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Q8VHG0 (FMO4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4

EC=1.14.13.8
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name=FMO 4
Gene names
Name:Fmo4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides By similarity.

Catalytic activity

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactor

FAD By similarity.

Subcellular location

Microsome membrane By similarity. Endoplasmic reticulum membrane By similarity.

Sequence similarities

Belongs to the FMO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Dimethylaniline monooxygenase [N-oxide-forming] 4
PRO_0000147661

Regions

Transmembrane516 – 53015Helical; Potential
Nucleotide binding9 – 146FAD Potential
Nucleotide binding191 – 1966NADP Potential

Sequences

Sequence LengthMass (Da)Tools
Q8VHG0 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 75C3AEE53693B7AD

FASTA56063,792
        10         20         30         40         50         60 
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERTSDFGGL WKFADTSEDG MTRVYRSLVT 

        70         80         90        100        110        120 
NVCKEMSCYS DFPFREDYPN FMSHEKFWDY LREFAEHFGL LRYIRFKTTV LSVTKRPDFS 

       130        140        150        160        170        180 
ETGQWDVVTE TEGKRDRAVF DAVMVCTGQF LSPHLPLESF PGIHKFKGQI LHSQEYRIPD 

       190        200        210        220        230        240 
AFRGKRILVV GLGNTGGDIA VELSEIAAQV FLSTRTGTWV LSRSSPGGYP FNMIQTRWLN 

       250        260        270        280        290        300 
FLVRVLPSRF INWTHERKMN KILNHENYGL SIAKGKKPKF IVNDELPTCI LCGKVTMKTS 

       310        320        330        340        350        360 
VKDFTESSVI FEDGTTEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKIIL YKRVFPPNLE 

       370        380        390        400        410        420 
RATLAIIGLI SLNGSILVGT EFQARWATRV FKGLCSIPPS QKLMAEATKT EQLIKRGVIK 

       430        440        450        460        470        480 
DTSQDKLDFI TYMDELTQCI GAKPSIPLLF IKDPRLAWEV FFGPCTPYQY RLVGPGRWDG 

       490        500        510        520        530        540 
ARNAILTQWD RTLKPLKTRI VPKSPEPTSL SHYLIAWGAP VLLVSLLLIY KSSHFLELVQ 

       550        560 
GKLPRRFPPY RLLWYMPQNS 

« Hide

References

[1]"The mouse flavin-containing monooxygenase gene cluster."
Hernandez D., Janmohamed A., Chandan P., Phillips I.R., Shephard E.A.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF461145 mRNA. Translation: AAL66366.1.
RefSeqNP_659127.1. NM_144878.1.
XP_006496839.1. XM_006496776.1.
XP_006496840.1. XM_006496777.1.
UniGeneMm.155164.

3D structure databases

ProteinModelPortalQ8VHG0.
SMRQ8VHG0. Positions 2-444.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8VHG0.

Proteomic databases

PaxDbQ8VHG0.
PRIDEQ8VHG0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028014; ENSMUSP00000028014; ENSMUSG00000026692.
ENSMUST00000111525; ENSMUSP00000107150; ENSMUSG00000026692.
GeneID226564.
KEGGmmu:226564.
UCSCuc007dgv.1. mouse.

Organism-specific databases

CTD2329.
MGIMGI:2429497. Fmo4.

Phylogenomic databases

eggNOGCOG2072.
GeneTreeENSGT00740000115433.
HOGENOMHOG000076537.
HOVERGENHBG002037.
InParanoidQ8VHG0.
KOK00485.
OMAINWTHER.
OrthoDBEOG7GXPB6.
PhylomeDBQ8VHG0.
TreeFamTF105285.

Gene expression databases

ArrayExpressQ8VHG0.
BgeeQ8VHG0.
CleanExMM_FMO4.
GenevestigatorQ8VHG0.

Family and domain databases

InterProIPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFPIRSF000332. FMO. 1 hit.
PRINTSPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
ProtoNetSearch...

Other

NextBio378238.
PROQ8VHG0.
SOURCESearch...

Entry information

Entry nameFMO4_MOUSE
AccessionPrimary (citable) accession number: Q8VHG0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot