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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 4

Gene

Fmo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.By similarity

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FADBy similarity5
Nucleotide bindingi40 – 41FADBy similarity2
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi195 – 198NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • drug catabolic process Source: MGI
  • oxidation-reduction process Source: GO_Central

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name:
FMO 4
Gene namesi
Name:Fmo4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2429497 Fmo4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476611 – 560Dimethylaniline monooxygenase [N-oxide-forming] 4Add BLAST560

Proteomic databases

MaxQBiQ8VHG0
PaxDbiQ8VHG0
PeptideAtlasiQ8VHG0
PRIDEiQ8VHG0

PTM databases

iPTMnetiQ8VHG0
PhosphoSitePlusiQ8VHG0

Expressioni

Gene expression databases

BgeeiENSMUSG00000026692
CleanExiMM_FMO4
ExpressionAtlasiQ8VHG0 baseline and differential
GenevisibleiQ8VHG0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028014

Structurei

3D structure databases

ProteinModelPortaliQ8VHG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00760000119232
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiQ8VHG0
KOiK00485
OMAiPLKSLCT
OrthoDBiEOG091G0465
PhylomeDBiQ8VHG0
TreeFamiTF105285

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002256 Flavin_mOase_4
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01124 FMOXYGENASE4
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Q8VHG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERTSDFGGL WKFADTSEDG
60 70 80 90 100
MTRVYRSLVT NVCKEMSCYS DFPFREDYPN FMSHEKFWDY LREFAEHFGL
110 120 130 140 150
LRYIRFKTTV LSVTKRPDFS ETGQWDVVTE TEGKRDRAVF DAVMVCTGQF
160 170 180 190 200
LSPHLPLESF PGIHKFKGQI LHSQEYRIPD AFRGKRILVV GLGNTGGDIA
210 220 230 240 250
VELSEIAAQV FLSTRTGTWV LSRSSPGGYP FNMIQTRWLN FLVRVLPSRF
260 270 280 290 300
INWTHERKMN KILNHENYGL SIAKGKKPKF IVNDELPTCI LCGKVTMKTS
310 320 330 340 350
VKDFTESSVI FEDGTTEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKIIL
360 370 380 390 400
YKRVFPPNLE RATLAIIGLI SLNGSILVGT EFQARWATRV FKGLCSIPPS
410 420 430 440 450
QKLMAEATKT EQLIKRGVIK DTSQDKLDFI TYMDELTQCI GAKPSIPLLF
460 470 480 490 500
IKDPRLAWEV FFGPCTPYQY RLVGPGRWDG ARNAILTQWD RTLKPLKTRI
510 520 530 540 550
VPKSPEPTSL SHYLIAWGAP VLLVSLLLIY KSSHFLELVQ GKLPRRFPPY
560
RLLWYMPQNS
Length:560
Mass (Da):63,792
Last modified:January 23, 2007 - v3
Checksum:i75C3AEE53693B7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461145 mRNA Translation: AAL66366.1
CCDSiCCDS15423.1
RefSeqiNP_659127.1, NM_144878.1
XP_006496839.1, XM_006496776.3
XP_006496840.1, XM_006496777.2
UniGeneiMm.155164

Genome annotation databases

EnsembliENSMUST00000028014; ENSMUSP00000028014; ENSMUSG00000026692
ENSMUST00000111525; ENSMUSP00000107150; ENSMUSG00000026692
GeneIDi226564
KEGGimmu:226564
UCSCiuc007dgv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFMO4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health