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Protein

Solute carrier family 2, facilitated glucose transporter member 10

Gene

Slc2a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-428790. Facilitative Na+-independent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 10
Alternative name(s):
Glucose transporter type 10
Short name:
GLUT-10
Gene namesi
Name:Slc2a10
Synonyms:Glut10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2156687. Slc2a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini37 – 4812ExtracellularSequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini70 – 8213CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini104 – 1074ExtracellularSequence analysis
Transmembranei108 – 12821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini129 – 1324CytoplasmicSequence analysis
Transmembranei133 – 15321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini154 – 16613ExtracellularSequence analysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini188 – 23245CytoplasmicSequence analysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini254 – 26916ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini291 – 2988CytoplasmicSequence analysis
Transmembranei299 – 31921Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini320 – 40283ExtracellularSequence analysisAdd
BLAST
Transmembranei403 – 42321Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini424 – 44219CytoplasmicSequence analysisAdd
BLAST
Transmembranei443 – 46321Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini464 – 4685ExtracellularSequence analysis
Transmembranei469 – 48921Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini490 – 53647CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • endomembrane system Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Solute carrier family 2, facilitated glucose transporter member 10PRO_0000270192Add
BLAST

Proteomic databases

PaxDbiQ8VHD6.
PRIDEiQ8VHD6.

PTM databases

PhosphoSiteiQ8VHD6.

Expressioni

Gene expression databases

BgeeiQ8VHD6.
ExpressionAtlasiQ8VHD6. baseline and differential.
GenevisibleiQ8VHD6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029196.

Structurei

3D structure databases

ProteinModelPortaliQ8VHD6.
SMRiQ8VHD6. Positions 2-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ8VHD6.
KOiK08147.
OMAiVTERPIH.
OrthoDBiEOG75B852.
PhylomeDBiQ8VHD6.
TreeFamiTF332408.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRPAVLLL CASVSLLGGL TFGYELAVIS GALLPLQLNF GLSCLEQELL
60 70 80 90 100
VGSLLLGALL ASLVGGFLID CYGRRRAILG SNAVLLAGSL ILGLASSLPW
110 120 130 140 150
LLLGRLSVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE VGITVGILFS
160 170 180 190 200
YGLNYVLAGS PWGWRHMFGW AAAPALLQSL SLFLLPAGAE GTAAPKDLIP
210 220 230 240 250
LQGRETSKPG LVKPQYSFLD LFRAQDGMWS RTVVGLGLVL FQQLTGQPNV
260 270 280 290 300
LYYASTIFRS VGFHGGSSAV LASVGLGTVK VAATLVATGL VDRAGRRVLL
310 320 330 340 350
LFGCALMALS VSGIGLVSFA VSLDSGPSCL ATSNASQQVD LPGSSGLLVR
360 370 380 390 400
SSLPPVLHTN GDQGQLVLSV TERPIHPVIT ASLGPVLNTA SPVPTSPILE
410 420 430 440 450
HTLLCWSALV CMMVYVSAFS VGFGPVTWLV LSEIYPAEIR GRAFAFCSSF
460 470 480 490 500
NWAANLFISL SFLDLIGAIG LAWTFLLYGL TAVLGLAFIY LLVPETKGQS
510 520 530
LAEIEQQFQT SRFPLNFGHR QRIGIQYHRL DVSSAS
Length:536
Mass (Da):56,579
Last modified:March 1, 2002 - v1
Checksum:i789D14FE3C2477A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029579 mRNA. Translation: AAK38739.1.
AK052156 mRNA. Translation: BAC34861.1.
CCDSiCCDS17083.1.
RefSeqiNP_569718.1. NM_130451.3.
UniGeneiMm.34147.

Genome annotation databases

EnsembliENSMUST00000029196; ENSMUSP00000029196; ENSMUSG00000027661.
GeneIDi170441.
KEGGimmu:170441.
UCSCiuc008nxv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029579 mRNA. Translation: AAK38739.1.
AK052156 mRNA. Translation: BAC34861.1.
CCDSiCCDS17083.1.
RefSeqiNP_569718.1. NM_130451.3.
UniGeneiMm.34147.

3D structure databases

ProteinModelPortaliQ8VHD6.
SMRiQ8VHD6. Positions 2-513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029196.

PTM databases

PhosphoSiteiQ8VHD6.

Proteomic databases

PaxDbiQ8VHD6.
PRIDEiQ8VHD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029196; ENSMUSP00000029196; ENSMUSG00000027661.
GeneIDi170441.
KEGGimmu:170441.
UCSCiuc008nxv.2. mouse.

Organism-specific databases

CTDi81031.
MGIiMGI:2156687. Slc2a10.

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ8VHD6.
KOiK08147.
OMAiVTERPIH.
OrthoDBiEOG75B852.
PhylomeDBiQ8VHD6.
TreeFamiTF332408.

Enzyme and pathway databases

ReactomeiR-MMU-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

NextBioi370083.
PROiQ8VHD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VHD6.
ExpressionAtlasiQ8VHD6. baseline and differential.
GenevisibleiQ8VHD6. MM.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1."
    Dawson P.A., Mychaleckyj J.C., Fossey S.C., Mihic S.J., Craddock A.L., Bowden D.W.
    Mol. Genet. Metab. 74:186-199(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.

Entry informationi

Entry nameiGTR10_MOUSE
AccessioniPrimary (citable) accession number: Q8VHD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.