SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8VHG0

- FMO4_MOUSE

UniProt

Q8VHG0 - FMO4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Dimethylaniline monooxygenase [N-oxide-forming] 4
Gene
Fmo4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides By similarity.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FAD By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FAD Reviewed prediction
Nucleotide bindingi191 – 1966NADP Reviewed prediction

GO - Molecular functioni

  1. N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro
  3. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. drug catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name:
FMO 4
Gene namesi
Name:Fmo4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2429497. Fmo4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei516 – 53015Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Dimethylaniline monooxygenase [N-oxide-forming] 4
PRO_0000147661Add
BLAST

Proteomic databases

MaxQBiQ8VHG0.
PaxDbiQ8VHG0.
PRIDEiQ8VHG0.

PTM databases

PhosphoSiteiQ8VHG0.

Expressioni

Gene expression databases

ArrayExpressiQ8VHG0.
BgeeiQ8VHG0.
CleanExiMM_FMO4.
GenevestigatoriQ8VHG0.

Structurei

3D structure databases

ProteinModelPortaliQ8VHG0.
SMRiQ8VHG0. Positions 2-364.

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2072.
GeneTreeiENSGT00740000115433.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ8VHG0.
KOiK00485.
OMAiVCTGHFL.
OrthoDBiEOG7GXPB6.
PhylomeDBiQ8VHG0.
TreeFamiTF105285.

Family and domain databases

InterProiIPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.

Sequencei

Sequence statusi: Complete.

Q8VHG0-1 [UniParc]FASTAAdd to Basket

« Hide

MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERTSDFGGL WKFADTSEDG    50
MTRVYRSLVT NVCKEMSCYS DFPFREDYPN FMSHEKFWDY LREFAEHFGL 100
LRYIRFKTTV LSVTKRPDFS ETGQWDVVTE TEGKRDRAVF DAVMVCTGQF 150
LSPHLPLESF PGIHKFKGQI LHSQEYRIPD AFRGKRILVV GLGNTGGDIA 200
VELSEIAAQV FLSTRTGTWV LSRSSPGGYP FNMIQTRWLN FLVRVLPSRF 250
INWTHERKMN KILNHENYGL SIAKGKKPKF IVNDELPTCI LCGKVTMKTS 300
VKDFTESSVI FEDGTTEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKIIL 350
YKRVFPPNLE RATLAIIGLI SLNGSILVGT EFQARWATRV FKGLCSIPPS 400
QKLMAEATKT EQLIKRGVIK DTSQDKLDFI TYMDELTQCI GAKPSIPLLF 450
IKDPRLAWEV FFGPCTPYQY RLVGPGRWDG ARNAILTQWD RTLKPLKTRI 500
VPKSPEPTSL SHYLIAWGAP VLLVSLLLIY KSSHFLELVQ GKLPRRFPPY 550
RLLWYMPQNS 560
Length:560
Mass (Da):63,792
Last modified:January 23, 2007 - v3
Checksum:i75C3AEE53693B7AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF461145 mRNA. Translation: AAL66366.1.
CCDSiCCDS15423.1.
RefSeqiNP_659127.1. NM_144878.1.
XP_006496839.1. XM_006496776.1.
XP_006496840.1. XM_006496777.1.
UniGeneiMm.155164.

Genome annotation databases

EnsembliENSMUST00000028014; ENSMUSP00000028014; ENSMUSG00000026692.
ENSMUST00000111525; ENSMUSP00000107150; ENSMUSG00000026692.
GeneIDi226564.
KEGGimmu:226564.
UCSCiuc007dgv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF461145 mRNA. Translation: AAL66366.1 .
CCDSi CCDS15423.1.
RefSeqi NP_659127.1. NM_144878.1.
XP_006496839.1. XM_006496776.1.
XP_006496840.1. XM_006496777.1.
UniGenei Mm.155164.

3D structure databases

ProteinModelPortali Q8VHG0.
SMRi Q8VHG0. Positions 2-364.
ModBasei Search...

PTM databases

PhosphoSitei Q8VHG0.

Proteomic databases

MaxQBi Q8VHG0.
PaxDbi Q8VHG0.
PRIDEi Q8VHG0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028014 ; ENSMUSP00000028014 ; ENSMUSG00000026692 .
ENSMUST00000111525 ; ENSMUSP00000107150 ; ENSMUSG00000026692 .
GeneIDi 226564.
KEGGi mmu:226564.
UCSCi uc007dgv.1. mouse.

Organism-specific databases

CTDi 2329.
MGIi MGI:2429497. Fmo4.

Phylogenomic databases

eggNOGi COG2072.
GeneTreei ENSGT00740000115433.
HOGENOMi HOG000076537.
HOVERGENi HBG002037.
InParanoidi Q8VHG0.
KOi K00485.
OMAi VCTGHFL.
OrthoDBi EOG7GXPB6.
PhylomeDBi Q8VHG0.
TreeFami TF105285.

Miscellaneous databases

NextBioi 378238.
PROi Q8VHG0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VHG0.
Bgeei Q8VHG0.
CleanExi MM_FMO4.
Genevestigatori Q8VHG0.

Family and domain databases

InterProi IPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view ]
Pfami PF00743. FMO-like. 1 hit.
[Graphical view ]
PIRSFi PIRSF000332. FMO. 1 hit.
PRINTSi PR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
ProtoNeti Search...

Publicationsi

  1. "The mouse flavin-containing monooxygenase gene cluster."
    Hernandez D., Janmohamed A., Chandan P., Phillips I.R., Shephard E.A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
    Tissue: Kidney.

Entry informationi

Entry nameiFMO4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi