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Protein

Endoplasmic reticulum lectin 1

Gene

Erlec1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5358346. Hedgehog ligand biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum lectin 1
Alternative name(s):
ER lectin
Short name:
Erlectin
Gene namesi
Name:Erlec1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914003. Erlec1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 483450Endoplasmic reticulum lectin 1PRO_0000042183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8VEH8.
MaxQBiQ8VEH8.
PaxDbiQ8VEH8.
PRIDEiQ8VEH8.

PTM databases

PhosphoSiteiQ8VEH8.

Expressioni

Gene expression databases

BgeeiQ8VEH8.
CleanExiMM_4933407N01RIK.
ExpressionAtlasiQ8VEH8. baseline and differential.
GenevisibleiQ8VEH8. MM.

Interactioni

Subunit structurei

May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VEH8. 2 interactions.
MINTiMINT-4120100.
STRINGi10090.ENSMUSP00000072929.

Structurei

3D structure databases

ProteinModelPortaliQ8VEH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 18070PRKCSH 1Add
BLAST
Domaini342 – 41877PRKCSH 2Add
BLAST

Sequence similaritiesi

Contains 2 PRKCSH domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3394. Eukaryota.
ENOG410XR8A. LUCA.
GeneTreeiENSGT00530000063603.
InParanoidiQ8VEH8.
KOiK14008.
OMAiQYHEERE.
OrthoDBiEOG7RJPR5.
PhylomeDBiQ8VEH8.
TreeFamiTF314309.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 2 hits.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VEH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGDGGLRS LVPGGPLLLV LYGLLEASGG GRALPQLSDD IPFRVNWPGT
60 70 80 90 100
EFSLPTTGVL YKEDNYIIMT TAHKEKYKCI LPLVTSGDEE EEKDYKGPNP
110 120 130 140 150
RELLEPLFKQ SSCSYRIESY WTYEVCHGKH IRQYHEEKET GQKVNIHEYY
160 170 180 190 200
LGNMLAKNLL YEKEREAKEN EKSNEIPTKN IEGQMTPYYP VGMGNGTPCS
210 220 230 240 250
LKQNRPRSST VMYICHPESK HEILSVAEVT TCEYEVVILT PLLCSHPKYK
260 270 280 290 300
FRASPVNDIF CQSLPGSPFK PLTLRQLEQQ EEILRVPFRR NKEEDLPSAK
310 320 330 340 350
EERFPAIHKP IAVGSQPVLT VGTTHISKLT DDQLIKEFLS GSYCFHGGVG
360 370 380 390 400
WWKYEFCYGK HVHQYHEDKD NGKTSVVVGT WNQEEHVEWA KKNTARAYHL
410 420 430 440 450
QDDGTQTVRM VSHFYGNGDI CDITDKPRQV TVKLKCKESD SPHAVTVYML
460 470 480
EPHSCQYILG VESPVICKIL DTADENGLLS LPN
Length:483
Mass (Da):54,906
Last modified:March 1, 2002 - v1
Checksum:iBB521BB85C3595D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101S → T in BAC36623 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077120 mRNA. Translation: BAC36623.1.
AK133874 mRNA. Translation: BAE21904.1.
AL662891 Genomic DNA. Translation: CAI24536.1.
BC018468 mRNA. Translation: AAH18468.1.
CCDSiCCDS24509.1.
RefSeqiNP_080021.3. NM_025745.3.
UniGeneiMm.294641.

Genome annotation databases

EnsembliENSMUST00000073192; ENSMUSP00000072929; ENSMUSG00000020311.
GeneIDi66753.
KEGGimmu:66753.
UCSCiuc007iic.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077120 mRNA. Translation: BAC36623.1.
AK133874 mRNA. Translation: BAE21904.1.
AL662891 Genomic DNA. Translation: CAI24536.1.
BC018468 mRNA. Translation: AAH18468.1.
CCDSiCCDS24509.1.
RefSeqiNP_080021.3. NM_025745.3.
UniGeneiMm.294641.

3D structure databases

ProteinModelPortaliQ8VEH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VEH8. 2 interactions.
MINTiMINT-4120100.
STRINGi10090.ENSMUSP00000072929.

PTM databases

PhosphoSiteiQ8VEH8.

Proteomic databases

EPDiQ8VEH8.
MaxQBiQ8VEH8.
PaxDbiQ8VEH8.
PRIDEiQ8VEH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073192; ENSMUSP00000072929; ENSMUSG00000020311.
GeneIDi66753.
KEGGimmu:66753.
UCSCiuc007iic.1. mouse.

Organism-specific databases

CTDi27248.
MGIiMGI:1914003. Erlec1.

Phylogenomic databases

eggNOGiKOG3394. Eukaryota.
ENOG410XR8A. LUCA.
GeneTreeiENSGT00530000063603.
InParanoidiQ8VEH8.
KOiK14008.
OMAiQYHEERE.
OrthoDBiEOG7RJPR5.
PhylomeDBiQ8VEH8.
TreeFamiTF314309.

Enzyme and pathway databases

ReactomeiR-MMU-5358346. Hedgehog ligand biogenesis.

Miscellaneous databases

NextBioi322546.
PROiQ8VEH8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VEH8.
CleanExiMM_4933407N01RIK.
ExpressionAtlasiQ8VEH8. baseline and differential.
GenevisibleiQ8VEH8. MM.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 2 hits.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiERLEC_MOUSE
AccessioniPrimary (citable) accession number: Q8VEH8
Secondary accession number(s): Q3UZF3, Q8BVN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.