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Q8VHJ7

- PRGC2_MOUSE

UniProt

Q8VHJ7 - PRGC2_MOUSE

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Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Gene
Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.4 Publications

GO - Molecular functioni

  1. AF-2 domain binding Source: UniProtKB
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  3. nucleotide binding Source: InterPro
  4. protein binding Source: UniProtKB
  5. receptor activator activity Source: Ensembl
  6. RNA binding Source: UniProtKB-KW
  7. RNA polymerase II transcription cofactor activity Source: Ensembl

GO - Biological processi

  1. actin filament organization Source: DFLAT
  2. bone trabecula formation Source: DFLAT
  3. cellular response to reactive oxygen species Source: DFLAT
  4. intracellular estrogen receptor signaling pathway Source: UniProtKB
  5. negative regulation of transcription, DNA-templated Source: DFLAT
  6. ossification Source: DFLAT
  7. positive regulation of alkaline phosphatase activity Source: DFLAT
  8. positive regulation of bone resorption Source: DFLAT
  9. positive regulation of osteoclast differentiation Source: DFLAT
  10. positive regulation of phosphorylation Source: DFLAT
  11. positive regulation of transcription, DNA-templated Source: DFLAT
  12. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  13. regulation of transcription, DNA-templated Source: UniProtKB
  14. response to cAMP Source: Ensembl
  15. response to glucocorticoid Source: Ensembl
  16. transcription from mitochondrial promoter Source: DFLAT
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_205251. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Short name:
PGC-1-beta
Short name:
PPAR-gamma coactivator 1-beta
Short name:
PPARGC-1-beta
Alternative name(s):
ERR ligand 1
Gene namesi
Name:Ppargc1b
Synonyms:Errl1, Pgc1, Pgc1b, Ppargc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2444934. Ppargc1b.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. mediator complex Source: Ensembl
  2. mitochondrion Source: GOC
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10141014Peroxisome proliferator-activated receptor gamma coactivator 1-betaPRO_0000240159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei519 – 5191Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8VHJ7.

PTM databases

PhosphoSiteiQ8VHJ7.

Expressioni

Tissue specificityi

Ubiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle.2 Publications

Inductioni

Induced by fasting in the liver, but not by cold exposure in brown adipose tissue. Induced also by saturated fatty acids in primary hepatocytes.2 Publications

Gene expression databases

BgeeiQ8VHJ7.
GenevestigatoriQ8VHJ7.

Interactioni

Subunit structurei

Interacts with estrogen receptor alpha/ESR1 By similarity. Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16.6 Publications

Protein-protein interaction databases

BioGridi228460. 3 interactions.
IntActiQ8VHJ7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8VHJ7.
SMRiQ8VHJ7. Positions 892-955.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini893 – 96775RRMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9191Abolishes DNA transcriptional activity when missing By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi140 – 1445LXXLL motif 1
Motifi156 – 1605LXXLL motif 2
Motifi343 – 3475LXXLL motif 3
Motifi683 – 6864HCFC1-binding-motif (HBM)

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 2505Poly-Glu
Compositional biasi429 – 45123Glu-richAdd
BLAST
Compositional biasi786 – 85671Ser-richAdd
BLAST

Domaini

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG87590.
GeneTreeiENSGT00530000063196.
HOGENOMiHOG000236356.
HOVERGENiHBG080730.
KOiK17962.
OMAiCESGCGD.
OrthoDBiEOG7S4X5H.
PhylomeDBiQ8VHJ7.
TreeFamiTF343068.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VHJ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGNDCGALL DEELSSFFLN YLSDTQGGDS GEEQLCADLP ELDLSQLDAS     50
DFDSATCFGE LQWCPETSET EPSQYSPDDS ELFQIDSENE ALLAALTKTL 100
DDIPEDDVGL AAFPELDEGD TPSCTPASPA PLSAPPSPTL ERLLSPASDV 150
DELSLLQKLL LATSSPTASS DALKDGATWS QTSLSSRSQR PCVKVDGTQD 200
KKTPTLRAQS RPCTELHKHL TSVLPCPRVK ACSPTPHPSP RLLSKEEEEE 250
VGEDCPSPWP TPASPQDSLA QDTASPDSAQ PPEEDVRAMV QLIRYMHTYC 300
LPQRKLPQRA PEPIPQACSS LSRQVQPRSR HPPKAFWTEF SILRELLAQD 350
ILCDVSKPYR LAIPVYASLT PQSRPRPPKD SQASPAHSAM AEEVRITASP 400
KSTGPRPSLR PLRLEVKRDV NKPTRQKREE DEEEEEEEEE EEEEKEEEEE 450
EWGRKRPGRG LPWTKLGRKM DSSVCPVRRS RRLNPELGPW LTFTDEPLGA 500
LPSMCLDTET HNLEEDLGSL TDSSQGRQLP QGSQIPALES PCESGCGDTD 550
EDPSCPQPTS RDSSRCLMLA LSQSDSLGKK SFEESLTVEL CGTAGLTPPT 600
TPPYKPMEED PFKPDTKLSP GQDTAPSLPS PEALPLTATP GASHKLPKRH 650
PERSELLSHL QHATTQPVSQ AGQKRPFSCS FGDHDYCQVL RPEAALQRKV 700
LRSWEPIGVH LEDLAQQGAP LPTETKAPRR EANQNCDPTH KDSMQLRDHE 750
IRASLTKHFG LLETALEGED LASCKSPEYD TVFEDSSSSS GESSFLLEEE 800
EEEEEGGEED DEGEDSGVSP PCSDHCPYQS PPSKASRQLC SRSRSSSGSS 850
SCSSWSPATR KNFRRESRGP CSDGTPSVRH ARKRREKAIG EGRVVYIRNL 900
SSDMSSRELK KRFEVFGEIV ECQVLTRSKR GQKHGFITFR CSEHAALSVR 950
NGATLRKRNE PSFHLSYGGL RHFRWPRYTD YDPTSEESLP SSGKSKYEAM 1000
DFDSLLKEAQ QSLH 1014
Length:1,014
Mass (Da):112,075
Last modified:March 1, 2002 - v1
Checksum:i004BCB7797EAFD1F
GO
Isoform 2 (identifier: Q8VHJ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MAGNDCGALLDEELSSFFLNYLSDTQ → MKSSRPSSSTISLTRRSAEGLEEVDHEALDRDGCGRRRLADM

Show »
Length:1,030
Mass (Da):113,898
Checksum:i4F2B27E32E91C84C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2626MAGND…LSDTQ → MKSSRPSSSTISLTRRSAEG LEEVDHEALDRDGCGRRRLA DM in isoform 2. VSP_019302Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551A → P in BAC25964. 1 Publication
Sequence conflicti579 – 5791K → R in BAC25964. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF453324 mRNA. Translation: AAL47054.1.
AK028464 mRNA. Translation: BAC25964.1.
CCDSiCCDS29284.1. [Q8VHJ7-1]
RefSeqiNP_573512.1. NM_133249.2. [Q8VHJ7-1]
UniGeneiMm.415302.

Genome annotation databases

EnsembliENSMUST00000063307; ENSMUSP00000069431; ENSMUSG00000033871. [Q8VHJ7-2]
ENSMUST00000075299; ENSMUSP00000074771; ENSMUSG00000033871. [Q8VHJ7-1]
GeneIDi170826.
KEGGimmu:170826.
UCSCiuc008fbx.1. mouse. [Q8VHJ7-1]
uc012bdq.1. mouse. [Q8VHJ7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF453324 mRNA. Translation: AAL47054.1 .
AK028464 mRNA. Translation: BAC25964.1 .
CCDSi CCDS29284.1. [Q8VHJ7-1 ]
RefSeqi NP_573512.1. NM_133249.2. [Q8VHJ7-1 ]
UniGenei Mm.415302.

3D structure databases

ProteinModelPortali Q8VHJ7.
SMRi Q8VHJ7. Positions 892-955.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228460. 3 interactions.
IntActi Q8VHJ7. 1 interaction.

PTM databases

PhosphoSitei Q8VHJ7.

Proteomic databases

PRIDEi Q8VHJ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063307 ; ENSMUSP00000069431 ; ENSMUSG00000033871 . [Q8VHJ7-2 ]
ENSMUST00000075299 ; ENSMUSP00000074771 ; ENSMUSG00000033871 . [Q8VHJ7-1 ]
GeneIDi 170826.
KEGGi mmu:170826.
UCSCi uc008fbx.1. mouse. [Q8VHJ7-1 ]
uc012bdq.1. mouse. [Q8VHJ7-2 ]

Organism-specific databases

CTDi 133522.
MGIi MGI:2444934. Ppargc1b.

Phylogenomic databases

eggNOGi NOG87590.
GeneTreei ENSGT00530000063196.
HOGENOMi HOG000236356.
HOVERGENi HBG080730.
KOi K17962.
OMAi CESGCGD.
OrthoDBi EOG7S4X5H.
PhylomeDBi Q8VHJ7.
TreeFami TF343068.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.
REACT_205251. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

ChiTaRSi PPARGC1B. mouse.
NextBioi 370487.
PROi Q8VHJ7.
SOURCEi Search...

Gene expression databases

Bgeei Q8VHJ7.
Genevestigatori Q8VHJ7.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor."
    Lin J., Puigserver P., Donovan J., Tarr P., Spiegelman B.M.
    J. Biol. Chem. 277:1645-1648(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, MOTIFS, FUNCTION, INDUCTION, SUBUNIT.
    Strain: C57BL/6.
  2. "PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity."
    Kamei Y., Ohizumi H., Fujitani Y., Nemoto T., Tanaka T., Takahashi N., Kawada T., Miyoshi M., Ezaki O., Kakizuka A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12378-12383(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ESRRA AND ESRRG.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Skin.
  4. "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma."
    Hentschke M., Suesens U., Borgmeyer U.
    Biochem. Biophys. Res. Commun. 299:872-879(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ESRRG.
  5. "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo."
    Meirhaeghe A., Crowley V., Lenaghan C., Lelliott C., Green K., Stewart A., Hart K., Schinner S., Sethi J.K., Yeo G., Brand M.D., Cortright R.N., O'Rahilly S., Montague C., Vidal-Puig A.J.
    Biochem. J. 373:155-165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  6. "Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP."
    Lin J., Yang R., Tarr P.T., Wu P.-H., Handschin C., Li S., Yang W., Pei L., Uldry M., Tontonoz P., Newgard C.B., Spiegelman B.M.
    Cell 120:261-273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SREBF1, INDUCTION.
  7. Cited for: INTERACTION WITH PRDM16.
  8. "Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex."
    Kajimura S., Seale P., Tomaru T., Erdjument-Bromage H., Cooper M.P., Ruas J.L., Chin S., Tempst P., Lazar M.A., Spiegelman B.M.
    Genes Dev. 22:1397-1409(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRDM16.

Entry informationi

Entry nameiPRGC2_MOUSE
AccessioniPrimary (citable) accession number: Q8VHJ7
Secondary accession number(s): Q8C1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Transgenic mice overexpressing PPARGC1B exhibits increased expression of medium-chain acyl CoA dehydrogenase. They are hyperphagic but lean, with increased energy expenditure and resistance to obesity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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