Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kelch domain-containing protein 3

Gene

Klhdc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in meiotic recombination process.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 3
Alternative name(s):
Protein Peas
Testis intracellular mediator protein
Gene namesi
Name:Klhdc3
Synonyms:Peas
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2651568. Klhdc3.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Also found in meiotic chromatin.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Kelch domain-containing protein 3PRO_0000228996Add
BLAST

Proteomic databases

MaxQBiQ8VEM9.
PaxDbiQ8VEM9.
PeptideAtlasiQ8VEM9.
PRIDEiQ8VEM9.

Expressioni

Tissue specificityi

Expressed specifically in testis, particularly in pachytene spermatocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000063576.
CleanExiMM_KLHDC3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071743.

Structurei

3D structure databases

ProteinModelPortaliQ8VEM9.
SMRiQ8VEM9. Positions 10-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 7753Kelch 1Add
BLAST
Repeati88 – 13851Kelch 2Add
BLAST
Repeati139 – 18951Kelch 3Add
BLAST
Repeati191 – 24959Kelch 4Add
BLAST
Repeati251 – 30151Kelch 5Add
BLAST

Sequence similaritiesi

Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
HOGENOMiHOG000276538.
HOVERGENiHBG071311.
InParanoidiQ8VEM9.
PhylomeDBiQ8VEM9.
TreeFamiTF354289.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamiPF07646. Kelch_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VEM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN
60 70 80 90 100
AVSLRWTKLP PVRPAVRGQA PVVPYMRYGH STVLIDDTVF LWGGRNDTEG
110 120 130 140 150
ACNVLYAFDV NTHKWSTPRV SGTVPGARDG HSACVLGKIM YIFGGYEQLA
160 170 180 190 200
DCFSNDIHKL DTSTMTWTLV CTKGNPARWR DFHSATMLGN HMYVFGGRAD
210 220 230 240 250
RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP HTPVLPEGRR SHSAFGYNGE
260 270 280 290 300
LYIFGGYNAR LNRHFHDLWK FNPGSFTWKK IEPKGKGPCP RRRQCCCIVG
310 320 330 340 350
DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYS
360 370 380
LDQSCLPHDI RWELNAMTTN SNISRPIVSS HG
Length:382
Mass (Da):43,082
Last modified:March 1, 2002 - v1
Checksum:i275296C5F7919B03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21L → I in BAE41917 (PubMed:16141072).Curated
Sequence conflicti19 – 191A → T in BAB62016 (PubMed:12606021).Curated
Sequence conflicti168 – 1681T → A in BAB23704 (PubMed:16141072).Curated
Sequence conflicti201 – 2011R → H in BAE24793 (PubMed:16141072).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231T → A.3 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074009 Genomic DNA. Translation: BAB91441.1.
AB053465 mRNA. Translation: BAB62016.1.
AJ278127 mRNA. Translation: CAC34582.1.
AK004964 mRNA. Translation: BAB23704.1.
AK141673 mRNA. Translation: BAE24793.1.
AK170623 mRNA. Translation: BAE41917.1.
BC018154 mRNA. Translation: AAH18154.1.
CCDSiCCDS28834.1.
RefSeqiNP_001157201.2. NM_001163729.2.
NP_082186.2. NM_027910.3.
XP_006525006.1. XM_006524943.2.
UniGeneiMm.254784.

Genome annotation databases

GeneIDi71765.
KEGGimmu:71765.
UCSCiuc008ctw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074009 Genomic DNA. Translation: BAB91441.1.
AB053465 mRNA. Translation: BAB62016.1.
AJ278127 mRNA. Translation: CAC34582.1.
AK004964 mRNA. Translation: BAB23704.1.
AK141673 mRNA. Translation: BAE24793.1.
AK170623 mRNA. Translation: BAE41917.1.
BC018154 mRNA. Translation: AAH18154.1.
CCDSiCCDS28834.1.
RefSeqiNP_001157201.2. NM_001163729.2.
NP_082186.2. NM_027910.3.
XP_006525006.1. XM_006524943.2.
UniGeneiMm.254784.

3D structure databases

ProteinModelPortaliQ8VEM9.
SMRiQ8VEM9. Positions 10-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071743.

Proteomic databases

MaxQBiQ8VEM9.
PaxDbiQ8VEM9.
PeptideAtlasiQ8VEM9.
PRIDEiQ8VEM9.

Protocols and materials databases

DNASUi71765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi71765.
KEGGimmu:71765.
UCSCiuc008ctw.2. mouse.

Organism-specific databases

CTDi116138.
MGIiMGI:2651568. Klhdc3.

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
HOGENOMiHOG000276538.
HOVERGENiHBG071311.
InParanoidiQ8VEM9.
PhylomeDBiQ8VEM9.
TreeFamiTF354289.

Miscellaneous databases

ChiTaRSiKlhdc3. mouse.
PROiQ8VEM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063576.
CleanExiMM_KLHDC3.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamiPF07646. Kelch_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLDC3_MOUSE
AccessioniPrimary (citable) accession number: Q8VEM9
Secondary accession number(s): Q3TCN9
, Q3UR95, Q91XU6, Q99JH9, Q9DBG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.