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Q8VE73

- CUL7_MOUSE

UniProt

Q8VE73 - CUL7_MOUSE

Protein

Cullin-7

Gene

Cul7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1. Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation. Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development. Does not promote polyubiquitination and proteasomal degradation of p53/TP53. While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions By similarity. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation.By similarity1 Publication

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. epithelial to mesenchymal transition Source: UniProtKB
    2. Golgi organization Source: UniProtKB
    3. microtubule cytoskeleton organization Source: UniProtKB
    4. mitotic cytokinesis Source: UniProtKB
    5. placenta development Source: UniProtKB
    6. positive regulation of dendrite morphogenesis Source: UniProtKB
    7. protein ubiquitination Source: UniProtKB
    8. regulation of endothelial cell differentiation Source: UniProtKB
    9. regulation of mitosis Source: UniProtKB
    10. ubiquitin-dependent protein catabolic process Source: InterPro
    11. vasculogenesis Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cullin-7
    Short name:
    CUL-7
    Alternative name(s):
    p185
    p193
    Gene namesi
    Name:Cul7
    Synonyms:Kiaa0076
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1913765. Cul7.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmperinuclear region By similarity. Golgi apparatus By similarity
    Note: Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus. CCDC8 is required for centrosomal location By similarity.By similarity

    GO - Cellular componenti

    1. 3M complex Source: UniProtKB
    2. centrosome Source: UniProtKB
    3. Cul7-RING ubiquitin ligase complex Source: UniProtKB
    4. cytoplasm Source: UniProtKB
    5. Golgi apparatus Source: UniProtKB
    6. intracellular Source: UniProtKB
    7. nucleus Source: Ensembl
    8. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Golgi apparatus

    Pathology & Biotechi

    Disruption phenotypei

    Mice are neonatal lethal and show vascular defects in both the embryo and the placenta.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16891689Cullin-7PRO_0000119803Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki1567 – 1567Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)Sequence Analysis

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ8VE73.
    PaxDbiQ8VE73.
    PRIDEiQ8VE73.

    PTM databases

    PhosphoSiteiQ8VE73.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VE73.
    BgeeiQ8VE73.
    CleanExiMM_CUL7.
    GenevestigatoriQ8VE73.

    Interactioni

    Subunit structurei

    Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Part of a Cul7-RING complex consisting of CUL7, RBX1, SKP1 and FBXW8. Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone. Interacts with CUL9; leading to inhibit CUL9 activity. Interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or p53/TP53. Interacts with p53/TP53; the interaction preferentially involves tetrameric and dimeric p53/TP53. The CUL7-CUL9 heterodimer seems to interact specifically with p53/TP53. Interacts with OBSL1 By similarity. Interacts with CUL1; the interactions seems to be mediated by FBXW8.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi211530. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VE73.
    SMRiQ8VE73. Positions 349-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini793 – 972180DOCPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni349 – 449101Interaction with TP53By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1308 – 137063Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cullin family.PROSITE-ProRule annotation
    Contains 1 DOC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG48148.
    GeneTreeiENSGT00700000104406.
    HOVERGENiHBG103792.
    InParanoidiQ8VE73.
    KOiK10613.
    OMAiTFEHYYQ.
    OrthoDBiEOG70S74H.
    PhylomeDBiQ8VE73.
    TreeFamiTF101154.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.25.10.10. 3 hits.
    2.30.30.30. 1 hit.
    2.60.120.260. 1 hit.
    InterProiIPR004939. APC_su10/DOC_dom.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR021097. CPH_domain.
    IPR016157. Cullin_CS.
    IPR016158. Cullin_homology.
    IPR001373. Cullin_N.
    IPR008979. Galactose-bd-like.
    IPR014722. Rib_L2_dom2.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF03256. APC10. 1 hit.
    PF11515. Cul7. 1 hit.
    PF00888. Cullin. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF75632. SSF75632. 2 hits.
    PROSITEiPS01256. CULLIN_1. 1 hit.
    PS50069. CULLIN_2. 1 hit.
    PS51284. DOC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VE73-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVGELRYREF RVPLGPGLHA YPDELIRQRV GHNGHPEYQI RWLILRRGDD     50
    GDRDSTVDCK AEHILLWMSD DEIYANCHKM LGENGQVIAP SRESTEAGAL 100
    DKSVLGEMET DVKSLIQRAL RQLEECVGTV PPAPLLHTVH VLSAYASIEP 150
    LTGIFKDRRV VNLLMHMLSS PDYQIRWSAG RMIQALSSHD AGTRTQILLS 200
    LSQQEAIEKH LDFDSRCALL ALFAQATLTE HPMSFEGVQL PQVPGRLLFS 250
    LVKRYLHVTF LLDRLNGDAG DQGAQNNFIP EELNVGRGRL ELEFSMAMGT 300
    LISELVQAMR WDGASSRPES SSSSTFQPRP AQFRPYTQRF RRSRRFRPRA 350
    SFASFNTYAL YVRDTLRPGM RVRMLENYEE IAAGDEGQFR QSNDGVPPAQ 400
    VLWDSTGHTY WVHWHMLEIL GFEEDIEDVI DIEELQELGA NGALSIVPPS 450
    QRWKPITQLF AEPYVVPEEE DREESENLTQ AEWWELLFFI RQLSEAERLH 500
    IVDLLQDHLE EERVLDYDML PELTVPVDLA QDLLLSLPQQ LEDSALRDLF 550
    SCSVYRKYGP EVLVGHLSYP FVPGAQPNLF GANEESEAKD PPLQSASPAL 600
    QRLVESLGPE GEVLVELEQA LGSEAPQETE VKSCLLQLQE QPQPFLALMR 650
    SLDTSASNKT LHLTVLRILM QLVNFPEALL LPWHEAMDAC VTCLRSPNTD 700
    REVLQELIFF LHRLTTTSRD YAVILNQLGA RDAISKVLEK HRGKLELAQE 750
    LRDMVSKCEK HAHLYRKLTT NILGGCIQMV LGQIEDHRRT HRPIQIPFFD 800
    VFLRYLCQGS SEEMKKNRYW EKVEVSSNPQ RASRLTDRNP KTYWESSGRA 850
    GSHFITLHMR PGVIIRQLTL LVAGEDSSYM PAWVVVCGGN SIKSVNKELN 900
    TVNVMPSASR VTLLENLTRF WPIIQIRIKR CQQGGINTRI RGLEVLGPKP 950
    TFWPVFREQL CRHTRLFYMV RAQAWSQDIA EDRRSLLHLS SRLNGALRHE 1000
    QNFAERFLPD MEAAQALSKT CWEALVSPLV QNITSPDEDS TSSLGWLLDQ 1050
    YLGCREAAYN PQSRAAAFSS RVRRLTHLLV HVEPREAAPP VVAIPRSKGR 1100
    NRIHDWSYLI TRGLPSSIMK NLTRCWRSVV EEQMNKFLTA SWKDDDFVPR 1150
    YCERYYVLQK SSSELFGPRA AFLLAMRNGC ADAVLRLPFL RAAHVSEQFA 1200
    RHIDQRIQGS RMGGARGMEM LAQLQRCLES VLIFSPLEIA TTFEHYYQHY 1250
    MADRLLSVGS SWLEGAVLEQ IGPCFPSRLP QQMLQSLNVS EELQRQFHVY 1300
    QLQQLDQELL KLEDTEKKIQ VAHEDSGRED KSKKEEAIGE AAAVAMAEEE 1350
    DQGKKEEGEE EGEGEDEEEE RYYKGTMPEV CVLVVTPRFW PVASVCQMLN 1400
    PATCLPAYLR GTINHYTNFY SKSQSRSSLE KEPQRRLQWT WQGRAEVQFG 1450
    GQILHVSTVQ MWLLLHLNNQ KEVSVESLQA ISELPPDVLH RAIGPLTSSR 1500
    GPLDLQEQKN VPGGVLKIRD DSEEPRPRRG NVWLIPPQTY LQAEAEEGRN 1550
    MEKRRNLLNC LVVRILKAHG DEGLHVDRLV YLVLEAWEKG PCPARGLVSS 1600
    LGRGATCRSS DVLSCILHLL VKGTLRRHDD RPQVLYYAVP VTVMEPHMES 1650
    LNPGSAGPNP PLTFHTLQIR SRGVPYASCT DNHTFSTFR 1689
    Length:1,689
    Mass (Da):192,292
    Last modified:January 9, 2007 - v2
    Checksum:i6ED4641B577E53CD
    GO
    Isoform 2 (identifier: Q8VE73-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1472-1472: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,688
    Mass (Da):192,163
    Checksum:i8AD13BBC66EAA8A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti395 – 3951G → V in BAE27723. (PubMed:16141072)Curated
    Sequence conflicti518 – 5181D → E in BAD32160. (PubMed:15368895)Curated
    Sequence conflicti777 – 7793IQM → DAW in AAH19645. (PubMed:15489334)Curated
    Sequence conflicti855 – 92268Missing in AAH59865. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti888 – 8881G → R in BAE27723. (PubMed:16141072)Curated
    Sequence conflicti959 – 9591Q → E in AAH59865. (PubMed:15489334)Curated
    Sequence conflicti1482 – 14821S → L in BAB25811. (PubMed:16141072)Curated
    Sequence conflicti1495 – 14951P → L in BAB25811. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1472 – 14721Missing in isoform 2. 1 PublicationVSP_038331

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008655 mRNA. Translation: BAB25811.1.
    AK147156 mRNA. Translation: BAE27723.1.
    CT030702 Genomic DNA. No translation available.
    BC019645 mRNA. Translation: AAH19645.1.
    BC026946 mRNA. Translation: AAH26946.2.
    BC059865 mRNA. Translation: AAH59865.1.
    BC100544 mRNA. Translation: AAI00545.1.
    AK172882 mRNA. Translation: BAD32160.1.
    CCDSiCCDS28833.1. [Q8VE73-1]
    RefSeqiNP_079887.3. NM_025611.5. [Q8VE73-1]
    UniGeneiMm.329078.

    Genome annotation databases

    EnsembliENSMUST00000043464; ENSMUSP00000049128; ENSMUSG00000038545. [Q8VE73-1]
    GeneIDi66515.
    KEGGimmu:66515.
    UCSCiuc008ctp.1. mouse. [Q8VE73-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008655 mRNA. Translation: BAB25811.1 .
    AK147156 mRNA. Translation: BAE27723.1 .
    CT030702 Genomic DNA. No translation available.
    BC019645 mRNA. Translation: AAH19645.1 .
    BC026946 mRNA. Translation: AAH26946.2 .
    BC059865 mRNA. Translation: AAH59865.1 .
    BC100544 mRNA. Translation: AAI00545.1 .
    AK172882 mRNA. Translation: BAD32160.1 .
    CCDSi CCDS28833.1. [Q8VE73-1 ]
    RefSeqi NP_079887.3. NM_025611.5. [Q8VE73-1 ]
    UniGenei Mm.329078.

    3D structure databases

    ProteinModelPortali Q8VE73.
    SMRi Q8VE73. Positions 349-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211530. 6 interactions.

    PTM databases

    PhosphoSitei Q8VE73.

    Proteomic databases

    MaxQBi Q8VE73.
    PaxDbi Q8VE73.
    PRIDEi Q8VE73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043464 ; ENSMUSP00000049128 ; ENSMUSG00000038545 . [Q8VE73-1 ]
    GeneIDi 66515.
    KEGGi mmu:66515.
    UCSCi uc008ctp.1. mouse. [Q8VE73-1 ]

    Organism-specific databases

    CTDi 9820.
    MGIi MGI:1913765. Cul7.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG48148.
    GeneTreei ENSGT00700000104406.
    HOVERGENi HBG103792.
    InParanoidi Q8VE73.
    KOi K10613.
    OMAi TFEHYYQ.
    OrthoDBi EOG70S74H.
    PhylomeDBi Q8VE73.
    TreeFami TF101154.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi CUL7. mouse.
    NextBioi 321916.
    PROi Q8VE73.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VE73.
    Bgeei Q8VE73.
    CleanExi MM_CUL7.
    Genevestigatori Q8VE73.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.25.10.10. 3 hits.
    2.30.30.30. 1 hit.
    2.60.120.260. 1 hit.
    InterProi IPR004939. APC_su10/DOC_dom.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR021097. CPH_domain.
    IPR016157. Cullin_CS.
    IPR016158. Cullin_homology.
    IPR001373. Cullin_N.
    IPR008979. Galactose-bd-like.
    IPR014722. Rib_L2_dom2.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF03256. APC10. 1 hit.
    PF11515. Cul7. 1 hit.
    PF00888. Cullin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF75632. SSF75632. 2 hits.
    PROSITEi PS01256. CULLIN_1. 1 hit.
    PS50069. CULLIN_2. 1 hit.
    PS51284. DOC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Stomach.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 299-1689 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 777-1689 (ISOFORM 1).
      Strain: C57BL/6 and Czech II.
      Tissue: Brain, Jaw, Limb and Mammary gland.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-1689 (ISOFORM 1).
      Tissue: Fetal brain.
    5. "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis."
      Arai T., Kasper J.S., Skaar J.R., Ali S.H., Takahashi C., DeCaprio J.A.
      Proc. Natl. Acad. Sci. U.S.A. 100:9855-9860(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development."
      Tsunematsu R., Nishiyama M., Kotoshiba S., Saiga T., Kamura T., Nakayama K.I.
      Mol. Cell. Biol. 26:6157-6169(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CUL1 AND FBXW8.

    Entry informationi

    Entry nameiCUL7_MOUSE
    AccessioniPrimary (citable) accession number: Q8VE73
    Secondary accession number(s): Q3UHY3
    , Q497I2, Q6A0D6, Q6PB63, Q8R3W4, Q9CVD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3