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Q8VEI3

- HYAL3_MOUSE

UniProt

Q8VEI3 - HYAL3_MOUSE

Protein

Hyaluronidase-3

Gene

Hyal3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Proton donorBy similarity

    GO - Molecular functioni

    1. hyaluronoglucuronidase activity Source: Ensembl
    2. hyalurononglucosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cartilage development Source: Ensembl
    3. cellular response to interleukin-1 Source: Ensembl
    4. cellular response to tumor necrosis factor Source: Ensembl
    5. cellular response to UV-B Source: Ensembl
    6. hyaluronan catabolic process Source: Ensembl
    7. inflammatory response Source: Ensembl
    8. response to antibiotic Source: Ensembl
    9. response to virus Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.35. 3474.

    Protein family/group databases

    CAZyiGH56. Glycoside Hydrolase Family 56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase-3 (EC:3.2.1.35)
    Short name:
    Hyal-3
    Alternative name(s):
    Hyaluronoglucosaminidase-3
    Gene namesi
    Name:Hyal3
    Synonyms:Hyl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1330288. Hyal3.

    Subcellular locationi

    Secreted By similarity. Lysosome By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 412390Hyaluronidase-3PRO_0000248201Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi42 ↔ 332By similarity
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi206 ↔ 221By similarity
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi357 ↔ 368By similarity
    Disulfide bondi362 ↔ 396By similarity
    Disulfide bondi398 ↔ 407By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8VEI3.

    Expressioni

    Tissue specificityi

    Liver, kidney, skin, brain, stomach and testis.1 Publication

    Gene expression databases

    BgeeiQ8VEI3.
    CleanExiMM_HYAL3.
    GenevestigatoriQ8VEI3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VEI3.
    SMRiQ8VEI3. Positions 26-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini353 – 40856EGF-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Curated
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG69101.
    GeneTreeiENSGT00550000074476.
    HOGENOMiHOG000015133.
    HOVERGENiHBG052053.
    InParanoidiB1AV95.
    KOiK01197.
    OMAiWEEWCPL.
    OrthoDBiEOG74J97S.
    PhylomeDBiQ8VEI3.
    TreeFamiTF321598.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR027260. Hyaluronidase-3.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
    PIRSF500776. Hyaluronidase_3. 1 hit.
    PRINTSiPR00846. GLHYDRLASE56.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VEI3-1 [UniParc]FASTAAdd to Basket

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    MIMHLGLMMV VGLTLCLMHG QALLQVPEHP FSVVWNVPSA RCKAHFGVHL    50
    PLDALGIVAN HGQHFHGQNI SIFYKNQFGL YPYFGPRGTA HNGGIPQAVS 100
    LDHHLARAAH QILHSLGSSF AGLAVLDWEE WYPLWAGNWG PHRQVYLAAS 150
    WVWTQQMFPG LDPQEQLHKA HTSFEQAARA LMEYTLQLGR TLRPSGLWGF 200
    YRYPACGNGW HKMASNYTGH CHAAITTRNT QLRWLWAASS ALFPSIYLPP 250
    RLPLAYRQAF VRHRLEEAFR VALLEHSHPL PVLAYSRLTH RSSGRFLSLD 300
    DLMQTIGVSA ALGTAGVVLW GDLSFSSSEE KCWRLHDYLV GTLGPYVINV 350
    TKAAMACSHQ RCHGHGRCAR KDPGQMEAFL HLQPDDSLGA WNSFRCHCYS 400
    GWAGPTCLEP KP 412
    Length:412
    Mass (Da):46,132
    Last modified:July 27, 2011 - v2
    Checksum:iB4EB888C556BE920
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti228 – 2281R → Q in AAL06145. (PubMed:11929860)Curated
    Sequence conflicti228 – 2281R → Q in AAH18457. (PubMed:15489334)Curated
    Sequence conflicti296 – 2961F → S in AAL54883. 1 PublicationCurated
    Sequence conflicti296 – 2961F → S in AAL57175. 1 PublicationCurated
    Sequence conflicti354 – 3541A → D in AAL06145. (PubMed:11929860)Curated
    Sequence conflicti354 – 3541A → D in AAH18457. (PubMed:15489334)Curated
    Sequence conflicti397 – 3971H → R in AAL54882. 1 PublicationCurated
    Sequence conflicti397 – 3971H → R in AAL54883. 1 PublicationCurated
    Sequence conflicti397 – 3971H → R in AAL57175. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY048681 mRNA. Translation: AAL06145.1.
    AF074489 mRNA. Translation: AAL54882.1.
    AF075576 Genomic DNA. Translation: AAL54883.1.
    AF338323 Genomic DNA. Translation: AAL57175.1.
    AL672219 Genomic DNA. Translation: CAP19324.1.
    BC018457 mRNA. Translation: AAH18457.1.
    CCDSiCCDS23499.1.
    RefSeqiNP_821139.2. NM_178020.3.
    UniGeneiMm.447916.

