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Q8VE88

- F1142_MOUSE

UniProt

Q8VE88 - F1142_MOUSE

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Protein
Protein FAM114A2
Gene
Fam114a2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM114A2
Gene namesi
Name:Fam114a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1917629. Fam114a2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Protein FAM114A2
PRO_0000274565Add
BLAST

Proteomic databases

MaxQBiQ8VE88.
PaxDbiQ8VE88.
PRIDEiQ8VE88.

PTM databases

PhosphoSiteiQ8VE88.

Expressioni

Gene expression databases

BgeeiQ8VE88.
GenevestigatoriQ8VE88.

Interactioni

Protein-protein interaction databases

IntActiQ8VE88. 1 interaction.
MINTiMINT-4392161.

Structurei

3D structure databases

ProteinModelPortaliQ8VE88.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi293 – 2986Poly-Glu

Sequence similaritiesi

Belongs to the FAM114 family.

Phylogenomic databases

eggNOGiNOG131151.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ8VE88.
OMAiDVPQTGW.
OrthoDBiEOG7P5T0T.
PhylomeDBiQ8VE88.
TreeFamiTF324360.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VE88-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MSDKDPPESP VVTGVASTLK DENCEPVEKP EDKSQPVVST RKRPETKPSS    50
DLEASALPAQ VSLAVAKETA SKDVPQTGWG YWGSWGKSLL SSASATVATV 100
GQGISNVIEK AETSLGIPSP TEISAEVKQA AGEKNAGENG SLLVAAPFGM 150
LSTISTAVQS TGKSVISGGL DALEFIGKKT MDVIAEGDPG FKRTKGLMNR 200
TSTLSQVLRE AKDKEEQRPS NEVTMETDKK THYGLLFDEF QGLSHLEALE 250
MLSRESEIKV KSILSSLSGE ELQTTRLELE QLKEVFSLAE FCEEEEEERQ 300
GDDNFTKEIT DLFAQLHVSS RPEKLARARN TAYKWIRTSL ARPVAEKEEG 350
EKESEAGNTE EAQKHSIEDI HAFAIRSLAE LTACSIELFH KTAALVLHGQ 400
KQEVTALERS QTLSQMTVML CKDLASLSKE FTTCLTTAGV REKADVLNPV 450
ITAVFLEASN SASYIQDAFQ LLLPVLQISL IESKTESSTC EPQSRDL 497
Length:497
Mass (Da):54,045
Last modified:February 6, 2007 - v2
Checksum:i9346964631460F6D
GO
Isoform 2 (identifier: Q8VE88-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-67: Missing.

Show »
Length:490
Mass (Da):53,376
Checksum:iEFD0D0464955F95E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei61 – 677Missing in isoform 2.
VSP_022796

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141G → E in AAH19518. 1 Publication
Sequence conflicti304 – 3041N → D in AAH19518. 1 Publication
Sequence conflicti318 – 3181V → I in AAH19518. 1 Publication
Sequence conflicti438 – 4381A → V in AAH19518. 1 Publication
Sequence conflicti488 – 4881S → P in BAE29069. 1 Publication
Sequence conflicti494 – 4941S → P in AAH19518. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK018570 mRNA. Translation: BAB31282.1.
AK149763 mRNA. Translation: BAE29069.1.
AL672236 Genomic DNA. Translation: CAI24469.1.
AL672236 Genomic DNA. Translation: CAI24470.1.
BC019518 mRNA. Translation: AAH19518.1.
CCDSiCCDS24717.1. [Q8VE88-2]
CCDS48801.1. [Q8VE88-1]
RefSeqiNP_001162138.1. NM_001168667.1. [Q8VE88-2]
NP_001162139.1. NM_001168668.1. [Q8VE88-1]
NP_080618.1. NM_026342.3. [Q8VE88-2]
XP_006534079.1. XM_006534016.1. [Q8VE88-1]
UniGeneiMm.25632.

Genome annotation databases

EnsembliENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523. [Q8VE88-2]
ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523. [Q8VE88-1]
GeneIDi67726.
KEGGimmu:67726.
UCSCiuc007izt.2. mouse. [Q8VE88-1]
uc007izu.2. mouse. [Q8VE88-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK018570 mRNA. Translation: BAB31282.1 .
AK149763 mRNA. Translation: BAE29069.1 .
AL672236 Genomic DNA. Translation: CAI24469.1 .
AL672236 Genomic DNA. Translation: CAI24470.1 .
BC019518 mRNA. Translation: AAH19518.1 .
CCDSi CCDS24717.1. [Q8VE88-2 ]
CCDS48801.1. [Q8VE88-1 ]
RefSeqi NP_001162138.1. NM_001168667.1. [Q8VE88-2 ]
NP_001162139.1. NM_001168668.1. [Q8VE88-1 ]
NP_080618.1. NM_026342.3. [Q8VE88-2 ]
XP_006534079.1. XM_006534016.1. [Q8VE88-1 ]
UniGenei Mm.25632.

3D structure databases

ProteinModelPortali Q8VE88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8VE88. 1 interaction.
MINTi MINT-4392161.

PTM databases

PhosphoSitei Q8VE88.

Proteomic databases

MaxQBi Q8VE88.
PaxDbi Q8VE88.
PRIDEi Q8VE88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020831 ; ENSMUSP00000020831 ; ENSMUSG00000020523 . [Q8VE88-2 ]
ENSMUST00000108850 ; ENSMUSP00000104478 ; ENSMUSG00000020523 . [Q8VE88-1 ]
GeneIDi 67726.
KEGGi mmu:67726.
UCSCi uc007izt.2. mouse. [Q8VE88-1 ]
uc007izu.2. mouse. [Q8VE88-2 ]

Organism-specific databases

CTDi 10827.
MGIi MGI:1917629. Fam114a2.

Phylogenomic databases

eggNOGi NOG131151.
GeneTreei ENSGT00390000010054.
HOGENOMi HOG000059573.
HOVERGENi HBG056879.
InParanoidi Q8VE88.
OMAi DVPQTGW.
OrthoDBi EOG7P5T0T.
PhylomeDBi Q8VE88.
TreeFami TF324360.

Miscellaneous databases

NextBioi 325383.
PROi Q8VE88.
SOURCEi Search...

Gene expression databases

Bgeei Q8VE88.
Genevestigatori Q8VE88.

Family and domain databases

InterProi IPR007998. DUF719.
[Graphical view ]
PANTHERi PTHR12842. PTHR12842. 1 hit.
Pfami PF05334. DUF719. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow and Colon.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiF1142_MOUSE
AccessioniPrimary (citable) accession number: Q8VE88
Secondary accession number(s): Q3UE42, Q5QNR1, Q9D310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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