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Protein

Kelch domain-containing protein 3

Gene

Klhdc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in meiotic recombination process.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 3
Alternative name(s):
Protein Peas
Testis intracellular mediator protein
Gene namesi
Name:Klhdc3
Synonyms:Peas
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2651568. Klhdc3.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Also found in meiotic chromatin.

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nuclear chromatin Source: MGI

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289961 – 382Kelch domain-containing protein 3Add BLAST382

Proteomic databases

MaxQBiQ8VEM9.
PaxDbiQ8VEM9.
PeptideAtlasiQ8VEM9.
PRIDEiQ8VEM9.

Expressioni

Tissue specificityi

Expressed specifically in testis, particularly in pachytene spermatocytes.1 Publication

Gene expression databases

CleanExiMM_KLHDC3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071743.

Structurei

3D structure databases

ProteinModelPortaliQ8VEM9.
SMRiQ8VEM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 77Kelch 1Add BLAST53
Repeati88 – 138Kelch 2Add BLAST51
Repeati139 – 189Kelch 3Add BLAST51
Repeati191 – 249Kelch 4Add BLAST59
Repeati251 – 301Kelch 5Add BLAST51

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
HOGENOMiHOG000276538.
HOVERGENiHBG071311.
InParanoidiQ8VEM9.
PhylomeDBiQ8VEM9.
TreeFamiTF354289.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiView protein in InterPro
IPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
PfamiView protein in Pfam
PF07646. Kelch_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8VEM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN
60 70 80 90 100
AVSLRWTKLP PVRPAVRGQA PVVPYMRYGH STVLIDDTVF LWGGRNDTEG
110 120 130 140 150
ACNVLYAFDV NTHKWSTPRV SGTVPGARDG HSACVLGKIM YIFGGYEQLA
160 170 180 190 200
DCFSNDIHKL DTSTMTWTLV CTKGNPARWR DFHSATMLGN HMYVFGGRAD
210 220 230 240 250
RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP HTPVLPEGRR SHSAFGYNGE
260 270 280 290 300
LYIFGGYNAR LNRHFHDLWK FNPGSFTWKK IEPKGKGPCP RRRQCCCIVG
310 320 330 340 350
DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYS
360 370 380
LDQSCLPHDI RWELNAMTTN SNISRPIVSS HG
Length:382
Mass (Da):43,082
Last modified:March 1, 2002 - v1
Checksum:i275296C5F7919B03
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2L → I in BAE41917 (PubMed:16141072).Curated1
Sequence conflicti19A → T in BAB62016 (PubMed:12606021).Curated1
Sequence conflicti168T → A in BAB23704 (PubMed:16141072).Curated1
Sequence conflicti201R → H in BAE24793 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti123T → A3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074009 Genomic DNA. Translation: BAB91441.1.
AB053465 mRNA. Translation: BAB62016.1.
AJ278127 mRNA. Translation: CAC34582.1.
AK004964 mRNA. Translation: BAB23704.1.
AK141673 mRNA. Translation: BAE24793.1.
AK170623 mRNA. Translation: BAE41917.1.
BC018154 mRNA. Translation: AAH18154.1.
CCDSiCCDS28834.1.
RefSeqiNP_001157201.2. NM_001163729.2.
NP_082186.2. NM_027910.3.
XP_006525006.1. XM_006524943.3.
UniGeneiMm.254784.

Genome annotation databases

GeneIDi71765.
KEGGimmu:71765.
UCSCiuc008ctw.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiKLDC3_MOUSE
AccessioniPrimary (citable) accession number: Q8VEM9
Secondary accession number(s): Q3TCN9
, Q3UR95, Q91XU6, Q99JH9, Q9DBG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2002
Last modified: August 30, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot