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Protein

Caskin-1

Gene

Caskin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May link the scaffolding protein CASK to downstream intracellular effectors.

GO - Molecular functioni

  • protein domain specific binding Source: RGD

GO - Biological processi

  • signal transduction Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-1
Alternative name(s):
CASK-interacting protein 1
Gene namesi
Name:Caskin1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620191. Caskin1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14301430Caskin-1PRO_0000066982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei253 – 2531PhosphotyrosineBy similarity
Modified residuei358 – 3581PhosphoserineBy similarity
Modified residuei423 – 4231PhosphoserineBy similarity
Modified residuei432 – 4321PhosphoserineCombined sources
Modified residuei635 – 6351PhosphoserineBy similarity
Modified residuei648 – 6481PhosphoserineBy similarity
Modified residuei722 – 7221PhosphoserineCombined sources
Modified residuei727 – 7271PhosphoserineBy similarity
Modified residuei740 – 7401PhosphothreonineCombined sources
Modified residuei790 – 7901PhosphoserineCombined sources
Modified residuei890 – 8901PhosphoserineCombined sources
Modified residuei892 – 8921PhosphoserineCombined sources
Modified residuei988 – 9881PhosphoserineBy similarity
Modified residuei1066 – 10661PhosphothreonineBy similarity
Modified residuei1068 – 10681PhosphoserineBy similarity
Modified residuei1258 – 12581PhosphoserineCombined sources
Modified residuei1267 – 12671PhosphothreonineBy similarity
Modified residuei1362 – 13621PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VHK2.
PRIDEiQ8VHK2.

PTM databases

iPTMnetiQ8VHK2.
PhosphoSiteiQ8VHK2.

Expressioni

Tissue specificityi

Expressed in brain. Localized primarily to the neuropil and enriched in synaptic areas (at protein level).1 Publication

Interactioni

Subunit structurei

Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble (By similarity). Binds the CaM kinase domain of CASK. Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-7049475,EBI-743598From a different organism.

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi250839. 13 interactions.
IntActiQ8VHK2. 11 interactions.
MINTiMINT-238952.
STRINGi10116.ENSRNOP00000004486.

