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Protein

Myotubularin-related protein 14

Gene

Mtmr14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei329 – 3291Phosphocysteine intermediateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1632852. Macroautophagy.
R-MMU-1660499. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 14 (EC:3.1.3.-)
Alternative name(s):
mJumpy
Gene namesi
Name:Mtmr14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916075. Mtmr14.

Subcellular locationi

  • Cytoplasm

  • Note: Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Myotubularin-related protein 14PRO_0000260215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei193 – 1931N6-acetyllysineBy similarity
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence analysis
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence analysis
Modified residuei516 – 5161PhosphoserineBy similarity
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence analysis
Modified residuei528 – 5281PhosphoserineCombined sources
Modified residuei578 – 5781PhosphoserineBy similarity
Modified residuei622 – 6221PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8VEL2.
MaxQBiQ8VEL2.
PaxDbiQ8VEL2.
PeptideAtlasiQ8VEL2.
PRIDEiQ8VEL2.

PTM databases

iPTMnetiQ8VEL2.
PhosphoSiteiQ8VEL2.

Expressioni

Developmental stagei

In C2C12 cell line, increased expression during myotube formation and differentiation in culture.1 Publication

Gene expression databases

BgeeiENSMUSG00000030269.
CleanExiMM_MTMR14.
ExpressionAtlasiQ8VEL2. baseline and differential.
GenevisibleiQ8VEL2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VEL2. 1 interaction.
STRINGi10090.ENSMUSP00000108771.

Structurei

3D structure databases

ProteinModelPortaliQ8VEL2.
SMRiQ8VEL2. Positions 302-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi479 – 56284Ser-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHSK. Eukaryota.
ENOG410XSF4. LUCA.
GeneTreeiENSGT00390000018852.
HOGENOMiHOG000294065.
HOVERGENiHBG062969.
InParanoidiQ8VEL2.
KOiK18086.
OMAiDTHLFDK.
OrthoDBiEOG091G03F3.
PhylomeDBiQ8VEL2.
TreeFamiTF324044.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8VEL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARAAAAA SAGSTASSGS PPPQEPGLWE LLEEFSRTQY RAKDSGGKSG
60 70 80 90 100
SKVERIEKRC LELFGRDYCF SVIPNVNGDI CGHYPRHIVF LEYESSEKEK
110 120 130 140 150
DTFQSTVQVN KLQDLIHRSK MARCRGRFVC PVILFKGKHI CRSATLAGWG
160 170 180 190 200
ELYGRSGYNY LFSGGADDTW ASTEDVTEED FVLRSGDTHL FDKVRGYDIK
210 220 230 240 250
LLQYLSVKYI CDLMVENKKV KFGMNVTSSE KVDKAQRYAN FTLLSIPYPG
260 270 280 290 300
CEFFKEYKDR DYMAEGLIFN WKQDYVDAPL NIPNFLTQSL NIDWSQYQSW
310 320 330 340 350
DLVQQTQNYL KLLLFIMNRD DDSGLLVHCI SGWDRTPLFI SLLRLSLWAD
360 370 380 390 400
GLIHTSLKPA EILYLTVAYD WFLFGHMLVD RLSKGEEIFF FCFNFLKHIT
410 420 430 440 450
SEEFCLKTQR RKSLPTRDAG FTVEDICMLR HKDRGSTTSL GSDFSLVLEH
460 470 480 490 500
SPGAVGSFSY ETVELAPAGA PTQAAWRKSH SSSPQSMLWS RPQPSEERLP
510 520 530 540 550
SHHGLTEAKS SSSSSSNHSD NFFRMGSSPL EVPKPRSVDH PLPGSSLSTD
560 570 580 590 600
FGSWQLVSGC GSIQDRPVLH TDSSLPFSFQ DELPNSCLLT ALSDRETRLQ
610 620 630 640
EVRSAFLAAY SSTVGLRAAT PSPSGAIGGL LEQFARGVGL RGTSTSTL
Length:648
Mass (Da):72,443
Last modified:November 28, 2006 - v2
Checksum:iE1927FE8F32BB38D
GO

Sequence cautioni

The sequence AAH18294 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018294 mRNA. Translation: AAH18294.1. Different initiation.
CCDSiCCDS20412.2.
RefSeqiNP_081125.2. NM_026849.2.
XP_006506888.1. XM_006506825.1.
UniGeneiMm.197816.

Genome annotation databases

EnsembliENSMUST00000113146; ENSMUSP00000108771; ENSMUSG00000030269.
GeneIDi97287.
KEGGimmu:97287.
UCSCiuc009dex.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018294 mRNA. Translation: AAH18294.1. Different initiation.
CCDSiCCDS20412.2.
RefSeqiNP_081125.2. NM_026849.2.
XP_006506888.1. XM_006506825.1.
UniGeneiMm.197816.

3D structure databases

ProteinModelPortaliQ8VEL2.
SMRiQ8VEL2. Positions 302-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VEL2. 1 interaction.
STRINGi10090.ENSMUSP00000108771.

PTM databases

iPTMnetiQ8VEL2.
PhosphoSiteiQ8VEL2.

Proteomic databases

EPDiQ8VEL2.
MaxQBiQ8VEL2.
PaxDbiQ8VEL2.
PeptideAtlasiQ8VEL2.
PRIDEiQ8VEL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113146; ENSMUSP00000108771; ENSMUSG00000030269.
GeneIDi97287.
KEGGimmu:97287.
UCSCiuc009dex.2. mouse.

Organism-specific databases

CTDi64419.
MGIiMGI:1916075. Mtmr14.

Phylogenomic databases

eggNOGiENOG410IHSK. Eukaryota.
ENOG410XSF4. LUCA.
GeneTreeiENSGT00390000018852.
HOGENOMiHOG000294065.
HOVERGENiHBG062969.
InParanoidiQ8VEL2.
KOiK18086.
OMAiDTHLFDK.
OrthoDBiEOG091G03F3.
PhylomeDBiQ8VEL2.
TreeFamiTF324044.

Enzyme and pathway databases

ReactomeiR-MMU-1632852. Macroautophagy.
R-MMU-1660499. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

PROiQ8VEL2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030269.
CleanExiMM_MTMR14.
ExpressionAtlasiQ8VEL2. baseline and differential.
GenevisibleiQ8VEL2. MM.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMTMRE_MOUSE
AccessioniPrimary (citable) accession number: Q8VEL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.