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UniProtKB - Q8VHK1 (CSKI2_MOUSE)

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Protein

Caskin-2

Gene

Caskin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-2
Gene namesi
Name:Caskin2
Synonyms:Kiaa1139
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2157062. Caskin2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669841 – 1201Caskin-2Add BLAST1201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei371PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei471PhosphoserineBy similarity1
Modified residuei724PhosphoserineBy similarity1
Modified residuei855PhosphoserineBy similarity1
Modified residuei874PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei880PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VHK1.
PaxDbiQ8VHK1.
PeptideAtlasiQ8VHK1.
PRIDEiQ8VHK1.

PTM databases

iPTMnetiQ8VHK1.
PhosphoSitePlusiQ8VHK1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034471.
CleanExiMM_CASKIN2.
ExpressionAtlasiQ8VHK1. baseline and differential.
GenevisibleiQ8VHK1. MM.

Interactioni

Subunit structurei

May not bind CASK.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041328.

Structurei

3D structure databases

ProteinModelPortaliQ8VHK1.
SMRiQ8VHK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini488 – 551SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini557 – 621SAM 2PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi686 – 1140Pro-richAdd BLAST455

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
KOG4384. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8VHK1.
OMAiPYVFMYP.
OrthoDBiEOG091G00P3.
TreeFamiTF320582.

Family and domain databases

CDDicd00204. ANK. 3 hits.
Gene3Di1.25.40.20. 3 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 7 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VHK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREQDLILA VKNGDVTCVQ KLVAKVKAAK TKLLGSTKRL NINYQDADGF 
        60         70         80         90        100
SALHHAALGG SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL 
       110        120        130        140        150
LLRASAAVNA ASLDGQIPLH LAAQYGHYEV SEMLLQHQSN PCLVNKLKKT 
       160        170        180        190        200
PLDLACEFGR LKVAQLLLNS HLCVALLEGE AKDPCDPNYT TPLHLAAKNG 
       210        220        230        240        250
HREVIRQLLK AGIEINRQTK TGTALHEAAL YGKTEVVRLL LEGGVDVNIR 
       260        270        280        290        300
NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA 
       310        320        330        340        350
LNVRAGDVIT VLEQHPDGRW KGHIHESQRG TDRVGYFPPG IVEVVSKRVG 
       360        370        380        390        400
IPVARLPSAP TPLRPSFSRI SQPAADDPLP SVPYGQLPRV GLSPDSPAGD 
       410        420        430        440        450
RNSVGSEGSV GSIRSAGSGQ SSEGTNGHGT GLLIENAQPL PSASEDQGLP 
       460        470        480        490        500
GLHAPSPADN LSHRPLAGYR SGEIFTQDVR PEQLLEGKDA QAIHNWLSEF 
       510        520        530        540        550
QLEGYTAHFL QAGYDVPTIS RMTPEDLTAI GVTKPGHRKK IASEIAQLSI 
       560        570        580        590        600
AEWLPNYIPV DLLEWLCALG LPQYHKQLVS SGYDSMGLVA DLTWEELQEI 
       610        620        630        640        650
GVNKLGHQKK LMLGVKRLAE LRRGLLHGEA LGEGGRRMTR GPELMAIEGL 
       660        670        680        690        700
ENGEGPTTAG PRLLTFQGSE LSPELQAAMA GGGSEPLPLP PARSPSQESI 
       710        720        730        740        750
GARSRGSGHS QEQPVPQPSV GDPSAPQERN LPEGTERPSK LCSPLPGQGP 
       760        770        780        790        800
APYVFMCPQN LPSSPAPGPP PGVPRAFSYL AGSPAAPPDP PRPKRRSHSL 
       810        820        830        840        850
SRPGPAEGEA EGEAEGPVGS ALGSYATLTR RPGRSTLART SPSLTPTRGT 
       860        870        880        890        900
PRSQSFALRA RRKGPPPPPP KRLSSVSGST EPPSLDGTSG PKEGATGPRR 
       910        920        930        940        950
RTLSEPTGPS ESPGPSAPTG PVSDTEEEPG PEGTPPSRGS SGEGLPFAEE 
       960        970        980        990       1000
GNLTIKQRPK PAGPPPRETP VPPGLDFNLT ESDTVKRRPK CKEREPLQTA 
      1010       1020       1030       1040       1050
LLAFGVVGSD TPGPSNPLST QAPCDPPSAS SNPPQRSEPS VLPSQGTSAS 
      1060       1070       1080       1090       1100
SLSSVTQSPG HPGPSAGPAL ANSTGSKPNV ETEPPAPPAA LLKVPGAGTA 
      1110       1120       1130       1140       1150
PKPVSVACTQ LAFSGPKLAP RLGPRPVPPP RPENTGPVCP GRAQQRLEQT 
      1160       1170       1180       1190       1200
SSSLEAALRA AEKSIGTEER DGPTGTSTKH ILDDISTMFD ALADQLDAML 

D
Length:1,201
Mass (Da):126,779
Last modified:July 27, 2011 - v3
Checksum:iB930742E6D407DB3
GO

Sequence cautioni

The sequence BAC98107 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29A → T in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti371S → P in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti374 – 381AADDPLPS → PAEEPPHP in AAL49759 (PubMed:12040031).Curated8
Sequence conflicti444S → G in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti448G → V in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti454A → P in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti457P → L in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti627H → Q in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti1141G → S in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti1141G → S in BAC98107 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451978 mRNA. Translation: AAL49759.1.
AK129297 mRNA. Translation: BAC98107.1. Different initiation.
AL645852 Genomic DNA. Translation: CAM21977.1.
BC053083 mRNA. Translation: AAH53083.1.
CCDSiCCDS25647.1.
RefSeqiNP_542374.2. NM_080643.2.
UniGeneiMm.383737.

Genome annotation databases

EnsembliENSMUST00000041684; ENSMUSP00000041328; ENSMUSG00000034471.
GeneIDi140721.
KEGGimmu:140721.
UCSCiuc007mip.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCSKI2_MOUSE
AccessioniPrimary (citable) accession number: Q8VHK1
Secondary accession number(s): B1ATA2, Q6ZPX1, Q7TS77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: July 5, 2017
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot