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Protein

Phosphate carrier protein, mitochondrial

Gene

Slc25a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transport of phosphate groups from the cytosol to mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.29.4.5 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate carrier protein, mitochondrial
Alternative name(s):
Phosphate transport protein
Short name:
PTP
Solute carrier family 25 member 3
Gene namesi
Name:Slc25a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1353498 Slc25a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 58Mitochondrial intermembraneSequence analysisAdd BLAST13
Transmembranei59 – 81Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini82 – 116Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei117 – 136Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini137 – 156Mitochondrial intermembraneSequence analysisAdd BLAST20
Transmembranei157 – 178Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini179 – 213Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei214 – 233Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini234 – 256Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei257 – 279Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini280 – 309Mitochondrial matrixSequence analysisAdd BLAST30
Transmembranei310 – 328Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini329 – 357Mitochondrial intermembraneSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionBy similarityAdd BLAST45
ChainiPRO_000001925746 – 357Phosphate carrier protein, mitochondrialAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-acetyllysineBy similarity1
Modified residuei107N6-methyllysineBy similarity1
Modified residuei191PhosphotyrosineBy similarity1
Modified residuei204N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8VEM8
MaxQBiQ8VEM8
PaxDbiQ8VEM8
PeptideAtlasiQ8VEM8
PRIDEiQ8VEM8
TopDownProteomicsiQ8VEM8

PTM databases

iPTMnetiQ8VEM8
PhosphoSitePlusiQ8VEM8
SwissPalmiQ8VEM8

Expressioni

Gene expression databases

BgeeiENSMUSG00000061904
ExpressionAtlasiQ8VEM8 baseline and differential
GenevisibleiQ8VEM8 MM

Interactioni

Subunit structurei

Interacts with PPIF; the interaction is impaired by CsA.By similarity

Protein-protein interaction databases

BioGridi202142, 9 interactors
DIPiDIP-32038N
IntActiQ8VEM8, 8 interactors
MINTiQ8VEM8
STRINGi10090.ENSMUSP00000075987

Structurei

3D structure databases

ProteinModelPortaliQ8VEM8
SMRiQ8VEM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 142Solcar 1Add BLAST85
Repeati155 – 239Solcar 2Add BLAST85
Repeati256 – 334Solcar 3Add BLAST79

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0767 Eukaryota
ENOG410XPST LUCA
GeneTreeiENSGT00390000008708
HOGENOMiHOG000164438
HOVERGENiHBG024440
InParanoidiQ8VEM8
KOiK15102
OMAiGFQWWIY
PhylomeDBiQ8VEM8
TreeFamiTF314119

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VEM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSVAHLAR ANPFNAPHLQ LVHDGLSGPR SPPAPPRRSR HLAAAAVEEY
60 70 80 90 100
SCEFGSMKYY ALCGFGGVLS CGLTHTAVVP LDLVKCRMQV DPQKYKGIFN
110 120 130 140 150
GFSITLKEDG VRGLAKGWAP TLIGYSMQGL CKFGFYEVFK ALYSNILGEE
160 170 180 190 200
NTYLWRTSLY LASSASAEFF ADIALAPMEA AKVRIQTQPG YANTLREAVP
210 220 230 240 250
KMYKEEGLNA FYKGVAPLWM RQIPYTMMKF ACFERTVEAL YKFVVPKPRS
260 270 280 290 300
ECTKAEQLVV TFVAGYIAGV FCAIVSHPAD SVVSVLNKEK GSTASQVLQR
310 320 330 340 350
LGFRGVWKGL FARIIMIGTL TALQWFIYDS VKVYFRLPRP PPPEMPESLK

KKLGLTE
Length:357
Mass (Da):39,632
Last modified:March 1, 2002 - v1
Checksum:i2887B9ADF034339E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077274 mRNA Translation: BAC36723.1
AK077723 mRNA Translation: BAC36982.1
AK088013 mRNA Translation: BAC40095.1
AK150641 mRNA Translation: BAE29729.1
AK150729 mRNA Translation: BAE29806.1
AK150870 mRNA Translation: BAE29921.1
AK151518 mRNA Translation: BAE30467.1
AK152006 mRNA Translation: BAE30870.1
AK152292 mRNA Translation: BAE31101.1
AK152341 mRNA Translation: BAE31137.1
AK167197 mRNA Translation: BAE39327.1
AK168580 mRNA Translation: BAE40449.1
BC018161 mRNA Translation: AAH18161.1
CCDSiCCDS24121.1
RefSeqiNP_598429.1, NM_133668.3
UniGeneiMm.298

Genome annotation databases

EnsembliENSMUST00000076694; ENSMUSP00000075987; ENSMUSG00000061904
ENSMUST00000164505; ENSMUSP00000132480; ENSMUSG00000061904
GeneIDi18674
KEGGimmu:18674
UCSCiuc007gtn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMPCP_MOUSE
AccessioniPrimary (citable) accession number: Q8VEM8
Secondary accession number(s): Q542V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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