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Protein

Selenoprotein M

Gene

Selenom

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45NucleophileBy similarity1
Active sitei48NucleophileBy similarity1

GO - Biological processi

  • adipose tissue development Source: MGI
  • corticosterone secretion Source: MGI
  • hormone metabolic process Source: MGI
  • multicellular organism growth Source: MGI
  • response to selenium ion Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein M1 Publication
Short name:
SelM1 Publication
Gene namesi
Name:SelenomImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2149786 Selenom

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002229924 – 145Selenoprotein MAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki45 ↔ 48Cysteinyl-selenocysteine (Cys-Sec)Sequence analysis

Proteomic databases

MaxQBiQ8VHC3
PaxDbiQ8VHC3
PeptideAtlasiQ8VHC3
PRIDEiQ8VHC3

PTM databases

iPTMnetiQ8VHC3
PhosphoSitePlusiQ8VHC3

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000075702
CleanExiMM_SELM
GenevisibleiQ8VHC3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092041

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi31 – 34Combined sources4
Beta strandi39 – 45Combined sources7
Helixi54 – 59Combined sources6
Turni60 – 62Combined sources3
Helixi63 – 66Combined sources4
Beta strandi70 – 77Combined sources8
Beta strandi81 – 85Combined sources5
Beta strandi87 – 89Combined sources3
Beta strandi93 – 96Combined sources4
Beta strandi98 – 100Combined sources3
Helixi102 – 112Combined sources11
Helixi126 – 128Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A2PNMR-A25-145[»]
ProteinModelPortaliQ8VHC3
SMRiQ8VHC3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VHC3

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein M/F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZY6 Eukaryota
ENOG4112CA8 LUCA
GeneTreeiENSGT00390000001255
HOGENOMiHOG000168390
HOVERGENiHBG108468
InParanoidiQ8VHC3
OMAiTFRPDWN
OrthoDBiEOG091G132J
PhylomeDBiQ8VHC3
TreeFamiTF333248

Family and domain databases

Gene3Di3.40.30.50, 1 hit
InterProiView protein in InterPro
IPR038219 Sep15/SelM_sf
IPR014912 Sep15_SelM
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF08806 Sep15_SelM, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILLSPPSL LLLLAALVAP ATSTTNYRPD WNRLRGLARG RVETCGGUQL
60 70 80 90 100
NRLKEVKAFV TEDIQLYHNL VMKHLPGADP ELVLLSRNYQ ELERIPLSQM
110 120 130 140
TRDEINALVQ ELGFYRKSAP EAQVPPEYLW APAKPPEEAS EHDDL
Length:145
Mass (Da):16,378
Last modified:February 26, 2008 - v3
Checksum:i29849559CF0445DF
GO

Sequence cautioni

The sequence AAH19742 differs from that shown. Reason: Erroneous termination at position 48. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107A → E in BAE43327 (PubMed:16141072).Curated1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei48Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043488 mRNA Translation: AAK95398.1
AK018791 mRNA Translation: BAE43252.1
AK035312 mRNA Translation: BAC29028.2
AK046034 mRNA Translation: BAE43327.1
BC019742 mRNA Translation: AAH19742.1 Sequence problems.
BC147332 mRNA Translation: AAI47333.1
BC147333 mRNA Translation: AAI47334.1
CCDSiCCDS24365.1
RefSeqiNP_444497.1, NM_053267.3
UniGeneiMm.34046

Genome annotation databases

EnsembliENSMUST00000094469; ENSMUSP00000092041; ENSMUSG00000075702
GeneIDi114679
KEGGimmu:114679
UCSCiuc007htd.1 mouse

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELM_MOUSE
AccessioniPrimary (citable) accession number: Q8VHC3
Secondary accession number(s): B2RVS9
, Q3V374, Q8CBT7, Q8VCJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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