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Q8VHH7

- ADCY3_MOUSE

UniProt

Q8VHH7 - ADCY3_MOUSE

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Protein

Adenylate cyclase type 3

Gene

Adcy3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.By similarity

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit.By similarity

Enzyme regulationi

Activated by calcium/calmodulin.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi324 – 3241Magnesium 1PROSITE-ProRule annotation
Metal bindingi324 – 3241Magnesium 2PROSITE-ProRule annotation
Metal bindingi325 – 3251Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi368 – 3681Magnesium 1PROSITE-ProRule annotation
Metal bindingi368 – 3681Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. cAMP biosynthetic process Source: MGI
  3. intracellular signal transduction Source: InterPro
  4. sensory perception of smell Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis, Olfaction, Sensory transduction

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 3 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 3
Adenylate cyclase type III
Short name:
AC-III
Adenylate cyclase, olfactive type
Adenylyl cyclase 3
Short name:
AC3
Gene namesi
Name:Adcy3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:99675. Adcy3.

Subcellular locationi

GO - Cellular componenti

  1. cilium Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11451145Adenylate cyclase type 3PRO_0000195688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi735 – 7351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8VHH7.
PaxDbiQ8VHH7.
PRIDEiQ8VHH7.

PTM databases

PhosphoSiteiQ8VHH7.

Expressioni

Gene expression databases

BgeeiQ8VHH7.
CleanExiMM_ADCY3.
ExpressionAtlasiQ8VHH7. baseline and differential.
GenevestigatoriQ8VHH7.

Interactioni

Protein-protein interaction databases

BioGridi222368. 2 interactions.
IntActiQ8VHH7. 1 interaction.
MINTiMINT-7290275.

Structurei

3D structure databases

ProteinModelPortaliQ8VHH7.
SMRiQ8VHH7. Positions 307-493, 913-1099.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7979CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini402 – 631230CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini855 – 1145291CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei632 – 65221HelicalSequence AnalysisAdd
BLAST
Transmembranei663 – 68321HelicalSequence AnalysisAdd
BLAST
Transmembranei707 – 72721HelicalSequence AnalysisAdd
BLAST
Transmembranei753 – 77321HelicalSequence AnalysisAdd
BLAST
Transmembranei774 – 79421HelicalSequence AnalysisAdd
BLAST
Transmembranei834 – 85421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ8VHH7.
KOiK08043.
OMAiVTLMNIN.
OrthoDBiEOG7B8S30.
PhylomeDBiQ8VHH7.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRNQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP
60 70 80 90 100
RFMRLTFVPE SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF
110 120 130 140 150
SSDKLAPLMV AGFGLVLDII LFVLCKKGLL PDRVSRKVVP YLLWLLISAQ
160 170 180 190 200
IFSYLGLNFS RAHAASDTVG WQAFFVFSFF ITLPLSLSPI VIISVVSCVV
210 220 230 240 250
HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG IMSYYMADRK
260 270 280 290 300
HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES
310 320 330 340 350
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR
360 370 380 390 400
FDKLAAKYHQ LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY
410 420 430 440 450
VREKTKTGVD MRVGVHTGTV LGGVLGQKRW QYDVWSTDVT VANKMEAGGI
460 470 480 490 500
PGRVHISQST MDCLKGEFDV EPGDGGSRCD YLDEKGIETY LIIASKPEVK
510 520 530 540 550
KTAQNGLNGS AVPNGAPASS KPSSPALIET KEPNGSAHAS GSTSEEAEEQ
560 570 580 590 600
EAQADNPSFP NPRRRLRLQD LADRVVDASE DEHELNQLLN EALLERESAQ
610 620 630 640 650
VVKKRNTFLL TMRFMDPEME TRYSVEKEKQ SGAAFSCSCV VLFCTAMVEI
660 670 680 690 700
LIDPWLMTNY VTFVVGEVLL LILTICSMAA IFPRSFPKKL VAFSSWIDRT
710 720 730 740 750
RWARNTWAML AIFILVMANV VDMLSCLQYY MGPYNMTAGM ELDGGCMENP
760 770 780 790 800
KYYNYVAVLS LIATIMLVQV SHMVKLTLML LVTGAVTALN LYAWCPVFDE
810 820 830 840 850
YDHKRFQEKD SPMVALEKMQ VLATPGLNGT DSRLPLVPSK YSMTVMMFVM
860 870 880 890 900
MLSFYYFSRH VEKLARTLFL WKIEVHDQKE RVYEMRRWNE ALVTNMLPEH
910 920 930 940 950
VARHFLGSKK RDEELYSQSY DEIGVMFASL PNFADFYTEE SINNGGIECL
960 970 980 990 1000
RFLNEIISDF DSLLDNPKFR VITKIKTIGS TYMAASGVTP DVNTNGFTSS
1010 1020 1030 1040 1050
SKEEKSDKER WQHLADLADF ALAMKDTLTN INNQSFNNFM LRIGMNKGGV
1060 1070 1080 1090 1100
LAGVIGARKP HYDIWGNTVN VASRMESTGV MGNIQVVEET QVILREYGFR
1110 1120 1130 1140
FVRRGPIFVK GKGELLTFFL KGRDRPAAFP NGSSVTLPHQ VVDNP
Length:1,145
Mass (Da):129,085
Last modified:July 27, 2011 - v2
Checksum:i09195176F4B3D61F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521F → L in AAL59384. 1 PublicationCurated
Sequence conflicti833 – 8353RLP → MLL in AAL59384. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF458089 mRNA. Translation: AAL59384.1.
CT572999 Genomic DNA. Translation: CAX15321.1.
CH466623 Genomic DNA. Translation: EDL01374.1.
CCDSiCCDS25787.1.
RefSeqiNP_612178.2. NM_138305.3.
XP_006514995.1. XM_006514932.1.
XP_006514996.1. XM_006514933.1.
XP_006514997.1. XM_006514934.1.
XP_006514998.1. XM_006514935.1.
UniGeneiMm.489807.

