Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8VHH7 (ADCY3_MOUSE)

Last modified October 13, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Adenylate cyclase type 3
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type III
      Short name=AC-III
    ATP pyrophosphate-lyase 3
    Adenylyl cyclase 3
      Short name=AC3
    Adenylate cyclase, olfactive type
Gene names
Name: Adcy3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length1145 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration By similarity.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Activated by calcium/calmodulin By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11451145Adenylate cyclase type 3
PRO_0000195688

Regions

Topological domain1 – 7979Cytoplasmic Potential
Transmembrane80 – 10021 Potential
Transmembrane105 – 12521 Potential
Transmembrane139 – 15921 Potential
Transmembrane173 – 19321 Potential
Transmembrane226 – 24621 Potential
Transmembrane381 – 40121 Potential
Topological domain402 – 631230Cytoplasmic Potential
Transmembrane632 – 65221 Potential
Transmembrane663 – 68321 Potential
Transmembrane707 – 72721 Potential
Transmembrane753 – 77321 Potential
Transmembrane774 – 79421 Potential
Transmembrane834 – 85421 Potential
Topological domain855 – 1145291Cytoplasmic Potential

Sites

Metal binding3241Magnesium 1 By similarity
Metal binding3241Magnesium 2 By similarity
Metal binding3251Magnesium 2; via carbonyl oxygen By similarity
Metal binding3681Magnesium 1 By similarity
Metal binding3681Magnesium 2 By similarity

Amino acid modifications

Glycosylation7351N-linked (GlcNAc...) Potential

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q8VHH7-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F6BD93A7AAE47915

FASTA1,145129,042
        10         20         30         40         50         60 
MPRNQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 

        70         80         90        100        110        120 
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLAPLMV AGFGLVLDII 

       130        140        150        160        170        180 
LFVLCKKGLL PDRVSRKVVP YLLWLLISAQ ILSYLGLNFS RAHAASDTVG WQAFFVFSFF 

       190        200        210        220        230        240 
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG 

       250        260        270        280        290        300 
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 

       310        320        330        340        350        360 
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 

       370        380        390        400        410        420 
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 

       430        440        450        460        470        480 
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 

       490        500        510        520        530        540 
YLDEKGIETY LIIASKPEVK KTAQNGLNGS AVPNGAPASS KPSSPALIET KEPNGSAHAS 

       550        560        570        580        590        600 
GSTSEEAEEQ EAQADNPSFP NPRRRLRLQD LADRVVDASE DEHELNQLLN EALLERESAQ 

       610        620        630        640        650        660 
VVKKRNTFLL TMRFMDPEME TRYSVEKEKQ SGAAFSCSCV VLFCTAMVEI LIDPWLMTNY 

       670        680        690        700        710        720 
VTFVVGEVLL LILTICSMAA IFPRSFPKKL VAFSSWIDRT RWARNTWAML AIFILVMANV 

       730        740        750        760        770        780 
VDMLSCLQYY MGPYNMTAGM ELDGGCMENP KYYNYVAVLS LIATIMLVQV SHMVKLTLML 

       790        800        810        820        830        840 
LVTGAVTALN LYAWCPVFDE YDHKRFQEKD SPMVALEKMQ VLATPGLNGT DSMLLLVPSK 

       850        860        870        880        890        900 
YSMTVMMFVM MLSFYYFSRH VEKLARTLFL WKIEVHDQKE RVYEMRRWNE ALVTNMLPEH 

       910        920        930        940        950        960 
VARHFLGSKK RDEELYSQSY DEIGVMFASL PNFADFYTEE SINNGGIECL RFLNEIISDF 

       970        980        990       1000       1010       1020 
DSLLDNPKFR VITKIKTIGS TYMAASGVTP DVNTNGFTSS SKEEKSDKER WQHLADLADF 

      1030       1040       1050       1060       1070       1080 
ALAMKDTLTN INNQSFNNFM LRIGMNKGGV LAGVIGARKP HYDIWGNTVN VASRMESTGV 

      1090       1100       1110       1120       1130       1140 
MGNIQVVEET QVILREYGFR FVRRGPIFVK GKGELLTFFL KGRDRPAAFP NGSSVTLPHQ 


VVDNP

« Hide

Hide | Top

References

[1]"Sequence of mouse Adcy3."
Pasternak S., Neumann P.E.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Brain.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF458089 mRNA. Translation: AAL59384.1.
IPIIPI00128323.
UniGeneMm.70546

3D structure databases

HSSPHSSP built from PDB template 1AB8 based on UniProtKB P26769.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8VHH7.

PTM databases

PhosphoSiteQ8VHH7.

Proteomic databases

PRIDEQ8VHH7.

Genome annotation databases

EnsemblENSMUST00000020984; ENSMUSP00000020984; ENSMUSG00000020654; Mus musculus. [Genome view]
UCSCuc007mxm.1. mouse.

Organism-specific databases

MGIMGI:99675. Adcy3.

Phylogenomic databases

HOVERGENQ8VHH7.

Enzyme and pathway databases

BRENDA4.6.1.1. 244.

Gene expression databases

ArrayExpressQ8VHH7.
BgeeQ8VHH7.
CleanExMM_ADCY3.
GenevestigatorQ8VHH7.
GermOnlineENSMUSG00000020654. Mus musculus.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
PfamPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio356544.
SOURCESearch...

Hide | Top

Entry information

Entry nameADCY3_MOUSE
AccessionPrimary (citable) accession number: Q8VHH7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: October 13, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents