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Protein

GTP-binding protein REM 2

Gene

Rem2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 129GTPBy similarity8
Nucleotide bindingi230 – 233GTPBy similarity4
Nucleotide bindingi261 – 262GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 2
Alternative name(s):
Rad and Gem-like GTP-binding protein 2
Gene namesi
Name:Rem2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2155260. Rem2.

Subcellular locationi

  • Cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224841 – 341GTP-binding protein REM 2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VEL9.
PRIDEiQ8VEL9.

PTM databases

iPTMnetiQ8VEL9.
PhosphoSitePlusiQ8VEL9.

Expressioni

Gene expression databases

CleanExiMM_REM2.

Interactioni

Protein-protein interaction databases

IntActiQ8VEL9. 2 interactors.
MINTiMINT-4132140.
STRINGi10090.ENSMUSP00000127199.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi115 – 121Combined sources7
Helixi128 – 136Combined sources9
Beta strandi152 – 159Combined sources8
Beta strandi162 – 169Combined sources8
Helixi184 – 188Combined sources5
Beta strandi190 – 197Combined sources8
Helixi201 – 205Combined sources5
Helixi207 – 217Combined sources11
Beta strandi225 – 230Combined sources6
Helixi235 – 237Combined sources3
Helixi242 – 251Combined sources10
Beta strandi255 – 258Combined sources4
Turni261 – 264Combined sources4
Helixi267 – 280Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q85X-ray1.76A/B114-282[»]
ProteinModelPortaliQ8VEL9.
SMRiQ8VEL9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VEL9.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ8VEL9.
KOiK07848.
PhylomeDBiQ8VEL9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VEL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTDLDTDMD MDTETVALCS SSSRQASPLG TPTPEADTTL LKQKPEKLLA
60 70 80 90 100
ELDLSGPPPA PGVPRRRGSM PVPYKHQLRR AQAVDELDWP PQASPSGSSD
110 120 130 140 150
SLGSGEAALT QKDGVFKVML VGESGVGKST LAGTFGGLQG DHAHEMENSE
160 170 180 190 200
DTYERRIMVD KEEVTLIVYD IWEQGDAGGW LQDHCLQTGD AFLIVFSVTD
210 220 230 240 250
RRGFSKVPET LLRLRAGRPH HDLPVILVGN KSDLARSREV SLEEGRHLAG
260 270 280 290 300
TLSCKHIETS AALHHNTREL FEGAVRQIRL RRGRGHAGGQ RPEPSSPDGP
310 320 330 340
APPTRRESLT KKAKRFLANL VPRNAKFFKQ RSRSCHDLSV L
Length:341
Mass (Da):37,367
Last modified:March 2, 2010 - v2
Checksum:iD7F415A9ABC86125
GO
Isoform 2 (identifier: Q8VEL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:272
Mass (Da):30,053
Checksum:iB5048BAF8925CA9F
GO

Sequence cautioni

The sequence AAH18219 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC36746 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 15TET → IEI in AAH18219 (PubMed:15489334).Curated3
Sequence conflicti203G → S in AAH18219 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0387491 – 69Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077317 mRNA. Translation: BAC36746.1. Different initiation.
AK090165 mRNA. Translation: BAC41120.1.
BC018219 mRNA. Translation: AAH18219.1. Different initiation.
CCDSiCCDS27090.2. [Q8VEL9-1]
RefSeqiNP_542764.2. NM_080726.3.
UniGeneiMm.274727.

Genome annotation databases

GeneIDi140743.
KEGGimmu:140743.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077317 mRNA. Translation: BAC36746.1. Different initiation.
AK090165 mRNA. Translation: BAC41120.1.
BC018219 mRNA. Translation: AAH18219.1. Different initiation.
CCDSiCCDS27090.2. [Q8VEL9-1]
RefSeqiNP_542764.2. NM_080726.3.
UniGeneiMm.274727.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q85X-ray1.76A/B114-282[»]
ProteinModelPortaliQ8VEL9.
SMRiQ8VEL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VEL9. 2 interactors.
MINTiMINT-4132140.
STRINGi10090.ENSMUSP00000127199.

PTM databases

iPTMnetiQ8VEL9.
PhosphoSitePlusiQ8VEL9.

Proteomic databases

PaxDbiQ8VEL9.
PRIDEiQ8VEL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140743.
KEGGimmu:140743.

Organism-specific databases

CTDi161253.
MGIiMGI:2155260. Rem2.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ8VEL9.
KOiK07848.
PhylomeDBiQ8VEL9.

Miscellaneous databases

EvolutionaryTraceiQ8VEL9.
PROiQ8VEL9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_REM2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREM2_MOUSE
AccessioniPrimary (citable) accession number: Q8VEL9
Secondary accession number(s): Q8BPB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.