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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 4

Gene

Fmo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.By similarity

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14FADSequence analysis6
Nucleotide bindingi191 – 196NADPSequence analysis6

GO - Molecular functioni

GO - Biological processi

  • drug catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name:
FMO 4
Gene namesi
Name:Fmo4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2429497. Fmo4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei516 – 530HelicalSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476611 – 560Dimethylaniline monooxygenase [N-oxide-forming] 4Add BLAST560

Proteomic databases

MaxQBiQ8VHG0.
PaxDbiQ8VHG0.
PeptideAtlasiQ8VHG0.
PRIDEiQ8VHG0.

PTM databases

iPTMnetiQ8VHG0.
PhosphoSitePlusiQ8VHG0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026692.
CleanExiMM_FMO4.
ExpressionAtlasiQ8VHG0. baseline and differential.
GenevisibleiQ8VHG0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028014.

Structurei

3D structure databases

ProteinModelPortaliQ8VHG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ8VHG0.
KOiK00485.
OMAiCKIPPSQ.
OrthoDBiEOG091G0465.
PhylomeDBiQ8VHG0.
TreeFamiTF105285.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8VHG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERTSDFGGL WKFADTSEDG
60 70 80 90 100
MTRVYRSLVT NVCKEMSCYS DFPFREDYPN FMSHEKFWDY LREFAEHFGL
110 120 130 140 150
LRYIRFKTTV LSVTKRPDFS ETGQWDVVTE TEGKRDRAVF DAVMVCTGQF
160 170 180 190 200
LSPHLPLESF PGIHKFKGQI LHSQEYRIPD AFRGKRILVV GLGNTGGDIA
210 220 230 240 250
VELSEIAAQV FLSTRTGTWV LSRSSPGGYP FNMIQTRWLN FLVRVLPSRF
260 270 280 290 300
INWTHERKMN KILNHENYGL SIAKGKKPKF IVNDELPTCI LCGKVTMKTS
310 320 330 340 350
VKDFTESSVI FEDGTTEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKIIL
360 370 380 390 400
YKRVFPPNLE RATLAIIGLI SLNGSILVGT EFQARWATRV FKGLCSIPPS
410 420 430 440 450
QKLMAEATKT EQLIKRGVIK DTSQDKLDFI TYMDELTQCI GAKPSIPLLF
460 470 480 490 500
IKDPRLAWEV FFGPCTPYQY RLVGPGRWDG ARNAILTQWD RTLKPLKTRI
510 520 530 540 550
VPKSPEPTSL SHYLIAWGAP VLLVSLLLIY KSSHFLELVQ GKLPRRFPPY
560
RLLWYMPQNS
Length:560
Mass (Da):63,792
Last modified:January 23, 2007 - v3
Checksum:i75C3AEE53693B7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461145 mRNA. Translation: AAL66366.1.
CCDSiCCDS15423.1.
RefSeqiNP_659127.1. NM_144878.1.
XP_006496839.1. XM_006496776.3.
XP_006496840.1. XM_006496777.2.
UniGeneiMm.155164.

Genome annotation databases

EnsembliENSMUST00000028014; ENSMUSP00000028014; ENSMUSG00000026692.
ENSMUST00000111525; ENSMUSP00000107150; ENSMUSG00000026692.
GeneIDi226564.
KEGGimmu:226564.
UCSCiuc007dgv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461145 mRNA. Translation: AAL66366.1.
CCDSiCCDS15423.1.
RefSeqiNP_659127.1. NM_144878.1.
XP_006496839.1. XM_006496776.3.
XP_006496840.1. XM_006496777.2.
UniGeneiMm.155164.

3D structure databases

ProteinModelPortaliQ8VHG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028014.

PTM databases

iPTMnetiQ8VHG0.
PhosphoSitePlusiQ8VHG0.

Proteomic databases

MaxQBiQ8VHG0.
PaxDbiQ8VHG0.
PeptideAtlasiQ8VHG0.
PRIDEiQ8VHG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028014; ENSMUSP00000028014; ENSMUSG00000026692.
ENSMUST00000111525; ENSMUSP00000107150; ENSMUSG00000026692.
GeneIDi226564.
KEGGimmu:226564.
UCSCiuc007dgv.1. mouse.

Organism-specific databases

CTDi2329.
MGIiMGI:2429497. Fmo4.

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ8VHG0.
KOiK00485.
OMAiCKIPPSQ.
OrthoDBiEOG091G0465.
PhylomeDBiQ8VHG0.
TreeFamiTF105285.

Enzyme and pathway databases

BRENDAi1.14.13.8. 3474.

Miscellaneous databases

PROiQ8VHG0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026692.
CleanExiMM_FMO4.
ExpressionAtlasiQ8VHG0. baseline and differential.
GenevisibleiQ8VHG0. MM.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFMO4_MOUSE
AccessioniPrimary (citable) accession number: Q8VHG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.