Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adhesion G-protein coupled receptor F1

Gene

Adgrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor F1
Alternative name(s):
G-protein coupled receptor 110
Gene namesi
Name:Adgrf1
Synonyms:Gpr110
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1924846. Adgrf1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 588ExtracellularCuratedAdd BLAST568
Transmembranei589 – 609Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini610 – 622CytoplasmicCuratedAdd BLAST13
Transmembranei623 – 643Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini644 – 658ExtracellularCuratedAdd BLAST15
Transmembranei659 – 679Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini680 – 697CytoplasmicCuratedAdd BLAST18
Transmembranei698 – 718Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini719 – 742ExtracellularCuratedAdd BLAST24
Transmembranei743 – 763Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini764 – 789CytoplasmicCuratedAdd BLAST26
Transmembranei790 – 810Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini811 – 818ExtracellularCurated8
Transmembranei819 – 839Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini840 – 908CytoplasmicCuratedAdd BLAST69

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Adgrf1 show no visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001289221 – 908Adhesion G-protein coupled receptor F1Add BLAST888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi328N-linked (GlcNAc...)Sequence analysis1
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1
Glycosylationi367N-linked (GlcNAc...)Sequence analysis1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Glycosylationi422N-linked (GlcNAc...)Sequence analysis1
Glycosylationi453N-linked (GlcNAc...)Sequence analysis1
Glycosylationi510N-linked (GlcNAc...)Sequence analysis1
Glycosylationi519N-linked (GlcNAc...)Sequence analysis1
Glycosylationi526N-linked (GlcNAc...)Sequence analysis1
Glycosylationi551N-linked (GlcNAc...)Sequence analysis1
Glycosylationi734N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VEC3.
PRIDEiQ8VEC3.

PTM databases

iPTMnetiQ8VEC3.
PhosphoSitePlusiQ8VEC3.

Expressioni

Tissue specificityi

Expressed in liver, kidney and adrenal gland. In kidney strong expression in the renal pelvis and the ureter.1 Publication

Gene expression databases

BgeeiENSMUSG00000041293.
CleanExiMM_GPR110.
GenevisibleiQ8VEC3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049380.

Structurei

3D structure databases

ProteinModelPortaliQ8VEC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 255SEAPROSITE-ProRule annotationAdd BLAST109
Domaini529 – 576GPSPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOGENOMiHOG000293229.
HOVERGENiHBG051767.
InParanoidiQ8VEC3.
KOiK08453.
OMAiGNITARC.
OrthoDBiEOG091G00IU.
TreeFamiTF316380.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VEC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIGLLWLVP LFTLTEGTDG FLQQKNDGRR TKEIVSMVEE RHPVHEYEVL
60 70 80 90 100
LQVTYRDPEE KRELKRFLKL LKSPSPSLRG PSKIIRVKAT TYCRSRKGFL
110 120 130 140 150
ECACEDSYTW FPPSCLDPQN CCLHTTGPVP SCNCSLRGLR QSINFCERAK
160 170 180 190 200
VWGTFEIDEK FPEDLWNSSS DVYAHYTVGI ENQLKEAYRR VHGFESVRVT
210 220 230 240 250
QFRKGSIVVG YEVTGSTSPP ELLFAIEQEA EKAQEALRRQ FPVKYGSFRV
260 270 280 290 300
FGKAPCNSIS FGFGSENDEY TVPCSSGFTG SMTVRCQSSG WQITRESCVL
310 320 330 340 350
SQLEELKKEL RMIAGKITEA GVASLVQNLS TILLQSPSTT VGNLGSVVSL
360 370 380 390 400
LSNISSLSLA NSLTVSNLTL MNVINIADHI LDSASITNWT ILLQDAKDAS
410 420 430 440 450
SQLLKTLESI SSLIPSMALP LNFSGKFIDW KGTPVTQIQS TRGYNYQMEM
460 470 480 490 500
RQNASLPIRG HVFIEPDQFQ KSHPKTIISM ASLTFGDILP ITQRGNAWVN
510 520 530 540 550
GPVISTLIQN YSISEIFLNF SKIKGNLTQP RCVFWDFSQL QWSNAGCQLV
560 570 580 590 600
NETLDTVLCR CSHLTSFSML MSPFVPSSVV PVVKWITYIG LSISIASLIL
610 620 630 640 650
CLIIESLFWK QTKRSQTSYT RNICLVNIAV SLLIADVWFI IAATVDPSVS
660 670 680 690 700
PSGVCVAAVF FTHFFYLAVF FWMLVLGILL AYRIILVFHH MALTTMMAIG
710 720 730 740 750
FCLGYGCPLL ISIITLAVTQ PSNSYKRNDV CWLNWSDKSK PLLAFVVPAL
760 770 780 790 800
TIVAVNLVVV LLVLRKLWRP AVGERLNQDD KATAIRMGKS LLVLTPLLGL
810 820 830 840 850
TWGFGIGTMA NSHNLAWHVL FALLNAFQGF FIFCFGILLD TKLRQLLSNK
860 870 880 890 900
LTTLSSWKQT SKRNASDTVT QPKCLRTFNI LQHRGMYALS HTGDSSSDIT

LTQFLSTE
Length:908
Mass (Da):101,469
Last modified:July 27, 2011 - v2
Checksum:iF5ECDE31B96BC0B0
GO

Sequence cautioni

The sequence BAC25606 differs from that shown. Reason: Frameshift at position 612.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72K → R in AAH19217 (PubMed:15489334).Curated1
Sequence conflicti143I → V in AAH19217 (PubMed:15489334).Curated1
Sequence conflicti160K → N in AAH19217 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025700 Genomic DNA. Translation: CAQ12617.1.
BC019217 mRNA. Translation: AAH19217.1.
AK019869 mRNA. Translation: BAC25606.1. Frameshift.
CCDSiCCDS28795.1.
RefSeqiNP_598537.2. NM_133776.2.
UniGeneiMm.159950.

Genome annotation databases

EnsembliENSMUST00000047399; ENSMUSP00000049380; ENSMUSG00000041293.
GeneIDi77596.
KEGGimmu:77596.
UCSCiuc008coz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025700 Genomic DNA. Translation: CAQ12617.1.
BC019217 mRNA. Translation: AAH19217.1.
AK019869 mRNA. Translation: BAC25606.1. Frameshift.
CCDSiCCDS28795.1.
RefSeqiNP_598537.2. NM_133776.2.
UniGeneiMm.159950.

3D structure databases

ProteinModelPortaliQ8VEC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049380.

Protein family/group databases

MEROPSiP02.026.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8VEC3.
PhosphoSitePlusiQ8VEC3.

Proteomic databases

PaxDbiQ8VEC3.
PRIDEiQ8VEC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047399; ENSMUSP00000049380; ENSMUSG00000041293.
GeneIDi77596.
KEGGimmu:77596.
UCSCiuc008coz.2. mouse.

Organism-specific databases

CTDi266977.
MGIiMGI:1924846. Adgrf1.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOGENOMiHOG000293229.
HOVERGENiHBG051767.
InParanoidiQ8VEC3.
KOiK08453.
OMAiGNITARC.
OrthoDBiEOG091G00IU.
TreeFamiTF316380.

Miscellaneous databases

PROiQ8VEC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041293.
CleanExiMM_GPR110.
GenevisibleiQ8VEC3. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRF1_MOUSE
AccessioniPrimary (citable) accession number: Q8VEC3
Secondary accession number(s): B0V2Q5, Q8BMV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.