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Q8VEI3 (HYAL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronidase-3

Short name=Hyal-3
EC=3.2.1.35
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene names
Name:Hyal3
Synonyms:Hyl3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Subcellular location

Secreted By similarity. Lysosome By similarity.

Tissue specificity

Liver, kidney, skin, brain, stomach and testis. Ref.1

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Contains 1 EGF-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 412390Hyaluronidase-3
PRO_0000248201

Regions

Domain353 – 40856EGF-like

Sites

Active site1291Proton donor By similarity

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 332 By similarity
Disulfide bond206 ↔ 221 By similarity
Disulfide bond357 ↔ 368 By similarity
Disulfide bond362 ↔ 396 By similarity
Disulfide bond398 ↔ 407 By similarity

Experimental info

Sequence conflict2281R → Q in AAL06145. Ref.1
Sequence conflict2281R → Q in AAH18457. Ref.5
Sequence conflict2961F → S in AAL54883. Ref.3
Sequence conflict2961F → S in AAL57175. Ref.3
Sequence conflict3541A → D in AAL06145. Ref.1
Sequence conflict3541A → D in AAH18457. Ref.5
Sequence conflict3971H → R in AAL54882. Ref.2
Sequence conflict3971H → R in AAL54883. Ref.3
Sequence conflict3971H → R in AAL57175. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8VEI3 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: B4EB888C556BE920

FASTA41246,132
        10         20         30         40         50         60 
MIMHLGLMMV VGLTLCLMHG QALLQVPEHP FSVVWNVPSA RCKAHFGVHL PLDALGIVAN 

        70         80         90        100        110        120 
HGQHFHGQNI SIFYKNQFGL YPYFGPRGTA HNGGIPQAVS LDHHLARAAH QILHSLGSSF 

       130        140        150        160        170        180 
AGLAVLDWEE WYPLWAGNWG PHRQVYLAAS WVWTQQMFPG LDPQEQLHKA HTSFEQAARA 

       190        200        210        220        230        240 
LMEYTLQLGR TLRPSGLWGF YRYPACGNGW HKMASNYTGH CHAAITTRNT QLRWLWAASS 

       250        260        270        280        290        300 
ALFPSIYLPP RLPLAYRQAF VRHRLEEAFR VALLEHSHPL PVLAYSRLTH RSSGRFLSLD 

       310        320        330        340        350        360 
DLMQTIGVSA ALGTAGVVLW GDLSFSSSEE KCWRLHDYLV GTLGPYVINV TKAAMACSHQ 

       370        380        390        400        410 
RCHGHGRCAR KDPGQMEAFL HLQPDDSLGA WNSFRCHCYS GWAGPTCLEP KP 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3."
Shuttleworth T.L., Wilson M.D., Wicklow B.A., Wilkins J.A., Triggs-Raine B.L.
J. Biol. Chem. 277:23008-23018(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: CD-1.
[2]"Cloning and characterization of human and mouse HYAL3, a third somatic hyaluronidase paralog."
Csoka A.B.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Genomic sequence of the mouse Hyal1 locus encoding the mouse Hyal1, Fus2, and Hyal3 genes."
Csoka A.B.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY048681 mRNA. Translation: AAL06145.1.
AF074489 mRNA. Translation: AAL54882.1.
AF075576 Genomic DNA. Translation: AAL54883.1.
AF338323 Genomic DNA. Translation: AAL57175.1.
AL672219 Genomic DNA. Translation: CAP19324.1.
BC018457 mRNA. Translation: AAH18457.1.
RefSeqNP_821139.2. NM_178020.3.
UniGeneMm.447916.

3D structure databases

ProteinModelPortalQ8VEI3.
SMRQ8VEI3. Positions 26-407.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEQ8VEI3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040059; ENSMUSP00000042667; ENSMUSG00000036091.
ENSMUST00000148440; ENSMUSP00000119499; ENSMUSG00000036091.
GeneID109685.
KEGGmmu:109685.
UCSCuc009rmc.2. mouse.

Organism-specific databases

CTD8372.
MGIMGI:1330288. Hyal3.

Phylogenomic databases

eggNOGNOG69101.
GeneTreeENSGT00550000074476.
HOGENOMHOG000015133.
HOVERGENHBG052053.
InParanoidB1AV95.
KOK01197.
OMAWEEWCPL.
OrthoDBEOG74J97S.
PhylomeDBQ8VEI3.
TreeFamTF321598.

Enzyme and pathway databases

BRENDA3.2.1.35. 3474.

Gene expression databases

BgeeQ8VEI3.
CleanExMM_HYAL3.
GenevestigatorQ8VEI3.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERPTHR11769. PTHR11769. 1 hit.
PfamPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSPR00846. GLHYDRLASE56.
SMARTSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio362575.
PROQ8VEI3.
SOURCESearch...

Entry information

Entry nameHYAL3_MOUSE
AccessionPrimary (citable) accession number: Q8VEI3
Secondary accession number(s): B1AV95, Q8VBX7, Q8VI77
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries