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Protein

E3 ubiquitin-protein ligase RNF130

Gene

Rnf130

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri264 – 305RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • programmed cell death Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF130 (EC:6.3.2.-)
Alternative name(s):
G1-related zinc finger protein
Goliath homolog
RING finger protein 130
Gene namesi
Name:Rnf130Imported
Synonyms:G1rpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1891717. Rnf130.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 194ExtracellularSequence analysisAdd BLAST167
Transmembranei195 – 217HelicalSequence analysisAdd BLAST23
Topological domaini218 – 419CytoplasmicSequence analysisAdd BLAST202

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000003071928 – 419E3 ubiquitin-protein ligase RNF130Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8VEM1.
MaxQBiQ8VEM1.
PaxDbiQ8VEM1.
PRIDEiQ8VEM1.

PTM databases

iPTMnetiQ8VEM1.
PhosphoSitePlusiQ8VEM1.

Expressioni

Tissue specificityi

Expression is highest in liver, with lesser amounts in the lung, spleen, brain, heart, kidney and testis.1 Publication

Inductioni

Up-regulated in response to interleukin-3 (IL-3) withdrawal-induced apoptosis of 32Dcl3 cells (derived from bone marrow).1 Publication

Gene expression databases

BgeeiENSMUSG00000020376.
CleanExiMM_RNF130.
ExpressionAtlasiQ8VEM1. baseline and differential.
GenevisibleiQ8VEM1. MM.

Interactioni

Protein-protein interaction databases

BioGridi208508. 2 interactors.
STRINGi10090.ENSMUSP00000099837.

Structurei

3D structure databases

ProteinModelPortaliQ8VEM1.
SMRiQ8VEM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 176PAAdd BLAST72

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri264 – 305RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000231432.
HOVERGENiHBG057659.
InParanoidiQ8VEM1.
KOiK15701.
OMAiPLRTSGM.
OrthoDBiEOG091G08OR.
PhylomeDBiQ8VEM1.
TreeFamiTF317486.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VEM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAARAGPA RLAALALLTC SLWPTRADNA SQEYYTALIN VTVQEPGRGT
60 70 80 90 100
PLTFRIDRGR YGLDSPKAEV RGQVLAPLPI HGVADHLGCD PQTRFFVPPN
110 120 130 140 150
IKQWIALLQR GNCTFKEKIS RAAFHNAVAV VIYNNKSKEE PVTMTHPGTG
160 170 180 190 200
DIIAVMITEL RGKDILSYLE KNISVQMTIA VGTRMPPKNF SRGSLVFVSI
210 220 230 240 250
SFIVLMIISS AWLIFYFIQK IRYTNARDRN QRRLGDAAKK AISKLTTRTV
260 270 280 290 300
KKGDKETDPD FDHCAVCIES YKQNDVVRVL PCKHVFHKSC VDPWLSEHCT
310 320 330 340 350
CPMCKLNILK ALGIVPNLPC TDNVAFDMER LTRTQAVNRR AALGDLAGDS
360 370 380 390 400
SLGLEPLRTS GISPLPQDGE LTPRTGEINI AVTKEWFIIA SFGLLSALTL
410
CYMIIRATAS LNANEVEWF
Length:419
Mass (Da):46,376
Last modified:March 1, 2002 - v1
Checksum:i4E699A66D658CBF2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310K → R in AAF05310 (PubMed:10806348).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171875 mRNA. Translation: AAF05310.1.
AL627187, AL645913 Genomic DNA. Translation: CAI25115.1.
AL645913, AL627187 Genomic DNA. Translation: CAI24372.1.
BC018199 mRNA. Translation: AAH18199.1.
BC048901 mRNA. Translation: AAH48901.2.
CCDSiCCDS24626.1.
RefSeqiNP_001277678.1. NM_001290749.1.
NP_001277679.1. NM_001290750.1.
NP_067515.2. NM_021540.4.
UniGeneiMm.359004.
Mm.487348.

Genome annotation databases

EnsembliENSMUST00000102776; ENSMUSP00000099837; ENSMUSG00000020376.
GeneIDi59044.
KEGGimmu:59044.
UCSCiuc007irl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171875 mRNA. Translation: AAF05310.1.
AL627187, AL645913 Genomic DNA. Translation: CAI25115.1.
AL645913, AL627187 Genomic DNA. Translation: CAI24372.1.
BC018199 mRNA. Translation: AAH18199.1.
BC048901 mRNA. Translation: AAH48901.2.
CCDSiCCDS24626.1.
RefSeqiNP_001277678.1. NM_001290749.1.
NP_001277679.1. NM_001290750.1.
NP_067515.2. NM_021540.4.
UniGeneiMm.359004.
Mm.487348.

3D structure databases

ProteinModelPortaliQ8VEM1.
SMRiQ8VEM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208508. 2 interactors.
STRINGi10090.ENSMUSP00000099837.

PTM databases

iPTMnetiQ8VEM1.
PhosphoSitePlusiQ8VEM1.

Proteomic databases

EPDiQ8VEM1.
MaxQBiQ8VEM1.
PaxDbiQ8VEM1.
PRIDEiQ8VEM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102776; ENSMUSP00000099837; ENSMUSG00000020376.
GeneIDi59044.
KEGGimmu:59044.
UCSCiuc007irl.2. mouse.

Organism-specific databases

CTDi55819.
MGIiMGI:1891717. Rnf130.

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000231432.
HOVERGENiHBG057659.
InParanoidiQ8VEM1.
KOiK15701.
OMAiPLRTSGM.
OrthoDBiEOG091G08OR.
PhylomeDBiQ8VEM1.
TreeFamiTF317486.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiRnf130. mouse.
PROiQ8VEM1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020376.
CleanExiMM_RNF130.
ExpressionAtlasiQ8VEM1. baseline and differential.
GenevisibleiQ8VEM1. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGOLI_MOUSE
AccessioniPrimary (citable) accession number: Q8VEM1
Secondary accession number(s): Q80VL7, Q9QZQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.