Q8VHC1 (Q8VHC1_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cystatin E/M EMBL EDM12473.1

Submitted name:
Cystatin N EMBL AAL02328.1
Submitted name:
Protein Cst6 Ensembl ENSRNOP00000027727

Gene names

Name:	Cst6 RGD 628799 Ensembl ENSRNOP00000027727 EMBL EDM12473.1
ORF Names:	rCG_47933 EMBL EDM12473.1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Protease inhibitor Thiol protease inhibitor SAAS SAAS027214
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	epidermis development Inferred from electronic annotation. Source: Compara
Cellular_component	cornified envelope Inferred from electronic annotation. Source: Compara
Molecular_function	cysteine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8VHC1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 190DD8A89EC133C0	FASTA	149	16,792
	10 20 30 40 50 60 MERPHFPLAM GLGLLAFCLL TLSPDARAEL RSRRTGERQN LSPDDPRVLK AAQAAVASYN 70 80 90 100 110 120 MDSNSLYYFR DTKVIDAKCQ LVAGIKYYMT VDIESTECRK TRVSGDHVDL TTCPLAAGVQ 130 140 QEKLRCNFEL LEVPWKNTTQ LLKHDCVQV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a noval cysteine proteinase inhibitor, cystatin N." Hong J., Rosner M.R. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000027727.
[3]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM12473.1.
[4]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM12473.1.
[5]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000027727.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06009535 Genomic DNA. No translation available. AY046415 mRNA. Translation: AAL02328.1. CH473953 Genomic DNA. Translation: EDM12473.1.
IPI	IPI00206880.
RefSeq	NP_598250.1. NM_133566.1.
UniGene	Rn.9609.
3D structure databases
HSSP	HSSP built from PDB template 1CEW based on UniProtKB P01038.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000027727.
Protein family/group databases
MEROPS	I25.006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000027727; ENSRNOP00000027727; ENSRNOG00000020455.
GeneID	171096.
KEGG	rno:171096.
UCSC	RGD:628799. rat.
Organism-specific databases
CTD	1474.
RGD	628799. Cst6.
Phylogenomic databases
eggNOG	NOG43465.
GeneTree	ENSGT00570000079039.
HOGENOM	HOG000231754.
HOVERGEN	HBG009556.
InParanoid	Q8VHC1.
KO	K13902.
OMA	SLYYFRD.
OrthoDB	EOG4Z8XXV.
Gene expression databases
Genevestigator	Q8VHC1.
Family and domain databases
InterPro	IPR027214. Cystatin. IPR000010. Prot_inh_cystat. IPR020381. Prot_inh_cystat_cons-reg. [Graphical view]
PANTHER	PTHR11413. PTHR11413. 1 hit.
Pfam	PF00031. Cystatin. 1 hit. [Graphical view]
ProDom	PD001231. Prot_inh_cystat_cons-reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00043. CY. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	621762.

Entry information

Entry name

Q8VHC1_RAT

Accession

Primary (citable) accession number: Q8VHC1

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)