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Q8VHJ7

- PRGC2_MOUSE

UniProt

Q8VHJ7 - PRGC2_MOUSE

Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Gene

Ppargc1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.4 Publications

    GO - Molecular functioni

    1. AF-2 domain binding Source: UniProtKB
    2. ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
    3. nucleotide binding Source: InterPro
    4. protein binding Source: UniProtKB
    5. receptor activator activity Source: Ensembl
    6. RNA binding Source: UniProtKB-KW
    7. RNA polymerase II transcription cofactor activity Source: Ensembl

    GO - Biological processi

    1. actin filament organization Source: DFLAT
    2. bone trabecula formation Source: DFLAT
    3. cellular response to reactive oxygen species Source: DFLAT
    4. intracellular estrogen receptor signaling pathway Source: UniProtKB
    5. negative regulation of transcription, DNA-templated Source: DFLAT
    6. ossification Source: DFLAT
    7. positive regulation of alkaline phosphatase activity Source: DFLAT
    8. positive regulation of bone resorption Source: DFLAT
    9. positive regulation of osteoclast differentiation Source: DFLAT
    10. positive regulation of phosphorylation Source: DFLAT
    11. positive regulation of transcription, DNA-templated Source: DFLAT
    12. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    13. regulation of transcription, DNA-templated Source: UniProtKB
    14. response to cAMP Source: Ensembl
    15. response to glucocorticoid Source: Ensembl
    16. transcription from mitochondrial promoter Source: DFLAT

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.
    REACT_205251. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator 1-beta
    Short name:
    PGC-1-beta
    Short name:
    PPAR-gamma coactivator 1-beta
    Short name:
    PPARGC-1-beta
    Alternative name(s):
    ERR ligand 1
    Gene namesi
    Name:Ppargc1b
    Synonyms:Errl1, Pgc1, Pgc1b, Ppargc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:2444934. Ppargc1b.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. mediator complex Source: Ensembl
    2. mitochondrion Source: GOC
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10141014Peroxisome proliferator-activated receptor gamma coactivator 1-betaPRO_0000240159Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei519 – 5191PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8VHJ7.

    PTM databases

    PhosphoSiteiQ8VHJ7.

    Expressioni

    Tissue specificityi

    Ubiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle.2 Publications

    Inductioni

    Induced by fasting in the liver, but not by cold exposure in brown adipose tissue. Induced also by saturated fatty acids in primary hepatocytes.2 Publications

    Gene expression databases

    BgeeiQ8VHJ7.
    GenevestigatoriQ8VHJ7.

    Interactioni

    Subunit structurei

    Interacts with estrogen receptor alpha/ESR1 By similarity. Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16.By similarity6 Publications

    Protein-protein interaction databases

    BioGridi228460. 3 interactions.
    IntActiQ8VHJ7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VHJ7.
    SMRiQ8VHJ7. Positions 892-955.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini893 – 96775RRMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9191Abolishes DNA transcriptional activity when missingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi140 – 1445LXXLL motif 1
    Motifi156 – 1605LXXLL motif 2
    Motifi343 – 3475LXXLL motif 3
    Motifi683 – 6864HCFC1-binding-motif (HBM)

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi246 – 2505Poly-Glu
    Compositional biasi429 – 45123Glu-richAdd
    BLAST
    Compositional biasi786 – 85671Ser-richAdd
    BLAST

