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Q8VHI4

- CARTF_MOUSE

UniProt

Q8VHI4 - CARTF_MOUSE

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Protein

Calcium-responsive transcription factor

Gene

Carf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cellular response to calcium ion Source: UniProtKB
  2. cellular response to potassium ion Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  4. positive regulation of transcription from RNA polymerase II promoter in response to calcium ion Source: UniProtKB
  5. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-responsive transcription factor
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
Calcium-response factor
Short name:
CaRF
Gene namesi
Name:Carf
Synonyms:Als2cr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2182269. Carf.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: MGI
  2. nucleoplasm Source: MGI
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Calcium-responsive transcription factorPRO_0000076173Add
BLAST

Proteomic databases

PaxDbiQ8VHI4.
PRIDEiQ8VHI4.

PTM databases

PhosphoSiteiQ8VHI4.

Expressioni

Tissue specificityi

Highly expressed in brain and testis.1 Publication

Gene expression databases

BgeeiQ8VHI4.
CleanExiMM_CARF.
ExpressionAtlasiQ8VHI4. baseline.
GenevestigatoriQ8VHI4.

Interactioni

Protein-protein interaction databases

BioGridi232270. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8VHI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminus is necessary for DNA-binding. The C-terminus is necessary for transcriptional activation.

Phylogenomic databases

eggNOGiNOG45356.
GeneTreeiENSGT00390000013916.
HOGENOMiHOG000033888.
HOVERGENiHBG080829.
InParanoidiQ8VHI4.
OMAiQLQPRFT.
OrthoDBiEOG761BTC.
PhylomeDBiQ8VHI4.
TreeFamiTF333279.

Family and domain databases

InterProiIPR029309. CaRF.
[Graphical view]
PfamiPF15299. ALS2CR8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQRHSLAGN CDDGEKSERE AQGFEHRTCM DSGDPSFGQN DPPTILPITA
60 70 80 90 100
PKTYDSLTSQ DMPETLTDTQ ALHEEQFHLL DQNGQPIQYD LQSLGNSTAQ
110 120 130 140 150
MTGMEQVAIP QEPFADEHSP QDISEEKPTG VRADVLEDST SNYGLRSPAS
160 170 180 190 200
LVLPKKAGAR LVEEPLLAPL QPLSCNTPMW ACRLRSCEKI GDSYRGYCVS
210 220 230 240 250
ETELESVLTF HKQQTQTVWG TRQSPSPAKP ATRLMWKSQY VPYDGIPFVN
260 270 280 290 300
AGSRAVVMEC QYGPRRKGFQ LKKISEQESR SCHLYKATCP ARIYIKKVQK
310 320 330 340 350
FPEYRVPTDP QIDRKIIRLE QEKAFTMLKK NLMDAGGVLR WYVQLPTQQA
360 370 380 390 400
HQYHESETPG VPLSPSPFPM SPLEEEEAIV RDENCALPSR LHPQVAHKIQ
410 420 430 440 450
ELVSQGVGQV YAVRKQLRKF VERELFKPDE IPERHNLSYF PTVNDIKNHI
460 470 480 490 500
HEVQKSLRTG DVVYNSEIIP ATLQWTTDSG NILRETVTVT FAEGNLLGEP
510 520 530 540 550
IPSKMGTSQT QTAVSPEPLS SFPPKIFTHF QALKLQPRLS SPDGSQALVS
560 570 580 590 600
VDSHASSSPP GLVDTVGNAE VDNHSVLLGQ SQNPGTDTCL TQDNSTSSST
610 620 630 640 650
GHLPESVPNP VAEDQLLEGE DVEDAGNPEG SVNRTLLGDV QTVPIQIIDS
660 670 680
RPVLVEESLS KNQVKQETNE PTLSTEAKTF LDCKKISAT
Length:689
Mass (Da):76,397
Last modified:March 1, 2002 - v1
Checksum:i34CFCD3B37D0B342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454947 mRNA. Translation: AAL62331.1.
BC138644 mRNA. Translation: AAI38645.1.
BC138645 mRNA. Translation: AAI38646.1.
CCDSiCCDS14989.1.
RefSeqiNP_001272402.1. NM_001285473.1.
NP_631889.1. NM_139150.5.
XP_006496035.1. XM_006495972.1.
UniGeneiMm.276441.
Mm.370325.

Genome annotation databases

EnsembliENSMUST00000180952; ENSMUSP00000137825; ENSMUSG00000026017.
ENSMUST00000187978; ENSMUSP00000141169; ENSMUSG00000026017.
GeneIDi241066.
KEGGimmu:241066.
UCSCiuc007beh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454947 mRNA. Translation: AAL62331.1 .
BC138644 mRNA. Translation: AAI38645.1 .
BC138645 mRNA. Translation: AAI38646.1 .
CCDSi CCDS14989.1.
RefSeqi NP_001272402.1. NM_001285473.1.
NP_631889.1. NM_139150.5.
XP_006496035.1. XM_006495972.1.
UniGenei Mm.276441.
Mm.370325.

3D structure databases

ProteinModelPortali Q8VHI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 232270. 1 interaction.

PTM databases

PhosphoSitei Q8VHI4.

Proteomic databases

PaxDbi Q8VHI4.
PRIDEi Q8VHI4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000180952 ; ENSMUSP00000137825 ; ENSMUSG00000026017 .
ENSMUST00000187978 ; ENSMUSP00000141169 ; ENSMUSG00000026017 .
GeneIDi 241066.
KEGGi mmu:241066.
UCSCi uc007beh.1. mouse.

Organism-specific databases

CTDi 79800.
MGIi MGI:2182269. Carf.

Phylogenomic databases

eggNOGi NOG45356.
GeneTreei ENSGT00390000013916.
HOGENOMi HOG000033888.
HOVERGENi HBG080829.
InParanoidi Q8VHI4.
OMAi QLQPRFT.
OrthoDBi EOG761BTC.
PhylomeDBi Q8VHI4.
TreeFami TF333279.

Miscellaneous databases

NextBioi 384851.
PROi Q8VHI4.
SOURCEi Search...

Gene expression databases

Bgeei Q8VHI4.
CleanExi MM_CARF.
ExpressionAtlasi Q8VHI4. baseline.
Genevestigatori Q8VHI4.

Family and domain databases

InterProi IPR029309. CaRF.
[Graphical view ]
Pfami PF15299. ALS2CR8. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF."
    Tao X., West A.E., Chen W.G., Corfas G., Greenberg M.E.
    Neuron 33:383-395(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCARTF_MOUSE
AccessioniPrimary (citable) accession number: Q8VHI4
Secondary accession number(s): B2RRZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3