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Q8VE62 (PAIP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyadenylate-binding protein-interacting protein 1

Short name=PABP-interacting protein 1
Short name=PAIP-1
Short name=Poly(A)-binding protein-interacting protein 1
Gene names
Name:Paip1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain By similarity.

Subunit structure

Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A By similarity.

Subcellular location

Cytoplasm Probable.

Domain

Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation By similarity.

Sequence similarities

Contains 1 MIF4G domain.

Ontologies

Keywords
   Biological processTranslation regulation
   Cellular componentCytoplasm
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 23055941. Source: MGI

translation activator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Polyadenylate-binding protein-interacting protein 1
PRO_0000058178

Regions

Domain80 – 297218MIF4G
Region37 – 6428PABPC1-interacting motif-2 (PAM2) By similarity
Region361 – 40040PABPC1-interacting motif-1 (PAM1) By similarity

Experimental info

Sequence conflict421A → V in AAD28259. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8VE62 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: C5B8A18F068A5E6B

FASTA40045,702
        10         20         30         40         50         60 
MSDSFDRAPE QTKPQRAPPS SQDKIPQQNS ESAMAKPQVV VAPVLMSKLS ANAPEFYPSG 

        70         80         90        100        110        120 
YSSNYTESYE DGCEDYPTLS EYVQDFLNHL TEQPGSFETE IEQFAETLNG WVTTDDALQE 

       130        140        150        160        170        180 
LVELIYQQAT SIPNFSYMGA RLCNYLSHHL TISPQSGNFR QLLLQRCRTE YEAKDQAAKG 

       190        200        210        220        230        240 
DEVTRKRFHA FVLFLGELYL NLEIKGTNGQ VTRADILQVG LRELLNALFS NPMDDNLICA 

       250        260        270        280        290        300 
VKLLKLTGSV LEDTWKEKGK TDMEEIIQRI ENVVLDANCS RDVKQMLLKL VELRSSNWGR 

       310        320        330        340        350        360 
VHATSTYREA TPENDPNYFM NEPTFYTSDG VPFTAADPDY QEKYQELLER EDFFPDYEEN 

       370        380        390        400 
GTDLSGAGDP YLDDIDDEMD PEIEEAYEKF CLESERKRKQ 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[2]"Mouse oocyte polyA binding protein-interacting protein."
Paynton B.V.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-367.
Strain: CB6F1/J.
Tissue: Oocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC019726 mRNA. Translation: AAH19726.1.
BC051042 mRNA. Translation: AAH51042.1.
AF128835 mRNA. Translation: AAD28259.1.
CCDSCCDS26796.1.
RefSeqNP_663432.1. NM_145457.4.
UniGeneMm.490243.

3D structure databases

ProteinModelPortalQ8VE62.
SMRQ8VE62. Positions 78-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8VE62. 2 interactions.
MINTMINT-4106496.
STRING10090.ENSMUSP00000117256.

PTM databases

PhosphoSiteQ8VE62.

Proteomic databases

MaxQBQ8VE62.
PaxDbQ8VE62.
PRIDEQ8VE62.

Protocols and materials databases

DNASU218693.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026520; ENSMUSP00000026520; ENSMUSG00000025451.
GeneID218693.
KEGGmmu:218693.
UCSCuc007rzc.1. mouse.

Organism-specific databases

CTD10605.
MGIMGI:2384993. Paip1.

Phylogenomic databases

eggNOGNOG253454.
GeneTreeENSGT00630000089897.
HOGENOMHOG000285987.
HOVERGENHBG053492.
InParanoidQ8VE62.
KOK14322.
PhylomeDBQ8VE62.
TreeFamTF325625.

Gene expression databases

ArrayExpressQ8VE62.
BgeeQ8VE62.
GenevestigatorQ8VE62.

Family and domain databases

Gene3D1.25.40.180. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR009818. Ataxin-2_C.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamPF02854. MIF4G. 1 hit.
PF07145. PAM2. 1 hit.
[Graphical view]
SMARTSM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

NextBio376373.
PROQ8VE62.
SOURCESearch...

Entry information

Entry namePAIP1_MOUSE
AccessionPrimary (citable) accession number: Q8VE62
Secondary accession number(s): Q9WUC9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot