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Protein
Submitted name:

Nesprin-1

Gene

Syne1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: RGD
  • receptor binding Source: RGD
  • structural molecule activity Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • cytoskeletal anchoring at nuclear membrane Source: InterPro
  • positive regulation of receptor-mediated endocytosis Source: RGD
  • regulation of dendrite morphogenesis Source: RGD
  • response to light stimulus Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nesprin-1Imported
Gene namesi
Name:Syne1Imported
Synonyms:CPG2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620546. Syne1.

Subcellular locationi

GO - Cellular componenti

  • dendritic spine Source: RGD
  • Golgi apparatus Source: RGD
  • integral component of membrane Source: InterPro
  • LINC complex Source: InterPro
  • midbody Source: RGD
  • nuclear envelope Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • spindle Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8VHJ9.
PRIDEiQ8VHJ9.

PTM databases

iPTMnetiQ8VHJ9.
PhosphoSiteiQ8VHJ9.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050794.

Structurei

3D structure databases

ProteinModelPortaliQ8VHJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2779 – 283860KASHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili75 – 11036Sequence analysisAdd
BLAST
Coiled coili179 – 21335Sequence analysisAdd
BLAST
Coiled coili1074 – 110835Sequence analysisAdd
BLAST
Coiled coili1829 – 185628Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG106534.
PhylomeDBiQ8VHJ9.

Family and domain databases

InterProiIPR012315. KASH.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR030265. SYNE1.
[Graphical view]
PANTHERiPTHR11915:SF267. PTHR11915:SF267. 4 hits.
PfamiPF10541. KASH. 1 hit.
PF00435. Spectrin. 7 hits.
[Graphical view]
SMARTiSM01249. KASH. 1 hit.
SM00150. SPEC. 16 hits.
[Graphical view]
PROSITEiPS51049. KASH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSESLQPG RSPESQMAEH QALMDEVQML QDEINGLQAS LAEELVAESH
60 70 80 90 100
ESDPAEQLAL QSTLTVLAER MSTIRMKAAG KRQLLEEKLN DQLEEQRQEQ
110 120 130 140 150
ALQRYRCEAE ELDHWLLNTK ATLDFAAGIP QEPMDTDAQL VDCQNMLVEI
160 170 180 190 200
EQKVVALSQL SVRSENLLLE GKAHTKDEAE QLASKLRMLK GSLMELQRAL
210 220 230 240 250
RDRQLNMQGV TQEKEENDVD FTATQSPGVQ EWLAQARNTR THQRQSSLQQ
260 270 280 290 300
QKEFEQELAE QKSLLRSVAS RGEEILIQHS TAEGSGGLGE KPDALSQELV
310 320 330 340 350
MEGAKSFAED QMRAKWESLH QEFSTKQKLL QNILEQEQEQ MLYSSPNRLL
360 370 380 390 400
SGVLPLRGEA QTQDKSSVTS LLDGLSQAFG EVSSQSGGTD RQNIHLEQKL
410 420 430 440 450
YDGVSATSTW LDDVEEHLFV ATALLPEETE TCLFNQEALA KDIKEMSEEM
460 470 480 490 500
DKNKNLFSQA FPEDSDNRDV IEDTLGCLLG RLSLLDSVVG QRCHQMKERL
510 520 530 540 550
QQVLSFQNDL KVLFTSLADN NYIILQKLAN MFKQPIVEQI QAIQQAEEGL
560 570 580 590 600
RELDGGISEL KQRGDKLQVD QSALQELSKL QDMYDELLVT ISSRRSNLNQ
610 620 630 640 650
NLALKSQYDK ALQDLVDLLD TGQEKMAGDQ KIIVSSKEEV QQLLSKHKEY
660 670 680 690 700
FQGLESHLIL TETLFRKIVD FAAMKETQLH SDRMAQASAV LKQAHKRGVE
710 720 730 740 750
LEYILEMWSH LDENLQELSR QLEVIENSIP SVGLVEESED RLVERTSLYQ
760 770 780 790 800
HLKSSLNEYQ PKLYQVLDDG KRLMMSISCS ELESQLNQLG ERWLGNTNKV
810 820 830 840 850
SKELHRLETI LKHWTRYQSE AADLIHWLES AKDKLAFWTQ QSVTVPQELE
860 870 880 890 900
MVRDHLNAFL EFSKEVDAKS SLKSSVTSTG NQLLRLKKVD TAALRAELSC
910 920 930 940 950
MDSQWTDLLA GIPAVQEKLH QLQMDKLPSR HAISEVMSWI SLMESVILKD
960 970 980 990 1000
EEDIRNAIGY KAIYEYLQKY KGFKIDLNCK QLTADFVNQS VLQISSQDVE
1010 1020 1030 1040 1050
SKRSDKTDFA EQLGAMNKSW QLLQGRVGEK IQMLEGLLES WSEYENSIQS
1060 1070 1080 1090 1100
LKAWFANQER KLEEHHQIGD QNSVQNALKD CQELEDLIKA KEKEVEKIEQ
1110 1120 1130 1140 1150
NGLALIQNKR EEVSCSVLNT LWELRQTWAS LERTVGQLKI QLTLVLGQWS
1160 1170 1180 1190 1200
IHKAAFEEIS NHLMEARYSL SRFRLLTGSS DAVQVQVDNL QNLHDDLEKQ
1210 1220 1230 1240 1250
EGDLQKFGSL TNHLLKECHP PVAEALSSTL QEVNMRWNNL LEEIAKQLHS
1260 1270 1280 1290 1300
SKALLQLWQR YKDYSKQCAS AVQRQEEQTN ALLKAATSKD IADDEVAKWI
1310 1320 1330 1340 1350
QDCNDLLKGL GTVKDSLFIL HELGEQLGQQ VDDSAATTIQ CEQLCFSQRL
1360 1370 1380 1390 1400
EALEQALCKQ QAVLQAGVVD YETFAKSLEA LEAWIVEAEG ILQAQDPTHS
1410 1420 1430 1440 1450
SDLSTIQERM EELKGQMLKF SSMAPDLDRL NELGYRLPLN DKEIKRMQNL
1460 1470 1480 1490 1500
NRHWSLISSQ TTERFSKLQS FLLQHQTFLE KCETWMEFLV QTEHKLAVEI
1510 1520 1530 1540 1550
SGNYQHLLEQ QRAHELFQAE MFSRQQILHS IIVDGQNLLE QGQVDDREEF
1560 1570 1580 1590 1600
SLKLTLLSNQ WQGVIRRAQQ RRGIIDSQIR QWQRYREMAE KLRKWLVEVS
1610 1620 1630 1640 1650
HLPLSGLGSI PVPLQQVRTL FDEVQFKEKV FLRQQGSYIL TVEAGKQLLL
1660 1670 1680 1690 1700
SADSGAEAAL QAELTDIQEK WKSASTHLEE QKKKLAFLLK DWEKCEKGIA
1710 1720 1730 1740 1750
DSLEKLRTFK KRLSQPLPDH HEELHAEQMR CKELENAVGR WTDDLAELVL
1760 1770 1780 1790 1800
LREALAAHLS AEDISILKER VELLQRQWEE LCHQVSLRRQ QVSERLNEWA
1810 1820 1830 1840 1850
VFSEKNKELC EWLTQMESKV SQNGDILIEE MIEKLKKDYQ EKIAVAQENK
1860 1870 1880 1890 1900
IQLQQMGERL AKASHESKAS EIQYKLSKVN DRWQHLLDLM AARVKKLKET
1910 1920 1930 1940 1950
LVAVQQLDKN MGSLRIWLAH MESELAKPIV YDSCNSEEIQ KKLSEQQELQ
1960 1970 1980 1990 2000
RDIEKHSTGV ASVLNLCEVL LHDCDACATD AECDSIQQAT RNLDRRWRNI
2010 2020 2030 2040 2050
CAMSMERRLK IEETWRLWQK FLDDYSRFED WLEISERTAA FPSSSGVLYT
2060 2070 2080 2090 2100
VAKEELKKFE AFQRQVHESL TQLELINKQY RRLARENRTD SACSLRQMAH
2110 2120 2130 2140 2150
GGNQRWDDLL KRVTSILRRL KHFISQREEF ETARDSILVW LTEMDLQLTN
2160 2170 2180 2190 2200
IEHFSECDVQ AKIKQLKAFQ QEISLNHSKI EQIIAQGEQL IEKSEPLDAA
2210 2220 2230 2240 2250
VIEEELDELR RYCQEVFGRV ERYHKKLIRL PLPDDHDLSD RELDLEDSMA
2260 2270 2280 2290 2300
LSDLHWQDPS EDGMPSPQPS SNPSLSLPQP LRSERSGRDT PASVDSIPLE
2310 2320 2330 2340 2350
WDHDYDHDYD LSRDLESASR TLPSEDEEGE EDKEFYLRGA VGLSDVVIPE
2360 2370 2380 2390 2400
NPEAYVKLTE NAIRNTSGDP TSLESQMRQL DKALDDSRFQ IQQTANILRG
2410 2420 2430 2440 2450
KTPTGPDLGT SYKGYMKLLG ECSGTIDSVR RLEHKLAEEE SFPGFTNPTS
2460 2470 2480 2490 2500
TETQPAGVID RWELLQAQAM SKELKMKQNL QKWQQFNSDL NNICAWLGET
2510 2520 2530 2540 2550
EEELDRLQHL ALSTVIHTIK SHIKKLKELQ KALDHRKAII LSINLCSSEF
2560 2570 2580 2590 2600
TQADSKESHD LQDRLSQMNR RWDRVCSLLE DWRGSLQDAL MQCQDFHEMT
2610 2620 2630 2640 2650
HALLLLLENT DRRKNEIVPI DSTLDPETLQ DHHTQLTQIK QELLKSQLRV
2660 2670 2680 2690 2700
ASLQNMSRQL LVNAEGSDCL EAKEKVHVIG NRLKLLLKEV SRHIKDLEKL
2710 2720 2730 2740 2750
LGMSSSQQDL SSWSSADEVD TSGSVSPTSG RSTPNRQKSP RGKCSLSQPG
2760 2770 2780 2790 2800
PSVSSPKSRS TKGGSDSSLS ETRPARAGRD FLFRVLRAAL PIQLLLLLLI
2810 2820 2830
GLTSRVPISE EDYSCALSNN FARSFHPMLR YTNGPPPL
Length:2,838
Mass (Da):325,098
Last modified:March 1, 2002 - v1
Checksum:i36B1BEB8A3F8B596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452647 mRNA. Translation: AAL47053.1.
UniGeneiRn.226002.
Rn.89150.

