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Protein

GTP-binding protein REM 2

Gene

Rem2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 129GTPBy similarity8
Nucleotide bindingi230 – 233GTPBy similarity4
Nucleotide bindingi261 – 262GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 2
Alternative name(s):
Rad and Gem-like GTP-binding protein 2
Gene namesi
Name:Rem2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2155260 Rem2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224841 – 341GTP-binding protein REM 2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VEL9
PRIDEiQ8VEL9

PTM databases

iPTMnetiQ8VEL9
PhosphoSitePlusiQ8VEL9

Expressioni

Gene expression databases

CleanExiMM_REM2

Interactioni

Protein-protein interaction databases

IntActiQ8VEL9, 2 interactors
MINTiQ8VEL9
STRINGi10090.ENSMUSP00000127199

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi115 – 121Combined sources7
Helixi128 – 136Combined sources9
Beta strandi152 – 159Combined sources8
Beta strandi162 – 169Combined sources8
Helixi184 – 188Combined sources5
Beta strandi190 – 197Combined sources8
Helixi201 – 205Combined sources5
Helixi207 – 217Combined sources11
Beta strandi225 – 230Combined sources6
Helixi235 – 237Combined sources3
Helixi242 – 251Combined sources10
Beta strandi255 – 258Combined sources4
Turni261 – 264Combined sources4
Helixi267 – 280Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q85X-ray1.76A/B114-282[»]
ProteinModelPortaliQ8VEL9
SMRiQ8VEL9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VEL9

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
HOGENOMiHOG000246961
HOVERGENiHBG104899
InParanoidiQ8VEL9
KOiK07848
PhylomeDBiQ8VEL9

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR017358 RGK
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PIRSFiPIRSF038017 GTP-binding_GEM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VEL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTDLDTDMD MDTETVALCS SSSRQASPLG TPTPEADTTL LKQKPEKLLA
60 70 80 90 100
ELDLSGPPPA PGVPRRRGSM PVPYKHQLRR AQAVDELDWP PQASPSGSSD
110 120 130 140 150
SLGSGEAALT QKDGVFKVML VGESGVGKST LAGTFGGLQG DHAHEMENSE
160 170 180 190 200
DTYERRIMVD KEEVTLIVYD IWEQGDAGGW LQDHCLQTGD AFLIVFSVTD
210 220 230 240 250
RRGFSKVPET LLRLRAGRPH HDLPVILVGN KSDLARSREV SLEEGRHLAG
260 270 280 290 300
TLSCKHIETS AALHHNTREL FEGAVRQIRL RRGRGHAGGQ RPEPSSPDGP
310 320 330 340
APPTRRESLT KKAKRFLANL VPRNAKFFKQ RSRSCHDLSV L
Length:341
Mass (Da):37,367
Last modified:March 2, 2010 - v2
Checksum:iD7F415A9ABC86125
GO
Isoform 2 (identifier: Q8VEL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:272
Mass (Da):30,053
Checksum:iB5048BAF8925CA9F
GO

Sequence cautioni

The sequence AAH18219 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC36746 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 15TET → IEI in AAH18219 (PubMed:15489334).Curated3
Sequence conflicti203G → S in AAH18219 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0387491 – 69Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077317 mRNA Translation: BAC36746.1 Different initiation.
AK090165 mRNA Translation: BAC41120.1
BC018219 mRNA Translation: AAH18219.1 Different initiation.
CCDSiCCDS27090.2 [Q8VEL9-1]
RefSeqiNP_542764.2, NM_080726.3
UniGeneiMm.274727

Genome annotation databases

GeneIDi140743
KEGGimmu:140743

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiREM2_MOUSE
AccessioniPrimary (citable) accession number: Q8VEL9
Secondary accession number(s): Q8BPB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 2, 2010
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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