Reviewed,
UniProtKB/Swiss-Prot Q8VHH7 (ADCY3_MOUSE)
Last modified
October 13, 2009.
Version 72.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Adenylate cyclase type 3 EC=4.6.1.1 Alternative name(s): Adenylate cyclase type III Short name=AC-III ATP pyrophosphate-lyase 3 Adenylyl cyclase 3 Short name=AC3 Adenylate cyclase, olfactive type | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1145 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration By similarity. |
| Catalytic activity | ATP = 3',5'-cyclic AMP + diphosphate. |
| Cofactor | Binds 2 magnesium ions per subunit By similarity. |
| Enzyme regulation | Activated by calcium/calmodulin By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1145 | 1145 | Adenylate cyclase type 3 | PRO_0000195688 | |||||
Regions | |||||||||
| Topological domain | 1 – 79 | 79 | Cytoplasmic Potential | ||||||
| Transmembrane | 80 – 100 | 21 | Potential | ||||||
| Transmembrane | 105 – 125 | 21 | Potential | ||||||
| Transmembrane | 139 – 159 | 21 | Potential | ||||||
| Transmembrane | 173 – 193 | 21 | Potential | ||||||
| Transmembrane | 226 – 246 | 21 | Potential | ||||||
| Transmembrane | 381 – 401 | 21 | Potential | ||||||
| Topological domain | 402 – 631 | 230 | Cytoplasmic Potential | ||||||
| Transmembrane | 632 – 652 | 21 | Potential | ||||||
| Transmembrane | 663 – 683 | 21 | Potential | ||||||
| Transmembrane | 707 – 727 | 21 | Potential | ||||||
| Transmembrane | 753 – 773 | 21 | Potential | ||||||
| Transmembrane | 774 – 794 | 21 | Potential | ||||||
| Transmembrane | 834 – 854 | 21 | Potential | ||||||
| Topological domain | 855 – 1145 | 291 | Cytoplasmic Potential | ||||||
Sites | |||||||||
| Metal binding | 324 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 324 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 325 | 1 | Magnesium 2; via carbonyl oxygen By similarity | ||||||
| Metal binding | 368 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 368 | 1 | Magnesium 2 By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 735 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Sequence of mouse Adcy3." Pasternak S., Neumann P.E. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF458089 mRNA. Translation: AAL59384.1. | |
| IPI | IPI00128323. |
| UniGene | Mm.70546 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AB8 based on UniProtKB P26769. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8VHH7. |
PTM databases | |
| PhosphoSite | Q8VHH7. |
Proteomic databases | |
| PRIDE | Q8VHH7. |
Genome annotation databases | |
| Ensembl | ENSMUST00000020984; ENSMUSP00000020984; ENSMUSG00000020654; Mus musculus. [Genome view] |
| UCSC | uc007mxm.1. mouse. |
Organism-specific databases | |
| MGI | MGI:99675. Adcy3. |
Phylogenomic databases | |
| HOVERGEN | Q8VHH7. |
Enzyme and pathway databases | |
| BRENDA | 4.6.1.1. 244. |
Gene expression databases | |
| ArrayExpress | Q8VHH7. |
| Bgee | Q8VHH7. |
| CleanEx | MM_ADCY3. |
| Genevestigator | Q8VHH7. |
| GermOnline | ENSMUSG00000020654. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. [Graphical view] |
| Gene3D | G3DSA:3.30.70.1230. A/G_cyclase. 2 hits. |
| Pfam | PF00211. Guanylate_cyc. 2 hits. [Graphical view] |
| SMART | SM00044. CYCc. 2 hits. [Graphical view] |
| PROSITE | PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 356544. |
| SOURCE | Search... |
Entry information
| Entry name | ADCY3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8VHH7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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