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Q8VHG0

- FMO4_MOUSE

UniProt

Q8VHG0 - FMO4_MOUSE

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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 4

Gene

Fmo4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.By similarity

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FAD.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FADSequence Analysis
Nucleotide bindingi191 – 1966NADPSequence Analysis

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
  3. NADP binding Source: InterPro

GO - Biological processi

  1. drug catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name:
FMO 4
Gene namesi
Name:Fmo4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2429497. Fmo4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Dimethylaniline monooxygenase [N-oxide-forming] 4PRO_0000147661Add
BLAST

Proteomic databases

MaxQBiQ8VHG0.
PaxDbiQ8VHG0.
PRIDEiQ8VHG0.

PTM databases

PhosphoSiteiQ8VHG0.

Expressioni

Gene expression databases

BgeeiQ8VHG0.
CleanExiMM_FMO4.
ExpressionAtlasiQ8VHG0. baseline and differential.
GenevestigatoriQ8VHG0.

Structurei

3D structure databases

ProteinModelPortaliQ8VHG0.
SMRiQ8VHG0. Positions 2-364.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei516 – 53015HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2072.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ8VHG0.
KOiK00485.
OMAiVCTGHFL.
OrthoDBiEOG7GXPB6.
PhylomeDBiQ8VHG0.
TreeFamiTF105285.

Family and domain databases

InterProiIPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.

Sequencei

Sequence statusi: Complete.

Q8VHG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERTSDFGGL WKFADTSEDG
60 70 80 90 100
MTRVYRSLVT NVCKEMSCYS DFPFREDYPN FMSHEKFWDY LREFAEHFGL
110 120 130 140 150
LRYIRFKTTV LSVTKRPDFS ETGQWDVVTE TEGKRDRAVF DAVMVCTGQF
160 170 180 190 200
LSPHLPLESF PGIHKFKGQI LHSQEYRIPD AFRGKRILVV GLGNTGGDIA
210 220 230 240 250
VELSEIAAQV FLSTRTGTWV LSRSSPGGYP FNMIQTRWLN FLVRVLPSRF
260 270 280 290 300
INWTHERKMN KILNHENYGL SIAKGKKPKF IVNDELPTCI LCGKVTMKTS
310 320 330 340 350
VKDFTESSVI FEDGTTEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKIIL
360 370 380 390 400
YKRVFPPNLE RATLAIIGLI SLNGSILVGT EFQARWATRV FKGLCSIPPS
410 420 430 440 450
QKLMAEATKT EQLIKRGVIK DTSQDKLDFI TYMDELTQCI GAKPSIPLLF
460 470 480 490 500
IKDPRLAWEV FFGPCTPYQY RLVGPGRWDG ARNAILTQWD RTLKPLKTRI
510 520 530 540 550
VPKSPEPTSL SHYLIAWGAP VLLVSLLLIY KSSHFLELVQ GKLPRRFPPY
560
RLLWYMPQNS
Length:560
Mass (Da):63,792
Last modified:January 23, 2007 - v3
Checksum:i75C3AEE53693B7AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF461145 mRNA. Translation: AAL66366.1.
CCDSiCCDS15423.1.
RefSeqiNP_659127.1. NM_144878.1.
XP_006496839.1. XM_006496776.1.
XP_006496840.1. XM_006496777.1.
UniGeneiMm.155164.

Genome annotation databases

EnsembliENSMUST00000028014; ENSMUSP00000028014; ENSMUSG00000026692.
ENSMUST00000111525; ENSMUSP00000107150; ENSMUSG00000026692.
GeneIDi226564.
KEGGimmu:226564.
UCSCiuc007dgv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF461145 mRNA. Translation: AAL66366.1 .
CCDSi CCDS15423.1.
RefSeqi NP_659127.1. NM_144878.1.
XP_006496839.1. XM_006496776.1.
XP_006496840.1. XM_006496777.1.
UniGenei Mm.155164.

3D structure databases

ProteinModelPortali Q8VHG0.
SMRi Q8VHG0. Positions 2-364.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8VHG0.

Proteomic databases

MaxQBi Q8VHG0.
PaxDbi Q8VHG0.
PRIDEi Q8VHG0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028014 ; ENSMUSP00000028014 ; ENSMUSG00000026692 .
ENSMUST00000111525 ; ENSMUSP00000107150 ; ENSMUSG00000026692 .
GeneIDi 226564.
KEGGi mmu:226564.
UCSCi uc007dgv.1. mouse.

Organism-specific databases

CTDi 2329.
MGIi MGI:2429497. Fmo4.

Phylogenomic databases

eggNOGi COG2072.
GeneTreei ENSGT00760000119232.
HOGENOMi HOG000076537.
HOVERGENi HBG002037.
InParanoidi Q8VHG0.
KOi K00485.
OMAi VCTGHFL.
OrthoDBi EOG7GXPB6.
PhylomeDBi Q8VHG0.
TreeFami TF105285.

Miscellaneous databases

NextBioi 378238.
PROi Q8VHG0.
SOURCEi Search...

Gene expression databases

Bgeei Q8VHG0.
CleanExi MM_FMO4.
ExpressionAtlasi Q8VHG0. baseline and differential.
Genevestigatori Q8VHG0.

Family and domain databases

InterProi IPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view ]
Pfami PF00743. FMO-like. 1 hit.
[Graphical view ]
PIRSFi PIRSF000332. FMO. 1 hit.
PRINTSi PR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
ProtoNeti Search...

Publicationsi

  1. "The mouse flavin-containing monooxygenase gene cluster."
    Hernandez D., Janmohamed A., Chandan P., Phillips I.R., Shephard E.A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
    Tissue: Kidney.

Entry informationi

Entry nameiFMO4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3