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Protein

Interleukin-13 receptor subunit alpha-2

Gene

Il13ra2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds as a monomer with high affinity to interleukin-13 (IL13).By similarity

GO - Molecular functioni

  • cytokine receptor activity Source: RGD

GO - Biological processi

  • cellular response to mechanical stimulus Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13 receptor subunit alpha-2
Short name:
IL-13 receptor subunit alpha-2
Short name:
IL-13R subunit alpha-2
Short name:
IL-13R-alpha-2
Short name:
IL-13RA2
Alternative name(s):
CD_antigen: CD213a2
Gene namesi
Name:Il13ra2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620838. Il13ra2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 336313ExtracellularSequence analysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence analysisAdd
BLAST
Topological domaini358 – 38528CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 385362Interleukin-13 receptor subunit alpha-2PRO_0000378453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 109By similarity
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi141 ↔ 151By similarity
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi180 ↔ 193By similarity
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi265 ↔ 312By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VHK6.
PRIDEiQ8VHK6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041564.

Structurei

3D structure databases

ProteinModelPortaliQ8VHK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 130101Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini133 – 22189Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini236 – 33499Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi318 – 3225WSXWS motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
HOGENOMiHOG000004823.
InParanoidiQ8VHK6.
PhylomeDBiQ8VHK6.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMAVNTRC LCLFLLCTIT GHSLEIKVNP PQDFEILDPG LLGYLYLQWK
60 70 80 90 100
PPVVMDNFKE CKLEYELKYR NVDSDSWKTI ITRNLIYKDG FDLNKGIEGK
110 120 130 140 150
IRTHLSEHCT NGSEVQSPWT EASYGIADEG SLGTKIQDMK CIYYNWQYLV
160 170 180 190 200
CSWKPGKTVH SDTNYTMFFW YEGLDHALQC ADYLQDNEKN VGCKLSNLDS
210 220 230 240 250
SDYKDFFIRV NGSSKLEPIR SSYMVFQLQN IVKPLPPEFL HISVENSIDI
260 270 280 290 300
RMKWSTPGGP IPPSCYTYEI VVREDDISWE SATDKNDMKL KRRANESEDL
310 320 330 340 350
CFFVRCKINI YCADDGIWSE WSEEECWEGY TGPDSKIVFI VPVCLFFIFL
360 370 380
LLLLCLIVEK EDPEPTLSLH VDLNKEMYAY EETLC
Length:385
Mass (Da):44,622
Last modified:March 1, 2002 - v1
Checksum:iEE06FF0E434737E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448818 mRNA. Translation: AAL57513.1.
UniGeneiRn.162308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448818 mRNA. Translation: AAL57513.1.
UniGeneiRn.162308.

3D structure databases

ProteinModelPortaliQ8VHK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041564.

Proteomic databases

PaxDbiQ8VHK6.
PRIDEiQ8VHK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi620838. Il13ra2.

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
HOGENOMiHOG000004823.
InParanoidiQ8VHK6.
PhylomeDBiQ8VHK6.

Miscellaneous databases

PROiQ8VHK6.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI13R2_RAT
AccessioniPrimary (citable) accession number: Q8VHK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.