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Protein

Phosphate carrier protein, mitochondrial

Gene

Slc25a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transport of phosphate groups from the cytosol to mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.29.4.5. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate carrier protein, mitochondrial
Alternative name(s):
Phosphate transport protein
Short name:
PTP
Solute carrier family 25 member 3
Gene namesi
Name:Slc25a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1353498. Slc25a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 58Mitochondrial intermembraneSequence analysisAdd BLAST13
Transmembranei59 – 81Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini82 – 116Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei117 – 136Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini137 – 156Mitochondrial intermembraneSequence analysisAdd BLAST20
Transmembranei157 – 178Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini179 – 213Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei214 – 233Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini234 – 256Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei257 – 279Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini280 – 309Mitochondrial matrixSequence analysisAdd BLAST30
Transmembranei310 – 328Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini329 – 357Mitochondrial intermembraneSequence analysisAdd BLAST29

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • myelin sheath Source: UniProtKB
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionBy similarityAdd BLAST45
ChainiPRO_000001925746 – 357Phosphate carrier protein, mitochondrialAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-acetyllysineBy similarity1
Modified residuei107N6-methyllysineBy similarity1
Modified residuei191PhosphotyrosineBy similarity1
Modified residuei204N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8VEM8.
MaxQBiQ8VEM8.
PaxDbiQ8VEM8.
PeptideAtlasiQ8VEM8.
PRIDEiQ8VEM8.
TopDownProteomicsiQ8VEM8.

PTM databases

iPTMnetiQ8VEM8.
PhosphoSitePlusiQ8VEM8.
SwissPalmiQ8VEM8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061904.
ExpressionAtlasiQ8VEM8. baseline and differential.
GenevisibleiQ8VEM8. MM.

Interactioni

Subunit structurei

Interacts with PPIF; the interaction is impaired by CsA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202142. 8 interactors.
DIPiDIP-32038N.
IntActiQ8VEM8. 8 interactors.
MINTiMINT-1842913.
STRINGi10090.ENSMUSP00000075987.

Structurei

3D structure databases

ProteinModelPortaliQ8VEM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 142Solcar 1Add BLAST85
Repeati155 – 239Solcar 2Add BLAST85
Repeati256 – 334Solcar 3Add BLAST79

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0767. Eukaryota.
ENOG410XPST. LUCA.
GeneTreeiENSGT00390000008708.
HOGENOMiHOG000164438.
HOVERGENiHBG024440.
InParanoidiQ8VEM8.
KOiK15102.
OMAiLKFYALC.
PhylomeDBiQ8VEM8.
TreeFamiTF314119.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VEM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSVAHLAR ANPFNAPHLQ LVHDGLSGPR SPPAPPRRSR HLAAAAVEEY
60 70 80 90 100
SCEFGSMKYY ALCGFGGVLS CGLTHTAVVP LDLVKCRMQV DPQKYKGIFN
110 120 130 140 150
GFSITLKEDG VRGLAKGWAP TLIGYSMQGL CKFGFYEVFK ALYSNILGEE
160 170 180 190 200
NTYLWRTSLY LASSASAEFF ADIALAPMEA AKVRIQTQPG YANTLREAVP
210 220 230 240 250
KMYKEEGLNA FYKGVAPLWM RQIPYTMMKF ACFERTVEAL YKFVVPKPRS
260 270 280 290 300
ECTKAEQLVV TFVAGYIAGV FCAIVSHPAD SVVSVLNKEK GSTASQVLQR
310 320 330 340 350
LGFRGVWKGL FARIIMIGTL TALQWFIYDS VKVYFRLPRP PPPEMPESLK

KKLGLTE
Length:357
Mass (Da):39,632
Last modified:March 1, 2002 - v1
Checksum:i2887B9ADF034339E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077274 mRNA. Translation: BAC36723.1.
AK077723 mRNA. Translation: BAC36982.1.
AK088013 mRNA. Translation: BAC40095.1.
AK150641 mRNA. Translation: BAE29729.1.
AK150729 mRNA. Translation: BAE29806.1.
AK150870 mRNA. Translation: BAE29921.1.
AK151518 mRNA. Translation: BAE30467.1.
AK152006 mRNA. Translation: BAE30870.1.
AK152292 mRNA. Translation: BAE31101.1.
AK152341 mRNA. Translation: BAE31137.1.
AK167197 mRNA. Translation: BAE39327.1.
AK168580 mRNA. Translation: BAE40449.1.
BC018161 mRNA. Translation: AAH18161.1.
CCDSiCCDS24121.1.
RefSeqiNP_598429.1. NM_133668.3.
UniGeneiMm.298.

Genome annotation databases

EnsembliENSMUST00000076694; ENSMUSP00000075987; ENSMUSG00000061904.
ENSMUST00000164505; ENSMUSP00000132480; ENSMUSG00000061904.
GeneIDi18674.
KEGGimmu:18674.
UCSCiuc007gtn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077274 mRNA. Translation: BAC36723.1.
AK077723 mRNA. Translation: BAC36982.1.
AK088013 mRNA. Translation: BAC40095.1.
AK150641 mRNA. Translation: BAE29729.1.
AK150729 mRNA. Translation: BAE29806.1.
AK150870 mRNA. Translation: BAE29921.1.
AK151518 mRNA. Translation: BAE30467.1.
AK152006 mRNA. Translation: BAE30870.1.
AK152292 mRNA. Translation: BAE31101.1.
AK152341 mRNA. Translation: BAE31137.1.
AK167197 mRNA. Translation: BAE39327.1.
AK168580 mRNA. Translation: BAE40449.1.
BC018161 mRNA. Translation: AAH18161.1.
CCDSiCCDS24121.1.
RefSeqiNP_598429.1. NM_133668.3.
UniGeneiMm.298.

3D structure databases

ProteinModelPortaliQ8VEM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202142. 8 interactors.
DIPiDIP-32038N.
IntActiQ8VEM8. 8 interactors.
MINTiMINT-1842913.
STRINGi10090.ENSMUSP00000075987.

Protein family/group databases

TCDBi2.A.29.4.5. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ8VEM8.
PhosphoSitePlusiQ8VEM8.
SwissPalmiQ8VEM8.

Proteomic databases

EPDiQ8VEM8.
MaxQBiQ8VEM8.
PaxDbiQ8VEM8.
PeptideAtlasiQ8VEM8.
PRIDEiQ8VEM8.
TopDownProteomicsiQ8VEM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076694; ENSMUSP00000075987; ENSMUSG00000061904.
ENSMUST00000164505; ENSMUSP00000132480; ENSMUSG00000061904.
GeneIDi18674.
KEGGimmu:18674.
UCSCiuc007gtn.1. mouse.

Organism-specific databases

CTDi5250.
MGIiMGI:1353498. Slc25a3.

Phylogenomic databases

eggNOGiKOG0767. Eukaryota.
ENOG410XPST. LUCA.
GeneTreeiENSGT00390000008708.
HOGENOMiHOG000164438.
HOVERGENiHBG024440.
InParanoidiQ8VEM8.
KOiK15102.
OMAiLKFYALC.
PhylomeDBiQ8VEM8.
TreeFamiTF314119.

Miscellaneous databases

ChiTaRSiSlc25a3. mouse.
PROiQ8VEM8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061904.
ExpressionAtlasiQ8VEM8. baseline and differential.
GenevisibleiQ8VEM8. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPCP_MOUSE
AccessioniPrimary (citable) accession number: Q8VEM8
Secondary accession number(s): Q542V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.