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Protein

Translocation protein SEC63 homolog

Gene

Sec63

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • liver development Source: MGI
  • multicellular organism aging Source: MGI
  • nitrogen compound metabolic process Source: MGI
  • posttranslational protein targeting to membrane Source: MGI
  • renal system development Source: MGI
  • SRP-dependent cotranslational protein targeting to membrane Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocation protein SEC63 homolog
Gene namesi
Name:Sec63
Synonyms:Sec63l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2155302. Sec63.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14LumenalSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 69CytoplasmicSequence analysisAdd BLAST34
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 188LumenalSequence analysisAdd BLAST98
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 760CytoplasmicSequence analysisAdd BLAST551

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710981 – 760Translocation protein SEC63 homologAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei537PhosphothreonineBy similarity1
Modified residuei742PhosphoserineBy similarity1
Modified residuei748PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VHE0.
MaxQBiQ8VHE0.
PaxDbiQ8VHE0.
PeptideAtlasiQ8VHE0.
PRIDEiQ8VHE0.

PTM databases

iPTMnetiQ8VHE0.
PhosphoSitePlusiQ8VHE0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019802.
CleanExiMM_SEC63.
GenevisibleiQ8VHE0. MM.

Interactioni

Subunit structurei

Part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63.By similarity

Protein-protein interaction databases

IntActiQ8VHE0. 2 interactors.
MINTiMINT-1851235.
STRINGi10090.ENSMUSP00000019937.

Structurei

3D structure databases

ProteinModelPortaliQ8VHE0.
SMRiQ8VHE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 165JPROSITE-ProRule annotationAdd BLAST62
Domaini367 – 457SEC63 1Add BLAST91
Domaini637 – 714SEC63 2Add BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili603 – 635Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi734 – 760Asp/Glu-rich (highly acidic)Add BLAST27

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation
Contains 2 SEC63 domains.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0721. Eukaryota.
KOG4434. Eukaryota.
COG5407. LUCA.
GeneTreeiENSGT00390000001965.
HOGENOMiHOG000037933.
HOVERGENiHBG057075.
InParanoidiQ8VHE0.
KOiK09540.
OMAiQFDYEMA.
OrthoDBiEOG091G03YI.
TreeFamiTF105904.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001623. DnaJ_domain.
IPR014756. Ig_E-set.
IPR004179. Sec63-dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF02889. Sec63. 2 hits.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00973. Sec63. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF81296. SSF81296. 2 hits.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR
60 70 80 90 100
KVYGRCMWYR LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY
110 120 130 140 150
QEYNPYEVLN LDPGATVAEI KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA
160 170 180 190 200
ALTDEESRKN WEEFGNPDGP QATSFGIALP AWIVDQKNSI LVLLVYGLAF
210 220 230 240 250
MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN MDMKRLIMVL
260 270 280 290 300
AGASEFDPQY NKDSTSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK
310 320 330 340 350
ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIIMARSR
360 370 380 390 400
EEREFRAPTL ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN
410 420 430 440 450
HKKYKIKTIQ DLVSLKESDR HSLLHFLEDE KYEEVMAVLG SFPYVTMDIK
460 470 480 490 500
SQVLDDEDSN NITVGSLVTV LVKLTRQTMA EVFEKEQSIC AAEEQPTEDG
510 520 530 540 550
QSDANKIKAK GGWQQKNKGP KKMPKSKKKK PLKKKPTTVP LPQAKQQKQK
560 570 580 590 600
QANGVVGSEA AIKEEEDDIS DKGSDSEEEE TNRDSQSEKE DGSDRESDRE
610 620 630 640 650
QDEKQSKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW
660 670 680 690 700
WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS
710 720 730 740 750
DSYMGLDQIK PLKLEVHEAK PVPENHPQWD TAIEGDEDQE DSEGFEDSFE
760
EEEEEEEGGD
Length:760
Mass (Da):87,870
Last modified:July 27, 2011 - v4
Checksum:i5966EDEE6F767384
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48N → S in AAK00580 (Ref. 1) Curated1
Sequence conflicti267R → K in AAH19366 (PubMed:15489334).Curated1
Sequence conflicti267R → K in AAH31846 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY024346 mRNA. Translation: AAK00580.1.
AC124998 Genomic DNA. No translation available.
BC019366 mRNA. Translation: AAH19366.1.
BC031846 mRNA. Translation: AAH31846.1.
CCDSiCCDS23815.1.
RefSeqiNP_694695.3. NM_153055.3.
UniGeneiMm.214344.

Genome annotation databases

EnsembliENSMUST00000019937; ENSMUSP00000019937; ENSMUSG00000019802.
GeneIDi140740.
KEGGimmu:140740.
UCSCiuc007eyx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY024346 mRNA. Translation: AAK00580.1.
AC124998 Genomic DNA. No translation available.
BC019366 mRNA. Translation: AAH19366.1.
BC031846 mRNA. Translation: AAH31846.1.
CCDSiCCDS23815.1.
RefSeqiNP_694695.3. NM_153055.3.
UniGeneiMm.214344.

3D structure databases

ProteinModelPortaliQ8VHE0.
SMRiQ8VHE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VHE0. 2 interactors.
MINTiMINT-1851235.
STRINGi10090.ENSMUSP00000019937.

PTM databases

iPTMnetiQ8VHE0.
PhosphoSitePlusiQ8VHE0.

Proteomic databases

EPDiQ8VHE0.
MaxQBiQ8VHE0.
PaxDbiQ8VHE0.
PeptideAtlasiQ8VHE0.
PRIDEiQ8VHE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019937; ENSMUSP00000019937; ENSMUSG00000019802.
GeneIDi140740.
KEGGimmu:140740.
UCSCiuc007eyx.2. mouse.

Organism-specific databases

CTDi11231.
MGIiMGI:2155302. Sec63.

Phylogenomic databases

eggNOGiKOG0721. Eukaryota.
KOG4434. Eukaryota.
COG5407. LUCA.
GeneTreeiENSGT00390000001965.
HOGENOMiHOG000037933.
HOVERGENiHBG057075.
InParanoidiQ8VHE0.
KOiK09540.
OMAiQFDYEMA.
OrthoDBiEOG091G03YI.
TreeFamiTF105904.

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSec63. mouse.
PROiQ8VHE0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019802.
CleanExiMM_SEC63.
GenevisibleiQ8VHE0. MM.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001623. DnaJ_domain.
IPR014756. Ig_E-set.
IPR004179. Sec63-dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF02889. Sec63. 2 hits.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00973. Sec63. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF81296. SSF81296. 2 hits.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC63_MOUSE
AccessioniPrimary (citable) accession number: Q8VHE0
Secondary accession number(s): E9QKG1, Q8VEB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.