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Protein

Polyadenylate-binding protein-interacting protein 1

Gene

Paip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 1
Short name:
PABP-interacting protein 1
Short name:
PAIP-1
Short name:
Poly(A)-binding protein-interacting protein 1
Gene namesi
Name:Paip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2384993 Paip1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581781 – 400Polyadenylate-binding protein-interacting protein 1Add BLAST400

Proteomic databases

EPDiQ8VE62
MaxQBiQ8VE62
PaxDbiQ8VE62
PeptideAtlasiQ8VE62
PRIDEiQ8VE62

PTM databases

iPTMnetiQ8VE62
PhosphoSitePlusiQ8VE62

Expressioni

Gene expression databases

BgeeiENSMUSG00000025451
ExpressionAtlasiQ8VE62 baseline and differential
GenevisibleiQ8VE62 MM

Interactioni

Subunit structurei

Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A (By similarity).By similarity

Protein-protein interaction databases

BioGridi230055, 3 interactors
IntActiQ8VE62, 2 interactors
MINTiQ8VE62
STRINGi10090.ENSMUSP00000026520

Structurei

3D structure databases

ProteinModelPortaliQ8VE62
SMRiQ8VE62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 297MIF4GAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 64PABPC1-interacting motif-2 (PAM2)By similarityAdd BLAST28
Regioni361 – 400PABPC1-interacting motif-1 (PAM1)By similarityAdd BLAST40

Domaini

Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.By similarity

Phylogenomic databases

eggNOGiENOG410IPIA Eukaryota
ENOG41109D3 LUCA
GeneTreeiENSGT00630000089897
HOGENOMiHOG000285987
HOVERGENiHBG053492
InParanoidiQ8VE62
KOiK14322
PhylomeDBiQ8VE62
TreeFamiTF325625

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR009818 Ataxin-2_C
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02854 MIF4G, 1 hit
PF07145 PAM2, 1 hit
SMARTiView protein in SMART
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VE62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSFDRAPE QTKPQRAPPS SQDKIPQQNS ESAMAKPQVV VAPVLMSKLS
60 70 80 90 100
ANAPEFYPSG YSSNYTESYE DGCEDYPTLS EYVQDFLNHL TEQPGSFETE
110 120 130 140 150
IEQFAETLNG WVTTDDALQE LVELIYQQAT SIPNFSYMGA RLCNYLSHHL
160 170 180 190 200
TISPQSGNFR QLLLQRCRTE YEAKDQAAKG DEVTRKRFHA FVLFLGELYL
210 220 230 240 250
NLEIKGTNGQ VTRADILQVG LRELLNALFS NPMDDNLICA VKLLKLTGSV
260 270 280 290 300
LEDTWKEKGK TDMEEIIQRI ENVVLDANCS RDVKQMLLKL VELRSSNWGR
310 320 330 340 350
VHATSTYREA TPENDPNYFM NEPTFYTSDG VPFTAADPDY QEKYQELLER
360 370 380 390 400
EDFFPDYEEN GTDLSGAGDP YLDDIDDEMD PEIEEAYEKF CLESERKRKQ
Length:400
Mass (Da):45,702
Last modified:March 1, 2002 - v1
Checksum:iC5B8A18F068A5E6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42A → V in AAD28259 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019726 mRNA Translation: AAH19726.1
BC051042 mRNA Translation: AAH51042.1
AF128835 mRNA Translation: AAD28259.1
CCDSiCCDS26796.1
RefSeqiNP_663432.1, NM_145457.4
UniGeneiMm.490243

Genome annotation databases

EnsembliENSMUST00000026520; ENSMUSP00000026520; ENSMUSG00000025451
GeneIDi218693
KEGGimmu:218693
UCSCiuc007rzc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPAIP1_MOUSE
AccessioniPrimary (citable) accession number: Q8VE62
Secondary accession number(s): Q9WUC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health