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Protein

Transmembrane protease serine 11D

Gene

Tmprss11d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions (By similarity). Plays a role in the proteolytic processing of ACE2. Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC.By similarity1 Publication

Catalytic activityi

Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei226Charge relay systemBy similarity1
Active sitei271Charge relay systemBy similarity1
Active sitei367Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11D (EC:3.4.21.-)
Alternative name(s):
Adrenal secretory serine protease
Short name:
AsP
Airway trypsin-like protease
Short name:
AT
Cleaved into the following 2 chains:
Gene namesi
Name:Tmprss11d
Synonyms:Mat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2385221. Tmprss11d.

Subcellular locationi

Chain Transmembrane protease serine 11D catalytic chain :
  • Secreted By similarity

  • Note: Activated by cleavage and secreted.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 417ExtracellularSequence analysisAdd BLAST379

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000278871 – 185Transmembrane protease serine 11D non-catalytic chainAdd BLAST185
ChainiPRO_0000027888186 – 417Transmembrane protease serine 11D catalytic chainAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi172 ↔ 291Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotation
Disulfide bondi211 ↔ 227PROSITE-ProRule annotation
Disulfide bondi336 ↔ 352PROSITE-ProRule annotation
Disulfide bondi363 ↔ 392PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ8VHK8.
PRIDEiQ8VHK8.

Expressioni

Tissue specificityi

Highly expressed in the esophagus, tongue, and trachea, low expression was seen in heart, lung, and adrenal gland. Isoform 2 is also highly expressed in the adrenal gland.1 Publication

Gene expression databases

BgeeiENSMUSG00000061259.
CleanExiMM_TMPRSS11D.
GenevisibleiQ8VHK8. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031175.

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 60Combined sources15
Helixi63 – 66Combined sources4
Helixi71 – 89Combined sources19
Turni92 – 96Combined sources5
Beta strandi97 – 108Combined sources12
Beta strandi111 – 122Combined sources12
Helixi128 – 139Combined sources12
Helixi140 – 142Combined sources3
Beta strandi144 – 150Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7VX-ray1.92A44-164[»]
ProteinModelPortaliQ8VHK8.
SMRiQ8VHK8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VHK8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 162SEAPROSITE-ProRule annotationAdd BLAST117
Domaini186 – 417Peptidase S1PROSITE-ProRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ8VHK8.
KOiK09641.
OMAiSNLRNQF.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ8VHK8.
TreeFamiTF351684.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VHK8-1) [UniParc]FASTAAdd to basket
Also known as: MAT1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRPRPMLSP SRFFTPFAVA FVVIITVGLL AMMAGLLIHF LAFDKKAYFY
60 70 80 90 100
HSSFQILNVE YTEALNSPAT HEYRTLSERI EAMITDEFRG SSLKSEFIRT
110 120 130 140 150
HVVKLRKEGT GVVADVVMKF RSSKRNNRKV MKTRIQSVLR RLSSSGNLEI
160 170 180 190 200
APSNEITSLT DQDTENVLTQ ECGARPDLIT LSEERIIGGM QAEPGDWPWQ
210 220 230 240 250
VSLQLNNVHH CGGALISNMW VLTAAHCFKS YPNPQYWTAT FGVSTMSPRL
260 270 280 290 300
RVRVRAILAH DGYSSVTRDN DIAVVQLDRS VAFSRNIHRV CLPAATQNII
310 320 330 340 350
PGSVAYVTGW GSLTYGGNAV TNLRQGEVRI ISSEECNTPA GYSGSVLPGM
360 370 380 390 400
LCAGMRSGAV DACQGDSGGP LVQEDSRRLW FVVGIVSWGY QCGLPNKPGV
410
YTRVTAYRNW IRQQTGI
Length:417
Mass (Da):46,254
Last modified:July 5, 2005 - v2
Checksum:iC7FACD21C06FEAEA
GO
Isoform 2 (identifier: Q8VHK8-2) [UniParc]FASTAAdd to basket
Also known as: MAT2

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     139-158: LRRLSSSGNLEIAPSNEITS → MIFSFCFVDFVLTFSFLMIA

Show »
Length:279
Mass (Da):30,593
Checksum:i7A8CF885250910F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43F → L in AAL47139 (PubMed:14691009).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0145191 – 138Missing in isoform 2. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_014520139 – 158LRRLS…NEITS → MIFSFCFVDFVLTFSFLMIA in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448809 mRNA. Translation: AAL47139.1.
AF539752 mRNA. Translation: AAP97729.1.
AB053953 mRNA. Translation: BAD89353.1.
BC020151 mRNA. Translation: AAH20151.1.
CCDSiCCDS39124.1. [Q8VHK8-1]
RefSeqiNP_663536.1. NM_145561.2. [Q8VHK8-1]
UniGeneiMm.240139.

Genome annotation databases

EnsembliENSMUST00000031175; ENSMUSP00000031175; ENSMUSG00000061259. [Q8VHK8-1]
ENSMUST00000122377; ENSMUSP00000113079; ENSMUSG00000061259. [Q8VHK8-2]
GeneIDi231382.
KEGGimmu:231382.
UCSCiuc008xxo.1. mouse. [Q8VHK8-2]
uc008xxp.1. mouse. [Q8VHK8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448809 mRNA. Translation: AAL47139.1.
AF539752 mRNA. Translation: AAP97729.1.
AB053953 mRNA. Translation: BAD89353.1.
BC020151 mRNA. Translation: AAH20151.1.
CCDSiCCDS39124.1. [Q8VHK8-1]
RefSeqiNP_663536.1. NM_145561.2. [Q8VHK8-1]
UniGeneiMm.240139.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7VX-ray1.92A44-164[»]
ProteinModelPortaliQ8VHK8.
SMRiQ8VHK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031175.

Proteomic databases

PaxDbiQ8VHK8.
PRIDEiQ8VHK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031175; ENSMUSP00000031175; ENSMUSG00000061259. [Q8VHK8-1]
ENSMUST00000122377; ENSMUSP00000113079; ENSMUSG00000061259. [Q8VHK8-2]
GeneIDi231382.
KEGGimmu:231382.
UCSCiuc008xxo.1. mouse. [Q8VHK8-2]
uc008xxp.1. mouse. [Q8VHK8-1]

Organism-specific databases

CTDi9407.
MGIiMGI:2385221. Tmprss11d.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ8VHK8.
KOiK09641.
OMAiSNLRNQF.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ8VHK8.
TreeFamiTF351684.

Miscellaneous databases

EvolutionaryTraceiQ8VHK8.
PROiQ8VHK8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061259.
CleanExiMM_TMPRSS11D.
GenevisibleiQ8VHK8. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM11D_MOUSE
AccessioniPrimary (citable) accession number: Q8VHK8
Secondary accession number(s): Q7TNX3, Q8VDV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.