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Q8VE65

- TAF12_MOUSE

UniProt

Q8VE65 - TAF12_MOUSE

Protein

Transcription initiation factor TFIID subunit 12

Gene

Taf12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. histone acetyltransferase activity Source: Ensembl
    3. protein binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: Ensembl
    5. transcription coactivator activity Source: Ensembl

    GO - Biological processi

    1. histone H3 acetylation Source: Ensembl
    2. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. transcription initiation from RNA polymerase II promoter Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor TFIID subunit 12
    Alternative name(s):
    Transcription initiation factor TFIID 20 kDa subunits
    Short name:
    TAFII-20
    Short name:
    TAFII20
    Gene namesi
    Name:Taf12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1913714. Taf12.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. PCAF complex Source: Ensembl
    3. STAGA complex Source: MGI
    4. transcription factor TFIID complex Source: MGI
    5. transcription factor TFTC complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Transcription initiation factor TFIID subunit 12PRO_0000118908Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431PhosphothreonineBy similarity
    Modified residuei51 – 511Phosphoserine2 Publications
    Modified residuei59 – 591PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8VE65.
    PRIDEiQ8VE65.

    PTM databases

    PhosphoSiteiQ8VE65.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VE65.
    BgeeiQ8VE65.
    GenevestigatoriQ8VE65.

    Interactioni

    Subunit structurei

    TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts with ATF7 (via its transactivation domain); the interaction promotes the transactivation of ATF7 and is prevented by sumoylation of ATF7 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-29178N.
    IntActiQ8VE65. 3 interactions.
    MINTiMINT-4136826.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VE65.
    SMRiQ8VE65. Positions 55-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TAF12 family.Curated
    Contains 1 histone-fold domain.Curated

    Phylogenomic databases

    eggNOGiCOG5624.
    GeneTreeiENSGT00390000002144.
    HOVERGENiHBG055174.
    InParanoidiQ8VE65.
    KOiK03126.
    OrthoDBiEOG769ZMW.
    PhylomeDBiQ8VE65.
    TreeFamiTF323652.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR003228. TFIID_sub.
    [Graphical view]
    PfamiPF03847. TFIID_20kDa. 1 hit.
    [Graphical view]
    ProDomiPD012998. PD012998. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47113. SSF47113. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8VE65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQFGPSALI NLSSFSSVKP EPASTPPQGS MANSTTVGKI AGTPGTGGRL    50
    SPENNQVLTK KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC 100
    QLARHRKSST LEVKDVQLHL ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ 150
    RMALIRKTTK K 161
    Length:161
    Mass (Da):17,875
    Last modified:March 1, 2002 - v1
    Checksum:iB3C11D70B6E94E35
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771D → G in BAB28669. (PubMed:16141072)Curated
    Sequence conflicti126 – 1261M → I in BAB28669. (PubMed:16141072)Curated
    Sequence conflicti157 – 1571K → N in BAB25276. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007811 mRNA. Translation: BAB25276.1.
    AK013133 mRNA. Translation: BAB28669.1.
    AK132927 mRNA. Translation: BAE21426.1.
    BC019668 mRNA. Translation: AAH19668.1.
    CCDSiCCDS18721.1.
    RefSeqiNP_079855.2. NM_025579.3.
    XP_006539172.1. XM_006539109.1.
    XP_006539173.1. XM_006539110.1.
    UniGeneiMm.331926.

    Genome annotation databases

    EnsembliENSMUST00000030731; ENSMUSP00000030731; ENSMUSG00000028899.
    GeneIDi66464.
    KEGGimmu:66464.
    UCSCiuc008vax.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007811 mRNA. Translation: BAB25276.1 .
    AK013133 mRNA. Translation: BAB28669.1 .
    AK132927 mRNA. Translation: BAE21426.1 .
    BC019668 mRNA. Translation: AAH19668.1 .
    CCDSi CCDS18721.1.
    RefSeqi NP_079855.2. NM_025579.3.
    XP_006539172.1. XM_006539109.1.
    XP_006539173.1. XM_006539110.1.
    UniGenei Mm.331926.

    3D structure databases

    ProteinModelPortali Q8VE65.
    SMRi Q8VE65. Positions 55-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29178N.
    IntActi Q8VE65. 3 interactions.
    MINTi MINT-4136826.

    PTM databases

    PhosphoSitei Q8VE65.

    Proteomic databases

    PaxDbi Q8VE65.
    PRIDEi Q8VE65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030731 ; ENSMUSP00000030731 ; ENSMUSG00000028899 .
    GeneIDi 66464.
    KEGGi mmu:66464.
    UCSCi uc008vax.3. mouse.

    Organism-specific databases

    CTDi 6883.
    MGIi MGI:1913714. Taf12.

    Phylogenomic databases

    eggNOGi COG5624.
    GeneTreei ENSGT00390000002144.
    HOVERGENi HBG055174.
    InParanoidi Q8VE65.
    KOi K03126.
    OrthoDBi EOG769ZMW.
    PhylomeDBi Q8VE65.
    TreeFami TF323652.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 321768.
    PROi Q8VE65.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VE65.
    Bgeei Q8VE65.
    Genevestigatori Q8VE65.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR003228. TFIID_sub.
    [Graphical view ]
    Pfami PF03847. TFIID_20kDa. 1 hit.
    [Graphical view ]
    ProDomi PD012998. PD012998. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Pancreas and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiTAF12_MOUSE
    AccessioniPrimary (citable) accession number: Q8VE65
    Secondary accession number(s): Q3V0S7, Q9CZ11, Q9D8Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3