Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8VHH7

- ADCY3_MOUSE

UniProt

Q8VHH7 - ADCY3_MOUSE

Protein

Adenylate cyclase type 3

Gene

Adcy3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.By similarity

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Activated by calcium/calmodulin.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi324 – 3241Magnesium 1PROSITE-ProRule annotation
    Metal bindingi324 – 3241Magnesium 2PROSITE-ProRule annotation
    Metal bindingi325 – 3251Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi368 – 3681Magnesium 1PROSITE-ProRule annotation
    Metal bindingi368 – 3681Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: MGI

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. cAMP biosynthetic process Source: MGI
    3. intracellular signal transduction Source: InterPro
    4. sensory perception of smell Source: MGI

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis, Olfaction, Sensory transduction

    Keywords - Ligandi

    ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 3 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 3
    Adenylate cyclase type III
    Short name:
    AC-III
    Adenylate cyclase, olfactive type
    Adenylyl cyclase 3
    Short name:
    AC3
    Gene namesi
    Name:Adcy3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:99675. Adcy3.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: MGI
    2. cytoplasm Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11451145Adenylate cyclase type 3PRO_0000195688Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi735 – 7351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8VHH7.
    PRIDEiQ8VHH7.

    PTM databases

    PhosphoSiteiQ8VHH7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VHH7.
    BgeeiQ8VHH7.
    CleanExiMM_ADCY3.
    GenevestigatoriQ8VHH7.

    Interactioni

    Protein-protein interaction databases

    BioGridi222368. 2 interactions.
    IntActiQ8VHH7. 1 interaction.
    MINTiMINT-7290275.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VHH7.
    SMRiQ8VHH7. Positions 307-493, 913-1099.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7979CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini402 – 631230CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini855 – 1145291CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei632 – 65221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei663 – 68321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei707 – 72721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei753 – 77321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei774 – 79421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei834 – 85421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    GeneTreeiENSGT00750000117304.
    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiQ8VHH7.
    KOiK08043.
    OMAiVTLMNIN.
    OrthoDBiEOG7B8S30.
    PhylomeDBiQ8VHH7.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VHH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRNQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP     50
    RFMRLTFVPE SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF 100
    SSDKLAPLMV AGFGLVLDII LFVLCKKGLL PDRVSRKVVP YLLWLLISAQ 150
    IFSYLGLNFS RAHAASDTVG WQAFFVFSFF ITLPLSLSPI VIISVVSCVV 200
    HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG IMSYYMADRK 250
    HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 300
    QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR 350
    FDKLAAKYHQ LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY 400
    VREKTKTGVD MRVGVHTGTV LGGVLGQKRW QYDVWSTDVT VANKMEAGGI 450
    PGRVHISQST MDCLKGEFDV EPGDGGSRCD YLDEKGIETY LIIASKPEVK 500
    KTAQNGLNGS AVPNGAPASS KPSSPALIET KEPNGSAHAS GSTSEEAEEQ 550
    EAQADNPSFP NPRRRLRLQD LADRVVDASE DEHELNQLLN EALLERESAQ 600
    VVKKRNTFLL TMRFMDPEME TRYSVEKEKQ SGAAFSCSCV VLFCTAMVEI 650
    LIDPWLMTNY VTFVVGEVLL LILTICSMAA IFPRSFPKKL VAFSSWIDRT 700
    RWARNTWAML AIFILVMANV VDMLSCLQYY MGPYNMTAGM ELDGGCMENP 750
    KYYNYVAVLS LIATIMLVQV SHMVKLTLML LVTGAVTALN LYAWCPVFDE 800
    YDHKRFQEKD SPMVALEKMQ VLATPGLNGT DSRLPLVPSK YSMTVMMFVM 850
    MLSFYYFSRH VEKLARTLFL WKIEVHDQKE RVYEMRRWNE ALVTNMLPEH 900
    VARHFLGSKK RDEELYSQSY DEIGVMFASL PNFADFYTEE SINNGGIECL 950
    RFLNEIISDF DSLLDNPKFR VITKIKTIGS TYMAASGVTP DVNTNGFTSS 1000
    SKEEKSDKER WQHLADLADF ALAMKDTLTN INNQSFNNFM LRIGMNKGGV 1050
    LAGVIGARKP HYDIWGNTVN VASRMESTGV MGNIQVVEET QVILREYGFR 1100
    FVRRGPIFVK GKGELLTFFL KGRDRPAAFP NGSSVTLPHQ VVDNP 1145
    Length:1,145
    Mass (Da):129,085
    Last modified:July 27, 2011 - v2
    Checksum:i09195176F4B3D61F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521F → L in AAL59384. 1 PublicationCurated
    Sequence conflicti833 – 8353RLP → MLL in AAL59384. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF458089 mRNA. Translation: AAL59384.1.
    CT572999 Genomic DNA. Translation: CAX15321.1.
    CH466623 Genomic DNA. Translation: EDL01374.1.
    CCDSiCCDS25787.1.
    RefSeqiNP_612178.2. NM_138305.3.
    XP_006514995.1. XM_006514932.1.
    XP_006514996.1. XM_006514933.1.
    XP_006514997.1. XM_006514934.1.
    XP_006514998.1. XM_006514935.1.
    UniGeneiMm.489807.