Genome annotation databases

EnsembliENSMUST00000020984; ENSMUSP00000020984; ENSMUSG00000020654.
ENSMUST00000127756; ENSMUSP00000115406; ENSMUSG00000020654.
GeneIDi104111.
KEGGimmu:104111.
UCSCiuc007mxm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF458089 mRNA. Translation: AAL59384.1 .
CT572999 Genomic DNA. Translation: CAX15321.1 .
CH466623 Genomic DNA. Translation: EDL01374.1 .
CCDSi CCDS25787.1.
RefSeqi NP_612178.2. NM_138305.3.
XP_006514995.1. XM_006514932.1.
XP_006514996.1. XM_006514933.1.
XP_006514997.1. XM_006514934.1.
XP_006514998.1. XM_006514935.1.
UniGenei Mm.489807.

3D structure databases

ProteinModelPortali Q8VHH7.
SMRi Q8VHH7. Positions 307-493, 913-1099.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222368. 2 interactions.
IntActi Q8VHH7. 1 interaction.
MINTi MINT-7290275.

Chemistry

BindingDBi Q8VHH7.

PTM databases

PhosphoSitei Q8VHH7.

Proteomic databases

MaxQBi Q8VHH7.
PaxDbi Q8VHH7.
PRIDEi Q8VHH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020984 ; ENSMUSP00000020984 ; ENSMUSG00000020654 .
ENSMUST00000127756 ; ENSMUSP00000115406 ; ENSMUSG00000020654 .
GeneIDi 104111.
KEGGi mmu:104111.
UCSCi uc007mxm.2. mouse.

Organism-specific databases

CTDi 109.
MGIi MGI:99675. Adcy3.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00760000119042.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi Q8VHH7.
KOi K08043.
OMAi VTLMNIN.
OrthoDBi EOG7B8S30.
PhylomeDBi Q8VHH7.

Enzyme and pathway databases

Reactomei REACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Miscellaneous databases

ChiTaRSi ADCY3. mouse.
NextBioi 356544.
PROi Q8VHH7.
SOURCEi Search...

Gene expression databases

Bgeei Q8VHH7.
CleanExi MM_ADCY3.
ExpressionAtlasi Q8VHH7. baseline and differential.
Genevestigatori Q8VHH7.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR029787. Nucleotide_cyclase.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of mouse Adcy3."
    Pasternak S., Neumann P.E.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiADCY3_MOUSE
AccessioniPrimary (citable) accession number: Q8VHH7
Secondary accession number(s): B8JK57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3