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Q8VHH7

- ADCY3_MOUSE

UniProt

Q8VHH7 - ADCY3_MOUSE

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Protein

Adenylate cyclase type 3

Gene
Adcy3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration By similarity.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulationi

Activated by calcium/calmodulin By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi324 – 3241Magnesium 1 By similarity
Metal bindingi324 – 3241Magnesium 2 By similarity
Metal bindingi325 – 3251Magnesium 2; via carbonyl oxygen By similarity
Metal bindingi368 – 3681Magnesium 1 By similarity
Metal bindingi368 – 3681Magnesium 2 By similarity

GO - Molecular functioni

  1. adenylate cyclase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: MGI

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. cAMP biosynthetic process Source: MGI
  3. intracellular signal transduction Source: InterPro
  4. sensory perception of smell Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis, Olfaction, Sensory transduction

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 3 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 3
Adenylate cyclase type III
Short name:
AC-III
Adenylate cyclase, olfactive type
Adenylyl cyclase 3
Short name:
AC3
Gene namesi
Name:Adcy3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:99675. Adcy3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7979Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei80 – 10021Helical; Reviewed predictionAdd
BLAST
Transmembranei105 – 12521Helical; Reviewed predictionAdd
BLAST
Transmembranei139 – 15921Helical; Reviewed predictionAdd
BLAST
Transmembranei173 – 19321Helical; Reviewed predictionAdd
BLAST
Transmembranei226 – 24621Helical; Reviewed predictionAdd
BLAST
Transmembranei381 – 40121Helical; Reviewed predictionAdd
BLAST
Topological domaini402 – 631230Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei632 – 65221Helical; Reviewed predictionAdd
BLAST
Transmembranei663 – 68321Helical; Reviewed predictionAdd
BLAST
Transmembranei707 – 72721Helical; Reviewed predictionAdd
BLAST
Transmembranei753 – 77321Helical; Reviewed predictionAdd
BLAST
Transmembranei774 – 79421Helical; Reviewed predictionAdd
BLAST
Transmembranei834 – 85421Helical; Reviewed predictionAdd
BLAST
Topological domaini855 – 1145291Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cilium Source: MGI
  2. cytoplasm Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11451145Adenylate cyclase type 3PRO_0000195688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi735 – 7351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VHH7.
PRIDEiQ8VHH7.

PTM databases

PhosphoSiteiQ8VHH7.

Expressioni

Gene expression databases

ArrayExpressiQ8VHH7.
BgeeiQ8VHH7.
CleanExiMM_ADCY3.
GenevestigatoriQ8VHH7.

Interactioni

Protein-protein interaction databases

BioGridi222368. 2 interactions.
IntActiQ8VHH7. 1 interaction.
MINTiMINT-7290275.

Structurei

3D structure databases

ProteinModelPortaliQ8VHH7.
SMRiQ8VHH7. Positions 307-493, 913-1099.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00750000117304.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ8VHH7.
KOiK08043.
OMAiVTLMNIN.
OrthoDBiEOG7B8S30.
PhylomeDBiQ8VHH7.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHH7-1 [UniParc]FASTAAdd to Basket

