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Protein

Protein FAM114A2

Gene

Fam114a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM114A2
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917629. Fam114a2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745651 – 497Protein FAM114A2Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VE88.
PeptideAtlasiQ8VE88.
PRIDEiQ8VE88.

PTM databases

iPTMnetiQ8VE88.
PhosphoSitePlusiQ8VE88.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020523.
GenevisibleiQ8VE88. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VE88. 1 interactor.
MINTiMINT-4392161.

Structurei

3D structure databases

ProteinModelPortaliQ8VE88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi293 – 298Poly-Glu6

Sequence similaritiesi

Belongs to the FAM114 family.Curated

Phylogenomic databases

eggNOGiENOG410IHQB. Eukaryota.
ENOG411029H. LUCA.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ8VE88.
OMAiNTAYEWI.
OrthoDBiEOG091G06FS.
PhylomeDBiQ8VE88.
TreeFamiTF324360.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VE88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKDPPESP VVTGVASTLK DENCEPVEKP EDKSQPVVST RKRPETKPSS
60 70 80 90 100
DLEASALPAQ VSLAVAKETA SKDVPQTGWG YWGSWGKSLL SSASATVATV
110 120 130 140 150
GQGISNVIEK AETSLGIPSP TEISAEVKQA AGEKNAGENG SLLVAAPFGM
160 170 180 190 200
LSTISTAVQS TGKSVISGGL DALEFIGKKT MDVIAEGDPG FKRTKGLMNR
210 220 230 240 250
TSTLSQVLRE AKDKEEQRPS NEVTMETDKK THYGLLFDEF QGLSHLEALE
260 270 280 290 300
MLSRESEIKV KSILSSLSGE ELQTTRLELE QLKEVFSLAE FCEEEEEERQ
310 320 330 340 350
GDDNFTKEIT DLFAQLHVSS RPEKLARARN TAYKWIRTSL ARPVAEKEEG
360 370 380 390 400
EKESEAGNTE EAQKHSIEDI HAFAIRSLAE LTACSIELFH KTAALVLHGQ
410 420 430 440 450
KQEVTALERS QTLSQMTVML CKDLASLSKE FTTCLTTAGV REKADVLNPV
460 470 480 490
ITAVFLEASN SASYIQDAFQ LLLPVLQISL IESKTESSTC EPQSRDL
Length:497
Mass (Da):54,045
Last modified:February 6, 2007 - v2
Checksum:i9346964631460F6D
GO
Isoform 2 (identifier: Q8VE88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-67: Missing.

Show »
Length:490
Mass (Da):53,376
Checksum:iEFD0D0464955F95E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14G → E in AAH19518 (PubMed:15489334).Curated1
Sequence conflicti304N → D in AAH19518 (PubMed:15489334).Curated1
Sequence conflicti318V → I in AAH19518 (PubMed:15489334).Curated1
Sequence conflicti438A → V in AAH19518 (PubMed:15489334).Curated1
Sequence conflicti488S → P in BAE29069 (PubMed:16141072).Curated1
Sequence conflicti494S → P in AAH19518 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02279661 – 67Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018570 mRNA. Translation: BAB31282.1.
AK149763 mRNA. Translation: BAE29069.1.
AL672236 Genomic DNA. Translation: CAI24469.1.
AL672236 Genomic DNA. Translation: CAI24470.1.
BC019518 mRNA. Translation: AAH19518.1.
CCDSiCCDS24717.1. [Q8VE88-2]
CCDS48801.1. [Q8VE88-1]
RefSeqiNP_001162138.1. NM_001168667.1. [Q8VE88-2]
NP_001162139.1. NM_001168668.1. [Q8VE88-1]
NP_080618.1. NM_026342.3. [Q8VE88-2]
XP_006534079.1. XM_006534016.3. [Q8VE88-1]
XP_011247496.1. XM_011249194.2. [Q8VE88-1]
XP_011247497.1. XM_011249195.2. [Q8VE88-2]
UniGeneiMm.25632.

Genome annotation databases

EnsembliENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523. [Q8VE88-2]
ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523. [Q8VE88-1]
GeneIDi67726.
KEGGimmu:67726.
UCSCiuc007izt.2. mouse. [Q8VE88-1]
uc007izu.2. mouse. [Q8VE88-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018570 mRNA. Translation: BAB31282.1.
AK149763 mRNA. Translation: BAE29069.1.
AL672236 Genomic DNA. Translation: CAI24469.1.
AL672236 Genomic DNA. Translation: CAI24470.1.
BC019518 mRNA. Translation: AAH19518.1.
CCDSiCCDS24717.1. [Q8VE88-2]
CCDS48801.1. [Q8VE88-1]
RefSeqiNP_001162138.1. NM_001168667.1. [Q8VE88-2]
NP_001162139.1. NM_001168668.1. [Q8VE88-1]
NP_080618.1. NM_026342.3. [Q8VE88-2]
XP_006534079.1. XM_006534016.3. [Q8VE88-1]
XP_011247496.1. XM_011249194.2. [Q8VE88-1]
XP_011247497.1. XM_011249195.2. [Q8VE88-2]
UniGeneiMm.25632.

3D structure databases

ProteinModelPortaliQ8VE88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VE88. 1 interactor.
MINTiMINT-4392161.

PTM databases

iPTMnetiQ8VE88.
PhosphoSitePlusiQ8VE88.

Proteomic databases

PaxDbiQ8VE88.
PeptideAtlasiQ8VE88.
PRIDEiQ8VE88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523. [Q8VE88-2]
ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523. [Q8VE88-1]
GeneIDi67726.
KEGGimmu:67726.
UCSCiuc007izt.2. mouse. [Q8VE88-1]
uc007izu.2. mouse. [Q8VE88-2]

Organism-specific databases

CTDi10827.
MGIiMGI:1917629. Fam114a2.

Phylogenomic databases

eggNOGiENOG410IHQB. Eukaryota.
ENOG411029H. LUCA.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ8VE88.
OMAiNTAYEWI.
OrthoDBiEOG091G06FS.
PhylomeDBiQ8VE88.
TreeFamiTF324360.

Miscellaneous databases

PROiQ8VE88.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020523.
GenevisibleiQ8VE88. MM.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1142_MOUSE
AccessioniPrimary (citable) accession number: Q8VE88
Secondary accession number(s): Q3UE42, Q5QNR1, Q9D310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.