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Protein
Submitted name:

IL25

Gene

Il25

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-17E receptor binding Source: MGI

GO - Biological processi

  • eosinophil differentiation Source: MGI
  • inflammatory response Source: MGI
  • inflammatory response to antigenic stimulus Source: Ensembl
  • interleukin-13 production Source: MGI
  • interleukin-5 production Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to fungus Source: MGI
  • response to nematode Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
IL25Imported
Submitted name:
Interleukin 25Imported
Gene namesi
Name:Il25Imported
Synonyms:Il17eImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2155888. Il25.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501097697317 – 169Sequence analysisAdd BLAST153

Expressioni

Gene expression databases

BgeeiENSMUSG00000040770.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-17E receptor binding Source: MGI

Protein-protein interaction databases

IntActiQ8VHH8. 1 interactor.
STRINGi10090.ENSMUSP00000039641.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IHJ5. Eukaryota.
ENOG4111VTD. LUCA.
GeneTreeiENSGT00690000102299.
HOGENOMiHOG000113041.
HOVERGENiHBG052097.
KOiK05493.
OMAiFYRRPCP.
OrthoDBiEOG091G17O0.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR010345. IL-17_fam.
PfamiView protein in Pfam
PF06083. IL17. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VHH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQAVAFLAM IVGTHTVSLR IQEGCSHLPS CCPSKEQEPP EEWLKWSSAS
60 70 80 90 100
VSPPEPLSHT HHAESCRASK DGPLNSRAIS PWSYELDRDL NRVPQDLYHA
110 120 130 140 150
RCLCPHCVSL QTGSHMDPLG NSVPLYHNQT VFYRRPCHGE EGTHRRYCLE
160
RRLYRVSLAC VCVRPRVMA
Length:169
Mass (Da):19,210
Last modified:March 1, 2002 - v1
Checksum:iCFAD2CEDE452C94D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025533 Genomic DNA. No translation available.
BC120568 mRNA. Translation: AAI20569.1.
BC125524 mRNA. Translation: AAI25525.1.
BC144962 mRNA. Translation: AAI44963.1.
AF458060 mRNA. Translation: AAL57623.1.
RefSeqiNP_542767.1. NM_080729.3.
UniGeneiMm.412733.
Mm.90154.

Genome annotation databases

EnsembliENSMUST00000037863; ENSMUSP00000039641; ENSMUSG00000040770.
GeneIDi140806.
KEGGimmu:140806.
UCSCiuc007txn.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ8VHH8_MOUSE
AccessioniPrimary (citable) accession number: Q8VHH8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported