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Protein

Selenoprotein M

Gene

Selm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45NucleophileBy similarity1
Active sitei48NucleophileBy similarity1

GO - Biological processi

  • adipose tissue development Source: MGI
  • corticosterone secretion Source: MGI
  • hormone metabolic process Source: MGI
  • multicellular organism growth Source: MGI
  • response to selenium ion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein M
Short name:
SelM
Gene namesi
Name:Selm
Synonyms:Sepm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2149786. Selm.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • Golgi apparatus Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002229924 – 145Selenoprotein MAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki45 ↔ 48Cysteinyl-selenocysteine (Cys-Sec)Sequence analysis

Proteomic databases

MaxQBiQ8VHC3.
PaxDbiQ8VHC3.
PeptideAtlasiQ8VHC3.
PRIDEiQ8VHC3.

PTM databases

iPTMnetiQ8VHC3.
PhosphoSitePlusiQ8VHC3.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000075702.
CleanExiMM_SELM.
GenevisibleiQ8VHC3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092041.

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi31 – 34Combined sources4
Beta strandi39 – 45Combined sources7
Helixi54 – 59Combined sources6
Turni60 – 62Combined sources3
Helixi63 – 66Combined sources4
Beta strandi70 – 77Combined sources8
Beta strandi81 – 85Combined sources5
Beta strandi87 – 89Combined sources3
Beta strandi93 – 96Combined sources4
Beta strandi98 – 100Combined sources3
Helixi102 – 112Combined sources11
Helixi126 – 128Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A2PNMR-A25-145[»]
ProteinModelPortaliQ8VHC3.
SMRiQ8VHC3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VHC3.

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein M/SEP15 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZY6. Eukaryota.
ENOG4112CA8. LUCA.
GeneTreeiENSGT00390000001255.
HOGENOMiHOG000168390.
HOVERGENiHBG108468.
InParanoidiQ8VHC3.
OMAiWAPAKPP.
OrthoDBiEOG091G132J.
PhylomeDBiQ8VHC3.
TreeFamiTF333248.

Family and domain databases

InterProiIPR014912. Sep15_SelM.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF08806. Sep15_SelM. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VHC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILLSPPSL LLLLAALVAP ATSTTNYRPD WNRLRGLARG RVETCGGUQL
60 70 80 90 100
NRLKEVKAFV TEDIQLYHNL VMKHLPGADP ELVLLSRNYQ ELERIPLSQM
110 120 130 140
TRDEINALVQ ELGFYRKSAP EAQVPPEYLW APAKPPEEAS EHDDL
Length:145
Mass (Da):16,378
Last modified:February 26, 2008 - v3
Checksum:i29849559CF0445DF
GO

Sequence cautioni

The sequence AAH19742 differs from that shown. Reason: Erroneous termination at position 48. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107A → E in BAE43327 (PubMed:16141072).Curated1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei48Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043488 mRNA. Translation: AAK95398.1.
AK018791 mRNA. Translation: BAE43252.1.
AK035312 mRNA. Translation: BAC29028.2.
AK046034 mRNA. Translation: BAE43327.1.
BC019742 mRNA. Translation: AAH19742.1. Sequence problems.
BC147332 mRNA. Translation: AAI47333.1.
BC147333 mRNA. Translation: AAI47334.1.
CCDSiCCDS24365.1.
RefSeqiNP_444497.1. NM_053267.2.
UniGeneiMm.34046.

Genome annotation databases

EnsembliENSMUST00000094469; ENSMUSP00000092041; ENSMUSG00000075702.
GeneIDi114679.
KEGGimmu:114679.
UCSCiuc007htd.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043488 mRNA. Translation: AAK95398.1.
AK018791 mRNA. Translation: BAE43252.1.
AK035312 mRNA. Translation: BAC29028.2.
AK046034 mRNA. Translation: BAE43327.1.
BC019742 mRNA. Translation: AAH19742.1. Sequence problems.
BC147332 mRNA. Translation: AAI47333.1.
BC147333 mRNA. Translation: AAI47334.1.
CCDSiCCDS24365.1.
RefSeqiNP_444497.1. NM_053267.2.
UniGeneiMm.34046.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A2PNMR-A25-145[»]
ProteinModelPortaliQ8VHC3.
SMRiQ8VHC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092041.

PTM databases

iPTMnetiQ8VHC3.
PhosphoSitePlusiQ8VHC3.

Proteomic databases

MaxQBiQ8VHC3.
PaxDbiQ8VHC3.
PeptideAtlasiQ8VHC3.
PRIDEiQ8VHC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094469; ENSMUSP00000092041; ENSMUSG00000075702.
GeneIDi114679.
KEGGimmu:114679.
UCSCiuc007htd.1. mouse.

Organism-specific databases

CTDi140606.
MGIiMGI:2149786. Selm.

Phylogenomic databases

eggNOGiENOG410IZY6. Eukaryota.
ENOG4112CA8. LUCA.
GeneTreeiENSGT00390000001255.
HOGENOMiHOG000168390.
HOVERGENiHBG108468.
InParanoidiQ8VHC3.
OMAiWAPAKPP.
OrthoDBiEOG091G132J.
PhylomeDBiQ8VHC3.
TreeFamiTF333248.

Miscellaneous databases

EvolutionaryTraceiQ8VHC3.
PROiQ8VHC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075702.
CleanExiMM_SELM.
GenevisibleiQ8VHC3. MM.

Family and domain databases

InterProiIPR014912. Sep15_SelM.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF08806. Sep15_SelM. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSELM_MOUSE
AccessioniPrimary (citable) accession number: Q8VHC3
Secondary accession number(s): B2RVS9
, Q3V374, Q8CBT7, Q8VCJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.