Structurei

3D structure databases

ProteinModelPortaliQ8VHK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati48 – 7730ANK 1Add
BLAST
Repeati81 – 11030ANK 2Add
BLAST
Repeati114 – 14330ANK 3Add
BLAST
Repeati147 – 17630ANK 4Add
BLAST
Repeati188 – 21730ANK 5Add
BLAST
Repeati220 – 24930ANK 6Add
BLAST
Domaini281 – 34767SH3PROSITE-ProRule annotationAdd
BLAST
Domaini474 – 53764SAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini543 – 60765SAM 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni375 – 47197CASK-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi760 – 877118Pro-richAdd
BLAST
Compositional biasi1153 – 1355203Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 2 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8VHK2.
PhylomeDBiQ8VHK2.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027013. Caskin-1.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR24177:SF12. PTHR24177:SF12. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF
60 70 80 90 100
SALHHAALNG NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL
110 120 130 140 150
VLKAGSAVNV PSDEGHIPLH LAAQHGHYDV SEMLLQHQSN PCIVDNSGKT
160 170 180 190 200
PLDLACEFGR VGVVQLLLSS NMCAALLEPR PGDTTDPNGT SPLHLAAKNG
210 220 230 240 250
HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL LDSGINAQVR
260 270 280 290 300
NTYSQTALDI VHQFTTSQAS KEIKQLLREA SAALQVRATK DYCNNYDLTS
310 320 330 340 350
LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG
360 370 380 390 400
SRTGSEPSPP QGGGSLGPSA PPEEIWVLRK PFAGGDRSGS LSNVAGGRST
410 420 430 440 450
GGHALHAGAE GVKLLATVLS QKSVSESSPG DSPVKPPEGS SGAARSQPPA
460 470 480 490 500
AHAGQVYGEQ PPKKLESSSA SEGKSAEAVS QWLATFQLQL YAPNFTSAGY
510 520 530 540 550
DLPTISRMTP EDLTAIGVTK PGHRKKITAE ISGLNIPDCL PEHKPANLAV
560 570 580 590 600
WLSMIGLAQY YKVLVDNGYE NIDFITDITW EDLQEIGITK LGHQKKLMLA
610 620 630 640 650
VRKLAELQKA EYSKYEGGPL RRKAPQSLEM MAIESPPPSE PAAAECQSPK
660 670 680 690 700
MTTFQDSELS GELQAALSGP AEAGAAAAEK SSNHLPATPR TTSRQESSLS
710 720 730 740 750
GRARHMSSSQ ELLGDGPQGP GSPMSRSQEY LLDEGPAPGT PPKEVRSSRH
760 770 780 790 800
GHSVKRASVP PVPGKPRQVL PSGVSHFTPP QTPTKAQPGS PQALGGPHGP
810 820 830 840 850
ATAKVKPTPQ LLPPTDRPMS PRSLPQSPTH RGFAYVLPQP VEGEAGPPAP
860 870 880 890 900
GPVPPPVPAA VPTLCLPPEA DVEPRRPKKR AHSLNRYAAS DSEPERDELL
910 920 930 940 950
VPAAAGPYAT VQRRVGRSHS VRAPAGTDKN VNRSQSFAVR PRKKGPPPPP
960 970 980 990 1000
PKRSSSAMAS ANLADEPSPD VETEDGRLGV RAQRRRASDL AGSVDTGSAG
1010 1020 1030 1040 1050
SVKSIAAMLE LSSIGGGGRA IRRPPEGHPT PRPASPDPGR VATVLASVKH
1060 1070 1080 1090 1100
KEAIGPDGEV VNRRRTLSGP VTGLLATARR GPGEPAEQSH FMEDGTARQR
1110 1120 1130 1140 1150
LRGPAKGEAG VEGPPLARVE ASATLKRRIR AKQSQQENVK FILTESDTVK
1160 1170 1180 1190 1200
RRPKAKEPDI GPEPPPPLSV YQNGTATIRR RPASEQAGPP ELPPPPPPAE
1210 1220 1230 1240 1250
PPPTDLMPLP PLPLPDGSAR KPVKPPVSPK PILAQPVSKI QGSPTPASKK
1260 1270 1280 1290 1300
VPLPGPGSPE VKRAHGTPPP VSPKPPPPPT APKPAKALAG LQSSSATPSP
1310 1320 1330 1340 1350
VPSPARQPPA ALIKPASSPP SQSASPAKPP SPGAPALQVP TKPPRAAASV
1360 1370 1380 1390 1400
VSGPPVASDC ASPGDSARQK LEETSACLAA ALQAVEEKIR QEDGQGPRPS
1410 1420 1430
SIEEKSTGSI LEDIGSMFDD LADQLDAMLE
Length:1,430
Mass (Da):150,347
Last modified:March 1, 2002 - v1
Checksum:iF2AE91EF10F5B746
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti782 – 7821T → K AA sequence (PubMed:12040031).Curated
Sequence conflicti813 – 8131P → I AA sequence (PubMed:12040031).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451975 mRNA. Translation: AAL49756.1.
RefSeqiNP_542421.2. NM_080690.2.
UniGeneiRn.48905.

Genome annotation databases

GeneIDi140722.
KEGGirno:140722.
UCSCiRGD:620191. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451975 mRNA. Translation: AAL49756.1.
RefSeqiNP_542421.2. NM_080690.2.
UniGeneiRn.48905.

3D structure databases

ProteinModelPortaliQ8VHK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250839. 13 interactions.
IntActiQ8VHK2. 11 interactions.
MINTiMINT-238952.
STRINGi10116.ENSRNOP00000004486.

PTM databases

iPTMnetiQ8VHK2.
PhosphoSiteiQ8VHK2.

Proteomic databases

PaxDbiQ8VHK2.
PRIDEiQ8VHK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140722.
KEGGirno:140722.
UCSCiRGD:620191. rat.

Organism-specific databases

CTDi57524.
RGDi620191. Caskin1.

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8VHK2.
PhylomeDBiQ8VHK2.

Miscellaneous databases

PROiQ8VHK2.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027013. Caskin-1.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR24177:SF12. PTHR24177:SF12. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSKI1_RAT
AccessioniPrimary (citable) accession number: Q8VHK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.