Reviewed,
UniProtKB/Swiss-Prot Q8VHG0 (FMO4_MOUSE)
Last modified
March 2, 2010.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dimethylaniline monooxygenase [N-oxide-forming] 4 EC=1.14.13.8 Alternative name(s): Hepatic flavin-containing monooxygenase 4 Short name=FMO 4 Dimethylaniline oxidase 4 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 560 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides By similarity. |
| Catalytic activity | N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. |
| Cofactor | FAD By similarity. |
| Subcellular location | Microsome membrane By similarity. Endoplasmic reticulum membrane By similarity. |
| Sequence similarities | Belongs to the FMO family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Domain | Transmembrane |
| Ligand | FAD Flavoprotein NADP |
| Molecular function | Monooxygenase Oxidoreductase |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membraneInferred from electronic annotation. Source: InterPro microsomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro NADP or NADPH bindingInferred from electronic annotation. Source: InterPro flavin-containing monooxygenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 560 | 559 | Dimethylaniline monooxygenase [N-oxide-forming] 4 | PRO_0000147661 | |||||
Regions | |||||||||
| Transmembrane | 516 – 530 | 15 | Potential | ||||||
| Nucleotide binding | 9 – 14 | 6 | FAD Potential | ||||||
| Nucleotide binding | 191 – 196 | 6 | NADP Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
Sequences
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References
| [1] | "The mouse flavin-containing monooxygenase gene cluster." Hernandez D., Janmohamed A., Chandan P., Phillips I.R., Shephard E.A. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/Sv. Tissue: Kidney. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF461145 mRNA. Translation: AAL66366.1. |
| IPI | IPI00128288. |
| RefSeq | NP_659127.1. |
| UniGene | Mm.155164 |
3D structure databases | |
| SMR | Q8VHG0. Positions 3-458. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8VHG0. |
PTM databases | |
| PhosphoSite | Q8VHG0. |
Proteomic databases | |
| PRIDE | Q8VHG0. |
Genome annotation databases | |
| Ensembl | ENSMUST00000028014; ENSMUSP00000028014; ENSMUSG00000026692; Mus musculus. [Genome view] ENSMUST00000111525; ENSMUSP00000107150; ENSMUSG00000026692; Mus musculus. [Genome view] |
| GeneID | 226564. |
| KEGG | mmu:226564. |
| UCSC | uc007dgv.1. mouse. |
Organism-specific databases | |
| CTD | 226564. |
| MGI | MGI:2429497. Fmo4. |
Phylogenomic databases | |
| HOGENOM | HBG700572. |
| HOVERGEN | HBG002037. |
| InParanoid | Q8VHG0. |
| OMA | PLKSLCT. |
| OrthoDB | EOG9GMXG7. |
| PhylomeDB | Q8VHG0. |
Enzyme and pathway databases | |
| BRENDA | 1.14.13.8. 244. |
Gene expression databases | |
| ArrayExpress | Q8VHG0. |
| Bgee | Q8VHG0. |
| CleanEx | MM_FMO4. |
| Genevestigator | Q8VHG0. |
| GermOnline | ENSMUSG00000026692. Mus musculus. |
Family and domain databases | |
| InterPro | IPR012143. dManiline_mOase. IPR000960. Flavin_mOase. IPR020946. Flavin_mOase-like. IPR002256. Flavin_mOase_4. [Graphical view] |
| Pfam | PF00743. FMO-like. 1 hit. [Graphical view] |
| PIRSF | PIRSF000332. FMO. 1 hit. |
| PRINTS | PR00370. FMOXYGENASE. PR01124. FMOXYGENASE4. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 378238. |
| SOURCE | Search... |
Entry information
| Entry name | FMO4_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8VHG0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


