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Q8VE62

- PAIP1_MOUSE

UniProt

Q8VE62 - PAIP1_MOUSE

Protein

Polyadenylate-binding protein-interacting protein 1

Gene

Paip1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. RNA binding Source: InterPro
    3. translation activator activity Source: Ensembl

    Keywords - Biological processi

    Translation regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyadenylate-binding protein-interacting protein 1
    Short name:
    PABP-interacting protein 1
    Short name:
    PAIP-1
    Short name:
    Poly(A)-binding protein-interacting protein 1
    Gene namesi
    Name:Paip1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2384993. Paip1.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Polyadenylate-binding protein-interacting protein 1PRO_0000058178Add
    BLAST

    Proteomic databases

    MaxQBiQ8VE62.
    PaxDbiQ8VE62.
    PRIDEiQ8VE62.

    PTM databases

    PhosphoSiteiQ8VE62.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VE62.
    BgeeiQ8VE62.
    GenevestigatoriQ8VE62.

    Interactioni

    Subunit structurei

    Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8VE62. 2 interactions.
    MINTiMINT-4106496.
    STRINGi10090.ENSMUSP00000117256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VE62.
    SMRiQ8VE62. Positions 78-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 297218MIF4GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 6428PABPC1-interacting motif-2 (PAM2)By similarityAdd
    BLAST
    Regioni361 – 40040PABPC1-interacting motif-1 (PAM1)By similarityAdd
    BLAST

    Domaini

    Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.By similarity

    Sequence similaritiesi

    Contains 1 MIF4G domain.Curated

    Phylogenomic databases

    eggNOGiNOG253454.
    GeneTreeiENSGT00630000089897.
    HOGENOMiHOG000285987.
    HOVERGENiHBG053492.
    InParanoidiQ8VE62.
    KOiK14322.
    PhylomeDBiQ8VE62.
    TreeFamiTF325625.

    Family and domain databases

    Gene3Di1.25.40.180. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR009818. Ataxin-2_C.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR003890. MIF4G-like_typ-3.
    [Graphical view]
    PfamiPF02854. MIF4G. 1 hit.
    PF07145. PAM2. 1 hit.
    [Graphical view]
    SMARTiSM00543. MIF4G. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8VE62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSFDRAPE QTKPQRAPPS SQDKIPQQNS ESAMAKPQVV VAPVLMSKLS    50
    ANAPEFYPSG YSSNYTESYE DGCEDYPTLS EYVQDFLNHL TEQPGSFETE 100
    IEQFAETLNG WVTTDDALQE LVELIYQQAT SIPNFSYMGA RLCNYLSHHL 150
    TISPQSGNFR QLLLQRCRTE YEAKDQAAKG DEVTRKRFHA FVLFLGELYL 200
    NLEIKGTNGQ VTRADILQVG LRELLNALFS NPMDDNLICA VKLLKLTGSV 250
    LEDTWKEKGK TDMEEIIQRI ENVVLDANCS RDVKQMLLKL VELRSSNWGR 300
    VHATSTYREA TPENDPNYFM NEPTFYTSDG VPFTAADPDY QEKYQELLER 350
    EDFFPDYEEN GTDLSGAGDP YLDDIDDEMD PEIEEAYEKF CLESERKRKQ 400
    Length:400
    Mass (Da):45,702
    Last modified:March 1, 2002 - v1
    Checksum:iC5B8A18F068A5E6B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421A → V in AAD28259. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC019726 mRNA. Translation: AAH19726.1.
    BC051042 mRNA. Translation: AAH51042.1.
    AF128835 mRNA. Translation: AAD28259.1.
    CCDSiCCDS26796.1.
    RefSeqiNP_663432.1. NM_145457.4.
    UniGeneiMm.490243.

    Genome annotation databases

    EnsembliENSMUST00000026520; ENSMUSP00000026520; ENSMUSG00000025451.
    GeneIDi218693.
    KEGGimmu:218693.
    UCSCiuc007rzc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC019726 mRNA. Translation: AAH19726.1 .
    BC051042 mRNA. Translation: AAH51042.1 .
    AF128835 mRNA. Translation: AAD28259.1 .
    CCDSi CCDS26796.1.
    RefSeqi NP_663432.1. NM_145457.4.
    UniGenei Mm.490243.

    3D structure databases

    ProteinModelPortali Q8VE62.
    SMRi Q8VE62. Positions 78-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8VE62. 2 interactions.
    MINTi MINT-4106496.
    STRINGi 10090.ENSMUSP00000117256.

    PTM databases

    PhosphoSitei Q8VE62.

    Proteomic databases

    MaxQBi Q8VE62.
    PaxDbi Q8VE62.
    PRIDEi Q8VE62.

    Protocols and materials databases

    DNASUi 218693.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026520 ; ENSMUSP00000026520 ; ENSMUSG00000025451 .
    GeneIDi 218693.
    KEGGi mmu:218693.
    UCSCi uc007rzc.1. mouse.

    Organism-specific databases

    CTDi 10605.
    MGIi MGI:2384993. Paip1.

    Phylogenomic databases

    eggNOGi NOG253454.
    GeneTreei ENSGT00630000089897.
    HOGENOMi HOG000285987.
    HOVERGENi HBG053492.
    InParanoidi Q8VE62.
    KOi K14322.
    PhylomeDBi Q8VE62.
    TreeFami TF325625.

    Miscellaneous databases

    NextBioi 376373.
    PROi Q8VE62.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VE62.
    Bgeei Q8VE62.
    Genevestigatori Q8VE62.

    Family and domain databases

    Gene3Di 1.25.40.180. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR009818. Ataxin-2_C.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR003890. MIF4G-like_typ-3.
    [Graphical view ]
    Pfami PF02854. MIF4G. 1 hit.
    PF07145. PAM2. 1 hit.
    [Graphical view ]
    SMARTi SM00543. MIF4G. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    2. "Mouse oocyte polyA binding protein-interacting protein."
      Paynton B.V.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-367.
      Strain: CB6F1/J.
      Tissue: Oocyte.

    Entry informationi

    Entry nameiPAIP1_MOUSE
    AccessioniPrimary (citable) accession number: Q8VE62
    Secondary accession number(s): Q9WUC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3