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Protein

Coiled-coil domain-containing protein 65

Gene

Ccdc65

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 65
Alternative name(s):
Testis development protein NYD-SP28
Gene namesi
Name:Ccdc65
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146001. Ccdc65.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Coiled-coil domain-containing protein 65PRO_0000284780Add
BLAST

Proteomic databases

MaxQBiQ8VHI7.
PaxDbiQ8VHI7.
PRIDEiQ8VHI7.

PTM databases

PhosphoSiteiQ8VHI7.

Expressioni

Gene expression databases

BgeeiQ8VHI7.
CleanExiMM_CCDC65.
GenevisibleiQ8VHI7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003444.

Structurei

3D structure databases

ProteinModelPortaliQ8VHI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili99 – 16365Sequence analysisAdd
BLAST
Coiled coili253 – 28028Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC65 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE4Y. Eukaryota.
ENOG410XQTS. LUCA.
GeneTreeiENSGT00730000111193.
HOGENOMiHOG000059628.
HOVERGENiHBG103693.
InParanoidiQ8VHI7.
OMAiIIEAAHV.
OrthoDBiEOG76DTSZ.
PhylomeDBiQ8VHI7.
TreeFamiTF326074.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VHI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKKGKKPKL PKAPLSEEDQ LLIFQQKMLA DEEAAKKKER LLTQFLKDKL
60 70 80 90 100
AKEEHNSALN LNKINTQWRT ILREVKTREL HQDIEILSQT FERVVDCKDS
110 120 130 140 150
VIKSLAKDLT EAEEQYAHAL RSHLHNIDQL LTLQRRRLGL LEENYNMELE
160 170 180 190 200
VLTKEFETER KLIIDHHEKE MHYLQDVFMA MEQNYIDSEY ESKLEFQSMW
210 220 230 240 250
DDLKNKNLEE KHFLRLQLEN IVEDLWRRFQ DALKNYTDAT EDRKIAFEYL
260 270 280 290 300
KVKDEKSSKE IETQMKKIQK LQETIGILKG KIVAHSREGE WQNQCIRNNK
310 320 330 340 350
ELVHVQLRKL KVQRTQARTL SQENLVKLTL ESNATLKALK KVVEKGEKIL
360 370 380 390 400
KLAEICRKFE TEEEKVLPFY SSVLTPEEQE EAKLQNPEDI TEDLAKIMMD
410 420 430 440 450
YAGMENFWKR YNKVKLEVLS LQHRRLQLLD ISSKLREMLK QYLDGISVSD
460 470 480 490
EVLSHLNPLF VVNHRSNLPQ LPPPSAQPVY NVIEAAHIAS HIL
Length:493
Mass (Da):58,170
Last modified:March 1, 2002 - v1
Checksum:i2BEE9457E4CB5154
GO
Isoform 2 (identifier: Q8VHI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-493: Missing.

Note: No experimental confirmation available.
Show »
Length:104
Mass (Da):12,172
Checksum:iAF8D3D8D4A77FB2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041S → V in AAH56947 (PubMed:16141072).Curated
Sequence conflicti104 – 1041S → V in AAH60155 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei105 – 493389Missing in isoform 2. 1 PublicationVSP_024645Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454432 mRNA. Translation: AAL51007.1.
AK077174 mRNA. Translation: BAC36661.1.
BC048073 mRNA. Translation: AAH48073.1.
BC056947 mRNA. Translation: AAH56947.1.
BC060155 mRNA. Translation: AAH60155.1.
CCDSiCCDS27802.1. [Q8VHI7-1]
RefSeqiNP_705738.1. NM_153518.1. [Q8VHI7-1]
UniGeneiMm.26205.

Genome annotation databases

EnsembliENSMUST00000003444; ENSMUSP00000003444; ENSMUSG00000003354. [Q8VHI7-1]
GeneIDi105833.
KEGGimmu:105833.
UCSCiuc007xnk.1. mouse. [Q8VHI7-2]
uc007xnl.1. mouse. [Q8VHI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454432 mRNA. Translation: AAL51007.1.
AK077174 mRNA. Translation: BAC36661.1.
BC048073 mRNA. Translation: AAH48073.1.
BC056947 mRNA. Translation: AAH56947.1.
BC060155 mRNA. Translation: AAH60155.1.
CCDSiCCDS27802.1. [Q8VHI7-1]
RefSeqiNP_705738.1. NM_153518.1. [Q8VHI7-1]
UniGeneiMm.26205.

3D structure databases

ProteinModelPortaliQ8VHI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003444.

PTM databases

PhosphoSiteiQ8VHI7.

Proteomic databases

MaxQBiQ8VHI7.
PaxDbiQ8VHI7.
PRIDEiQ8VHI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003444; ENSMUSP00000003444; ENSMUSG00000003354. [Q8VHI7-1]
GeneIDi105833.
KEGGimmu:105833.
UCSCiuc007xnk.1. mouse. [Q8VHI7-2]
uc007xnl.1. mouse. [Q8VHI7-1]

Organism-specific databases

CTDi85478.
MGIiMGI:2146001. Ccdc65.

Phylogenomic databases

eggNOGiENOG410IE4Y. Eukaryota.
ENOG410XQTS. LUCA.
GeneTreeiENSGT00730000111193.
HOGENOMiHOG000059628.
HOVERGENiHBG103693.
InParanoidiQ8VHI7.
OMAiIIEAAHV.
OrthoDBiEOG76DTSZ.
PhylomeDBiQ8VHI7.
TreeFamiTF326074.

Miscellaneous databases

NextBioi357906.
PROiQ8VHI7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHI7.
CleanExiMM_CCDC65.
GenevisibleiQ8VHI7. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new mouse nucleoprotein mNYD-SP28: similar to NYD-SP28."
    Li J.M., Sha J.H.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: ICR.
    Tissue: Brain and Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Olfactory epithelium.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiCCD65_MOUSE
AccessioniPrimary (citable) accession number: Q8VHI7
Secondary accession number(s): Q6PAP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2002
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.