ID Q8VFW8_MOUSE Unreviewed; 312 AA. AC Q8VFW8; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 27-MAR-2024, entry version 167. DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047}; GN Name=Or5b95 {ECO:0000313|Ensembl:ENSMUSP00000059886.7, GN ECO:0000313|MGI:MGI:3031277}; GN Synonyms=Olfr1443 {ECO:0000313|EMBL:AAH65104.1, GN ECO:0000313|MGI:MGI:3031277}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAL61060.1}; RN [1] {ECO:0000313|EMBL:AAL61060.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11875048; DOI=10.1093/hmg/11.5.535; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human olfactory RT receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [2] {ECO:0000313|EMBL:AAL61060.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11802173; DOI=10.1038/nn800; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [3] {ECO:0000313|EMBL:AAL61060.1} RP NUCLEOTIDE SEQUENCE. RA Adams M.; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:AAP71813.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71; RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A., RA Walker M., Williams E.M., Trask B.J.; RT "Odorant receptor expressed sequence tags demonstrate olfactory expression RT of over 400 genes, extensive alternate splicing and unequal expression RT levels."; RL Genome Biol. 4:R71.1-R71.13(2003). RN [5] {ECO:0000313|EMBL:AAP71813.1} RP NUCLEOTIDE SEQUENCE. RA Sanders K.; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AAH65104.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH65104.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH65104.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] {ECO:0000313|Ensembl:ENSMUSP00000059886.7, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000059886.7, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [8] {ECO:0000313|Ensembl:ENSMUSP00000059886.7} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000059886.7}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363047}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC065104; AAH65104.1; -; mRNA. DR EMBL; AY073397; AAL61060.1; -; Genomic_DNA. DR EMBL; AY318662; AAP71813.1; -; Genomic_DNA. DR RefSeq; NP_666909.1; NM_146698.2. DR STRING; 10090.ENSMUSP00000059886; -. DR PaxDb; 10090-ENSMUSP00000059886; -. DR DNASU; 258693; -. DR Ensembl; ENSMUST00000049724.8; ENSMUSP00000059886.7; ENSMUSG00000045030.9. DR Ensembl; ENSMUST00000213486.2; ENSMUSP00000148908.2; ENSMUSG00000045030.9. DR Ensembl; ENSMUST00000215134.2; ENSMUSP00000150063.2; ENSMUSG00000045030.9. DR GeneID; 258693; -. DR KEGG; mmu:258693; -. DR UCSC; uc008guk.1; mouse. DR AGR; MGI:3031277; -. DR CTD; 258693; -. DR MGI; MGI:3031277; Or5b95. DR VEuPathDB; HostDB:ENSMUSG00000045030; -. DR eggNOG; ENOG502QVH7; Eukaryota. DR GeneTree; ENSGT01100000263498; -. DR HOGENOM; CLU_012526_1_0_1; -. DR OMA; TTSVCAQ; -. DR OrthoDB; 5401587at2759; -. DR TreeFam; TF352753; -. DR BioGRID-ORCS; 258693; 0 hits in 71 CRISPR screens. DR Proteomes; UP000000589; Chromosome 19. DR Bgee; ENSMUSG00000045030; Expressed in proximal tubule. DR GO; GO:0016020; C:membrane; ISA:MGI. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0005549; F:odorant binding; IBA:GO_Central. DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI. DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI. DR CDD; cd15407; 7tmA_OR5B-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR48018:SF25; OLFACTORY RECEPTOR 5B17; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, KW ECO:0000256|RuleBase:RU363047}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU000688}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047}; KW Olfaction {ECO:0000256|ARBA:ARBA00022725, ECO:0000256|RuleBase:RU363047}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606, KW ECO:0000256|RuleBase:RU363047}; KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU363047}. FT TRANSMEM 25..49 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 69..87 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 99..118 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 196..223 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 235..259 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 271..290 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT DOMAIN 39..288 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 312 AA; 34759 MW; 0ACF9DD6F810EE4A CRC64; MENRTEVTEF ILLGVTNAPA LQTPLFILFT LIYFINMTGN LGMLVLILWD SRLHTPMYIF LGNLSLVDIF YSSAVTPTVV AGLLVGNQAI SYNACAAQMF LFVVFATAEN FLLAAMAYDR YAAVCKPLHY TTTMTPTTCA CLTMACYAGG FLNSSIHTGD TFRLYFCKSN VVHHFFCDVP AVMVLSCSDR HISEMVLLYG ASFVICSALL VILISYIFIF ITIFKMRSAA GYQKAMSTCV SHFTAVSIFY GTLIFMYLQP SSSHSMDTDK IVSVFYTMVI PMLNPVVYSL RNKEVKSAFK KVVEKAKYTL GF //