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Protein

Transcription initiation factor TFIID subunit 12

Gene

Taf12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 12
Alternative name(s):
Transcription initiation factor TFIID 20 kDa subunits
Short name:
TAFII-20
Short name:
TAFII20
Gene namesi
Name:Taf12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913714. Taf12.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
  • SAGA complex Source: GO_Central
  • STAGA complex Source: MGI
  • transcription factor TFIID complex Source: MGI
  • transcription factor TFTC complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189081 – 161Transcription initiation factor TFIID subunit 12Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphothreonineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei59PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VE65.
PaxDbiQ8VE65.
PeptideAtlasiQ8VE65.
PRIDEiQ8VE65.

PTM databases

iPTMnetiQ8VE65.
PhosphoSitePlusiQ8VE65.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028899.
ExpressionAtlasiQ8VE65. baseline and differential.
GenevisibleiQ8VE65. MM.

Interactioni

Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts with ATF7 (via its transactivation domain); the interaction promotes the transactivation of ATF7 and is prevented by sumoylation of ATF7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29178N.
IntActiQ8VE65. 3 interactors.
MINTiMINT-4136826.
STRINGi10090.ENSMUSP00000030731.

Structurei

3D structure databases

ProteinModelPortaliQ8VE65.
SMRiQ8VE65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF12 family.Curated
Contains 1 histone-fold domain.Curated

Phylogenomic databases

eggNOGiKOG1142. Eukaryota.
COG5624. LUCA.
GeneTreeiENSGT00390000002144.
HOVERGENiHBG055174.
InParanoidiQ8VE65.
KOiK03126.
PhylomeDBiQ8VE65.
TreeFamiTF323652.

Family and domain databases

CDDicd07981. TAF12. 1 hit.
Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003228. TFIID_TAF12.
[Graphical view]
PfamiPF03847. TFIID_20kDa. 1 hit.
[Graphical view]
ProDomiPD012998. PD012998. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VE65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQFGPSALI NLSSFSSVKP EPASTPPQGS MANSTTVGKI AGTPGTGGRL
60 70 80 90 100
SPENNQVLTK KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC
110 120 130 140 150
QLARHRKSST LEVKDVQLHL ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ
160
RMALIRKTTK K
Length:161
Mass (Da):17,875
Last modified:March 1, 2002 - v1
Checksum:iB3C11D70B6E94E35
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77D → G in BAB28669 (PubMed:16141072).Curated1
Sequence conflicti126M → I in BAB28669 (PubMed:16141072).Curated1
Sequence conflicti157K → N in BAB25276 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007811 mRNA. Translation: BAB25276.1.
AK013133 mRNA. Translation: BAB28669.1.
AK132927 mRNA. Translation: BAE21426.1.
BC019668 mRNA. Translation: AAH19668.1.
CCDSiCCDS18721.1.
RefSeqiNP_079855.2. NM_025579.3.
XP_006539170.2. XM_006539107.3.
XP_006539172.1. XM_006539109.1.
XP_006539173.1. XM_006539110.1.
XP_017175839.1. XM_017320350.1.
UniGeneiMm.331926.

Genome annotation databases

EnsembliENSMUST00000030731; ENSMUSP00000030731; ENSMUSG00000028899.
GeneIDi66464.
KEGGimmu:66464.
UCSCiuc008vax.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007811 mRNA. Translation: BAB25276.1.
AK013133 mRNA. Translation: BAB28669.1.
AK132927 mRNA. Translation: BAE21426.1.
BC019668 mRNA. Translation: AAH19668.1.
CCDSiCCDS18721.1.
RefSeqiNP_079855.2. NM_025579.3.
XP_006539170.2. XM_006539107.3.
XP_006539172.1. XM_006539109.1.
XP_006539173.1. XM_006539110.1.
XP_017175839.1. XM_017320350.1.
UniGeneiMm.331926.

3D structure databases

ProteinModelPortaliQ8VE65.
SMRiQ8VE65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29178N.
IntActiQ8VE65. 3 interactors.
MINTiMINT-4136826.
STRINGi10090.ENSMUSP00000030731.

PTM databases

iPTMnetiQ8VE65.
PhosphoSitePlusiQ8VE65.

Proteomic databases

MaxQBiQ8VE65.
PaxDbiQ8VE65.
PeptideAtlasiQ8VE65.
PRIDEiQ8VE65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030731; ENSMUSP00000030731; ENSMUSG00000028899.
GeneIDi66464.
KEGGimmu:66464.
UCSCiuc008vax.3. mouse.

Organism-specific databases

CTDi6883.
MGIiMGI:1913714. Taf12.

Phylogenomic databases

eggNOGiKOG1142. Eukaryota.
COG5624. LUCA.
GeneTreeiENSGT00390000002144.
HOVERGENiHBG055174.
InParanoidiQ8VE65.
KOiK03126.
PhylomeDBiQ8VE65.
TreeFamiTF323652.

Enzyme and pathway databases

ReactomeiR-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiQ8VE65.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028899.
ExpressionAtlasiQ8VE65. baseline and differential.
GenevisibleiQ8VE65. MM.

Family and domain databases

CDDicd07981. TAF12. 1 hit.
Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003228. TFIID_TAF12.
[Graphical view]
PfamiPF03847. TFIID_20kDa. 1 hit.
[Graphical view]
ProDomiPD012998. PD012998. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAF12_MOUSE
AccessioniPrimary (citable) accession number: Q8VE65
Secondary accession number(s): Q3V0S7, Q9CZ11, Q9D8Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.