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Protein

Caskin-2

Gene

Caskin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-2
Gene namesi
Name:Caskin2
Synonyms:Kiaa1139
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2157062. Caskin2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12011201Caskin-2PRO_0000066984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei371 – 3711PhosphoserineCombined sources
Modified residuei393 – 3931PhosphoserineBy similarity
Modified residuei396 – 3961PhosphoserineBy similarity
Modified residuei403 – 4031PhosphoserineCombined sources
Modified residuei406 – 4061PhosphoserineCombined sources
Modified residuei409 – 4091PhosphoserineCombined sources
Modified residuei471 – 4711PhosphoserineBy similarity
Modified residuei855 – 8551PhosphoserineBy similarity
Modified residuei874 – 8741PhosphoserineCombined sources
Modified residuei875 – 8751PhosphoserineCombined sources
Modified residuei880 – 8801PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VHK1.
MaxQBiQ8VHK1.
PaxDbiQ8VHK1.
PRIDEiQ8VHK1.

PTM databases

iPTMnetiQ8VHK1.
PhosphoSiteiQ8VHK1.

Expressioni

Gene expression databases

BgeeiQ8VHK1.
CleanExiMM_CASKIN2.
ExpressionAtlasiQ8VHK1. baseline and differential.
GenevisibleiQ8VHK1. MM.

Interactioni

Subunit structurei

May not bind CASK.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041328.

Structurei

3D structure databases

ProteinModelPortaliQ8VHK1.
SMRiQ8VHK1. Positions 282-348, 487-626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati48 – 7730ANK 1Add
BLAST
Repeati81 – 11030ANK 2Add
BLAST
Repeati114 – 14330ANK 3Add
BLAST
Repeati147 – 17630ANK 4Add
BLAST
Repeati188 – 21730ANK 5Add
BLAST
Repeati220 – 24930ANK 6Add
BLAST
Domaini281 – 34767SH3PROSITE-ProRule annotationAdd
BLAST
Domaini488 – 55164SAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini557 – 62165SAM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi686 – 1140455Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 2 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
KOG4384. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8VHK1.
OMAiPYVFMYP.
OrthoDBiEOG7V49XK.
TreeFamiTF320582.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREQDLILA VKNGDVTCVQ KLVAKVKAAK TKLLGSTKRL NINYQDADGF
60 70 80 90 100
SALHHAALGG SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL
110 120 130 140 150
LLRASAAVNA ASLDGQIPLH LAAQYGHYEV SEMLLQHQSN PCLVNKLKKT
160 170 180 190 200
PLDLACEFGR LKVAQLLLNS HLCVALLEGE AKDPCDPNYT TPLHLAAKNG
210 220 230 240 250
HREVIRQLLK AGIEINRQTK TGTALHEAAL YGKTEVVRLL LEGGVDVNIR
260 270 280 290 300
NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA
310 320 330 340 350
LNVRAGDVIT VLEQHPDGRW KGHIHESQRG TDRVGYFPPG IVEVVSKRVG
360 370 380 390 400
IPVARLPSAP TPLRPSFSRI SQPAADDPLP SVPYGQLPRV GLSPDSPAGD
410 420 430 440 450
RNSVGSEGSV GSIRSAGSGQ SSEGTNGHGT GLLIENAQPL PSASEDQGLP
460 470 480 490 500
GLHAPSPADN LSHRPLAGYR SGEIFTQDVR PEQLLEGKDA QAIHNWLSEF
510 520 530 540 550
QLEGYTAHFL QAGYDVPTIS RMTPEDLTAI GVTKPGHRKK IASEIAQLSI
560 570 580 590 600
AEWLPNYIPV DLLEWLCALG LPQYHKQLVS SGYDSMGLVA DLTWEELQEI
610 620 630 640 650
GVNKLGHQKK LMLGVKRLAE LRRGLLHGEA LGEGGRRMTR GPELMAIEGL
660 670 680 690 700
ENGEGPTTAG PRLLTFQGSE LSPELQAAMA GGGSEPLPLP PARSPSQESI
710 720 730 740 750
GARSRGSGHS QEQPVPQPSV GDPSAPQERN LPEGTERPSK LCSPLPGQGP
760 770 780 790 800
APYVFMCPQN LPSSPAPGPP PGVPRAFSYL AGSPAAPPDP PRPKRRSHSL
810 820 830 840 850
SRPGPAEGEA EGEAEGPVGS ALGSYATLTR RPGRSTLART SPSLTPTRGT
860 870 880 890 900
PRSQSFALRA RRKGPPPPPP KRLSSVSGST EPPSLDGTSG PKEGATGPRR
910 920 930 940 950
RTLSEPTGPS ESPGPSAPTG PVSDTEEEPG PEGTPPSRGS SGEGLPFAEE
960 970 980 990 1000
GNLTIKQRPK PAGPPPRETP VPPGLDFNLT ESDTVKRRPK CKEREPLQTA
1010 1020 1030 1040 1050
LLAFGVVGSD TPGPSNPLST QAPCDPPSAS SNPPQRSEPS VLPSQGTSAS
1060 1070 1080 1090 1100
SLSSVTQSPG HPGPSAGPAL ANSTGSKPNV ETEPPAPPAA LLKVPGAGTA
1110 1120 1130 1140 1150
PKPVSVACTQ LAFSGPKLAP RLGPRPVPPP RPENTGPVCP GRAQQRLEQT
1160 1170 1180 1190 1200
SSSLEAALRA AEKSIGTEER DGPTGTSTKH ILDDISTMFD ALADQLDAML

D
Length:1,201
Mass (Da):126,779
Last modified:July 27, 2011 - v3
Checksum:iB930742E6D407DB3
GO

Sequence cautioni

The sequence BAC98107.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291A → T in AAL49759 (PubMed:12040031).Curated
Sequence conflicti371 – 3711S → P in AAL49759 (PubMed:12040031).Curated
Sequence conflicti374 – 3818AADDPLPS → PAEEPPHP in AAL49759 (PubMed:12040031).Curated
Sequence conflicti444 – 4441S → G in AAL49759 (PubMed:12040031).Curated
Sequence conflicti448 – 4481G → V in AAL49759 (PubMed:12040031).Curated
Sequence conflicti454 – 4541A → P in AAL49759 (PubMed:12040031).Curated
Sequence conflicti457 – 4571P → L in AAL49759 (PubMed:12040031).Curated
Sequence conflicti627 – 6271H → Q in AAL49759 (PubMed:12040031).Curated
Sequence conflicti1141 – 11411G → S in AAL49759 (PubMed:12040031).Curated
Sequence conflicti1141 – 11411G → S in BAC98107 (PubMed:14621295).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451978 mRNA. Translation: AAL49759.1.
AK129297 mRNA. Translation: BAC98107.1. Different initiation.
AL645852 Genomic DNA. Translation: CAM21977.1.
BC053083 mRNA. Translation: AAH53083.1.
CCDSiCCDS25647.1.
RefSeqiNP_542374.2. NM_080643.2.
UniGeneiMm.383737.

Genome annotation databases

EnsembliENSMUST00000041684; ENSMUSP00000041328; ENSMUSG00000034471.
GeneIDi140721.
KEGGimmu:140721.
UCSCiuc007mip.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451978 mRNA. Translation: AAL49759.1.
AK129297 mRNA. Translation: BAC98107.1. Different initiation.
AL645852 Genomic DNA. Translation: CAM21977.1.
BC053083 mRNA. Translation: AAH53083.1.
CCDSiCCDS25647.1.
RefSeqiNP_542374.2. NM_080643.2.
UniGeneiMm.383737.

3D structure databases

ProteinModelPortaliQ8VHK1.
SMRiQ8VHK1. Positions 282-348, 487-626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041328.

PTM databases

iPTMnetiQ8VHK1.
PhosphoSiteiQ8VHK1.

Proteomic databases

EPDiQ8VHK1.
MaxQBiQ8VHK1.
PaxDbiQ8VHK1.
PRIDEiQ8VHK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041684; ENSMUSP00000041328; ENSMUSG00000034471.
GeneIDi140721.
KEGGimmu:140721.
UCSCiuc007mip.1. mouse.

Organism-specific databases

CTDi57513.
MGIiMGI:2157062. Caskin2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
KOG4384. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8VHK1.
OMAiPYVFMYP.
OrthoDBiEOG7V49XK.
TreeFamiTF320582.

Miscellaneous databases

PROiQ8VHK1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHK1.
CleanExiMM_CASKIN2.
ExpressionAtlasiQ8VHK1. baseline and differential.
GenevisibleiQ8VHK1. MM.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with Caskin 1, a novel CASK-binding protein."
    Tabuchi K., Biederer T., Butz S., Suedhof T.C.
    J. Neurosci. 22:4264-4273(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-403, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371; SER-403; SER-406; SER-409; SER-874; SER-875 AND THR-880, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCSKI2_MOUSE
AccessioniPrimary (citable) accession number: Q8VHK1
Secondary accession number(s): B1ATA2, Q6ZPX1, Q7TS77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.