ID CARTF_MOUSE Reviewed; 689 AA. AC Q8VHI4; B2RRZ9; DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 24-JAN-2024, entry version 125. DE RecName: Full=Calcium-responsive transcription factor; DE AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; DE AltName: Full=Calcium-response factor; DE Short=CaRF; GN Name=Carf; Synonyms=Als2cr8; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RC STRAIN=C57BL/6J; RX PubMed=11832226; DOI=10.1016/s0896-6273(01)00561-x; RA Tao X., West A.E., Chen W.G., Corfas G., Greenberg M.E.; RT "A calcium-responsive transcription factor, CaRF, that regulates neuronal RT activity-dependent expression of BDNF."; RL Neuron 33:383-395(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Acts as a transcriptional activator that mediates the CC calcium- and neuron-selective induction of BDNF exon III transcription. CC Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' CC sequence (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11832226}. CC -!- TISSUE SPECIFICITY: Highly expressed in brain and testis. CC {ECO:0000269|PubMed:11832226}. CC -!- DOMAIN: The N-terminus is necessary for DNA-binding. The C-terminus is CC necessary for transcriptional activation. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF454947; AAL62331.1; -; mRNA. DR EMBL; BC138644; AAI38645.1; -; mRNA. DR EMBL; BC138645; AAI38646.1; -; mRNA. DR CCDS; CCDS14989.1; -. DR RefSeq; NP_001272402.1; NM_001285473.1. DR RefSeq; NP_631889.1; NM_139150.5. DR RefSeq; XP_011236812.1; XM_011238510.1. DR RefSeq; XP_017176083.1; XM_017320594.1. DR AlphaFoldDB; Q8VHI4; -. DR BioGRID; 232270; 1. DR IntAct; Q8VHI4; 1. DR STRING; 10090.ENSMUSP00000141169; -. DR iPTMnet; Q8VHI4; -. DR PhosphoSitePlus; Q8VHI4; -. DR PaxDb; 10090-ENSMUSP00000141169; -. DR ProteomicsDB; 265531; -. DR Antibodypedia; 34159; 228 antibodies from 28 providers. DR DNASU; 241066; -. DR Ensembl; ENSMUST00000180952.8; ENSMUSP00000137825.2; ENSMUSG00000026017.14. DR Ensembl; ENSMUST00000187978.7; ENSMUSP00000141169.2; ENSMUSG00000026017.14. DR GeneID; 241066; -. DR KEGG; mmu:241066; -. DR UCSC; uc007beh.2; mouse. DR AGR; MGI:2182269; -. DR CTD; 79800; -. DR MGI; MGI:2182269; Carf. DR VEuPathDB; HostDB:ENSMUSG00000026017; -. DR eggNOG; ENOG502QWYS; Eukaryota. DR GeneTree; ENSGT00390000013916; -. DR InParanoid; Q8VHI4; -. DR OMA; MMIVTSQ; -. DR OrthoDB; 2956653at2759; -. DR PhylomeDB; Q8VHI4; -. DR TreeFam; TF333279; -. DR BioGRID-ORCS; 241066; 3 hits in 80 CRISPR screens. DR ChiTaRS; Carf; mouse. DR PRO; PR:Q8VHI4; -. DR Proteomes; UP000000589; Chromosome 1. DR RNAct; Q8VHI4; Protein. DR Bgee; ENSMUSG00000026017; Expressed in spermatocyte and 215 other cell types or tissues. DR ExpressionAtlas; Q8VHI4; baseline and differential. DR GO; GO:0001652; C:granular component; IDA:MGI. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB. DR GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR InterPro; IPR029309; CaRF. DR PANTHER; PTHR14694; CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR; 1. DR PANTHER; PTHR14694:SF1; CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR; 1. DR Pfam; PF15299; ALS2CR8; 1. DR Genevisible; Q8VHI4; MM. PE 2: Evidence at transcript level; KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription; KW Transcription regulation. FT CHAIN 1..689 FT /note="Calcium-responsive transcription factor" FT /id="PRO_0000076173" FT REGION 1..46 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 541..609 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..27 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 541..563 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 574..605 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 689 AA; 76397 MW; 34CFCD3B37D0B342 CRC64; MEQRHSLAGN CDDGEKSERE AQGFEHRTCM DSGDPSFGQN DPPTILPITA PKTYDSLTSQ DMPETLTDTQ ALHEEQFHLL DQNGQPIQYD LQSLGNSTAQ MTGMEQVAIP QEPFADEHSP QDISEEKPTG VRADVLEDST SNYGLRSPAS LVLPKKAGAR LVEEPLLAPL QPLSCNTPMW ACRLRSCEKI GDSYRGYCVS ETELESVLTF HKQQTQTVWG TRQSPSPAKP ATRLMWKSQY VPYDGIPFVN AGSRAVVMEC QYGPRRKGFQ LKKISEQESR SCHLYKATCP ARIYIKKVQK FPEYRVPTDP QIDRKIIRLE QEKAFTMLKK NLMDAGGVLR WYVQLPTQQA HQYHESETPG VPLSPSPFPM SPLEEEEAIV RDENCALPSR LHPQVAHKIQ ELVSQGVGQV YAVRKQLRKF VERELFKPDE IPERHNLSYF PTVNDIKNHI HEVQKSLRTG DVVYNSEIIP ATLQWTTDSG NILRETVTVT FAEGNLLGEP IPSKMGTSQT QTAVSPEPLS SFPPKIFTHF QALKLQPRLS SPDGSQALVS VDSHASSSPP GLVDTVGNAE VDNHSVLLGQ SQNPGTDTCL TQDNSTSSST GHLPESVPNP VAEDQLLEGE DVEDAGNPEG SVNRTLLGDV QTVPIQIIDS RPVLVEESLS KNQVKQETNE PTLSTEAKTF LDCKKISAT //