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Protein

RNA-binding protein 4B

Gene

Rbm4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

  • circadian regulation of gene expression Source: UniProtKB
  • circadian rhythm Source: UniProtKB
  • entrainment of circadian clock by photoperiod Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • positive regulation of gene expression Source: MGI
  • regulation of translation Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, RNA-binding
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 4B
Alternative name(s):
RNA-binding motif protein 30
RNA-binding motif protein 4B
RNA-binding protein 30
Gene namesi
Name:Rbm4b
Synonyms:Rbm30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1913954 Rbm4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817881 – 357RNA-binding protein 4BAdd BLAST357

Proteomic databases

EPDiQ8VE92
MaxQBiQ8VE92
PaxDbiQ8VE92
PeptideAtlasiQ8VE92
PRIDEiQ8VE92

PTM databases

iPTMnetiQ8VE92
PhosphoSitePlusiQ8VE92

Expressioni

Tissue specificityi

Expressed in the suprachiasmatic nucleus (SCN) (at protein level). Expressed in the suprachiasmatic nucleus (SCN).1 Publication

Inductioni

Accumulates according to a circadian rhythm in the SCN.1 Publication

Gene expression databases

BgeeiENSMUSG00000033760
CleanExiMM_RBM4B
ExpressionAtlasiQ8VE92 baseline and differential
GenevisibleiQ8VE92 MM

Interactioni

Subunit structurei

Interacts with TNPO3, which may mediate nuclear import of the protein.By similarity

Protein-protein interaction databases

BioGridi2116571 interactor.
IntActiQ8VE92 2 interactors.
MINTiQ8VE92
STRINGi10090.ENSMUSP00000038256

Structurei

3D structure databases

ProteinModelPortaliQ8VE92
SMRiQ8VE92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 72RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini78 – 148RRM 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 357Interaction with TNPO3By similarityAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 240Poly-Ala10
Compositional biasi286 – 292Poly-Ala7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0109 Eukaryota
ENOG41105PP LUCA
GeneTreeiENSGT00390000020883
HOGENOMiHOG000026790
HOVERGENiHBG062217
InParanoidiQ8VE92
KOiK13187
OMAiVYYNDAY
OrthoDBiEOG091G08PZ
PhylomeDBiQ8VE92
TreeFamiTF320661

Family and domain databases

CDDicd12606 RRM1_RBM4, 1 hit
cd12607 RRM2_RBM4, 1 hit
Gene3Di3.30.70.3302 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034897 RBM4_RRM1
IPR034898 RBM4_RRM2
IPR000504 RRM_dom
IPR001878 Znf_CCHC
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
PS50158 ZF_CCHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VE92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED
60 70 80 90 100
AIRNLHHYKL HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE
110 120 130 140 150
YGPVIECDIV KDYAFVHMER AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL
160 170 180 190 200
RTAPGMGDQS GCYRCGKEGH WSKECPVDRT GRVADFTEQY NEQYGAVRTP
210 220 230 240 250
YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA YNYAEQTMSH
260 270 280 290 300
LPQVQSSAVP SHLNSTSVDP YDRHLLQNSG SAATSAAMAA AASSSYYGRD
310 320 330 340 350
RSPLRRNAAV LPAVGEGYGY GPESEMSQAS AATRNSLYDM ARYEREQYVD

RTRYSAF
Length:357
Mass (Da):39,991
Last modified:March 1, 2002 - v1
Checksum:i3BD8274D837DCC28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019488 mRNA Translation: AAH19488.1
CCDSiCCDS29435.1
RefSeqiNP_079993.2, NM_025717.3
XP_006531886.1, XM_006531823.3
XP_006531887.1, XM_006531824.3
XP_006531888.1, XM_006531825.3
XP_006531889.1, XM_006531826.2
UniGeneiMm.396734

Genome annotation databases

EnsembliENSMUST00000036744; ENSMUSP00000038256; ENSMUSG00000033760
GeneIDi66704
KEGGimmu:66704
UCSCiuc008gar.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRBM4B_MOUSE
AccessioniPrimary (citable) accession number: Q8VE92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome