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Protein
Submitted name:

Cystatin E/M

Gene

Cst6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiI25.006.

Names & Taxonomyi

Protein namesi
Submitted name:
Cystatin E/MImported
Submitted name:
Cystatin NImported
Submitted name:
Cystatin-BImported
Gene namesi
Name:Cst6Imported
ORF Names:rCG_47933Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628799. Cst6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 149121Sequence analysisPRO_5007214902Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 147115CystatinInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J4P1. Eukaryota.
ENOG410Y20I. LUCA.
GeneTreeiENSGT00840000129890.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
KOiK13902.
OMAiSLYYFRD.
OrthoDBiEOG7M98J9.

Family and domain databases

InterProiIPR000010. Cystatin_dom.
IPR020381. Prot_inh_cystat_cons-reg.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
ProDomiPD001231. Prot_inh_cystat_cons-reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VHC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPHFPLAM GLGLLAFCLL TLSPDARAEL RSRRTGERQN LSPDDPRVLK
60 70 80 90 100
AAQAAVASYN MDSNSLYYFR DTKVIDAKCQ LVAGIKYYMT VDIESTECRK
110 120 130 140
TRVSGDHVDL TTCPLAAGVQ QEKLRCNFEL LEVPWKNTTQ LLKHDCVQV
Length:149
Mass (Da):16,792
Last modified:March 1, 2002 - v1
Checksum:i190DD8A89EC133C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006112 Genomic DNA. No translation available.
AY046415 mRNA. Translation: AAL02328.1.
CH473953 Genomic DNA. Translation: EDM12473.1.
RefSeqiNP_598250.1. NM_133566.1.
UniGeneiRn.9609.

Genome annotation databases

EnsembliENSRNOT00000027727; ENSRNOP00000027727; ENSRNOG00000020455.
GeneIDi171096.
KEGGirno:171096.
UCSCiRGD:628799. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006112 Genomic DNA. No translation available.
AY046415 mRNA. Translation: AAL02328.1.
CH473953 Genomic DNA. Translation: EDM12473.1.
RefSeqiNP_598250.1. NM_133566.1.
UniGeneiRn.9609.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI25.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027727; ENSRNOP00000027727; ENSRNOG00000020455.
GeneIDi171096.
KEGGirno:171096.
UCSCiRGD:628799. rat.

Organism-specific databases

CTDi1474.
RGDi628799. Cst6.

Phylogenomic databases

eggNOGiENOG410J4P1. Eukaryota.
ENOG410Y20I. LUCA.
GeneTreeiENSGT00840000129890.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
KOiK13902.
OMAiSLYYFRD.
OrthoDBiEOG7M98J9.

Miscellaneous databases

NextBioi621762.

Family and domain databases

InterProiIPR000010. Cystatin_dom.
IPR020381. Prot_inh_cystat_cons-reg.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
ProDomiPD001231. Prot_inh_cystat_cons-reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a noval cysteine proteinase inhibitor, cystatin N."
    Hong J., Rosner M.R.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ8VHC1_RAT
AccessioniPrimary (citable) accession number: Q8VHC1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.