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Q8VE88

- F1142_MOUSE

UniProt

Q8VE88 - F1142_MOUSE

Protein

Protein FAM114A2

Gene

Fam114a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM114A2
    Gene namesi
    Name:Fam114a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1917629. Fam114a2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Protein FAM114A2PRO_0000274565Add
    BLAST

    Proteomic databases

    MaxQBiQ8VE88.
    PaxDbiQ8VE88.
    PRIDEiQ8VE88.

    PTM databases

    PhosphoSiteiQ8VE88.

    Expressioni

    Gene expression databases

    BgeeiQ8VE88.
    GenevestigatoriQ8VE88.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8VE88. 1 interaction.
    MINTiMINT-4392161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VE88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi293 – 2986Poly-Glu

    Sequence similaritiesi

    Belongs to the FAM114 family.Curated

    Phylogenomic databases

    eggNOGiNOG131151.
    GeneTreeiENSGT00390000010054.
    HOGENOMiHOG000059573.
    HOVERGENiHBG056879.
    InParanoidiQ8VE88.
    OMAiDVPQTGW.
    OrthoDBiEOG7P5T0T.
    PhylomeDBiQ8VE88.
    TreeFamiTF324360.

    Family and domain databases

    InterProiIPR007998. DUF719.
    [Graphical view]
    PANTHERiPTHR12842. PTHR12842. 1 hit.
    PfamiPF05334. DUF719. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VE88-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDKDPPESP VVTGVASTLK DENCEPVEKP EDKSQPVVST RKRPETKPSS    50
    DLEASALPAQ VSLAVAKETA SKDVPQTGWG YWGSWGKSLL SSASATVATV 100
    GQGISNVIEK AETSLGIPSP TEISAEVKQA AGEKNAGENG SLLVAAPFGM 150
    LSTISTAVQS TGKSVISGGL DALEFIGKKT MDVIAEGDPG FKRTKGLMNR 200
    TSTLSQVLRE AKDKEEQRPS NEVTMETDKK THYGLLFDEF QGLSHLEALE 250
    MLSRESEIKV KSILSSLSGE ELQTTRLELE QLKEVFSLAE FCEEEEEERQ 300
    GDDNFTKEIT DLFAQLHVSS RPEKLARARN TAYKWIRTSL ARPVAEKEEG 350
    EKESEAGNTE EAQKHSIEDI HAFAIRSLAE LTACSIELFH KTAALVLHGQ 400
    KQEVTALERS QTLSQMTVML CKDLASLSKE FTTCLTTAGV REKADVLNPV 450
    ITAVFLEASN SASYIQDAFQ LLLPVLQISL IESKTESSTC EPQSRDL 497
    Length:497
    Mass (Da):54,045
    Last modified:February 6, 2007 - v2
    Checksum:i9346964631460F6D
    GO
    Isoform 2 (identifier: Q8VE88-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         61-67: Missing.

    Show »
    Length:490
    Mass (Da):53,376
    Checksum:iEFD0D0464955F95E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141G → E in AAH19518. (PubMed:15489334)Curated
    Sequence conflicti304 – 3041N → D in AAH19518. (PubMed:15489334)Curated
    Sequence conflicti318 – 3181V → I in AAH19518. (PubMed:15489334)Curated
    Sequence conflicti438 – 4381A → V in AAH19518. (PubMed:15489334)Curated
    Sequence conflicti488 – 4881S → P in BAE29069. (PubMed:16141072)Curated
    Sequence conflicti494 – 4941S → P in AAH19518. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei61 – 677Missing in isoform 2. 1 PublicationVSP_022796

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018570 mRNA. Translation: BAB31282.1.
    AK149763 mRNA. Translation: BAE29069.1.
    AL672236 Genomic DNA. Translation: CAI24469.1.
    AL672236 Genomic DNA. Translation: CAI24470.1.
    BC019518 mRNA. Translation: AAH19518.1.
    CCDSiCCDS24717.1. [Q8VE88-2]
    CCDS48801.1. [Q8VE88-1]
    RefSeqiNP_001162138.1. NM_001168667.1. [Q8VE88-2]
    NP_001162139.1. NM_001168668.1. [Q8VE88-1]
    NP_080618.1. NM_026342.3. [Q8VE88-2]
    XP_006534079.1. XM_006534016.1. [Q8VE88-1]
    UniGeneiMm.25632.

    Genome annotation databases

    EnsembliENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523. [Q8VE88-2]
    ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523. [Q8VE88-1]
    GeneIDi67726.
    KEGGimmu:67726.
    UCSCiuc007izt.2. mouse. [Q8VE88-1]
    uc007izu.2. mouse. [Q8VE88-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018570 mRNA. Translation: BAB31282.1 .
    AK149763 mRNA. Translation: BAE29069.1 .
    AL672236 Genomic DNA. Translation: CAI24469.1 .
    AL672236 Genomic DNA. Translation: CAI24470.1 .
    BC019518 mRNA. Translation: AAH19518.1 .
    CCDSi CCDS24717.1. [Q8VE88-2 ]
    CCDS48801.1. [Q8VE88-1 ]
    RefSeqi NP_001162138.1. NM_001168667.1. [Q8VE88-2 ]
    NP_001162139.1. NM_001168668.1. [Q8VE88-1 ]
    NP_080618.1. NM_026342.3. [Q8VE88-2 ]
    XP_006534079.1. XM_006534016.1. [Q8VE88-1 ]
    UniGenei Mm.25632.

    3D structure databases

    ProteinModelPortali Q8VE88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8VE88. 1 interaction.
    MINTi MINT-4392161.

    PTM databases

    PhosphoSitei Q8VE88.

    Proteomic databases

    MaxQBi Q8VE88.
    PaxDbi Q8VE88.
    PRIDEi Q8VE88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020831 ; ENSMUSP00000020831 ; ENSMUSG00000020523 . [Q8VE88-2 ]
    ENSMUST00000108850 ; ENSMUSP00000104478 ; ENSMUSG00000020523 . [Q8VE88-1 ]
    GeneIDi 67726.
    KEGGi mmu:67726.
    UCSCi uc007izt.2. mouse. [Q8VE88-1 ]
    uc007izu.2. mouse. [Q8VE88-2 ]

    Organism-specific databases

    CTDi 10827.
    MGIi MGI:1917629. Fam114a2.

    Phylogenomic databases

    eggNOGi NOG131151.
    GeneTreei ENSGT00390000010054.
    HOGENOMi HOG000059573.
    HOVERGENi HBG056879.
    InParanoidi Q8VE88.
    OMAi DVPQTGW.
    OrthoDBi EOG7P5T0T.
    PhylomeDBi Q8VE88.
    TreeFami TF324360.

    Miscellaneous databases

    NextBioi 325383.
    PROi Q8VE88.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VE88.
    Genevestigatori Q8VE88.

    Family and domain databases

    InterProi IPR007998. DUF719.
    [Graphical view ]
    PANTHERi PTHR12842. PTHR12842. 1 hit.
    Pfami PF05334. DUF719. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Bone marrow and Colon.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiF1142_MOUSE
    AccessioniPrimary (citable) accession number: Q8VE88
    Secondary accession number(s): Q3UE42, Q5QNR1, Q9D310
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3