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Q8VHH7 (ADCY3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase type 3

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 3
Adenylate cyclase type III
Short name=AC-III
Adenylate cyclase, olfactive type
Adenylyl cyclase 3
Short name=AC3
Gene names
Name:Adcy3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1145 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration By similarity.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Activated by calcium/calmodulin By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11451145Adenylate cyclase type 3
PRO_0000195688

Regions

Topological domain1 – 7979Cytoplasmic Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane139 – 15921Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane381 – 40121Helical; Potential
Topological domain402 – 631230Cytoplasmic Potential
Transmembrane632 – 65221Helical; Potential
Transmembrane663 – 68321Helical; Potential
Transmembrane707 – 72721Helical; Potential
Transmembrane753 – 77321Helical; Potential
Transmembrane774 – 79421Helical; Potential
Transmembrane834 – 85421Helical; Potential
Topological domain855 – 1145291Cytoplasmic Potential

Sites

Metal binding3241Magnesium 1 By similarity
Metal binding3241Magnesium 2 By similarity
Metal binding3251Magnesium 2; via carbonyl oxygen By similarity
Metal binding3681Magnesium 1 By similarity
Metal binding3681Magnesium 2 By similarity

Amino acid modifications

Glycosylation7351N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1521F → L in AAL59384. Ref.1
Sequence conflict833 – 8353RLP → MLL in AAL59384. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8VHH7 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 09195176F4B3D61F

FASTA1,145129,085
        10         20         30         40         50         60 
MPRNQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 

        70         80         90        100        110        120 
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLAPLMV AGFGLVLDII 

       130        140        150        160        170        180 
LFVLCKKGLL PDRVSRKVVP YLLWLLISAQ IFSYLGLNFS RAHAASDTVG WQAFFVFSFF 

       190        200        210        220        230        240 
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG 

       250        260        270        280        290        300 
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 

       310        320        330        340        350        360 
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 

       370        380        390        400        410        420 
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 

       430        440        450        460        470        480 
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 

       490        500        510        520        530        540 
YLDEKGIETY LIIASKPEVK KTAQNGLNGS AVPNGAPASS KPSSPALIET KEPNGSAHAS 

       550        560        570        580        590        600 
GSTSEEAEEQ EAQADNPSFP NPRRRLRLQD LADRVVDASE DEHELNQLLN EALLERESAQ 

       610        620        630        640        650        660 
VVKKRNTFLL TMRFMDPEME TRYSVEKEKQ SGAAFSCSCV VLFCTAMVEI LIDPWLMTNY 

       670        680        690        700        710        720 
VTFVVGEVLL LILTICSMAA IFPRSFPKKL VAFSSWIDRT RWARNTWAML AIFILVMANV 

       730        740        750        760        770        780 
VDMLSCLQYY MGPYNMTAGM ELDGGCMENP KYYNYVAVLS LIATIMLVQV SHMVKLTLML 

       790        800        810        820        830        840 
LVTGAVTALN LYAWCPVFDE YDHKRFQEKD SPMVALEKMQ VLATPGLNGT DSRLPLVPSK 

       850        860        870        880        890        900 
YSMTVMMFVM MLSFYYFSRH VEKLARTLFL WKIEVHDQKE RVYEMRRWNE ALVTNMLPEH 

       910        920        930        940        950        960 
VARHFLGSKK RDEELYSQSY DEIGVMFASL PNFADFYTEE SINNGGIECL RFLNEIISDF 

       970        980        990       1000       1010       1020 
DSLLDNPKFR VITKIKTIGS TYMAASGVTP DVNTNGFTSS SKEEKSDKER WQHLADLADF 

      1030       1040       1050       1060       1070       1080 
ALAMKDTLTN INNQSFNNFM LRIGMNKGGV LAGVIGARKP HYDIWGNTVN VASRMESTGV 

      1090       1100       1110       1120       1130       1140 
MGNIQVVEET QVILREYGFR FVRRGPIFVK GKGELLTFFL KGRDRPAAFP NGSSVTLPHQ 


VVDNP 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of mouse Adcy3."
Pasternak S., Neumann P.E.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF458089 mRNA. Translation: AAL59384.1.
CT572999 Genomic DNA. Translation: CAX15321.1.
CH466623 Genomic DNA. Translation: EDL01374.1.
CCDSCCDS25787.1.
RefSeqNP_612178.2. NM_138305.3.
XP_006514995.1. XM_006514932.1.
XP_006514996.1. XM_006514933.1.
XP_006514997.1. XM_006514934.1.
XP_006514998.1. XM_006514935.1.
UniGeneMm.489807.

3D structure databases

ProteinModelPortalQ8VHH7.
SMRQ8VHH7. Positions 307-493, 913-1099.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid222368. 2 interactions.
IntActQ8VHH7. 1 interaction.
MINTMINT-7290275.

Chemistry

BindingDBQ8VHH7.

PTM databases

PhosphoSiteQ8VHH7.

Proteomic databases

PaxDbQ8VHH7.
PRIDEQ8VHH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020984; ENSMUSP00000020984; ENSMUSG00000020654.
ENSMUST00000127756; ENSMUSP00000115406; ENSMUSG00000020654.
GeneID104111.
KEGGmmu:104111.
UCSCuc007mxm.2. mouse.

Organism-specific databases

CTD109.
MGIMGI:99675. Adcy3.

Phylogenomic databases

eggNOGCOG2114.
GeneTreeENSGT00750000117304.
HOGENOMHOG000006941.
HOVERGENHBG050458.
InParanoidQ8VHH7.
KOK08043.
OMAVTLMNIN.
OrthoDBEOG7B8S30.
PhylomeDBQ8VHH7.

Gene expression databases

ArrayExpressQ8VHH7.
BgeeQ8VHH7.
CleanExMM_ADCY3.
GenevestigatorQ8VHH7.

Family and domain databases

Gene3D3.30.70.1230. 2 hits.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
PfamPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMSSF55073. SSF55073. 2 hits.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADCY3. mouse.
NextBio356544.
PROQ8VHH7.
SOURCESearch...

Entry information

Entry nameADCY3_MOUSE
AccessionPrimary (citable) accession number: Q8VHH7
Secondary accession number(s): B8JK57
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot