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Q8VE88 (F1142_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM114A2
Gene names
Name:Fam114a2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM114 family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8VE88-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8VE88-2)

The sequence of this isoform differs from the canonical sequence as follows:
     61-67: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Protein FAM114A2
PRO_0000274565

Regions

Compositional bias293 – 2986Poly-Glu

Natural variations

Alternative sequence61 – 677Missing in isoform 2.
VSP_022796

Experimental info

Sequence conflict141G → E in AAH19518. Ref.3
Sequence conflict3041N → D in AAH19518. Ref.3
Sequence conflict3181V → I in AAH19518. Ref.3
Sequence conflict4381A → V in AAH19518. Ref.3
Sequence conflict4881S → P in BAE29069. Ref.1
Sequence conflict4941S → P in AAH19518. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2007. Version 2.
Checksum: 9346964631460F6D

FASTA49754,045
        10         20         30         40         50         60 
MSDKDPPESP VVTGVASTLK DENCEPVEKP EDKSQPVVST RKRPETKPSS DLEASALPAQ 

        70         80         90        100        110        120 
VSLAVAKETA SKDVPQTGWG YWGSWGKSLL SSASATVATV GQGISNVIEK AETSLGIPSP 

       130        140        150        160        170        180 
TEISAEVKQA AGEKNAGENG SLLVAAPFGM LSTISTAVQS TGKSVISGGL DALEFIGKKT 

       190        200        210        220        230        240 
MDVIAEGDPG FKRTKGLMNR TSTLSQVLRE AKDKEEQRPS NEVTMETDKK THYGLLFDEF 

       250        260        270        280        290        300 
QGLSHLEALE MLSRESEIKV KSILSSLSGE ELQTTRLELE QLKEVFSLAE FCEEEEEERQ 

       310        320        330        340        350        360 
GDDNFTKEIT DLFAQLHVSS RPEKLARARN TAYKWIRTSL ARPVAEKEEG EKESEAGNTE 

       370        380        390        400        410        420 
EAQKHSIEDI HAFAIRSLAE LTACSIELFH KTAALVLHGQ KQEVTALERS QTLSQMTVML 

       430        440        450        460        470        480 
CKDLASLSKE FTTCLTTAGV REKADVLNPV ITAVFLEASN SASYIQDAFQ LLLPVLQISL 

       490 
IESKTESSTC EPQSRDL 

« Hide

Isoform 2 [UniParc].

Checksum: EFD0D0464955F95E
Show »

FASTA49053,376

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Bone marrow and Colon.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK018570 mRNA. Translation: BAB31282.1.
AK149763 mRNA. Translation: BAE29069.1.
AL672236 Genomic DNA. Translation: CAI24469.1.
AL672236 Genomic DNA. Translation: CAI24470.1.
BC019518 mRNA. Translation: AAH19518.1.
CCDSCCDS24717.1. [Q8VE88-2]
CCDS48801.1. [Q8VE88-1]
RefSeqNP_001162138.1. NM_001168667.1. [Q8VE88-2]
NP_001162139.1. NM_001168668.1. [Q8VE88-1]
NP_080618.1. NM_026342.3. [Q8VE88-2]
XP_006534079.1. XM_006534016.1. [Q8VE88-1]
UniGeneMm.25632.

3D structure databases

ProteinModelPortalQ8VE88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8VE88. 1 interaction.
MINTMINT-4392161.

PTM databases

PhosphoSiteQ8VE88.

Proteomic databases

MaxQBQ8VE88.
PaxDbQ8VE88.
PRIDEQ8VE88.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523. [Q8VE88-2]
ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523. [Q8VE88-1]
GeneID67726.
KEGGmmu:67726.
UCSCuc007izt.2. mouse. [Q8VE88-1]
uc007izu.2. mouse. [Q8VE88-2]

Organism-specific databases

CTD10827.
MGIMGI:1917629. Fam114a2.

Phylogenomic databases

eggNOGNOG131151.
GeneTreeENSGT00390000010054.
HOGENOMHOG000059573.
HOVERGENHBG056879.
InParanoidQ8VE88.
OMADVPQTGW.
OrthoDBEOG7P5T0T.
PhylomeDBQ8VE88.
TreeFamTF324360.

Gene expression databases

BgeeQ8VE88.
GenevestigatorQ8VE88.

Family and domain databases

InterProIPR007998. DUF719.
[Graphical view]
PANTHERPTHR12842. PTHR12842. 1 hit.
PfamPF05334. DUF719. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio325383.
PROQ8VE88.
SOURCESearch...

Entry information

Entry nameF1142_MOUSE
AccessionPrimary (citable) accession number: Q8VE88
Secondary accession number(s): Q3UE42, Q5QNR1, Q9D310
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot