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Q8VHI4 (CARTF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-responsive transcription factor
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
Calcium-response factor
Short name=CaRF
Gene names
Name:Carf
Synonyms:Als2cr8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length689 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence By similarity.

Subcellular location

Nucleus Ref.1.

Tissue specificity

Highly expressed in brain and testis. Ref.1

Domain

The N-terminus is necessary for DNA-binding. The C-terminus is necessary for transcriptional activation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 689689Calcium-responsive transcription factor
PRO_0000076173

Sequences

Sequence LengthMass (Da)Tools
Q8VHI4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 34CFCD3B37D0B342

FASTA68976,397
        10         20         30         40         50         60 
MEQRHSLAGN CDDGEKSERE AQGFEHRTCM DSGDPSFGQN DPPTILPITA PKTYDSLTSQ 

        70         80         90        100        110        120 
DMPETLTDTQ ALHEEQFHLL DQNGQPIQYD LQSLGNSTAQ MTGMEQVAIP QEPFADEHSP 

       130        140        150        160        170        180 
QDISEEKPTG VRADVLEDST SNYGLRSPAS LVLPKKAGAR LVEEPLLAPL QPLSCNTPMW 

       190        200        210        220        230        240 
ACRLRSCEKI GDSYRGYCVS ETELESVLTF HKQQTQTVWG TRQSPSPAKP ATRLMWKSQY 

       250        260        270        280        290        300 
VPYDGIPFVN AGSRAVVMEC QYGPRRKGFQ LKKISEQESR SCHLYKATCP ARIYIKKVQK 

       310        320        330        340        350        360 
FPEYRVPTDP QIDRKIIRLE QEKAFTMLKK NLMDAGGVLR WYVQLPTQQA HQYHESETPG 

       370        380        390        400        410        420 
VPLSPSPFPM SPLEEEEAIV RDENCALPSR LHPQVAHKIQ ELVSQGVGQV YAVRKQLRKF 

       430        440        450        460        470        480 
VERELFKPDE IPERHNLSYF PTVNDIKNHI HEVQKSLRTG DVVYNSEIIP ATLQWTTDSG 

       490        500        510        520        530        540 
NILRETVTVT FAEGNLLGEP IPSKMGTSQT QTAVSPEPLS SFPPKIFTHF QALKLQPRLS 

       550        560        570        580        590        600 
SPDGSQALVS VDSHASSSPP GLVDTVGNAE VDNHSVLLGQ SQNPGTDTCL TQDNSTSSST 

       610        620        630        640        650        660 
GHLPESVPNP VAEDQLLEGE DVEDAGNPEG SVNRTLLGDV QTVPIQIIDS RPVLVEESLS 

       670        680 
KNQVKQETNE PTLSTEAKTF LDCKKISAT 

« Hide

References

« Hide 'large scale' references
[1]"A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF."
Tao X., West A.E., Chen W.G., Corfas G., Greenberg M.E.
Neuron 33:383-395(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF454947 mRNA. Translation: AAL62331.1.
BC138644 mRNA. Translation: AAI38645.1.
BC138645 mRNA. Translation: AAI38646.1.
RefSeqNP_001272402.1. NM_001285473.1.
NP_631889.1. NM_139150.5.
XP_006496035.1. XM_006495972.1.
UniGeneMm.276441.
Mm.370325.

3D structure databases

ProteinModelPortalQ8VHI4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid232270. 1 interaction.

PTM databases

PhosphoSiteQ8VHI4.

Proteomic databases

PaxDbQ8VHI4.
PRIDEQ8VHI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027171; ENSMUSP00000027171; ENSMUSG00000026017.
ENSMUST00000180952; ENSMUSP00000137825; ENSMUSG00000026017.
GeneID241066.
KEGGmmu:241066.
UCSCuc007beh.1. mouse.

Organism-specific databases

CTD79800.
MGIMGI:2182269. Carf.

Phylogenomic databases

eggNOGNOG45356.
GeneTreeENSGT00390000013916.
HOGENOMHOG000033888.
HOVERGENHBG080829.
InParanoidB2RRZ9.
OMAQLQPRFT.
OrthoDBEOG761BTC.
PhylomeDBQ8VHI4.
TreeFamTF333279.

Gene expression databases

ArrayExpressQ8VHI4.
BgeeQ8VHI4.
CleanExMM_CARF.
GenevestigatorQ8VHI4.

Family and domain databases

ProtoNetSearch...

Other

NextBio384851.
PROQ8VHI4.
SOURCESearch...

Entry information

Entry nameCARTF_MOUSE
AccessionPrimary (citable) accession number: Q8VHI4
Secondary accession number(s): B2RRZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot