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Protein

Caskin-2

Gene

Caskin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-2
Gene namesi
Name:Caskin2
Synonyms:Kiaa1139
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2157062. Caskin2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669841 – 1201Caskin-2Add BLAST1201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei371PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei471PhosphoserineBy similarity1
Modified residuei724PhosphoserineBy similarity1
Modified residuei855PhosphoserineBy similarity1
Modified residuei874PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei880PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VHK1.
PaxDbiQ8VHK1.
PeptideAtlasiQ8VHK1.
PRIDEiQ8VHK1.

PTM databases

iPTMnetiQ8VHK1.
PhosphoSitePlusiQ8VHK1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034471.
CleanExiMM_CASKIN2.
ExpressionAtlasiQ8VHK1. baseline and differential.
GenevisibleiQ8VHK1. MM.

Interactioni

Subunit structurei

May not bind CASK.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041328.

Structurei

3D structure databases

ProteinModelPortaliQ8VHK1.
SMRiQ8VHK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini488 – 551SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini557 – 621SAM 2PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi686 – 1140Pro-richAdd BLAST455

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 2 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
KOG4384. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8VHK1.
OMAiPYVFMYP.
OrthoDBiEOG091G00P3.
TreeFamiTF320582.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREQDLILA VKNGDVTCVQ KLVAKVKAAK TKLLGSTKRL NINYQDADGF
60 70 80 90 100
SALHHAALGG SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL
110 120 130 140 150
LLRASAAVNA ASLDGQIPLH LAAQYGHYEV SEMLLQHQSN PCLVNKLKKT
160 170 180 190 200
PLDLACEFGR LKVAQLLLNS HLCVALLEGE AKDPCDPNYT TPLHLAAKNG
210 220 230 240 250
HREVIRQLLK AGIEINRQTK TGTALHEAAL YGKTEVVRLL LEGGVDVNIR
260 270 280 290 300
NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA
310 320 330 340 350
LNVRAGDVIT VLEQHPDGRW KGHIHESQRG TDRVGYFPPG IVEVVSKRVG
360 370 380 390 400
IPVARLPSAP TPLRPSFSRI SQPAADDPLP SVPYGQLPRV GLSPDSPAGD
410 420 430 440 450
RNSVGSEGSV GSIRSAGSGQ SSEGTNGHGT GLLIENAQPL PSASEDQGLP
460 470 480 490 500
GLHAPSPADN LSHRPLAGYR SGEIFTQDVR PEQLLEGKDA QAIHNWLSEF
510 520 530 540 550
QLEGYTAHFL QAGYDVPTIS RMTPEDLTAI GVTKPGHRKK IASEIAQLSI
560 570 580 590 600
AEWLPNYIPV DLLEWLCALG LPQYHKQLVS SGYDSMGLVA DLTWEELQEI
610 620 630 640 650
GVNKLGHQKK LMLGVKRLAE LRRGLLHGEA LGEGGRRMTR GPELMAIEGL
660 670 680 690 700
ENGEGPTTAG PRLLTFQGSE LSPELQAAMA GGGSEPLPLP PARSPSQESI
710 720 730 740 750
GARSRGSGHS QEQPVPQPSV GDPSAPQERN LPEGTERPSK LCSPLPGQGP
760 770 780 790 800
APYVFMCPQN LPSSPAPGPP PGVPRAFSYL AGSPAAPPDP PRPKRRSHSL
810 820 830 840 850
SRPGPAEGEA EGEAEGPVGS ALGSYATLTR RPGRSTLART SPSLTPTRGT
860 870 880 890 900
PRSQSFALRA RRKGPPPPPP KRLSSVSGST EPPSLDGTSG PKEGATGPRR
910 920 930 940 950
RTLSEPTGPS ESPGPSAPTG PVSDTEEEPG PEGTPPSRGS SGEGLPFAEE
960 970 980 990 1000
GNLTIKQRPK PAGPPPRETP VPPGLDFNLT ESDTVKRRPK CKEREPLQTA
1010 1020 1030 1040 1050
LLAFGVVGSD TPGPSNPLST QAPCDPPSAS SNPPQRSEPS VLPSQGTSAS
1060 1070 1080 1090 1100
SLSSVTQSPG HPGPSAGPAL ANSTGSKPNV ETEPPAPPAA LLKVPGAGTA
1110 1120 1130 1140 1150
PKPVSVACTQ LAFSGPKLAP RLGPRPVPPP RPENTGPVCP GRAQQRLEQT
1160 1170 1180 1190 1200
SSSLEAALRA AEKSIGTEER DGPTGTSTKH ILDDISTMFD ALADQLDAML

D
Length:1,201
Mass (Da):126,779
Last modified:July 27, 2011 - v3
Checksum:iB930742E6D407DB3
GO

Sequence cautioni

The sequence BAC98107 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29A → T in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti371S → P in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti374 – 381AADDPLPS → PAEEPPHP in AAL49759 (PubMed:12040031).Curated8
Sequence conflicti444S → G in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti448G → V in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti454A → P in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti457P → L in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti627H → Q in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti1141G → S in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti1141G → S in BAC98107 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451978 mRNA. Translation: AAL49759.1.
AK129297 mRNA. Translation: BAC98107.1. Different initiation.
AL645852 Genomic DNA. Translation: CAM21977.1.
BC053083 mRNA. Translation: AAH53083.1.
CCDSiCCDS25647.1.
RefSeqiNP_542374.2. NM_080643.2.
UniGeneiMm.383737.

Genome annotation databases

EnsembliENSMUST00000041684; ENSMUSP00000041328; ENSMUSG00000034471.
GeneIDi140721.
KEGGimmu:140721.
UCSCiuc007mip.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451978 mRNA. Translation: AAL49759.1.
AK129297 mRNA. Translation: BAC98107.1. Different initiation.
AL645852 Genomic DNA. Translation: CAM21977.1.
BC053083 mRNA. Translation: AAH53083.1.
CCDSiCCDS25647.1.
RefSeqiNP_542374.2. NM_080643.2.
UniGeneiMm.383737.

3D structure databases

ProteinModelPortaliQ8VHK1.
SMRiQ8VHK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041328.

PTM databases

iPTMnetiQ8VHK1.
PhosphoSitePlusiQ8VHK1.

Proteomic databases

MaxQBiQ8VHK1.
PaxDbiQ8VHK1.
PeptideAtlasiQ8VHK1.
PRIDEiQ8VHK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041684; ENSMUSP00000041328; ENSMUSG00000034471.
GeneIDi140721.
KEGGimmu:140721.
UCSCiuc007mip.1. mouse.

Organism-specific databases

CTDi57513.
MGIiMGI:2157062. Caskin2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
KOG4384. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ8VHK1.
OMAiPYVFMYP.
OrthoDBiEOG091G00P3.
TreeFamiTF320582.

Miscellaneous databases

PROiQ8VHK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034471.
CleanExiMM_CASKIN2.
ExpressionAtlasiQ8VHK1. baseline and differential.
GenevisibleiQ8VHK1. MM.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSKI2_MOUSE
AccessioniPrimary (citable) accession number: Q8VHK1
Secondary accession number(s): B1ATA2, Q6ZPX1, Q7TS77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.