« Hide

MPRNQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP     50
RFMRLTFVPE SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF 100
SSDKLAPLMV AGFGLVLDII LFVLCKKGLL PDRVSRKVVP YLLWLLISAQ 150
IFSYLGLNFS RAHAASDTVG WQAFFVFSFF ITLPLSLSPI VIISVVSCVV 200
HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG IMSYYMADRK 250
HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 300
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR 350
FDKLAAKYHQ LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY 400
VREKTKTGVD MRVGVHTGTV LGGVLGQKRW QYDVWSTDVT VANKMEAGGI 450
PGRVHISQST MDCLKGEFDV EPGDGGSRCD YLDEKGIETY LIIASKPEVK 500
KTAQNGLNGS AVPNGAPASS KPSSPALIET KEPNGSAHAS GSTSEEAEEQ 550
EAQADNPSFP NPRRRLRLQD LADRVVDASE DEHELNQLLN EALLERESAQ 600
VVKKRNTFLL TMRFMDPEME TRYSVEKEKQ SGAAFSCSCV VLFCTAMVEI 650
LIDPWLMTNY VTFVVGEVLL LILTICSMAA IFPRSFPKKL VAFSSWIDRT 700
RWARNTWAML AIFILVMANV VDMLSCLQYY MGPYNMTAGM ELDGGCMENP 750
KYYNYVAVLS LIATIMLVQV SHMVKLTLML LVTGAVTALN LYAWCPVFDE 800
YDHKRFQEKD SPMVALEKMQ VLATPGLNGT DSRLPLVPSK YSMTVMMFVM 850
MLSFYYFSRH VEKLARTLFL WKIEVHDQKE RVYEMRRWNE ALVTNMLPEH 900
VARHFLGSKK RDEELYSQSY DEIGVMFASL PNFADFYTEE SINNGGIECL 950
RFLNEIISDF DSLLDNPKFR VITKIKTIGS TYMAASGVTP DVNTNGFTSS 1000
SKEEKSDKER WQHLADLADF ALAMKDTLTN INNQSFNNFM LRIGMNKGGV 1050
LAGVIGARKP HYDIWGNTVN VASRMESTGV MGNIQVVEET QVILREYGFR 1100
FVRRGPIFVK GKGELLTFFL KGRDRPAAFP NGSSVTLPHQ VVDNP 1145
Length:1,145
Mass (Da):129,085
Last modified:July 27, 2011 - v2
Checksum:i09195176F4B3D61F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521F → L in AAL59384. 1 Publication
Sequence conflicti833 – 8353RLP → MLL in AAL59384. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF458089 mRNA. Translation: AAL59384.1.
CT572999 Genomic DNA. Translation: CAX15321.1.
CH466623 Genomic DNA. Translation: EDL01374.1.
CCDSiCCDS25787.1.
RefSeqiNP_612178.2. NM_138305.3.
XP_006514995.1. XM_006514932.1.
XP_006514996.1. XM_006514933.1.
XP_006514997.1. XM_006514934.1.
XP_006514998.1. XM_006514935.1.
UniGeneiMm.489807.

Genome annotation databases

EnsembliENSMUST00000020984; ENSMUSP00000020984; ENSMUSG00000020654.
ENSMUST00000127756; ENSMUSP00000115406; ENSMUSG00000020654.
GeneIDi104111.
KEGGimmu:104111.
UCSCiuc007mxm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF458089 mRNA. Translation: AAL59384.1 .
CT572999 Genomic DNA. Translation: CAX15321.1 .
CH466623 Genomic DNA. Translation: EDL01374.1 .
CCDSi CCDS25787.1.
RefSeqi NP_612178.2. NM_138305.3.
XP_006514995.1. XM_006514932.1.
XP_006514996.1. XM_006514933.1.
XP_006514997.1. XM_006514934.1.
XP_006514998.1. XM_006514935.1.
UniGenei Mm.489807.

3D structure databases

ProteinModelPortali Q8VHH7.
SMRi Q8VHH7. Positions 307-493, 913-1099.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222368. 2 interactions.
IntActi Q8VHH7. 1 interaction.
MINTi MINT-7290275.

Chemistry

BindingDBi Q8VHH7.

PTM databases

PhosphoSitei Q8VHH7.

Proteomic databases

PaxDbi Q8VHH7.
PRIDEi Q8VHH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020984 ; ENSMUSP00000020984 ; ENSMUSG00000020654 .
ENSMUST00000127756 ; ENSMUSP00000115406 ; ENSMUSG00000020654 .
GeneIDi 104111.
KEGGi mmu:104111.
UCSCi uc007mxm.2. mouse.

Organism-specific databases

CTDi 109.
MGIi MGI:99675. Adcy3.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00750000117304.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi Q8VHH7.
KOi K08043.
OMAi VTLMNIN.
OrthoDBi EOG7B8S30.
PhylomeDBi Q8VHH7.

Enzyme and pathway databases

Reactomei REACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Miscellaneous databases

ChiTaRSi ADCY3. mouse.
NextBioi 356544.
PROi Q8VHH7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VHH7.
Bgeei Q8VHH7.
CleanExi MM_ADCY3.
Genevestigatori Q8VHH7.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of mouse Adcy3."
    Pasternak S., Neumann P.E.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiADCY3_MOUSE
AccessioniPrimary (citable) accession number: Q8VHH7
Secondary accession number(s): B8JK57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi