Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

IL25

Gene

Il25

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • cytokine receptor binding Source: GO_Central
  • interleukin-17E receptor binding Source: MGI

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • eosinophil differentiation Source: MGI
  • inflammatory response Source: MGI
  • inflammatory response to antigenic stimulus Source: Ensembl
  • interleukin-13 production Source: MGI
  • interleukin-5 production Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to fungus Source: MGI
  • response to nematode Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
IL25Imported
Submitted name:
Interleukin 25Imported
Submitted name:
Myeloid-derived growth factorImported
Gene namesi
Name:Il25Imported
Synonyms:Il17eImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2155888. Il25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 169153Sequence analysisPRO_5007714687Add
BLAST

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • cytokine receptor binding Source: GO_Central
  • interleukin-17E receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039641.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IHJ5. Eukaryota.
ENOG4111VTD. LUCA.
GeneTreeiENSGT00690000102299.
HOGENOMiHOG000113041.
HOVERGENiHBG052097.
KOiK05493.
OMAiFYRRPCP.
OrthoDBiEOG7KSX9Z.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VHH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQAVAFLAM IVGTHTVSLR IQEGCSHLPS CCPSKEQEPP EEWLKWSSAS
60 70 80 90 100
VSPPEPLSHT HHAESCRASK DGPLNSRAIS PWSYELDRDL NRVPQDLYHA
110 120 130 140 150
RCLCPHCVSL QTGSHMDPLG NSVPLYHNQT VFYRRPCHGE EGTHRRYCLE
160
RRLYRVSLAC VCVRPRVMA
Length:169
Mass (Da):19,210
Last modified:March 1, 2002 - v1
Checksum:iCFAD2CEDE452C94D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025533 Genomic DNA. No translation available.
BC120568 mRNA. Translation: AAI20569.1.
BC125524 mRNA. Translation: AAI25525.1.
BC144962 mRNA. Translation: AAI44963.1.
AF458060 mRNA. Translation: AAL57623.1.
RefSeqiNP_542767.1. NM_080729.3.
UniGeneiMm.412733.
Mm.90154.

Genome annotation databases

EnsembliENSMUST00000037863; ENSMUSP00000039641; ENSMUSG00000040770.
GeneIDi140806.
KEGGimmu:140806.
UCSCiuc007txn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025533 Genomic DNA. No translation available.
BC120568 mRNA. Translation: AAI20569.1.
BC125524 mRNA. Translation: AAI25525.1.
BC144962 mRNA. Translation: AAI44963.1.
AF458060 mRNA. Translation: AAL57623.1.
RefSeqiNP_542767.1. NM_080729.3.
UniGeneiMm.412733.
Mm.90154.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037863; ENSMUSP00000039641; ENSMUSG00000040770.
GeneIDi140806.
KEGGimmu:140806.
UCSCiuc007txn.2. mouse.

Organism-specific databases

CTDi64806.
MGIiMGI:2155888. Il25.

Phylogenomic databases

eggNOGiENOG410IHJ5. Eukaryota.
ENOG4111VTD. LUCA.
GeneTreeiENSGT00690000102299.
HOGENOMiHOG000113041.
HOVERGENiHBG052097.
KOiK05493.
OMAiFYRRPCP.
OrthoDBiEOG7KSX9Z.
TreeFamiTF314701.

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
  2. "New IL-17 family members promote Th1 or Th2 responses in the lung: In vivo function of the novel cytokine IL-25."
    Hurst S.D., Muchamuel T., Gorman D.M., Gilbert J.M., Clifford T., Kwan S., Menon S., Seymour B., Jackson C., Kung T., Brieland J., Zurawski S.M., Chapman R., Zurawski G., Coffman R.L.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8VHH8_MOUSE
AccessioniPrimary (citable) accession number: Q8VHH8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.