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Protein

Keratin, type II cytoskeletal 79

Gene

Krt79

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei391Stutter1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 79
Alternative name(s):
Cytokeratin-79
Short name:
CK-79
Keratin-79
Short name:
K79
Type-II keratin Kb38
Gene namesi
Name:Krt79
Synonyms:Kb38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2385030 Krt79

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148941 – 531Keratin, type II cytoskeletal 79Add BLAST531

Proteomic databases

PaxDbiQ8VED5
PeptideAtlasiQ8VED5
PRIDEiQ8VED5

PTM databases

iPTMnetiQ8VED5
PhosphoSitePlusiQ8VED5

Expressioni

Gene expression databases

BgeeiENSMUSG00000061397
CleanExiMM_KRT79
GenevisibleiQ8VED5 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230211, 4 interactors
IntActiQ8VED5, 3 interactors
MINTiQ8VED5
STRINGi10090.ENSMUSP00000023799

Structurei

3D structure databases

ProteinModelPortaliQ8VED5
SMRiQ8VED5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 453IF rodPROSITE-ProRule annotationAdd BLAST315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 138HeadAdd BLAST138
Regioni139 – 174Coil 1AAdd BLAST36
Regioni175 – 194Linker 1Add BLAST20
Regioni195 – 286Coil 1BAdd BLAST92
Regioni287 – 310Linker 12Add BLAST24
Regioni311 – 449Coil 2Add BLAST139
Regioni450 – 531TailAdd BLAST82

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEK5 Eukaryota
ENOG410XUTQ LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ8VED5
KOiK07605
OMAiHLYEMEL
OrthoDBiEOG091G09KR
PhylomeDBiQ8VED5
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 2 hits
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VED5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSLSRQTF STKGGFSSNS ASGGGGSRMR TSYSSVTMSR GSGGGGGVRS
60 70 80 90 100
GSSSGGFGSR SLYNLGGKNI SVSMACGASS GRALGGFGSG AYVGLGASRQ
110 120 130 140 150
TFGPVCPPGG IQEVTVNQSL LTPLNVEIDP EIQRVRTQER EQIKTLNNKF
160 170 180 190 200
ASFIDKVRFL EQQNKVLETK WALLQEQSQN TGVARSLEPF FENYLSTLRR
210 220 230 240 250
QLDTKQSERG RLDMELRNVQ DNLEDFKNKY EDEINKRTAL ENEFVLLKKD
260 270 280 290 300
VDAAYMGRMD LHGKVDSLTQ EIDFLQQLFE MELSQVQTNV SDTNVILSMD
310 320 330 340 350
NNRNLDLDSI IAEVKAQYEL IAQKSRAEAE SWYQTKYEEL QVTAGKHGDS
360 370 380 390 400
LRDTKNEIAE LTRTTQRLQG EVDAAKKQCQ QLQTAIAEAE QNGEMALKDA
410 420 430 440 450
KKKLGDLDTA LHQAKEDLAR MLREYQDLVS VKLALDMEIA TYRKLLESEE
460 470 480 490 500
SRMSGDCPSA ISISVTGNST SVCAGGTAGF GNGLSLGGAG GASKGGFGSS
510 520 530
VSYGAAKGGQ VSGGTSILRK TTTVKTSSRR Y
Length:531
Mass (Da):57,552
Last modified:October 17, 2006 - v2
Checksum:iF3D9893938F72BF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019155 mRNA Translation: AAH19155.2
BC031593 mRNA Translation: AAH31593.1
CCDSiCCDS27867.1
RefSeqiNP_666175.1, NM_146063.1
UniGeneiMm.162744

Genome annotation databases

EnsembliENSMUST00000023799; ENSMUSP00000023799; ENSMUSG00000061397
GeneIDi223917
KEGGimmu:223917
UCSCiuc007xug.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK2C79_MOUSE
AccessioniPrimary (citable) accession number: Q8VED5
Secondary accession number(s): Q8K2E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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