ID   F1142_MOUSE             Reviewed;         497 AA.
AC   Q8VE88; Q3UE42; Q5QNR1; Q9D310;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 2.
DT   24-JAN-2024, entry version 121.
DE   RecName: Full=Protein FAM114A2;
GN   Name=Fam114a2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, and Colon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Pancreas, Spleen,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8VE88-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8VE88-2; Sequence=VSP_022796;
CC   -!- SIMILARITY: Belongs to the FAM114 family. {ECO:0000305}.
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DR   EMBL; AK018570; BAB31282.1; -; mRNA.
DR   EMBL; AK149763; BAE29069.1; -; mRNA.
DR   EMBL; AL672236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC019518; AAH19518.1; -; mRNA.
DR   CCDS; CCDS24717.1; -. [Q8VE88-2]
DR   CCDS; CCDS48801.1; -. [Q8VE88-1]
DR   RefSeq; NP_001162138.1; NM_001168667.1. [Q8VE88-2]
DR   RefSeq; NP_001162139.1; NM_001168668.1. [Q8VE88-1]
DR   RefSeq; NP_080618.1; NM_026342.3. [Q8VE88-2]
DR   RefSeq; XP_006534079.1; XM_006534016.3. [Q8VE88-1]
DR   RefSeq; XP_011247496.1; XM_011249194.2. [Q8VE88-1]
DR   RefSeq; XP_011247497.1; XM_011249195.2. [Q8VE88-2]
DR   AlphaFoldDB; Q8VE88; -.
DR   BioGRID; 212397; 1.
DR   STRING; 10090.ENSMUSP00000104478; -.
DR   GlyGen; Q8VE88; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8VE88; -.
DR   PhosphoSitePlus; Q8VE88; -.
DR   SwissPalm; Q8VE88; -.
DR   EPD; Q8VE88; -.
DR   jPOST; Q8VE88; -.
DR   MaxQB; Q8VE88; -.
DR   PaxDb; 10090-ENSMUSP00000104478; -.
DR   PeptideAtlas; Q8VE88; -.
DR   ProteomicsDB; 275814; -. [Q8VE88-1]
DR   ProteomicsDB; 275815; -. [Q8VE88-2]
DR   Pumba; Q8VE88; -.
DR   Antibodypedia; 48470; 86 antibodies from 16 providers.
DR   DNASU; 67726; -.
DR   Ensembl; ENSMUST00000020831.13; ENSMUSP00000020831.7; ENSMUSG00000020523.15. [Q8VE88-2]
DR   Ensembl; ENSMUST00000108850.2; ENSMUSP00000104478.2; ENSMUSG00000020523.15. [Q8VE88-1]
DR   GeneID; 67726; -.
DR   KEGG; mmu:67726; -.
DR   UCSC; uc007izt.2; mouse. [Q8VE88-1]
DR   UCSC; uc007izu.2; mouse. [Q8VE88-2]
DR   AGR; MGI:1917629; -.
DR   CTD; 10827; -.
DR   MGI; MGI:1917629; Fam114a2.
DR   VEuPathDB; HostDB:ENSMUSG00000020523; -.
DR   eggNOG; ENOG502QS74; Eukaryota.
DR   GeneTree; ENSGT00390000010054; -.
DR   HOGENOM; CLU_035724_1_0_1; -.
DR   InParanoid; Q8VE88; -.
DR   OMA; VLFENYC; -.
DR   OrthoDB; 5401701at2759; -.
DR   PhylomeDB; Q8VE88; -.
DR   TreeFam; TF324360; -.
DR   BioGRID-ORCS; 67726; 5 hits in 79 CRISPR screens.
DR   PRO; PR:Q8VE88; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8VE88; Protein.
DR   Bgee; ENSMUSG00000020523; Expressed in seminal vesicle and 279 other cell types or tissues.
DR   InterPro; IPR007998; DUF719.
DR   PANTHER; PTHR12842; FI01459P; 1.
DR   PANTHER; PTHR12842:SF3; PROTEIN FAM114A2; 1.
DR   Pfam; PF05334; DUF719; 1.
DR   Genevisible; Q8VE88; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..497
FT                   /note="Protein FAM114A2"
FT                   /id="PRO_0000274565"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         84
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRY5"
FT   MOD_RES         205
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRY5"
FT   VAR_SEQ         61..67
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_022796"
FT   CONFLICT        14
FT                   /note="G -> E (in Ref. 3; AAH19518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        304
FT                   /note="N -> D (in Ref. 3; AAH19518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        318
FT                   /note="V -> I (in Ref. 3; AAH19518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        438
FT                   /note="A -> V (in Ref. 3; AAH19518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        488
FT                   /note="S -> P (in Ref. 1; BAE29069)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        494
FT                   /note="S -> P (in Ref. 3; AAH19518)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   497 AA;  54045 MW;  9346964631460F6D CRC64;
     MSDKDPPESP VVTGVASTLK DENCEPVEKP EDKSQPVVST RKRPETKPSS DLEASALPAQ
     VSLAVAKETA SKDVPQTGWG YWGSWGKSLL SSASATVATV GQGISNVIEK AETSLGIPSP
     TEISAEVKQA AGEKNAGENG SLLVAAPFGM LSTISTAVQS TGKSVISGGL DALEFIGKKT
     MDVIAEGDPG FKRTKGLMNR TSTLSQVLRE AKDKEEQRPS NEVTMETDKK THYGLLFDEF
     QGLSHLEALE MLSRESEIKV KSILSSLSGE ELQTTRLELE QLKEVFSLAE FCEEEEEERQ
     GDDNFTKEIT DLFAQLHVSS RPEKLARARN TAYKWIRTSL ARPVAEKEEG EKESEAGNTE
     EAQKHSIEDI HAFAIRSLAE LTACSIELFH KTAALVLHGQ KQEVTALERS QTLSQMTVML
     CKDLASLSKE FTTCLTTAGV REKADVLNPV ITAVFLEASN SASYIQDAFQ LLLPVLQISL
     IESKTESSTC EPQSRDL
//