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Protein

Translocation protein SEC63 homolog

Gene

Sec63

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • liver development Source: MGI
  • multicellular organism aging Source: MGI
  • nitrogen compound metabolic process Source: MGI
  • posttranslational protein targeting to membrane Source: MGI
  • renal system development Source: MGI
  • SRP-dependent cotranslational protein targeting to membrane Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocation protein SEC63 homolog
Gene namesi
Name:Sec63
Synonyms:Sec63l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2155302. Sec63.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414LumenalSequence analysisAdd
BLAST
Transmembranei15 – 3521HelicalSequence analysisAdd
BLAST
Topological domaini36 – 6934CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Topological domaini91 – 18898LumenalSequence analysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Topological domaini210 – 760551CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Translocation protein SEC63 homologPRO_0000071098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei537 – 5371PhosphothreonineBy similarity
Modified residuei742 – 7421PhosphoserineBy similarity
Modified residuei748 – 7481PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VHE0.
MaxQBiQ8VHE0.
PaxDbiQ8VHE0.
PeptideAtlasiQ8VHE0.
PRIDEiQ8VHE0.

PTM databases

iPTMnetiQ8VHE0.
PhosphoSiteiQ8VHE0.

Expressioni

Gene expression databases

BgeeiQ8VHE0.
CleanExiMM_SEC63.
GenevisibleiQ8VHE0. MM.

Interactioni

Subunit structurei

Part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63.By similarity

Protein-protein interaction databases

IntActiQ8VHE0. 2 interactions.
MINTiMINT-1851235.
STRINGi10090.ENSMUSP00000019937.

Structurei

3D structure databases

ProteinModelPortaliQ8VHE0.
SMRiQ8VHE0. Positions 106-176, 243-477, 628-708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 16562JPROSITE-ProRule annotationAdd
BLAST
Domaini367 – 45791SEC63 1Add
BLAST
Domaini637 – 71478SEC63 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili603 – 63533Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi734 – 76027Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation
Contains 2 SEC63 domains.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0721. Eukaryota.
KOG4434. Eukaryota.
COG5407. LUCA.
GeneTreeiENSGT00390000001965.
HOGENOMiHOG000037933.
HOVERGENiHBG057075.
InParanoidiQ8VHE0.
KOiK09540.
OMAiQFDYEMA.
OrthoDBiEOG7HMS0K.
TreeFamiTF105904.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001623. DnaJ_domain.
IPR014756. Ig_E-set.
IPR004179. Sec63-dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF02889. Sec63. 2 hits.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00973. Sec63. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF81296. SSF81296. 2 hits.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR
60 70 80 90 100
KVYGRCMWYR LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY
110 120 130 140 150
QEYNPYEVLN LDPGATVAEI KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA
160 170 180 190 200
ALTDEESRKN WEEFGNPDGP QATSFGIALP AWIVDQKNSI LVLLVYGLAF
210 220 230 240 250
MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN MDMKRLIMVL
260 270 280 290 300
AGASEFDPQY NKDSTSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK
310 320 330 340 350
ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIIMARSR
360 370 380 390 400
EEREFRAPTL ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN
410 420 430 440 450
HKKYKIKTIQ DLVSLKESDR HSLLHFLEDE KYEEVMAVLG SFPYVTMDIK
460 470 480 490 500
SQVLDDEDSN NITVGSLVTV LVKLTRQTMA EVFEKEQSIC AAEEQPTEDG
510 520 530 540 550
QSDANKIKAK GGWQQKNKGP KKMPKSKKKK PLKKKPTTVP LPQAKQQKQK
560 570 580 590 600
QANGVVGSEA AIKEEEDDIS DKGSDSEEEE TNRDSQSEKE DGSDRESDRE
610 620 630 640 650
QDEKQSKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW
660 670 680 690 700
WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS
710 720 730 740 750
DSYMGLDQIK PLKLEVHEAK PVPENHPQWD TAIEGDEDQE DSEGFEDSFE
760
EEEEEEEGGD
Length:760
Mass (Da):87,870
Last modified:July 27, 2011 - v4
Checksum:i5966EDEE6F767384
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481N → S in AAK00580 (Ref. 1) Curated
Sequence conflicti267 – 2671R → K in AAH19366 (PubMed:15489334).Curated
Sequence conflicti267 – 2671R → K in AAH31846 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY024346 mRNA. Translation: AAK00580.1.
AC124998 Genomic DNA. No translation available.
BC019366 mRNA. Translation: AAH19366.1.
BC031846 mRNA. Translation: AAH31846.1.
CCDSiCCDS23815.1.
RefSeqiNP_694695.3. NM_153055.3.
UniGeneiMm.214344.

Genome annotation databases

EnsembliENSMUST00000019937; ENSMUSP00000019937; ENSMUSG00000019802.
GeneIDi140740.
KEGGimmu:140740.
UCSCiuc007eyx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY024346 mRNA. Translation: AAK00580.1.
AC124998 Genomic DNA. No translation available.
BC019366 mRNA. Translation: AAH19366.1.
BC031846 mRNA. Translation: AAH31846.1.
CCDSiCCDS23815.1.
RefSeqiNP_694695.3. NM_153055.3.
UniGeneiMm.214344.

3D structure databases

ProteinModelPortaliQ8VHE0.
SMRiQ8VHE0. Positions 106-176, 243-477, 628-708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VHE0. 2 interactions.
MINTiMINT-1851235.
STRINGi10090.ENSMUSP00000019937.

PTM databases

iPTMnetiQ8VHE0.
PhosphoSiteiQ8VHE0.

Proteomic databases

EPDiQ8VHE0.
MaxQBiQ8VHE0.
PaxDbiQ8VHE0.
PeptideAtlasiQ8VHE0.
PRIDEiQ8VHE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019937; ENSMUSP00000019937; ENSMUSG00000019802.
GeneIDi140740.
KEGGimmu:140740.
UCSCiuc007eyx.2. mouse.

Organism-specific databases

CTDi11231.
MGIiMGI:2155302. Sec63.

Phylogenomic databases

eggNOGiKOG0721. Eukaryota.
KOG4434. Eukaryota.
COG5407. LUCA.
GeneTreeiENSGT00390000001965.
HOGENOMiHOG000037933.
HOVERGENiHBG057075.
InParanoidiQ8VHE0.
KOiK09540.
OMAiQFDYEMA.
OrthoDBiEOG7HMS0K.
TreeFamiTF105904.

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSec63. mouse.
PROiQ8VHE0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHE0.
CleanExiMM_SEC63.
GenevisibleiQ8VHE0. MM.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001623. DnaJ_domain.
IPR014756. Ig_E-set.
IPR004179. Sec63-dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF02889. Sec63. 2 hits.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00973. Sec63. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF81296. SSF81296. 2 hits.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Phenotypic characterization and positional mapping of the mouse deafness mutation jackson circler (jc)."
    Mack M., Noben-Trauth K.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSEC63_MOUSE
AccessioniPrimary (citable) accession number: Q8VHE0
Secondary accession number(s): E9QKG1, Q8VEB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 122 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.