    Domaini

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG87590.
    GeneTreeiENSGT00530000063196.
    HOGENOMiHOG000236356.
    HOVERGENiHBG080730.
    KOiK17962.
    OMAiCESGCGD.
    OrthoDBiEOG7S4X5H.
    PhylomeDBiQ8VHJ7.
    TreeFamiTF343068.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VHJ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGNDCGALL DEELSSFFLN YLSDTQGGDS GEEQLCADLP ELDLSQLDAS     50
    DFDSATCFGE LQWCPETSET EPSQYSPDDS ELFQIDSENE ALLAALTKTL 100
    DDIPEDDVGL AAFPELDEGD TPSCTPASPA PLSAPPSPTL ERLLSPASDV 150
    DELSLLQKLL LATSSPTASS DALKDGATWS QTSLSSRSQR PCVKVDGTQD 200
    KKTPTLRAQS RPCTELHKHL TSVLPCPRVK ACSPTPHPSP RLLSKEEEEE 250
    VGEDCPSPWP TPASPQDSLA QDTASPDSAQ PPEEDVRAMV QLIRYMHTYC 300
    LPQRKLPQRA PEPIPQACSS LSRQVQPRSR HPPKAFWTEF SILRELLAQD 350
    ILCDVSKPYR LAIPVYASLT PQSRPRPPKD SQASPAHSAM AEEVRITASP 400
    KSTGPRPSLR PLRLEVKRDV NKPTRQKREE DEEEEEEEEE EEEEKEEEEE 450
    EWGRKRPGRG LPWTKLGRKM DSSVCPVRRS RRLNPELGPW LTFTDEPLGA 500
    LPSMCLDTET HNLEEDLGSL TDSSQGRQLP QGSQIPALES PCESGCGDTD 550
    EDPSCPQPTS RDSSRCLMLA LSQSDSLGKK SFEESLTVEL CGTAGLTPPT 600
    TPPYKPMEED PFKPDTKLSP GQDTAPSLPS PEALPLTATP GASHKLPKRH 650
    PERSELLSHL QHATTQPVSQ AGQKRPFSCS FGDHDYCQVL RPEAALQRKV 700
    LRSWEPIGVH LEDLAQQGAP LPTETKAPRR EANQNCDPTH KDSMQLRDHE 750
    IRASLTKHFG LLETALEGED LASCKSPEYD TVFEDSSSSS GESSFLLEEE 800
    EEEEEGGEED DEGEDSGVSP PCSDHCPYQS PPSKASRQLC SRSRSSSGSS 850
    SCSSWSPATR KNFRRESRGP CSDGTPSVRH ARKRREKAIG EGRVVYIRNL 900
    SSDMSSRELK KRFEVFGEIV ECQVLTRSKR GQKHGFITFR CSEHAALSVR 950
    NGATLRKRNE PSFHLSYGGL RHFRWPRYTD YDPTSEESLP SSGKSKYEAM 1000
    DFDSLLKEAQ QSLH 1014
    Length:1,014
    Mass (Da):112,075
    Last modified:March 1, 2002 - v1
    Checksum:i004BCB7797EAFD1F
    GO
    Isoform 2 (identifier: Q8VHJ7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-26: MAGNDCGALLDEELSSFFLNYLSDTQ → MKSSRPSSSTISLTRRSAEGLEEVDHEALDRDGCGRRRLADM

    Show »
    Length:1,030
    Mass (Da):113,898
    Checksum:i4F2B27E32E91C84C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551A → P in BAC25964. (PubMed:16141072)Curated
    Sequence conflicti579 – 5791K → R in BAC25964. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2626MAGND…LSDTQ → MKSSRPSSSTISLTRRSAEG LEEVDHEALDRDGCGRRRLA DM in isoform 2. 1 PublicationVSP_019302Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF453324 mRNA. Translation: AAL47054.1.
    AK028464 mRNA. Translation: BAC25964.1.
    CCDSiCCDS29284.1. [Q8VHJ7-1]
    RefSeqiNP_573512.1. NM_133249.2. [Q8VHJ7-1]
    UniGeneiMm.415302.

    Genome annotation databases

    EnsembliENSMUST00000063307; ENSMUSP00000069431; ENSMUSG00000033871. [Q8VHJ7-2]
    ENSMUST00000075299; ENSMUSP00000074771; ENSMUSG00000033871. [Q8VHJ7-1]
    GeneIDi170826.
    KEGGimmu:170826.
    UCSCiuc008fbx.1. mouse. [Q8VHJ7-1]
    uc012bdq.1. mouse. [Q8VHJ7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF453324 mRNA. Translation: AAL47054.1 .
    AK028464 mRNA. Translation: BAC25964.1 .
    CCDSi CCDS29284.1. [Q8VHJ7-1 ]
    RefSeqi NP_573512.1. NM_133249.2. [Q8VHJ7-1 ]
    UniGenei Mm.415302.

