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Q8VEM8

- MPCP_MOUSE

UniProt

Q8VEM8 - MPCP_MOUSE

Protein

Phosphate carrier protein, mitochondrial

Gene

Slc25a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Transport of phosphate groups from the cytosol to mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP) By similarity.By similarity

    GO - Molecular functioni

    1. protein complex binding Source: MGI
    2. symporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Symport, Transport

    Protein family/group databases

    TCDBi2.A.29.4.5. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphate carrier protein, mitochondrial
    Alternative name(s):
    Phosphate transport protein
    Short name:
    PTP
    Solute carrier family 25 member 3
    Gene namesi
    Name:Slc25a3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1353498. Slc25a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4545MitochondrionBy similarityAdd
    BLAST
    Chaini46 – 357312Phosphate carrier protein, mitochondrialPRO_0000019257Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei94 – 941N6-acetyllysineBy similarity
    Modified residuei191 – 1911PhosphotyrosineBy similarity
    Modified residuei204 – 2041N6-acetyllysine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8VEM8.
    PaxDbiQ8VEM8.
    PRIDEiQ8VEM8.

    PTM databases

    PhosphoSiteiQ8VEM8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VEM8.
    BgeeiQ8VEM8.
    GenevestigatoriQ8VEM8.

    Interactioni

    Subunit structurei

    Interacts with PPIF; the interaction is impaired by CsA.By similarity

    Protein-protein interaction databases

    BioGridi202142. 12 interactions.
    DIPiDIP-32038N.
    IntActiQ8VEM8. 5 interactions.
    MINTiMINT-1842913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VEM8.
    SMRiQ8VEM8. Positions 53-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini46 – 5813Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini82 – 11635Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15620Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini179 – 21335Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini234 – 25623Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini280 – 30930Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini329 – 35729Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei59 – 8123Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13620Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23320Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27923Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 32819Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati58 – 14285Solcar 1Add
    BLAST
    Repeati155 – 23985Solcar 2Add
    BLAST
    Repeati256 – 33479Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265500.
    GeneTreeiENSGT00390000008708.
    HOGENOMiHOG000164438.
    HOVERGENiHBG024440.
    InParanoidiQ8VEM8.
    KOiK15102.
    OMAiSAWRQIF.
    OrthoDBiEOG7KQ228.
    PhylomeDBiQ8VEM8.
    TreeFamiTF314119.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VEM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSSVAHLAR ANPFNAPHLQ LVHDGLSGPR SPPAPPRRSR HLAAAAVEEY    50
    SCEFGSMKYY ALCGFGGVLS CGLTHTAVVP LDLVKCRMQV DPQKYKGIFN 100
    GFSITLKEDG VRGLAKGWAP TLIGYSMQGL CKFGFYEVFK ALYSNILGEE 150
    NTYLWRTSLY LASSASAEFF ADIALAPMEA AKVRIQTQPG YANTLREAVP 200
    KMYKEEGLNA FYKGVAPLWM RQIPYTMMKF ACFERTVEAL YKFVVPKPRS 250
    ECTKAEQLVV TFVAGYIAGV FCAIVSHPAD SVVSVLNKEK GSTASQVLQR 300
    LGFRGVWKGL FARIIMIGTL TALQWFIYDS VKVYFRLPRP PPPEMPESLK 350
    KKLGLTE 357
    Length:357
    Mass (Da):39,632
    Last modified:March 1, 2002 - v1
    Checksum:i2887B9ADF034339E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK077274 mRNA. Translation: BAC36723.1.
    AK077723 mRNA. Translation: BAC36982.1.
    AK088013 mRNA. Translation: BAC40095.1.
    AK150641 mRNA. Translation: BAE29729.1.
    AK150729 mRNA. Translation: BAE29806.1.
    AK150870 mRNA. Translation: BAE29921.1.
    AK151518 mRNA. Translation: BAE30467.1.
    AK152006 mRNA. Translation: BAE30870.1.
    AK152292 mRNA. Translation: BAE31101.1.
    AK152341 mRNA. Translation: BAE31137.1.
    AK167197 mRNA. Translation: BAE39327.1.
    AK168580 mRNA. Translation: BAE40449.1.
    BC018161 mRNA. Translation: AAH18161.1.
    CCDSiCCDS24121.1.
    RefSeqiNP_598429.1. NM_133668.3.
    UniGeneiMm.298.

    Genome annotation databases

    EnsembliENSMUST00000076694; ENSMUSP00000075987; ENSMUSG00000061904.
    ENSMUST00000164505; ENSMUSP00000132480; ENSMUSG00000061904.
    GeneIDi18674.
    KEGGimmu:18674.
    UCSCiuc007gtn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK077274 mRNA. Translation: BAC36723.1 .
    AK077723 mRNA. Translation: BAC36982.1 .
    AK088013 mRNA. Translation: BAC40095.1 .
    AK150641 mRNA. Translation: BAE29729.1 .
    AK150729 mRNA. Translation: BAE29806.1 .
    AK150870 mRNA. Translation: BAE29921.1 .
    AK151518 mRNA. Translation: BAE30467.1 .
    AK152006 mRNA. Translation: BAE30870.1 .
    AK152292 mRNA. Translation: BAE31101.1 .
    AK152341 mRNA. Translation: BAE31137.1 .
    AK167197 mRNA. Translation: BAE39327.1 .
    AK168580 mRNA. Translation: BAE40449.1 .
    BC018161 mRNA. Translation: AAH18161.1 .
    CCDSi CCDS24121.1.
    RefSeqi NP_598429.1. NM_133668.3.
    UniGenei Mm.298.

    3D structure databases

    ProteinModelPortali Q8VEM8.
    SMRi Q8VEM8. Positions 53-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202142. 12 interactions.
    DIPi DIP-32038N.
    IntActi Q8VEM8. 5 interactions.
    MINTi MINT-1842913.

    Protein family/group databases

    TCDBi 2.A.29.4.5. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei Q8VEM8.

    Proteomic databases

    MaxQBi Q8VEM8.
    PaxDbi Q8VEM8.
    PRIDEi Q8VEM8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076694 ; ENSMUSP00000075987 ; ENSMUSG00000061904 .
    ENSMUST00000164505 ; ENSMUSP00000132480 ; ENSMUSG00000061904 .
    GeneIDi 18674.
    KEGGi mmu:18674.
    UCSCi uc007gtn.1. mouse.

    Organism-specific databases

    CTDi 5250.
    MGIi MGI:1353498. Slc25a3.

    Phylogenomic databases

    eggNOGi NOG265500.
    GeneTreei ENSGT00390000008708.
    HOGENOMi HOG000164438.
    HOVERGENi HBG024440.
    InParanoidi Q8VEM8.
    KOi K15102.
    OMAi SAWRQIF.
    OrthoDBi EOG7KQ228.
    PhylomeDBi Q8VEM8.
    TreeFami TF314119.

    Miscellaneous databases

    ChiTaRSi slc25a3. mouse.
    NextBioi 294694.
    PROi Q8VEM8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VEM8.
    Bgeei Q8VEM8.
    Genevestigatori Q8VEM8.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Amnion, Bone marrow, Ovary, Thymus and Uterus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 88-94; 97-107; 117-156; 185-196; 202-242; 291-300 AND 337-350, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiMPCP_MOUSE
    AccessioniPrimary (citable) accession number: Q8VEM8
    Secondary accession number(s): Q542V7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3