    Genome annotation databases

    EnsembliENSMUST00000040059; ENSMUSP00000042667; ENSMUSG00000036091.
    ENSMUST00000148440; ENSMUSP00000119499; ENSMUSG00000036091.
    GeneIDi109685.
    KEGGimmu:109685.
    UCSCiuc009rmc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY048681 mRNA. Translation: AAL06145.1 .
    AF074489 mRNA. Translation: AAL54882.1 .
    AF075576 Genomic DNA. Translation: AAL54883.1 .
    AF338323 Genomic DNA. Translation: AAL57175.1 .
    AL672219 Genomic DNA. Translation: CAP19324.1 .
    BC018457 mRNA. Translation: AAH18457.1 .
    CCDSi CCDS23499.1.
    RefSeqi NP_821139.2. NM_178020.3.
    UniGenei Mm.447916.

    3D structure databases

    ProteinModelPortali Q8VEI3.
    SMRi Q8VEI3. Positions 26-407.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH56. Glycoside Hydrolase Family 56.

    Proteomic databases

    PRIDEi Q8VEI3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040059 ; ENSMUSP00000042667 ; ENSMUSG00000036091 .
    ENSMUST00000148440 ; ENSMUSP00000119499 ; ENSMUSG00000036091 .
    GeneIDi 109685.
    KEGGi mmu:109685.
    UCSCi uc009rmc.2. mouse.

    Organism-specific databases

    CTDi 8372.
    MGIi MGI:1330288. Hyal3.

    Phylogenomic databases

    eggNOGi NOG69101.
    GeneTreei ENSGT00550000074476.
    HOGENOMi HOG000015133.
    HOVERGENi HBG052053.
    InParanoidi B1AV95.
    KOi K01197.
    OMAi WEEWCPL.
    OrthoDBi EOG74J97S.
    PhylomeDBi Q8VEI3.
    TreeFami TF321598.

    Enzyme and pathway databases

    BRENDAi 3.2.1.35. 3474.

    Miscellaneous databases

    NextBioi 362575.
    PROi Q8VEI3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VEI3.
    CleanExi MM_HYAL3.
    Genevestigatori Q8VEI3.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR027260. Hyaluronidase-3.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
    PIRSF500776. Hyaluronidase_3. 1 hit.
    PRINTSi PR00846. GLHYDRLASE56.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3."
      Shuttleworth T.L., Wilson M.D., Wicklow B.A., Wilkins J.A., Triggs-Raine B.L.
      J. Biol. Chem. 277:23008-23018(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: CD-1.
    2. "Cloning and characterization of human and mouse HYAL3, a third somatic hyaluronidase paralog."
      Csoka A.B.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Genomic sequence of the mouse Hyal1 locus encoding the mouse Hyal1, Fus2, and Hyal3 genes."
      Csoka A.B.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiHYAL3_MOUSE
    AccessioniPrimary (citable) accession number: Q8VEI3
    Secondary accession number(s): B1AV95, Q8VBX7, Q8VI77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3