Reviewed,
UniProtKB/Swiss-Prot Q8VHI3 (OFUT2_MOUSE)
Last modified
January 19, 2010.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: GDP-fucose protein O-fucosyltransferase 2 EC=2.4.1.221 Alternative name(s): Peptide-O-fucosyltransferase 2 Short name=O-FucT-2 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 429 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats By similarity. |
| Catalytic activity | Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor. |
| Pathway | |
| Subcellular location | Endoplasmic reticulum By similarity. |
| Sequence similarities | Belongs to the glycosyltransferase 68 family. |
| Sequence caution | The sequence BC018194 differs from that shown. Reason: Frameshift at position 380. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Fucose metabolism |
| Cellular component | Endoplasmic reticulum |
| Domain | Signal |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | fucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | peptide-O-fucosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||
| Chain | 22 – 429 | 408 | GDP-fucose protein O-fucosyltransferase 2 | PRO_0000012155 | |||||
Amino acid modifications | |||||||||
| Glycosylation | 189 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 209 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 259 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "C21orf80, a new gene from the 21q22.3 region: using RNAi to get insight into the function." Menzel O., Reymond A., Antonarakis S.E., Guipponi M. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-119. Strain: C57BL/6J. Tissue: Tongue. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF455270 mRNA. Translation: AAL65192.1. BC018194 mRNA. No translation available. AK009301 mRNA. Translation: BAB26202.1. |
| IPI | IPI00128336. |
| RefSeq | NP_084538.2. |
| UniGene | Mm.203556 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8VHI3. |
Protein family/group databases | |
| CAZy | GT68. Glycosyltransferase Family 68. |
Proteomic databases | |
| PRIDE | Q8VHI3. |
Genome annotation databases | |
| Ensembl | ENSMUST00000020493; ENSMUSP00000020493; ENSMUSG00000020260; Mus musculus. [Genome view] |
| GeneID | 80294. |
| KEGG | mmu:80294. |
| UCSC | uc007fvj.1. mouse. |
Organism-specific databases | |
| CTD | 80294. |
| MGI | MGI:1916863. Pofut2. |
Phylogenomic databases | |
| HOGENOM | HBG314645. |
| HOVERGEN | Q8VHI3. |
| InParanoid | Q8VHI3. |
| OMA | HARFFIG. |
| PhylomeDB | Q8VHI3. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.221. 244. |
Gene expression databases | |
| ArrayExpress | Q8VHI3. |
| Bgee | Q8VHI3. |
| CleanEx | MM_POFUT2. |
| Genevestigator | Q8VHI3. |
| GermOnline | ENSMUSG00000020260. Mus musculus. |
Family and domain databases | |
| InterPro | IPR019378. GDP-Fuc_prot_O-FucTrfase. [Graphical view] |
| Pfam | PF10250. O-FucT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 350013. |
| SOURCE | Search... |
Entry information
| Entry name | OFUT2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8VHI3 Secondary accession number(s): Q8VEM2, Q9CV66 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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