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Protein

Keratin, type II cytoskeletal 79

Gene

Krt79

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei391 – 3911Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 79
Alternative name(s):
Cytokeratin-79
Short name:
CK-79
Keratin-79
Short name:
K79
Type-II keratin Kb38
Gene namesi
Name:Krt79
Synonyms:Kb38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2385030. Krt79.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Keratin, type II cytoskeletal 79PRO_0000314894Add
BLAST

Proteomic databases

MaxQBiQ8VED5.
PaxDbiQ8VED5.
PRIDEiQ8VED5.

PTM databases

iPTMnetiQ8VED5.
PhosphoSiteiQ8VED5.

Expressioni

Gene expression databases

BgeeiQ8VED5.
CleanExiMM_KRT79.
GenevisibleiQ8VED5. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230211. 4 interactions.
IntActiQ8VED5. 2 interactions.
MINTiMINT-4120018.
STRINGi10090.ENSMUSP00000023799.

Structurei

3D structure databases

ProteinModelPortaliQ8VED5.
SMRiQ8VED5. Positions 136-278, 306-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 138138HeadAdd
BLAST
Regioni139 – 449311RodAdd
BLAST
Regioni139 – 17436Coil 1AAdd
BLAST
Regioni175 – 19420Linker 1Add
BLAST
Regioni195 – 28692Coil 1BAdd
BLAST
Regioni287 – 31024Linker 12Add
BLAST
Regioni311 – 449139Coil 2Add
BLAST
Regioni450 – 53182TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEK5. Eukaryota.
ENOG410XUTQ. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ8VED5.
KOiK07605.
OMAiHLYEMEL.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ8VED5.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 2 hits.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VED5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSLSRQTF STKGGFSSNS ASGGGGSRMR TSYSSVTMSR GSGGGGGVRS
60 70 80 90 100
GSSSGGFGSR SLYNLGGKNI SVSMACGASS GRALGGFGSG AYVGLGASRQ
110 120 130 140 150
TFGPVCPPGG IQEVTVNQSL LTPLNVEIDP EIQRVRTQER EQIKTLNNKF
160 170 180 190 200
ASFIDKVRFL EQQNKVLETK WALLQEQSQN TGVARSLEPF FENYLSTLRR
210 220 230 240 250
QLDTKQSERG RLDMELRNVQ DNLEDFKNKY EDEINKRTAL ENEFVLLKKD
260 270 280 290 300
VDAAYMGRMD LHGKVDSLTQ EIDFLQQLFE MELSQVQTNV SDTNVILSMD
310 320 330 340 350
NNRNLDLDSI IAEVKAQYEL IAQKSRAEAE SWYQTKYEEL QVTAGKHGDS
360 370 380 390 400
LRDTKNEIAE LTRTTQRLQG EVDAAKKQCQ QLQTAIAEAE QNGEMALKDA
410 420 430 440 450
KKKLGDLDTA LHQAKEDLAR MLREYQDLVS VKLALDMEIA TYRKLLESEE
460 470 480 490 500
SRMSGDCPSA ISISVTGNST SVCAGGTAGF GNGLSLGGAG GASKGGFGSS
510 520 530
VSYGAAKGGQ VSGGTSILRK TTTVKTSSRR Y
Length:531
Mass (Da):57,552
Last modified:October 17, 2006 - v2
Checksum:iF3D9893938F72BF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019155 mRNA. Translation: AAH19155.2.
BC031593 mRNA. Translation: AAH31593.1.
CCDSiCCDS27867.1.
RefSeqiNP_666175.1. NM_146063.1.
UniGeneiMm.162744.

Genome annotation databases

EnsembliENSMUST00000023799; ENSMUSP00000023799; ENSMUSG00000061397.
GeneIDi223917.
KEGGimmu:223917.
UCSCiuc007xug.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019155 mRNA. Translation: AAH19155.2.
BC031593 mRNA. Translation: AAH31593.1.
CCDSiCCDS27867.1.
RefSeqiNP_666175.1. NM_146063.1.
UniGeneiMm.162744.

3D structure databases

ProteinModelPortaliQ8VED5.
SMRiQ8VED5. Positions 136-278, 306-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230211. 4 interactions.
IntActiQ8VED5. 2 interactions.
MINTiMINT-4120018.
STRINGi10090.ENSMUSP00000023799.

PTM databases

iPTMnetiQ8VED5.
PhosphoSiteiQ8VED5.

Proteomic databases

MaxQBiQ8VED5.
PaxDbiQ8VED5.
PRIDEiQ8VED5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023799; ENSMUSP00000023799; ENSMUSG00000061397.
GeneIDi223917.
KEGGimmu:223917.
UCSCiuc007xug.1. mouse.

Organism-specific databases

CTDi338785.
MGIiMGI:2385030. Krt79.

Phylogenomic databases

eggNOGiENOG410IEK5. Eukaryota.
ENOG410XUTQ. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ8VED5.
KOiK07605.
OMAiHLYEMEL.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ8VED5.
TreeFamiTF317854.

Miscellaneous databases

PROiQ8VED5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VED5.
CleanExiMM_KRT79.
GenevisibleiQ8VED5. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 2 hits.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiK2C79_MOUSE
AccessioniPrimary (citable) accession number: Q8VED5
Secondary accession number(s): Q8K2E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: June 8, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.