Genome annotation databases

UCSCiRGD:620546. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452647 mRNA. Translation: AAL47053.1.
UniGeneiRn.226002.
Rn.89150.

3D structure databases

ProteinModelPortaliQ8VHJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050794.

PTM databases

iPTMnetiQ8VHJ9.
PhosphoSiteiQ8VHJ9.

Proteomic databases

PaxDbiQ8VHJ9.
PRIDEiQ8VHJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620546. rat.

Organism-specific databases

RGDi620546. Syne1.

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG106534.
PhylomeDBiQ8VHJ9.

Family and domain databases

InterProiIPR012315. KASH.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR030265. SYNE1.
[Graphical view]
PANTHERiPTHR11915:SF267. PTHR11915:SF267. 4 hits.
PfamiPF10541. KASH. 1 hit.
PF00435. Spectrin. 7 hits.
[Graphical view]
SMARTiSM01249. KASH. 1 hit.
SM00150. SPEC. 16 hits.
[Graphical view]
PROSITEiPS51049. KASH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues."
    Zhang Q., Skepper J.N., Yang F., Davies J.D., Hegyi L., Roberts R.G., Weissberg P.L., Ellis J.A., Shanahan C.M.
    J. Cell Sci. 114:4485-4498(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8VHJ9_RAT
AccessioniPrimary (citable) accession number: Q8VHJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.