    Genome annotation databases

    EnsembliENSMUST00000020984; ENSMUSP00000020984; ENSMUSG00000020654.
    ENSMUST00000127756; ENSMUSP00000115406; ENSMUSG00000020654.
    GeneIDi104111.
    KEGGimmu:104111.
    UCSCiuc007mxm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF458089 mRNA. Translation: AAL59384.1 .
    CT572999 Genomic DNA. Translation: CAX15321.1 .
    CH466623 Genomic DNA. Translation: EDL01374.1 .
    CCDSi CCDS25787.1.
    RefSeqi NP_612178.2. NM_138305.3.
    XP_006514995.1. XM_006514932.1.
    XP_006514996.1. XM_006514933.1.
    XP_006514997.1. XM_006514934.1.
    XP_006514998.1. XM_006514935.1.
    UniGenei Mm.489807.

    3D structure databases

    ProteinModelPortali Q8VHH7.
    SMRi Q8VHH7. Positions 307-493, 913-1099.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 222368. 2 interactions.
    IntActi Q8VHH7. 1 interaction.
    MINTi MINT-7290275.

    Chemistry

    BindingDBi Q8VHH7.

    PTM databases

    PhosphoSitei Q8VHH7.

    Proteomic databases

    PaxDbi Q8VHH7.
    PRIDEi Q8VHH7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020984 ; ENSMUSP00000020984 ; ENSMUSG00000020654 .
    ENSMUST00000127756 ; ENSMUSP00000115406 ; ENSMUSG00000020654 .
    GeneIDi 104111.
    KEGGi mmu:104111.
    UCSCi uc007mxm.2. mouse.

    Organism-specific databases

    CTDi 109.
    MGIi MGI:99675. Adcy3.

    Phylogenomic databases

    eggNOGi COG2114.
    GeneTreei ENSGT00750000117304.
    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi Q8VHH7.
    KOi K08043.
    OMAi VTLMNIN.
    OrthoDBi EOG7B8S30.
    PhylomeDBi Q8VHH7.

    Enzyme and pathway databases

    Reactomei REACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Miscellaneous databases

    ChiTaRSi ADCY3. mouse.
    NextBioi 356544.
    PROi Q8VHH7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VHH7.
    Bgeei Q8VHH7.
    CleanExi MM_ADCY3.
    Genevestigatori Q8VHH7.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of mouse Adcy3."
      Pasternak S., Neumann P.E.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiADCY3_MOUSE
    AccessioniPrimary (citable) accession number: Q8VHH7
    Secondary accession number(s): B8JK57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3