ID   Q8VFU6_MOUSE            Unreviewed;       313 AA.
AC   Q8VFU6;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 167.
DE   RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN   Name=Or9k2b {ECO:0000313|Ensembl:ENSMUSP00000077436.3,
GN   ECO:0000313|MGI:MGI:3030660};
GN   Synonyms=Olfr825 {ECO:0000313|MGI:MGI:3030660}, Olfr826
GN   {ECO:0000313|EMBL:AAP71313.1, ECO:0000313|MGI:MGI:3030660};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAL61082.1};
RN   [1] {ECO:0000313|EMBL:AAL61082.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA   Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA   Trask B.J.;
RT   "Different evolutionary processes shaped the mouse and human olfactory
RT   receptor gene families.";
RL   Hum. Mol. Genet. 11:535-546(2002).
RN   [2] {ECO:0000313|EMBL:AAL61082.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11802173; DOI=10.1038/nn800;
RA   Zhang X., Firestein S.;
RT   "The olfactory receptor gene superfamily of the mouse.";
RL   Nat. Neurosci. 5:124-133(2002).
RN   [3] {ECO:0000313|EMBL:AAL61082.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Adams M.;
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAP71313.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA   Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA   Walker M., Williams E.M., Trask B.J.;
RT   "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT   of over 400 genes, extensive alternate splicing and unequal expression
RT   levels.";
RL   Genome Biol. 4:R71.1-R71.13(2003).
RN   [5] {ECO:0000313|EMBL:AAP71313.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sanders K.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000077436.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077436.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [7] {ECO:0000313|EMBL:ALI87909.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6 {ECO:0000313|EMBL:ALI87909.1};
RA   Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.;
RT   "Human Olfactory Receptor Responses to Odorants.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|Ensembl:ENSMUSP00000077436.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077436.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363047};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; AY073419; AAL61082.1; -; Genomic_DNA.
DR   EMBL; AY318001; AAP71313.1; -; Genomic_DNA.
DR   EMBL; KP290751; ALI87909.1; -; Genomic_DNA.
DR   RefSeq; NP_666887.1; NM_146676.1.
DR   RefSeq; XP_006513730.1; XM_006513667.1.
DR   STRING; 10090.ENSMUSP00000149119; -.
DR   PaxDb; 10090-ENSMUSP00000077436; -.
DR   ProteomicsDB; 341464; -.
DR   Ensembl; ENSMUST00000078322.3; ENSMUSP00000077436.3; ENSMUSG00000059862.5.
DR   Ensembl; ENSMUST00000203720.3; ENSMUSP00000144755.2; ENSMUSG00000059862.5.
DR   Ensembl; ENSMUST00000216661.2; ENSMUSP00000149119.2; ENSMUSG00000059862.5.
DR   GeneID; 258671; -.
DR   KEGG; mmu:258671; -.
DR   UCSC; uc007hrg.1; mouse.
DR   AGR; MGI:3030660; -.
DR   CTD; 258671; -.
DR   MGI; MGI:3030660; Or9k2b.
DR   VEuPathDB; HostDB:ENSMUSG00000059862; -.
DR   eggNOG; ENOG502SJ6B; Eukaryota.
DR   GeneTree; ENSGT01100000263494; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   OMA; QYSIRMS; -.
DR   OrthoDB; 5401587at2759; -.
DR   TreeFam; TF352758; -.
DR   BioGRID-ORCS; 258671; 2 hits in 38 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 10.
DR   GO; GO:0016020; C:membrane; ISA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR   CDD; cd15419; 7tmA_OR9K2-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26452; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26452:SF409; OLFACTORY RECEPTOR; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363047};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW   ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047};
KW   Olfaction {ECO:0000256|RuleBase:RU363047};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW   ECO:0000256|RuleBase:RU363047};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM        28..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363047"
FT   TRANSMEM        63..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363047"
FT   TRANSMEM        101..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363047"
FT   TRANSMEM        143..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363047"
FT   TRANSMEM        200..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363047"
FT   TRANSMEM        244..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363047"
FT   TRANSMEM        274..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363047"
FT   DOMAIN          44..291
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   313 AA;  35175 MW;  02B901BB7F14F0CD CRC64;
     MGDRETSNHS DMTDFILVGF RVSPELHILL FLLFLLVYAM ILLGNLGMMA IIMTDPRLNT
     PMYFFLGNLS FIDLFYSSVI APKAMSNFWT ESKSISFAGC VAQLFLFALF IVAEGFLLAA
     MAYDRFIAIC NPLLYSVHMS TRLCTQLVAG SYFCGCISSV LQTSMTFTLS FCASRAIDHF
     YCDTRPVQRL SCNNLFVHKI VSFSLSSIII LPTVIVIIVS YMYIVSTVLK IRSVEGRKKA
     FSTCSSHLGV VSVLYGAVFF MYLTPDRFPE LSKLASLCFS LVTPMLNPLI YSLRNKDVRD
     ALSKLLEKKK FIL
//