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Q8VHJ4

- TM11D_RAT

UniProt

Q8VHJ4 - TM11D_RAT

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Protein

Transmembrane protease serine 11D

Gene

Tmprss11d

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2 (By similarity). Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC.By similarity1 Publication

Catalytic activityi

Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261Charge relay systemBy similarity
Active sitei271 – 2711Charge relay systemBy similarity
Active sitei367 – 3671Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type peptidase activity Source: RGD

GO - Biological processi

  1. regulation of growth Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.047.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11D (EC:3.4.21.-)
Alternative name(s):
Adrenal secretory serine protease
Short name:
AsP
Airway trypsin-like protease
Short name:
AT
Cleaved into the following 2 chains:
Gene namesi
Name:Tmprss11d
Synonyms:Rat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620654. Tmprss11d.

Subcellular locationi

Transmembrane protease serine 11D catalytic chain : Secreted By similarity
Note: Activated by cleavage and secreted.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini39 – 417379ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: RGD
  2. extracellular region Source: UniProtKB-KW
  3. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Transmembrane protease serine 11D non-catalytic chainPRO_0000027889Add
BLAST
Chaini186 – 417232Transmembrane protease serine 11D catalytic chainPRO_0000027890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi172 ↔ 291Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotation
Disulfide bondi211 ↔ 227PROSITE-ProRule annotation
Disulfide bondi336 ↔ 352PROSITE-ProRule annotation
Disulfide bondi363 ↔ 392PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiQ8VHJ4.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in the esophagus, tongue and trachea. Isoform 2 is also highly expressed in the adrenal cortex and heart.2 Publications

Gene expression databases

GenevestigatoriQ8VHJ4.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8VHJ4.
SMRiQ8VHJ4. Positions 45-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 162117SEAPROSITE-ProRule annotationAdd
BLAST
Domaini186 – 416231Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ8VHJ4.
KOiK09641.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00200. SEA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VHJ4-1) [UniParc]FASTAAdd to Basket

Also known as: RAT1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRPRSMVSP SRFFNPFMVA LIVIITVGLL AMTAGLLIHF LAFDKRAYFY
60 70 80 90 100
HSNFHILNVD YTEALNSPAT HEYRTLSERI ESMITDAFRE SNLRSEFIRT
110 120 130 140 150
HVVKLRKEGS GVVADVVMKF RSSKRNNKKA IKTRIQSVLQ RLSSSGNLEI
160 170 180 190 200
APSNGITSLT DQDTENVLTQ ECGARPDLIT LSEERIIGGT QAETGDWPWQ
210 220 230 240 250
VSLQLNNVHH CGGTLISNLW VLTAAHCFRS YSNPQQWTAT FGVSTISPRL
260 270 280 290 300
RVRVRAILAH AEYNSITRDN DIAVVQLDRP VTFTRNIHRV CLPAATQNIM
310 320 330 340 350
PDSVAYVTGW GSLTYGGNTV TNLQQGEVRI VSSEVCNEPA GYGGSVLPGM
360 370 380 390 400
LCAGVRSGAV DACQGDSGGP LVQEDTRRLW FVVGIVSWGY QCGLPNKPGV
410
YTRVTAYRNW IRQQTGI
Length:417
Mass (Da):46,288
Last modified:March 1, 2002 - v1
Checksum:iDB9504158B018E21
GO
Isoform 2 (identifier: Q8VHJ4-2) [UniParc]FASTAAdd to Basket

Also known as: RAT2

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     139-158: LQRLSSSGNLEIAPSNGITS → MSFSFCFVDLLLVLSFLTLA

Note: Secreted and retained on the cell surface after secretion.

Show »
Length:279
Mass (Da):30,569
Checksum:i8745B04284971A81
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti300 – 3001M → I in AAF13253. (PubMed:11439186)Curated
Sequence conflicti307 – 3071V → A in AAF13253. (PubMed:11439186)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 138138Missing in isoform 2. 1 PublicationVSP_014521Add
BLAST
Alternative sequencei139 – 15820LQRLS…NGITS → MSFSFCFVDLLLVLSFLTLA in isoform 2. 1 PublicationVSP_014522Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198087 mRNA. Translation: AAF13253.1.
AF453776 mRNA. Translation: AAL50817.1.
RefSeqiNP_001028824.1. NM_001033652.1. [Q8VHJ4-1]
NP_072152.1. NM_022630.1.
UniGeneiRn.48747.

Genome annotation databases

GeneIDi64565.
KEGGirno:64565.
UCSCiRGD:620654. rat. [Q8VHJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198087 mRNA. Translation: AAF13253.1 .
AF453776 mRNA. Translation: AAL50817.1 .
RefSeqi NP_001028824.1. NM_001033652.1. [Q8VHJ4-1 ]
NP_072152.1. NM_022630.1.
UniGenei Rn.48747.

3D structure databases

ProteinModelPortali Q8VHJ4.
SMRi Q8VHJ4. Positions 45-163.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.047.

Proteomic databases

PRIDEi Q8VHJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64565.
KEGGi rno:64565.
UCSCi RGD:620654. rat. [Q8VHJ4-1 ]

Organism-specific databases

CTDi 9407.
RGDi 620654. Tmprss11d.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251823.
HOVERGENi HBG013304.
InParanoidi Q8VHJ4.
KOi K09641.

Miscellaneous databases

NextBioi 613502.
PROi Q8VHJ4.

Gene expression databases

Genevestigatori Q8VHJ4.

Family and domain databases

Gene3Di 3.30.70.960. 1 hit.
InterProi IPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00200. SEA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEi PS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a serine protease that cleaves pro-gamma-melanotropin at the adrenal to stimulate growth."
    Bicknell A.B., Lomthaisong K., Woods R.J., Hutchinson E.G., Bennett H.P.J., Gladwell R.T., Lowry P.J.
    Cell 105:903-912(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Strain: New England Deaconess Hospital.
  2. "The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease."
    Hansen I.A., Fassnacht M., Hahner S., Hammer F., Schammann M., Meyer S.R., Bicknell A.B., Allolio B.
    Endocrinology 145:1898-1905(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Strain: Wistar.
    Tissue: Trachea.

Entry informationi

Entry nameiTM11D_RAT
AccessioniPrimary (citable) accession number: Q8VHJ4
Secondary accession number(s): Q9QZ74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3