    3D structure databases

    ProteinModelPortali Q8VHJ7.
    SMRi Q8VHJ7. Positions 892-955.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228460. 3 interactions.
    IntActi Q8VHJ7. 1 interaction.

    PTM databases

    PhosphoSitei Q8VHJ7.

    Proteomic databases

    PRIDEi Q8VHJ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063307 ; ENSMUSP00000069431 ; ENSMUSG00000033871 . [Q8VHJ7-2 ]
    ENSMUST00000075299 ; ENSMUSP00000074771 ; ENSMUSG00000033871 . [Q8VHJ7-1 ]
    GeneIDi 170826.
    KEGGi mmu:170826.
    UCSCi uc008fbx.1. mouse. [Q8VHJ7-1 ]
    uc012bdq.1. mouse. [Q8VHJ7-2 ]

    Organism-specific databases

    CTDi 133522.
    MGIi MGI:2444934. Ppargc1b.

    Phylogenomic databases

    eggNOGi NOG87590.
    GeneTreei ENSGT00530000063196.
    HOGENOMi HOG000236356.
    HOVERGENi HBG080730.
    KOi K17962.
    OMAi CESGCGD.
    OrthoDBi EOG7S4X5H.
    PhylomeDBi Q8VHJ7.
    TreeFami TF343068.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.
    REACT_205251. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    ChiTaRSi PPARGC1B. mouse.
    NextBioi 370487.
    PROi Q8VHJ7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VHJ7.
    Genevestigatori Q8VHJ7.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor."
      Lin J., Puigserver P., Donovan J., Tarr P., Spiegelman B.M.
      J. Biol. Chem. 277:1645-1648(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, MOTIFS, FUNCTION, INDUCTION, SUBUNIT.
      Strain: C57BL/6.
    2. "PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity."
      Kamei Y., Ohizumi H., Fujitani Y., Nemoto T., Tanaka T., Takahashi N., Kawada T., Miyoshi M., Ezaki O., Kakizuka A.
      Proc. Natl. Acad. Sci. U.S.A. 100:12378-12383(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ESRRA AND ESRRG.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Skin.
    4. "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma."
      Hentschke M., Suesens U., Borgmeyer U.
      Biochem. Biophys. Res. Commun. 299:872-879(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ESRRG.
    5. "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo."
      Meirhaeghe A., Crowley V., Lenaghan C., Lelliott C., Green K., Stewart A., Hart K., Schinner S., Sethi J.K., Yeo G., Brand M.D., Cortright R.N., O'Rahilly S., Montague C., Vidal-Puig A.J.
      Biochem. J. 373:155-165(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    6. "Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP."
      Lin J., Yang R., Tarr P.T., Wu P.-H., Handschin C., Li S., Yang W., Pei L., Uldry M., Tontonoz P., Newgard C.B., Spiegelman B.M.
      Cell 120:261-273(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SREBF1, INDUCTION.
    7. Cited for: INTERACTION WITH PRDM16.
    8. "Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex."
      Kajimura S., Seale P., Tomaru T., Erdjument-Bromage H., Cooper M.P., Ruas J.L., Chin S., Tempst P., Lazar M.A., Spiegelman B.M.
      Genes Dev. 22:1397-1409(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRDM16.

    Entry informationi

    Entry nameiPRGC2_MOUSE
    AccessioniPrimary (citable) accession number: Q8VHJ7
    Secondary accession number(s): Q8C1C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Transgenic mice overexpressing PPARGC1B exhibits increased expression of medium-chain acyl CoA dehydrogenase. They are hyperphagic but lean, with increased energy expenditure and resistance to obesity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3