Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caskin-2

Gene

Caskin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-2
Gene namesi
Name:Caskin2
Synonyms:Kiaa1139
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2157062 Caskin2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669841 – 1201Caskin-2Add BLAST1201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei371PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei471PhosphoserineBy similarity1
Modified residuei724PhosphoserineBy similarity1
Modified residuei855PhosphoserineBy similarity1
Modified residuei874PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei880PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VHK1
PaxDbiQ8VHK1
PeptideAtlasiQ8VHK1
PRIDEiQ8VHK1

PTM databases

iPTMnetiQ8VHK1
PhosphoSitePlusiQ8VHK1

Expressioni

Gene expression databases

BgeeiENSMUSG00000034471
CleanExiMM_CASKIN2
ExpressionAtlasiQ8VHK1 baseline and differential
GenevisibleiQ8VHK1 MM

Interactioni

Subunit structurei

May not bind CASK.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041328

Structurei

3D structure databases

ProteinModelPortaliQ8VHK1
SMRiQ8VHK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini488 – 551SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini557 – 621SAM 2PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi686 – 1140Pro-richAdd BLAST455

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0507 Eukaryota
KOG4384 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148972
HOGENOMiHOG000049168
HOVERGENiHBG051133
InParanoidiQ8VHK1
KOiK21952
OMAiPYVFMYP
OrthoDBiEOG091G00P3
TreeFamiTF320582

Family and domain databases

CDDicd00204 ANK, 3 hits
cd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12063 SH3_Caskin2, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035499 Caskin2_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 7 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VHK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREQDLILA VKNGDVTCVQ KLVAKVKAAK TKLLGSTKRL NINYQDADGF
60 70 80 90 100
SALHHAALGG SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL
110 120 130 140 150
LLRASAAVNA ASLDGQIPLH LAAQYGHYEV SEMLLQHQSN PCLVNKLKKT
160 170 180 190 200
PLDLACEFGR LKVAQLLLNS HLCVALLEGE AKDPCDPNYT TPLHLAAKNG
210 220 230 240 250
HREVIRQLLK AGIEINRQTK TGTALHEAAL YGKTEVVRLL LEGGVDVNIR
260 270 280 290 300
NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA
310 320 330 340 350
LNVRAGDVIT VLEQHPDGRW KGHIHESQRG TDRVGYFPPG IVEVVSKRVG
360 370 380 390 400
IPVARLPSAP TPLRPSFSRI SQPAADDPLP SVPYGQLPRV GLSPDSPAGD
410 420 430 440 450
RNSVGSEGSV GSIRSAGSGQ SSEGTNGHGT GLLIENAQPL PSASEDQGLP
460 470 480 490 500
GLHAPSPADN LSHRPLAGYR SGEIFTQDVR PEQLLEGKDA QAIHNWLSEF
510 520 530 540 550
QLEGYTAHFL QAGYDVPTIS RMTPEDLTAI GVTKPGHRKK IASEIAQLSI
560 570 580 590 600
AEWLPNYIPV DLLEWLCALG LPQYHKQLVS SGYDSMGLVA DLTWEELQEI
610 620 630 640 650
GVNKLGHQKK LMLGVKRLAE LRRGLLHGEA LGEGGRRMTR GPELMAIEGL
660 670 680 690 700
ENGEGPTTAG PRLLTFQGSE LSPELQAAMA GGGSEPLPLP PARSPSQESI
710 720 730 740 750
GARSRGSGHS QEQPVPQPSV GDPSAPQERN LPEGTERPSK LCSPLPGQGP
760 770 780 790 800
APYVFMCPQN LPSSPAPGPP PGVPRAFSYL AGSPAAPPDP PRPKRRSHSL
810 820 830 840 850
SRPGPAEGEA EGEAEGPVGS ALGSYATLTR RPGRSTLART SPSLTPTRGT
860 870 880 890 900
PRSQSFALRA RRKGPPPPPP KRLSSVSGST EPPSLDGTSG PKEGATGPRR
910 920 930 940 950
RTLSEPTGPS ESPGPSAPTG PVSDTEEEPG PEGTPPSRGS SGEGLPFAEE
960 970 980 990 1000
GNLTIKQRPK PAGPPPRETP VPPGLDFNLT ESDTVKRRPK CKEREPLQTA
1010 1020 1030 1040 1050
LLAFGVVGSD TPGPSNPLST QAPCDPPSAS SNPPQRSEPS VLPSQGTSAS
1060 1070 1080 1090 1100
SLSSVTQSPG HPGPSAGPAL ANSTGSKPNV ETEPPAPPAA LLKVPGAGTA
1110 1120 1130 1140 1150
PKPVSVACTQ LAFSGPKLAP RLGPRPVPPP RPENTGPVCP GRAQQRLEQT
1160 1170 1180 1190 1200
SSSLEAALRA AEKSIGTEER DGPTGTSTKH ILDDISTMFD ALADQLDAML

D
Length:1,201
Mass (Da):126,779
Last modified:July 27, 2011 - v3
Checksum:iB930742E6D407DB3
GO

Sequence cautioni

The sequence BAC98107 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29A → T in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti371S → P in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti374 – 381AADDPLPS → PAEEPPHP in AAL49759 (PubMed:12040031).Curated8
Sequence conflicti444S → G in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti448G → V in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti454A → P in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti457P → L in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti627H → Q in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti1141G → S in AAL49759 (PubMed:12040031).Curated1
Sequence conflicti1141G → S in BAC98107 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451978 mRNA Translation: AAL49759.1
AK129297 mRNA Translation: BAC98107.1 Different initiation.
AL645852 Genomic DNA No translation available.
BC053083 mRNA Translation: AAH53083.1
CCDSiCCDS25647.1
RefSeqiNP_542374.2, NM_080643.2
UniGeneiMm.383737

Genome annotation databases

EnsembliENSMUST00000041684; ENSMUSP00000041328; ENSMUSG00000034471
GeneIDi140721
KEGGimmu:140721
UCSCiuc007mip.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCSKI2_MOUSE
AccessioniPrimary (citable) accession number: Q8VHK1
Secondary accession number(s): B1ATA2, Q6ZPX1, Q7TS77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health