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Protein

Protein FAM114A2

Gene

Fam114a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM114A2
Gene namesi
Name:Fam114a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917629. Fam114a2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Protein FAM114A2PRO_0000274565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei205 – 2051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VE88.
PaxDbiQ8VE88.
PRIDEiQ8VE88.

PTM databases

PhosphoSiteiQ8VE88.

Expressioni

Gene expression databases

BgeeiQ8VE88.
GenevestigatoriQ8VE88.

Interactioni

Protein-protein interaction databases

IntActiQ8VE88. 1 interaction.
MINTiMINT-4392161.

Structurei

3D structure databases

ProteinModelPortaliQ8VE88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi293 – 2986Poly-Glu

Sequence similaritiesi

Belongs to the FAM114 family.Curated

Phylogenomic databases

eggNOGiNOG131151.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ8VE88.
OMAiSKDVPQT.
OrthoDBiEOG7P5T0T.
PhylomeDBiQ8VE88.
TreeFamiTF324360.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VE88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKDPPESP VVTGVASTLK DENCEPVEKP EDKSQPVVST RKRPETKPSS
60 70 80 90 100
DLEASALPAQ VSLAVAKETA SKDVPQTGWG YWGSWGKSLL SSASATVATV
110 120 130 140 150
GQGISNVIEK AETSLGIPSP TEISAEVKQA AGEKNAGENG SLLVAAPFGM
160 170 180 190 200
LSTISTAVQS TGKSVISGGL DALEFIGKKT MDVIAEGDPG FKRTKGLMNR
210 220 230 240 250
TSTLSQVLRE AKDKEEQRPS NEVTMETDKK THYGLLFDEF QGLSHLEALE
260 270 280 290 300
MLSRESEIKV KSILSSLSGE ELQTTRLELE QLKEVFSLAE FCEEEEEERQ
310 320 330 340 350
GDDNFTKEIT DLFAQLHVSS RPEKLARARN TAYKWIRTSL ARPVAEKEEG
360 370 380 390 400
EKESEAGNTE EAQKHSIEDI HAFAIRSLAE LTACSIELFH KTAALVLHGQ
410 420 430 440 450
KQEVTALERS QTLSQMTVML CKDLASLSKE FTTCLTTAGV REKADVLNPV
460 470 480 490
ITAVFLEASN SASYIQDAFQ LLLPVLQISL IESKTESSTC EPQSRDL
Length:497
Mass (Da):54,045
Last modified:February 6, 2007 - v2
Checksum:i9346964631460F6D
GO
Isoform 2 (identifier: Q8VE88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-67: Missing.

Show »
Length:490
Mass (Da):53,376
Checksum:iEFD0D0464955F95E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141G → E in AAH19518 (PubMed:15489334).Curated
Sequence conflicti304 – 3041N → D in AAH19518 (PubMed:15489334).Curated
Sequence conflicti318 – 3181V → I in AAH19518 (PubMed:15489334).Curated
Sequence conflicti438 – 4381A → V in AAH19518 (PubMed:15489334).Curated
Sequence conflicti488 – 4881S → P in BAE29069 (PubMed:16141072).Curated
Sequence conflicti494 – 4941S → P in AAH19518 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei61 – 677Missing in isoform 2. 1 PublicationVSP_022796

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018570 mRNA. Translation: BAB31282.1.
AK149763 mRNA. Translation: BAE29069.1.
AL672236 Genomic DNA. Translation: CAI24469.1.
AL672236 Genomic DNA. Translation: CAI24470.1.
BC019518 mRNA. Translation: AAH19518.1.
CCDSiCCDS24717.1. [Q8VE88-2]
CCDS48801.1. [Q8VE88-1]
RefSeqiNP_001162138.1. NM_001168667.1. [Q8VE88-2]
NP_001162139.1. NM_001168668.1. [Q8VE88-1]
NP_080618.1. NM_026342.3. [Q8VE88-2]
XP_006534079.1. XM_006534016.2. [Q8VE88-1]
UniGeneiMm.25632.

Genome annotation databases

EnsembliENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523. [Q8VE88-2]
ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523. [Q8VE88-1]
GeneIDi67726.
KEGGimmu:67726.
UCSCiuc007izt.2. mouse. [Q8VE88-1]
uc007izu.2. mouse. [Q8VE88-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018570 mRNA. Translation: BAB31282.1.
AK149763 mRNA. Translation: BAE29069.1.
AL672236 Genomic DNA. Translation: CAI24469.1.
AL672236 Genomic DNA. Translation: CAI24470.1.
BC019518 mRNA. Translation: AAH19518.1.
CCDSiCCDS24717.1. [Q8VE88-2]
CCDS48801.1. [Q8VE88-1]
RefSeqiNP_001162138.1. NM_001168667.1. [Q8VE88-2]
NP_001162139.1. NM_001168668.1. [Q8VE88-1]
NP_080618.1. NM_026342.3. [Q8VE88-2]
XP_006534079.1. XM_006534016.2. [Q8VE88-1]
UniGeneiMm.25632.

3D structure databases

ProteinModelPortaliQ8VE88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VE88. 1 interaction.
MINTiMINT-4392161.

PTM databases

PhosphoSiteiQ8VE88.

Proteomic databases

MaxQBiQ8VE88.
PaxDbiQ8VE88.
PRIDEiQ8VE88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523. [Q8VE88-2]
ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523. [Q8VE88-1]
GeneIDi67726.
KEGGimmu:67726.
UCSCiuc007izt.2. mouse. [Q8VE88-1]
uc007izu.2. mouse. [Q8VE88-2]

Organism-specific databases

CTDi10827.
MGIiMGI:1917629. Fam114a2.

Phylogenomic databases

eggNOGiNOG131151.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ8VE88.
OMAiSKDVPQT.
OrthoDBiEOG7P5T0T.
PhylomeDBiQ8VE88.
TreeFamiTF324360.

Miscellaneous databases

NextBioi325383.
PROiQ8VE88.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VE88.
GenevestigatoriQ8VE88.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow and Colon.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiF1142_MOUSE
AccessioniPrimary (citable) accession number: Q8VE88
Secondary accession number(s): Q3UE42, Q5QNR1, Q9D310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 1, 2015
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.