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Protein

Transmembrane protease serine 11D

Gene

Tmprss11d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2 (By similarity). Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC.By similarity1 Publication

Catalytic activityi

Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei226Charge relay systemBy similarity1
Active sitei271Charge relay systemBy similarity1
Active sitei367Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: RGD

GO - Biological processi

  • regulation of growth Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.047.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11D (EC:3.4.21.-)
Alternative name(s):
Adrenal secretory serine protease
Short name:
AsP
Airway trypsin-like protease
Short name:
AT
Cleaved into the following 2 chains:
Gene namesi
Name:Tmprss11d
Synonyms:Rat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620654. Tmprss11d.

Subcellular locationi

Chain Transmembrane protease serine 11D catalytic chain :
  • Secreted By similarity

  • Note: Activated by cleavage and secreted.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 417ExtracellularSequence analysisAdd BLAST379

GO - Cellular componenti

  • cell surface Source: RGD
  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000278891 – 185Transmembrane protease serine 11D non-catalytic chainAdd BLAST185
ChainiPRO_0000027890186 – 417Transmembrane protease serine 11D catalytic chainAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi172 ↔ 291Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotation
Disulfide bondi211 ↔ 227PROSITE-ProRule annotation
Disulfide bondi336 ↔ 352PROSITE-ProRule annotation
Disulfide bondi363 ↔ 392PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ8VHJ4.
PRIDEiQ8VHJ4.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in the esophagus, tongue and trachea. Isoform 2 is also highly expressed in the adrenal cortex and heart.2 Publications

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002748.

Structurei

3D structure databases

ProteinModelPortaliQ8VHJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 162SEAPROSITE-ProRule annotationAdd BLAST117
Domaini186 – 416Peptidase S1PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ8VHJ4.
KOiK09641.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VHJ4-1) [UniParc]FASTAAdd to basket
Also known as: RAT1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRPRSMVSP SRFFNPFMVA LIVIITVGLL AMTAGLLIHF LAFDKRAYFY
60 70 80 90 100
HSNFHILNVD YTEALNSPAT HEYRTLSERI ESMITDAFRE SNLRSEFIRT
110 120 130 140 150
HVVKLRKEGS GVVADVVMKF RSSKRNNKKA IKTRIQSVLQ RLSSSGNLEI
160 170 180 190 200
APSNGITSLT DQDTENVLTQ ECGARPDLIT LSEERIIGGT QAETGDWPWQ
210 220 230 240 250
VSLQLNNVHH CGGTLISNLW VLTAAHCFRS YSNPQQWTAT FGVSTISPRL
260 270 280 290 300
RVRVRAILAH AEYNSITRDN DIAVVQLDRP VTFTRNIHRV CLPAATQNIM
310 320 330 340 350
PDSVAYVTGW GSLTYGGNTV TNLQQGEVRI VSSEVCNEPA GYGGSVLPGM
360 370 380 390 400
LCAGVRSGAV DACQGDSGGP LVQEDTRRLW FVVGIVSWGY QCGLPNKPGV
410
YTRVTAYRNW IRQQTGI
Length:417
Mass (Da):46,288
Last modified:March 1, 2002 - v1
Checksum:iDB9504158B018E21
GO
Isoform 2 (identifier: Q8VHJ4-2) [UniParc]FASTAAdd to basket
Also known as: RAT2

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     139-158: LQRLSSSGNLEIAPSNGITS → MSFSFCFVDLLLVLSFLTLA

Note: Secreted and retained on the cell surface after secretion.
Show »
Length:279
Mass (Da):30,569
Checksum:i8745B04284971A81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti300M → I in AAF13253 (PubMed:11439186).Curated1
Sequence conflicti307V → A in AAF13253 (PubMed:11439186).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0145211 – 138Missing in isoform 2. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_014522139 – 158LQRLS…NGITS → MSFSFCFVDLLLVLSFLTLA in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198087 mRNA. Translation: AAF13253.1.
AF453776 mRNA. Translation: AAL50817.1.
RefSeqiNP_001028824.1. NM_001033652.1. [Q8VHJ4-1]
NP_072152.1. NM_022630.1.
UniGeneiRn.48747.

Genome annotation databases

GeneIDi64565.
KEGGirno:64565.
UCSCiRGD:620654. rat. [Q8VHJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198087 mRNA. Translation: AAF13253.1.
AF453776 mRNA. Translation: AAL50817.1.
RefSeqiNP_001028824.1. NM_001033652.1. [Q8VHJ4-1]
NP_072152.1. NM_022630.1.
UniGeneiRn.48747.

3D structure databases

ProteinModelPortaliQ8VHJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002748.

Protein family/group databases

MEROPSiS01.047.

Proteomic databases

PaxDbiQ8VHJ4.
PRIDEiQ8VHJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64565.
KEGGirno:64565.
UCSCiRGD:620654. rat. [Q8VHJ4-1]

Organism-specific databases

CTDi9407.
RGDi620654. Tmprss11d.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ8VHJ4.
KOiK09641.

Miscellaneous databases

PROiQ8VHJ4.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM11D_RAT
AccessioniPrimary (citable) accession number: Q8VHJ4
Secondary accession number(s): Q9QZ74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2002
Last modified: October 5, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.