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Q8VHJ4

- TM11D_RAT

UniProt

Q8VHJ4 - TM11D_RAT

Protein

Transmembrane protease serine 11D

Gene

Tmprss11d

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2 By similarity. Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC.By similarity1 Publication

    Catalytic activityi

    Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei226 – 2261Charge relay systemBy similarity
    Active sitei271 – 2711Charge relay systemBy similarity
    Active sitei367 – 3671Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. serine-type peptidase activity Source: RGD

    GO - Biological processi

    1. regulation of growth Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.047.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protease serine 11D (EC:3.4.21.-)
    Alternative name(s):
    Adrenal secretory serine protease
    Short name:
    AsP
    Airway trypsin-like protease
    Short name:
    AT
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Tmprss11d
    Synonyms:Rat
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620654. Tmprss11d.

    Subcellular locationi

    Transmembrane protease serine 11D catalytic chain : Secreted By similarity
    Note: Activated by cleavage and secreted.By similarity

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. extracellular region Source: UniProtKB-SubCell
    3. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Transmembrane protease serine 11D non-catalytic chainPRO_0000027889Add
    BLAST
    Chaini186 – 417232Transmembrane protease serine 11D catalytic chainPRO_0000027890Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi172 ↔ 291Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotation
    Disulfide bondi211 ↔ 227PROSITE-ProRule annotation
    Disulfide bondi336 ↔ 352PROSITE-ProRule annotation
    Disulfide bondi363 ↔ 392PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PRIDEiQ8VHJ4.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 2 are expressed in the esophagus, tongue and trachea. Isoform 2 is also highly expressed in the adrenal cortex and heart.2 Publications

    Gene expression databases

    GenevestigatoriQ8VHJ4.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VHJ4.
    SMRiQ8VHJ4. Positions 45-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 417379ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 162117SEAPROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 416231Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
    Contains 1 SEA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251823.
    HOVERGENiHBG013304.
    KOiK09641.

    Family and domain databases

    Gene3Di3.30.70.960. 1 hit.
    InterProiIPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00200. SEA. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEiPS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VHJ4-1) [UniParc]FASTAAdd to Basket

    Also known as: RAT1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYRPRSMVSP SRFFNPFMVA LIVIITVGLL AMTAGLLIHF LAFDKRAYFY    50
    HSNFHILNVD YTEALNSPAT HEYRTLSERI ESMITDAFRE SNLRSEFIRT 100
    HVVKLRKEGS GVVADVVMKF RSSKRNNKKA IKTRIQSVLQ RLSSSGNLEI 150
    APSNGITSLT DQDTENVLTQ ECGARPDLIT LSEERIIGGT QAETGDWPWQ 200
    VSLQLNNVHH CGGTLISNLW VLTAAHCFRS YSNPQQWTAT FGVSTISPRL 250
    RVRVRAILAH AEYNSITRDN DIAVVQLDRP VTFTRNIHRV CLPAATQNIM 300
    PDSVAYVTGW GSLTYGGNTV TNLQQGEVRI VSSEVCNEPA GYGGSVLPGM 350
    LCAGVRSGAV DACQGDSGGP LVQEDTRRLW FVVGIVSWGY QCGLPNKPGV 400
    YTRVTAYRNW IRQQTGI 417
    Length:417
    Mass (Da):46,288
    Last modified:March 1, 2002 - v1
    Checksum:iDB9504158B018E21
    GO
    Isoform 2 (identifier: Q8VHJ4-2) [UniParc]FASTAAdd to Basket

    Also known as: RAT2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: Missing.
         139-158: LQRLSSSGNLEIAPSNGITS → MSFSFCFVDLLLVLSFLTLA

    Note: Secreted and retained on the cell surface after secretion.

    Show »
    Length:279
    Mass (Da):30,569
    Checksum:i8745B04284971A81
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti300 – 3001M → I in AAF13253. (PubMed:11439186)Curated
    Sequence conflicti307 – 3071V → A in AAF13253. (PubMed:11439186)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 138138Missing in isoform 2. 1 PublicationVSP_014521Add
    BLAST
    Alternative sequencei139 – 15820LQRLS…NGITS → MSFSFCFVDLLLVLSFLTLA in isoform 2. 1 PublicationVSP_014522Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198087 mRNA. Translation: AAF13253.1.
    AF453776 mRNA. Translation: AAL50817.1.
    RefSeqiNP_001028824.1. NM_001033652.1. [Q8VHJ4-1]
    NP_072152.1. NM_022630.1.
    UniGeneiRn.48747.

    Genome annotation databases

    GeneIDi64565.
    KEGGirno:64565.
    UCSCiRGD:620654. rat. [Q8VHJ4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198087 mRNA. Translation: AAF13253.1 .
    AF453776 mRNA. Translation: AAL50817.1 .
    RefSeqi NP_001028824.1. NM_001033652.1. [Q8VHJ4-1 ]
    NP_072152.1. NM_022630.1.
    UniGenei Rn.48747.

    3D structure databases

    ProteinModelPortali Q8VHJ4.
    SMRi Q8VHJ4. Positions 45-163.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.047.

    Proteomic databases

    PRIDEi Q8VHJ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 64565.
    KEGGi rno:64565.
    UCSCi RGD:620654. rat. [Q8VHJ4-1 ]

    Organism-specific databases

    CTDi 9407.
    RGDi 620654. Tmprss11d.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251823.
    HOVERGENi HBG013304.
    KOi K09641.

    Miscellaneous databases

    NextBioi 613502.
    PROi Q8VHJ4.

    Gene expression databases

    Genevestigatori Q8VHJ4.

    Family and domain databases

    Gene3Di 3.30.70.960. 1 hit.
    InterProi IPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00200. SEA. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEi PS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a serine protease that cleaves pro-gamma-melanotropin at the adrenal to stimulate growth."
      Bicknell A.B., Lomthaisong K., Woods R.J., Hutchinson E.G., Bennett H.P.J., Gladwell R.T., Lowry P.J.
      Cell 105:903-912(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
      Strain: New England Deaconess Hospital.
    2. "The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease."
      Hansen I.A., Fassnacht M., Hahner S., Hammer F., Schammann M., Meyer S.R., Bicknell A.B., Allolio B.
      Endocrinology 145:1898-1905(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
      Strain: Wistar.
      Tissue: Trachea.

    Entry informationi

    Entry nameiTM11D_RAT
    AccessioniPrimary (citable) accession number: Q8VHJ4
    Secondary accession number(s): Q9QZ74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3