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Protein

GTP-binding protein REM 2

Gene

Rem2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi122 – 1298GTPBy similarity
Nucleotide bindingi230 – 2334GTPBy similarity
Nucleotide bindingi261 – 2622GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 2
Alternative name(s):
Rad and Gem-like GTP-binding protein 2
Gene namesi
Name:Rem2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2155260. Rem2.

Subcellular locationi

  • Cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341GTP-binding protein REM 2PRO_0000122484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei296 – 2961PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VEL9.
PaxDbiQ8VEL9.
PRIDEiQ8VEL9.

PTM databases

iPTMnetiQ8VEL9.
PhosphoSiteiQ8VEL9.

Expressioni

Gene expression databases

CleanExiMM_REM2.

Interactioni

Protein-protein interaction databases

IntActiQ8VEL9. 2 interactions.
MINTiMINT-4132140.
STRINGi10090.ENSMUSP00000127199.

Structurei

Secondary structure

1
341
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi115 – 1217Combined sources
Helixi128 – 1369Combined sources
Beta strandi152 – 1598Combined sources
Beta strandi162 – 1698Combined sources
Helixi184 – 1885Combined sources
Beta strandi190 – 1978Combined sources
Helixi201 – 2055Combined sources
Helixi207 – 21711Combined sources
Beta strandi225 – 2306Combined sources
Helixi235 – 2373Combined sources
Helixi242 – 25110Combined sources
Beta strandi255 – 2584Combined sources
Turni261 – 2644Combined sources
Helixi267 – 28014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q85X-ray1.76A/B114-282[»]
ProteinModelPortaliQ8VEL9.
SMRiQ8VEL9. Positions 114-282.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VEL9.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ8VEL9.
KOiK07848.
PhylomeDBiQ8VEL9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VEL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTDLDTDMD MDTETVALCS SSSRQASPLG TPTPEADTTL LKQKPEKLLA
60 70 80 90 100
ELDLSGPPPA PGVPRRRGSM PVPYKHQLRR AQAVDELDWP PQASPSGSSD
110 120 130 140 150
SLGSGEAALT QKDGVFKVML VGESGVGKST LAGTFGGLQG DHAHEMENSE
160 170 180 190 200
DTYERRIMVD KEEVTLIVYD IWEQGDAGGW LQDHCLQTGD AFLIVFSVTD
210 220 230 240 250
RRGFSKVPET LLRLRAGRPH HDLPVILVGN KSDLARSREV SLEEGRHLAG
260 270 280 290 300
TLSCKHIETS AALHHNTREL FEGAVRQIRL RRGRGHAGGQ RPEPSSPDGP
310 320 330 340
APPTRRESLT KKAKRFLANL VPRNAKFFKQ RSRSCHDLSV L
Length:341
Mass (Da):37,367
Last modified:March 2, 2010 - v2
Checksum:iD7F415A9ABC86125
GO
Isoform 2 (identifier: Q8VEL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:272
Mass (Da):30,053
Checksum:iB5048BAF8925CA9F
GO

Sequence cautioni

The sequence AAH18219 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC36746 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 153TET → IEI in AAH18219 (PubMed:15489334).Curated
Sequence conflicti203 – 2031G → S in AAH18219 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969Missing in isoform 2. 1 PublicationVSP_038749Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077317 mRNA. Translation: BAC36746.1. Different initiation.
AK090165 mRNA. Translation: BAC41120.1.
BC018219 mRNA. Translation: AAH18219.1. Different initiation.
CCDSiCCDS27090.2. [Q8VEL9-1]
RefSeqiNP_542764.2. NM_080726.3.
UniGeneiMm.274727.

Genome annotation databases

GeneIDi140743.
KEGGimmu:140743.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077317 mRNA. Translation: BAC36746.1. Different initiation.
AK090165 mRNA. Translation: BAC41120.1.
BC018219 mRNA. Translation: AAH18219.1. Different initiation.
CCDSiCCDS27090.2. [Q8VEL9-1]
RefSeqiNP_542764.2. NM_080726.3.
UniGeneiMm.274727.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q85X-ray1.76A/B114-282[»]
ProteinModelPortaliQ8VEL9.
SMRiQ8VEL9. Positions 114-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VEL9. 2 interactions.
MINTiMINT-4132140.
STRINGi10090.ENSMUSP00000127199.

PTM databases

iPTMnetiQ8VEL9.
PhosphoSiteiQ8VEL9.

Proteomic databases

MaxQBiQ8VEL9.
PaxDbiQ8VEL9.
PRIDEiQ8VEL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140743.
KEGGimmu:140743.

Organism-specific databases

CTDi161253.
MGIiMGI:2155260. Rem2.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ8VEL9.
KOiK07848.
PhylomeDBiQ8VEL9.

Miscellaneous databases

EvolutionaryTraceiQ8VEL9.
PROiQ8VEL9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_REM2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREM2_MOUSE
AccessioniPrimary (citable) accession number: Q8VEL9
Secondary accession number(s): Q8BPB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 2, 2010
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.