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Q8VHI4

- CARTF_MOUSE

UniProt

Q8VHI4 - CARTF_MOUSE

Protein

Calcium-responsive transcription factor

Gene

Carf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cellular response to calcium ion Source: UniProtKB
    2. cellular response to potassium ion Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    4. positive regulation of transcription from RNA polymerase II promoter in response to calcium ion Source: UniProtKB
    5. regulation of transcription, DNA-templated Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-responsive transcription factor
    Alternative name(s):
    Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
    Calcium-response factor
    Short name:
    CaRF
    Gene namesi
    Name:Carf
    Synonyms:Als2cr8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2182269. Carf.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: MGI
    2. nucleoplasm Source: MGI
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689Calcium-responsive transcription factorPRO_0000076173Add
    BLAST

    Proteomic databases

    PaxDbiQ8VHI4.
    PRIDEiQ8VHI4.

    PTM databases

    PhosphoSiteiQ8VHI4.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ8VHI4.
    BgeeiQ8VHI4.
    CleanExiMM_CARF.
    GenevestigatoriQ8VHI4.

    Interactioni

    Protein-protein interaction databases

    BioGridi232270. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VHI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The N-terminus is necessary for DNA-binding. The C-terminus is necessary for transcriptional activation.

    Phylogenomic databases

    eggNOGiNOG45356.
    GeneTreeiENSGT00390000013916.
    HOGENOMiHOG000033888.
    HOVERGENiHBG080829.
    InParanoidiB2RRZ9.
    OMAiQLQPRFT.
    OrthoDBiEOG761BTC.
    PhylomeDBiQ8VHI4.
    TreeFamiTF333279.

    Family and domain databases

    InterProiIPR029309. CaRF.
    [Graphical view]
    PfamiPF15299. ALS2CR8. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VHI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQRHSLAGN CDDGEKSERE AQGFEHRTCM DSGDPSFGQN DPPTILPITA    50
    PKTYDSLTSQ DMPETLTDTQ ALHEEQFHLL DQNGQPIQYD LQSLGNSTAQ 100
    MTGMEQVAIP QEPFADEHSP QDISEEKPTG VRADVLEDST SNYGLRSPAS 150
    LVLPKKAGAR LVEEPLLAPL QPLSCNTPMW ACRLRSCEKI GDSYRGYCVS 200
    ETELESVLTF HKQQTQTVWG TRQSPSPAKP ATRLMWKSQY VPYDGIPFVN 250
    AGSRAVVMEC QYGPRRKGFQ LKKISEQESR SCHLYKATCP ARIYIKKVQK 300
    FPEYRVPTDP QIDRKIIRLE QEKAFTMLKK NLMDAGGVLR WYVQLPTQQA 350
    HQYHESETPG VPLSPSPFPM SPLEEEEAIV RDENCALPSR LHPQVAHKIQ 400
    ELVSQGVGQV YAVRKQLRKF VERELFKPDE IPERHNLSYF PTVNDIKNHI 450
    HEVQKSLRTG DVVYNSEIIP ATLQWTTDSG NILRETVTVT FAEGNLLGEP 500
    IPSKMGTSQT QTAVSPEPLS SFPPKIFTHF QALKLQPRLS SPDGSQALVS 550
    VDSHASSSPP GLVDTVGNAE VDNHSVLLGQ SQNPGTDTCL TQDNSTSSST 600
    GHLPESVPNP VAEDQLLEGE DVEDAGNPEG SVNRTLLGDV QTVPIQIIDS 650
    RPVLVEESLS KNQVKQETNE PTLSTEAKTF LDCKKISAT 689
    Length:689
    Mass (Da):76,397
    Last modified:March 1, 2002 - v1
    Checksum:i34CFCD3B37D0B342
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454947 mRNA. Translation: AAL62331.1.
    BC138644 mRNA. Translation: AAI38645.1.
    BC138645 mRNA. Translation: AAI38646.1.
    CCDSiCCDS14989.1.
    RefSeqiNP_001272402.1. NM_001285473.1.
    NP_631889.1. NM_139150.5.
    XP_006496035.1. XM_006495972.1.
    UniGeneiMm.276441.
    Mm.370325.

    Genome annotation databases

    EnsembliENSMUST00000027171; ENSMUSP00000027171; ENSMUSG00000026017.
    ENSMUST00000180952; ENSMUSP00000137825; ENSMUSG00000026017.
    GeneIDi241066.
    KEGGimmu:241066.
    UCSCiuc007beh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454947 mRNA. Translation: AAL62331.1 .
    BC138644 mRNA. Translation: AAI38645.1 .
    BC138645 mRNA. Translation: AAI38646.1 .
    CCDSi CCDS14989.1.
    RefSeqi NP_001272402.1. NM_001285473.1.
    NP_631889.1. NM_139150.5.
    XP_006496035.1. XM_006495972.1.
    UniGenei Mm.276441.
    Mm.370325.

    3D structure databases

    ProteinModelPortali Q8VHI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 232270. 1 interaction.

    PTM databases

    PhosphoSitei Q8VHI4.

    Proteomic databases

    PaxDbi Q8VHI4.
    PRIDEi Q8VHI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027171 ; ENSMUSP00000027171 ; ENSMUSG00000026017 .
    ENSMUST00000180952 ; ENSMUSP00000137825 ; ENSMUSG00000026017 .
    GeneIDi 241066.
    KEGGi mmu:241066.
    UCSCi uc007beh.1. mouse.

    Organism-specific databases

    CTDi 79800.
    MGIi MGI:2182269. Carf.

    Phylogenomic databases

    eggNOGi NOG45356.
    GeneTreei ENSGT00390000013916.
    HOGENOMi HOG000033888.
    HOVERGENi HBG080829.
    InParanoidi B2RRZ9.
    OMAi QLQPRFT.
    OrthoDBi EOG761BTC.
    PhylomeDBi Q8VHI4.
    TreeFami TF333279.

    Miscellaneous databases

    NextBioi 384851.
    PROi Q8VHI4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VHI4.
    Bgeei Q8VHI4.
    CleanExi MM_CARF.
    Genevestigatori Q8VHI4.

    Family and domain databases

    InterProi IPR029309. CaRF.
    [Graphical view ]
    Pfami PF15299. ALS2CR8. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF."
      Tao X., West A.E., Chen W.G., Corfas G., Greenberg M.E.
      Neuron 33:383-395(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCARTF_MOUSE
    AccessioniPrimary (citable) accession number: Q8VHI4
    Secondary accession number(s): B2RRZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3