Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8VHG0

- FMO4_MOUSE

UniProt

Q8VHG0 - FMO4_MOUSE

Protein

Dimethylaniline monooxygenase [N-oxide-forming] 4

Gene

Fmo4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.By similarity

    Catalytic activityi

    N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

    Cofactori

    FAD.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146FADSequence Analysis
    Nucleotide bindingi191 – 1966NADPSequence Analysis

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
    3. NADP binding Source: InterPro

    GO - Biological processi

    1. drug catabolic process Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
    Alternative name(s):
    Dimethylaniline oxidase 4
    Hepatic flavin-containing monooxygenase 4
    Short name:
    FMO 4
    Gene namesi
    Name:Fmo4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2429497. Fmo4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Dimethylaniline monooxygenase [N-oxide-forming] 4PRO_0000147661Add
    BLAST

    Proteomic databases

    MaxQBiQ8VHG0.
    PaxDbiQ8VHG0.
    PRIDEiQ8VHG0.

    PTM databases

    PhosphoSiteiQ8VHG0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VHG0.
    BgeeiQ8VHG0.
    CleanExiMM_FMO4.
    GenevestigatoriQ8VHG0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VHG0.
    SMRiQ8VHG0. Positions 2-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei516 – 53015HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FMO family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2072.
    GeneTreeiENSGT00740000115433.
    HOGENOMiHOG000076537.
    HOVERGENiHBG002037.
    InParanoidiQ8VHG0.
    KOiK00485.
    OMAiVCTGHFL.
    OrthoDBiEOG7GXPB6.
    PhylomeDBiQ8VHG0.
    TreeFamiTF105285.

    Family and domain databases

    InterProiIPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002256. Flavin_mOase_4.
    [Graphical view]
    PfamiPF00743. FMO-like. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000332. FMO. 1 hit.
    PRINTSiPR00370. FMOXYGENASE.
    PR01124. FMOXYGENASE4.

    Sequencei

    Sequence statusi: Complete.

    Q8VHG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERTSDFGGL WKFADTSEDG    50
    MTRVYRSLVT NVCKEMSCYS DFPFREDYPN FMSHEKFWDY LREFAEHFGL 100
    LRYIRFKTTV LSVTKRPDFS ETGQWDVVTE TEGKRDRAVF DAVMVCTGQF 150
    LSPHLPLESF PGIHKFKGQI LHSQEYRIPD AFRGKRILVV GLGNTGGDIA 200
    VELSEIAAQV FLSTRTGTWV LSRSSPGGYP FNMIQTRWLN FLVRVLPSRF 250
    INWTHERKMN KILNHENYGL SIAKGKKPKF IVNDELPTCI LCGKVTMKTS 300
    VKDFTESSVI FEDGTTEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKIIL 350
    YKRVFPPNLE RATLAIIGLI SLNGSILVGT EFQARWATRV FKGLCSIPPS 400
    QKLMAEATKT EQLIKRGVIK DTSQDKLDFI TYMDELTQCI GAKPSIPLLF 450
    IKDPRLAWEV FFGPCTPYQY RLVGPGRWDG ARNAILTQWD RTLKPLKTRI 500
    VPKSPEPTSL SHYLIAWGAP VLLVSLLLIY KSSHFLELVQ GKLPRRFPPY 550
    RLLWYMPQNS 560
    Length:560
    Mass (Da):63,792
    Last modified:January 23, 2007 - v3
    Checksum:i75C3AEE53693B7AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF461145 mRNA. Translation: AAL66366.1.
    CCDSiCCDS15423.1.
    RefSeqiNP_659127.1. NM_144878.1.
    XP_006496839.1. XM_006496776.1.
    XP_006496840.1. XM_006496777.1.
    UniGeneiMm.155164.

    Genome annotation databases

    EnsembliENSMUST00000028014; ENSMUSP00000028014; ENSMUSG00000026692.
    ENSMUST00000111525; ENSMUSP00000107150; ENSMUSG00000026692.
    GeneIDi226564.
    KEGGimmu:226564.
    UCSCiuc007dgv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF461145 mRNA. Translation: AAL66366.1 .
    CCDSi CCDS15423.1.
    RefSeqi NP_659127.1. NM_144878.1.
    XP_006496839.1. XM_006496776.1.
    XP_006496840.1. XM_006496777.1.
    UniGenei Mm.155164.

    3D structure databases

    ProteinModelPortali Q8VHG0.
    SMRi Q8VHG0. Positions 2-364.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8VHG0.

    Proteomic databases

    MaxQBi Q8VHG0.
    PaxDbi Q8VHG0.
    PRIDEi Q8VHG0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028014 ; ENSMUSP00000028014 ; ENSMUSG00000026692 .
    ENSMUST00000111525 ; ENSMUSP00000107150 ; ENSMUSG00000026692 .
    GeneIDi 226564.
    KEGGi mmu:226564.
    UCSCi uc007dgv.1. mouse.

    Organism-specific databases

    CTDi 2329.
    MGIi MGI:2429497. Fmo4.

    Phylogenomic databases

    eggNOGi COG2072.
    GeneTreei ENSGT00740000115433.
    HOGENOMi HOG000076537.
    HOVERGENi HBG002037.
    InParanoidi Q8VHG0.
    KOi K00485.
    OMAi VCTGHFL.
    OrthoDBi EOG7GXPB6.
    PhylomeDBi Q8VHG0.
    TreeFami TF105285.

    Miscellaneous databases

    NextBioi 378238.
    PROi Q8VHG0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VHG0.
    Bgeei Q8VHG0.
    CleanExi MM_FMO4.
    Genevestigatori Q8VHG0.

    Family and domain databases

    InterProi IPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002256. Flavin_mOase_4.
    [Graphical view ]
    Pfami PF00743. FMO-like. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000332. FMO. 1 hit.
    PRINTSi PR00370. FMOXYGENASE.
    PR01124. FMOXYGENASE4.
    ProtoNeti Search...

    Publicationsi

    1. "The mouse flavin-containing monooxygenase gene cluster."
      Hernandez D., Janmohamed A., Chandan P., Phillips I.R., Shephard E.A.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
      Tissue: Kidney.

    Entry informationi

    Entry nameiFMO4_MOUSE
    AccessioniPrimary (citable) accession number: Q8VHG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3