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Protein

Wiskott-Aldrich syndrome protein family member 3

Gene

Wasf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).By similarity

GO - Biological processi

  • actin cytoskeleton organization Source: InterPro
  • cytoskeleton organization Source: UniProtKB
  • lamellipodium assembly Source: MGI
  • oligodendrocyte development Source: MGI
  • positive regulation of myelination Source: MGI
  • regulation of cell shape Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Wiskott-Aldrich syndrome protein family member 3
Short name:
WASP family protein member 3
Alternative name(s):
Protein WAVE-3
Gene namesi
Name:Wasf3
Synonyms:Wave3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2658986. Wasf3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • extracellular exosome Source: MGI
  • lamellipodium Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Wiskott-Aldrich syndrome protein family member 3PRO_0000188997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphotyrosine; by ABL1By similarity
Modified residuei248 – 2481Phosphotyrosine; by ABL1By similarity
Modified residuei337 – 3371Phosphotyrosine; by ABL1By similarity
Modified residuei485 – 4851Phosphotyrosine; by ABL1By similarity

Post-translational modificationi

Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VHI6.
PaxDbiQ8VHI6.
PRIDEiQ8VHI6.

PTM databases

iPTMnetiQ8VHI6.
PhosphoSiteiQ8VHI6.

Expressioni

Gene expression databases

BgeeiQ8VHI6.
CleanExiMM_WASF3.
GenevisibleiQ8VHI6. MM.

Interactioni

Subunit structurei

Binds actin and the Arp2/3 complex.By similarity

Protein-protein interaction databases

BioGridi232846. 1 interaction.
IntActiQ8VHI6. 1 interaction.
MINTiMINT-4140233.
STRINGi10090.ENSMUSP00000016143.

Structurei

3D structure databases

ProteinModelPortaliQ8VHI6.
SMRiQ8VHI6. Positions 17-200, 438-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini439 – 45618WH2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili57 – 9337Sequence analysisAdd
BLAST
Coiled coili162 – 20645Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi304 – 3107Poly-Pro
Compositional biasi343 – 3508Poly-Pro
Compositional biasi395 – 41016Poly-ProAdd
BLAST

Domaini

Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.

Sequence similaritiesi

Belongs to the SCAR/WAVE family.Curated
Contains 1 WH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1830. Eukaryota.
ENOG410XRBQ. LUCA.
GeneTreeiENSGT00730000110593.
HOGENOMiHOG000021456.
HOVERGENiHBG058482.
InParanoidiQ8VHI6.
KOiK06083.
OMAiDQHHYPN.
PhylomeDBiQ8VHI6.
TreeFamiTF315031.

Family and domain databases

InterProiIPR028288. SCAR/WAVE_fam.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR12902. PTHR12902. 1 hit.
PfamiPF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVKRNIEP RHLCRGALPE GVTSELECVT NSTLAAIIRQ LSSLSKHAED
60 70 80 90 100
IFGELFNEAN NFYIRANSLQ DRIDRLAVKV TQLDSTVEEV SLQDINMKKA
110 120 130 140 150
FKSSTIQDQQ VVSKNSIPNP VADIYNQSDK PPPLSILTPY RDDKKDGLKF
160 170 180 190 200
YTDPSYFFDL WKEKMLQDTE DKRKEKRRQK EQKRVDGTTR EVKKVRKARN
210 220 230 240 250
RRQEWNMMAY DKELRPDNRL SQSVHHGASS EGSLSPDTRS HTSDVTDYSY
260 270 280 290 300
PATPNHALQA QPATPSYTAG DAPLHGTTNQ GAEHEYRPSS ASARHMALNR
310 320 330 340 350
PQQPPPPPPP QAPEGSQAST SVAPADYGML PAQIIEYYSP SGPPPPPPPP
360 370 380 390 400
MIPSAQTAFV SPLQMPTQPP FPASAVSTYP TPPHQPSTGL LATAPPPPGP
410 420 430 440 450
PPPPPGPPGP SSLSSSPMHG PPVAEAKRPE PAQPPISDAR SDLLAAIRMG
460 470 480 490 500
IQLKKVQEQR EQEAKREPVG NDVATILSRR IAVEYSDSDD DSEFDENDWS

D
Length:501
Mass (Da):55,204
Last modified:March 1, 2002 - v1
Checksum:iFD30EEC6867D4AF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454703 mRNA. Translation: AAL51033.1.
BC027038 mRNA. Translation: AAH27038.1.
CCDSiCCDS19870.1.
RefSeqiNP_660137.1. NM_145155.3.
XP_006504896.1. XM_006504833.2.
UniGeneiMm.472750.

Genome annotation databases

EnsembliENSMUST00000016143; ENSMUSP00000016143; ENSMUSG00000029636.
GeneIDi245880.
KEGGimmu:245880.
UCSCiuc009anf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454703 mRNA. Translation: AAL51033.1.
BC027038 mRNA. Translation: AAH27038.1.
CCDSiCCDS19870.1.
RefSeqiNP_660137.1. NM_145155.3.
XP_006504896.1. XM_006504833.2.
UniGeneiMm.472750.

3D structure databases

ProteinModelPortaliQ8VHI6.
SMRiQ8VHI6. Positions 17-200, 438-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232846. 1 interaction.
IntActiQ8VHI6. 1 interaction.
MINTiMINT-4140233.
STRINGi10090.ENSMUSP00000016143.

PTM databases

iPTMnetiQ8VHI6.
PhosphoSiteiQ8VHI6.

Proteomic databases

MaxQBiQ8VHI6.
PaxDbiQ8VHI6.
PRIDEiQ8VHI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016143; ENSMUSP00000016143; ENSMUSG00000029636.
GeneIDi245880.
KEGGimmu:245880.
UCSCiuc009anf.1. mouse.

Organism-specific databases

CTDi10810.
MGIiMGI:2658986. Wasf3.

Phylogenomic databases

eggNOGiKOG1830. Eukaryota.
ENOG410XRBQ. LUCA.
GeneTreeiENSGT00730000110593.
HOGENOMiHOG000021456.
HOVERGENiHBG058482.
InParanoidiQ8VHI6.
KOiK06083.
OMAiDQHHYPN.
PhylomeDBiQ8VHI6.
TreeFamiTF315031.

Miscellaneous databases

ChiTaRSiWasf3. mouse.
NextBioi386984.
PROiQ8VHI6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHI6.
CleanExiMM_WASF3.
GenevisibleiQ8VHI6. MM.

Family and domain databases

InterProiIPR028288. SCAR/WAVE_fam.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR12902. PTHR12902. 1 hit.
PfamiPF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and expression profile of the human and mouse WAVE gene family."
    Sossey-Alaoui K., Head K., Nowak N., Cowell J.K.
    Mamm. Genome 14:314-322(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Liver.

Entry informationi

Entry nameiWASF3_MOUSE
AccessioniPrimary (citable) accession number: Q8VHI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2002
Last modified: January 20, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.