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Q8VE62

- PAIP1_MOUSE

UniProt

Q8VE62 - PAIP1_MOUSE

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Protein

Polyadenylate-binding protein-interacting protein 1

Gene

Paip1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. translation activator activity Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Translation regulation

Enzyme and pathway databases

ReactomeiREACT_244119. Deadenylation of mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 1
Short name:
PABP-interacting protein 1
Short name:
PAIP-1
Short name:
Poly(A)-binding protein-interacting protein 1
Gene namesi
Name:Paip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:2384993. Paip1.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Polyadenylate-binding protein-interacting protein 1PRO_0000058178Add
BLAST

Proteomic databases

MaxQBiQ8VE62.
PaxDbiQ8VE62.
PRIDEiQ8VE62.

PTM databases

PhosphoSiteiQ8VE62.

Expressioni

Gene expression databases

BgeeiQ8VE62.
ExpressionAtlasiQ8VE62. baseline and differential.
GenevestigatoriQ8VE62.

Interactioni

Subunit structurei

Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8VE62. 2 interactions.
MINTiMINT-4106496.
STRINGi10090.ENSMUSP00000117256.

Structurei

3D structure databases

ProteinModelPortaliQ8VE62.
SMRiQ8VE62. Positions 78-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 297218MIF4GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 6428PABPC1-interacting motif-2 (PAM2)By similarityAdd
BLAST
Regioni361 – 40040PABPC1-interacting motif-1 (PAM1)By similarityAdd
BLAST

Domaini

Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.By similarity

Sequence similaritiesi

Contains 1 MIF4G domain.Curated

Phylogenomic databases

eggNOGiNOG253454.
GeneTreeiENSGT00630000089897.
HOGENOMiHOG000285987.
HOVERGENiHBG053492.
InParanoidiQ8VE62.
KOiK14322.
PhylomeDBiQ8VE62.
TreeFamiTF325625.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR009818. Ataxin-2_C.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02854. MIF4G. 1 hit.
PF07145. PAM2. 1 hit.
[Graphical view]
SMARTiSM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VE62-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSFDRAPE QTKPQRAPPS SQDKIPQQNS ESAMAKPQVV VAPVLMSKLS
60 70 80 90 100
ANAPEFYPSG YSSNYTESYE DGCEDYPTLS EYVQDFLNHL TEQPGSFETE
110 120 130 140 150
IEQFAETLNG WVTTDDALQE LVELIYQQAT SIPNFSYMGA RLCNYLSHHL
160 170 180 190 200
TISPQSGNFR QLLLQRCRTE YEAKDQAAKG DEVTRKRFHA FVLFLGELYL
210 220 230 240 250
NLEIKGTNGQ VTRADILQVG LRELLNALFS NPMDDNLICA VKLLKLTGSV
260 270 280 290 300
LEDTWKEKGK TDMEEIIQRI ENVVLDANCS RDVKQMLLKL VELRSSNWGR
310 320 330 340 350
VHATSTYREA TPENDPNYFM NEPTFYTSDG VPFTAADPDY QEKYQELLER
360 370 380 390 400
EDFFPDYEEN GTDLSGAGDP YLDDIDDEMD PEIEEAYEKF CLESERKRKQ
Length:400
Mass (Da):45,702
Last modified:March 1, 2002 - v1
Checksum:iC5B8A18F068A5E6B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421A → V in AAD28259. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019726 mRNA. Translation: AAH19726.1.
BC051042 mRNA. Translation: AAH51042.1.
AF128835 mRNA. Translation: AAD28259.1.
CCDSiCCDS26796.1.
RefSeqiNP_663432.1. NM_145457.4.
UniGeneiMm.490243.

Genome annotation databases

EnsembliENSMUST00000026520; ENSMUSP00000026520; ENSMUSG00000025451.
GeneIDi218693.
KEGGimmu:218693.
UCSCiuc007rzc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019726 mRNA. Translation: AAH19726.1 .
BC051042 mRNA. Translation: AAH51042.1 .
AF128835 mRNA. Translation: AAD28259.1 .
CCDSi CCDS26796.1.
RefSeqi NP_663432.1. NM_145457.4.
UniGenei Mm.490243.

3D structure databases

ProteinModelPortali Q8VE62.
SMRi Q8VE62. Positions 78-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8VE62. 2 interactions.
MINTi MINT-4106496.
STRINGi 10090.ENSMUSP00000117256.

PTM databases

PhosphoSitei Q8VE62.

Proteomic databases

MaxQBi Q8VE62.
PaxDbi Q8VE62.
PRIDEi Q8VE62.

Protocols and materials databases

DNASUi 218693.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026520 ; ENSMUSP00000026520 ; ENSMUSG00000025451 .
GeneIDi 218693.
KEGGi mmu:218693.
UCSCi uc007rzc.1. mouse.

Organism-specific databases

CTDi 10605.
MGIi MGI:2384993. Paip1.

Phylogenomic databases

eggNOGi NOG253454.
GeneTreei ENSGT00630000089897.
HOGENOMi HOG000285987.
HOVERGENi HBG053492.
InParanoidi Q8VE62.
KOi K14322.
PhylomeDBi Q8VE62.
TreeFami TF325625.

Enzyme and pathway databases

Reactomei REACT_244119. Deadenylation of mRNA.

Miscellaneous databases

NextBioi 376373.
PROi Q8VE62.
SOURCEi Search...

Gene expression databases

Bgeei Q8VE62.
ExpressionAtlasi Q8VE62. baseline and differential.
Genevestigatori Q8VE62.

Family and domain databases

Gene3Di 1.25.40.180. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR009818. Ataxin-2_C.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view ]
Pfami PF02854. MIF4G. 1 hit.
PF07145. PAM2. 1 hit.
[Graphical view ]
SMARTi SM00543. MIF4G. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  2. "Mouse oocyte polyA binding protein-interacting protein."
    Paynton B.V.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-367.
    Strain: CB6F1/J.
    Tissue: Oocyte.

Entry informationi

Entry nameiPAIP1_MOUSE
AccessioniPrimary (citable) accession number: Q8VE62
Secondary accession number(s): Q9WUC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3