PRIRRGNKLQ YWLHTSQKIH RALNTGPPEG QQERAEQERS 900
    GPKDELPATD GAGRWRRVRR AVERERRVRF LLEPGEAGGD RPWLCSNGPG 950
    LQAELRELEL RIEAARERLR SALLRRGELR ALLGDGTRLR PLRLLHAAPA 1000
    ES 1002
    Length:1,002
    Mass (Da):109,158
    Last modified:June 1, 2002 - v2
    Checksum:i4AC840EF97E0AB83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF440691 mRNA. Translation: AAL69893.2.
    RefSeqiNP_579842.2. NM_133308.2.
    UniGeneiRn.162906.

    Genome annotation databases

    GeneIDi170796.
    KEGGirno:170796.
    UCSCiRGD:621705. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF440691 mRNA. Translation: AAL69893.2 .
    RefSeqi NP_579842.2. NM_133308.2.
    UniGenei Rn.162906.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2RCA X-ray 1.58 A/B 413-560 [» ]
    A/B 676-815 [» ]
    2RCB X-ray 1.62 A/B 413-560 [» ]
    A/B 676-815 [» ]
    ProteinModelPortali Q8VHN2.
    SMRi Q8VHN2. Positions 414-808.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000017064.

    Chemistry

    BindingDBi Q8VHN2.
    ChEMBLi CHEMBL2096669.
    GuidetoPHARMACOLOGYi 461.

    Proteomic databases

    PaxDbi Q8VHN2.
    PRIDEi Q8VHN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 170796.
    KEGGi rno:170796.
    UCSCi RGD:621705. rat.

    Organism-specific databases

    CTDi 116444.
    RGDi 621705. Grin3b.

    Phylogenomic databases

    eggNOGi NOG320645.
    HOGENOMi HOG000231528.
    HOVERGENi HBG052634.
    KOi K05214.
    PhylomeDBi Q8VHN2.

    Miscellaneous databases

    EvolutionaryTracei Q8VHN2.
    NextBioi 621215.
    PROi Q8VHN2.

    Gene expression databases

    Genevestigatori Q8VHN2.

    Family and domain databases

    InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view ]
    Pfami PF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. Chatterton J.E., Awobuluyi M., Cui J., Sevarino K.K.A., Lipton S.A., Zhang D.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
      Andersson O., Stenqvist A., Attersand A., von Euler G.
      Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNMD3B_RAT
    AccessioniPrimary (citable) accession number: Q8VHN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3