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Q8VEM8

- MPCP_MOUSE

UniProt

Q8VEM8 - MPCP_MOUSE

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Protein

Phosphate carrier protein, mitochondrial

Gene

Slc25a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transport of phosphate groups from the cytosol to mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity).By similarity

GO - Molecular functioni

  1. protein complex binding Source: MGI
  2. symporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.29.4.5. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate carrier protein, mitochondrial
Alternative name(s):
Phosphate transport protein
Short name:
PTP
Solute carrier family 25 member 3
Gene namesi
Name:Slc25a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1353498. Slc25a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini46 – 5813Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei59 – 8123Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini82 – 11635Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei117 – 13620Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini137 – 15620Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei157 – 17822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini179 – 21335Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei214 – 23320Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini234 – 25623Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei257 – 27923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini280 – 30930Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei310 – 32819Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini329 – 35729Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: MGI
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4545MitochondrionBy similarityAdd
BLAST
Chaini46 – 357312Phosphate carrier protein, mitochondrialPRO_0000019257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-acetyllysineBy similarity
Modified residuei191 – 1911PhosphotyrosineBy similarity
Modified residuei204 – 2041N6-acetyllysine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8VEM8.
PaxDbiQ8VEM8.
PRIDEiQ8VEM8.

PTM databases

PhosphoSiteiQ8VEM8.

Expressioni

Gene expression databases

BgeeiQ8VEM8.
ExpressionAtlasiQ8VEM8. baseline and differential.
GenevestigatoriQ8VEM8.

Interactioni

Subunit structurei

Interacts with PPIF; the interaction is impaired by CsA.By similarity

Protein-protein interaction databases

BioGridi202142. 12 interactions.
DIPiDIP-32038N.
IntActiQ8VEM8. 5 interactions.
MINTiMINT-1842913.

Structurei

3D structure databases

ProteinModelPortaliQ8VEM8.
SMRiQ8VEM8. Positions 53-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 14285Solcar 1Add
BLAST
Repeati155 – 23985Solcar 2Add
BLAST
Repeati256 – 33479Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265500.
GeneTreeiENSGT00390000008708.
HOGENOMiHOG000164438.
HOVERGENiHBG024440.
InParanoidiQ8VEM8.
KOiK15102.
OMAiSAWRQIF.
OrthoDBiEOG7KQ228.
PhylomeDBiQ8VEM8.
TreeFamiTF314119.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VEM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSSVAHLAR ANPFNAPHLQ LVHDGLSGPR SPPAPPRRSR HLAAAAVEEY
60 70 80 90 100
SCEFGSMKYY ALCGFGGVLS CGLTHTAVVP LDLVKCRMQV DPQKYKGIFN
110 120 130 140 150
GFSITLKEDG VRGLAKGWAP TLIGYSMQGL CKFGFYEVFK ALYSNILGEE
160 170 180 190 200
NTYLWRTSLY LASSASAEFF ADIALAPMEA AKVRIQTQPG YANTLREAVP
210 220 230 240 250
KMYKEEGLNA FYKGVAPLWM RQIPYTMMKF ACFERTVEAL YKFVVPKPRS
260 270 280 290 300
ECTKAEQLVV TFVAGYIAGV FCAIVSHPAD SVVSVLNKEK GSTASQVLQR
310 320 330 340 350
LGFRGVWKGL FARIIMIGTL TALQWFIYDS VKVYFRLPRP PPPEMPESLK

KKLGLTE
Length:357
Mass (Da):39,632
Last modified:March 1, 2002 - v1
Checksum:i2887B9ADF034339E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077274 mRNA. Translation: BAC36723.1.
AK077723 mRNA. Translation: BAC36982.1.
AK088013 mRNA. Translation: BAC40095.1.
AK150641 mRNA. Translation: BAE29729.1.
AK150729 mRNA. Translation: BAE29806.1.
AK150870 mRNA. Translation: BAE29921.1.
AK151518 mRNA. Translation: BAE30467.1.
AK152006 mRNA. Translation: BAE30870.1.
AK152292 mRNA. Translation: BAE31101.1.
AK152341 mRNA. Translation: BAE31137.1.
AK167197 mRNA. Translation: BAE39327.1.
AK168580 mRNA. Translation: BAE40449.1.
BC018161 mRNA. Translation: AAH18161.1.
CCDSiCCDS24121.1.
RefSeqiNP_598429.1. NM_133668.3.
UniGeneiMm.298.

Genome annotation databases

EnsembliENSMUST00000076694; ENSMUSP00000075987; ENSMUSG00000061904.
ENSMUST00000164505; ENSMUSP00000132480; ENSMUSG00000061904.
GeneIDi18674.
KEGGimmu:18674.
UCSCiuc007gtn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077274 mRNA. Translation: BAC36723.1 .
AK077723 mRNA. Translation: BAC36982.1 .
AK088013 mRNA. Translation: BAC40095.1 .
AK150641 mRNA. Translation: BAE29729.1 .
AK150729 mRNA. Translation: BAE29806.1 .
AK150870 mRNA. Translation: BAE29921.1 .
AK151518 mRNA. Translation: BAE30467.1 .
AK152006 mRNA. Translation: BAE30870.1 .
AK152292 mRNA. Translation: BAE31101.1 .
AK152341 mRNA. Translation: BAE31137.1 .
AK167197 mRNA. Translation: BAE39327.1 .
AK168580 mRNA. Translation: BAE40449.1 .
BC018161 mRNA. Translation: AAH18161.1 .
CCDSi CCDS24121.1.
RefSeqi NP_598429.1. NM_133668.3.
UniGenei Mm.298.

3D structure databases

ProteinModelPortali Q8VEM8.
SMRi Q8VEM8. Positions 53-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202142. 12 interactions.
DIPi DIP-32038N.
IntActi Q8VEM8. 5 interactions.
MINTi MINT-1842913.

Protein family/group databases

TCDBi 2.A.29.4.5. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei Q8VEM8.

Proteomic databases

MaxQBi Q8VEM8.
PaxDbi Q8VEM8.
PRIDEi Q8VEM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076694 ; ENSMUSP00000075987 ; ENSMUSG00000061904 .
ENSMUST00000164505 ; ENSMUSP00000132480 ; ENSMUSG00000061904 .
GeneIDi 18674.
KEGGi mmu:18674.
UCSCi uc007gtn.1. mouse.

Organism-specific databases

CTDi 5250.
MGIi MGI:1353498. Slc25a3.

Phylogenomic databases

eggNOGi NOG265500.
GeneTreei ENSGT00390000008708.
HOGENOMi HOG000164438.
HOVERGENi HBG024440.
InParanoidi Q8VEM8.
KOi K15102.
OMAi SAWRQIF.
OrthoDBi EOG7KQ228.
PhylomeDBi Q8VEM8.
TreeFami TF314119.

Miscellaneous databases

ChiTaRSi Slc25a3. mouse.
NextBioi 294694.
PROi Q8VEM8.
SOURCEi Search...

Gene expression databases

Bgeei Q8VEM8.
ExpressionAtlasi Q8VEM8. baseline and differential.
Genevestigatori Q8VEM8.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Amnion, Bone marrow, Ovary, Thymus and Uterus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 88-94; 97-107; 117-156; 185-196; 202-242; 291-300 AND 337-350, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMPCP_MOUSE
AccessioniPrimary (citable) accession number: Q8VEM8
Secondary accession number(s): Q542V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3