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Protein

Dual oxidase maturation factor 1

Gene

Duoxa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1.By similarity

GO - Biological processi

  • hydrogen peroxide metabolic process Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of reactive oxygen species metabolic process Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of inflammatory response Source: MGI
  • regulation of thyroid hormone generation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Dual oxidase maturation factor 1
Alternative name(s):
Dual oxidase activator 1
Gene namesi
Name:Duoxa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2384861. Duoxa1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Topological domaini46 – 516CytoplasmicSequence analysis
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 183111ExtracellularSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Topological domaini205 – 2051CytoplasmicSequence analysis
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Topological domaini227 – 24923ExtracellularSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Topological domaini271 – 34171CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: InterPro
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Dual oxidase maturation factor 1PRO_0000264242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VE49.
PRIDEiQ8VE49.

Expressioni

Gene expression databases

BgeeiQ8VE49.
CleanExiMM_DUOXA1.
ExpressionAtlasiQ8VE49. baseline and differential.
GenevisibleiQ8VE49. MM.

Interactioni

Subunit structurei

May interact with NUMB.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028653.

Family & Domainsi

Sequence similaritiesi

Belongs to the DUOXA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3921. Eukaryota.
ENOG410ZP7G. LUCA.
GeneTreeiENSGT00390000008240.
HOGENOMiHOG000231775.
HOVERGENiHBG080429.
InParanoidiQ8VE49.
KOiK17233.
OMAiKPTFPMD.
TreeFamiTF312996.

Family and domain databases

InterProiIPR018469. Dual_oxidase_maturation_fac.
[Graphical view]
PfamiPF10204. DuoxA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VE49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALGHTLPF YTGTKPTFPM DTTLAVIITI FLTALVTFII ILPGIRGKTR
60 70 80 90 100
LFWLLRVVTS LFIGAVILAV NFSSEWSVGH VNANTTYKAF SPKWVSVDVG
110 120 130 140 150
LQIGLGGVNI TLTGTPVQQL NETINYNEAF AWRLGRSYAE EYAKALEKGL
160 170 180 190 200
PDPVLYLAEK FTPRSPCGLY NQYRLAGHYA SAMLWVAFLC WLLANVMLSM
210 220 230 240 250
PVLVYGGHML LATGLFQLLA LFFFSMTTSL ISPCPLRLGT AVLHTHHGPA
260 270 280 290 300
FWITLATGLL CILLGLVMAV AHRMQPHRLK AFFNQSSEDP VLEWGSEEGG
310 320 330 340
LLSPHYRSIA ESPETQDIPM SVASSETCFK EEHPKESDCS L
Length:341
Mass (Da):37,588
Last modified:July 27, 2011 - v2
Checksum:i9555188CFEF6F8AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121L → F in AAH19755 (PubMed:15489334).Curated
Sequence conflicti285 – 2851Q → L in AAH19755 (PubMed:15489334).Curated
Sequence conflicti318 – 3181I → T in AAH19755 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844566 Genomic DNA. Translation: CAM16336.1.
BC019755 mRNA. Translation: AAH19755.1.
CCDSiCCDS16661.1.
RefSeqiNP_001292191.1. NM_001305262.1.
XP_006499154.1. XM_006499091.2.
XP_006499157.1. XM_006499094.2.
XP_006499158.1. XM_006499095.2.
UniGeneiMm.247121.

Genome annotation databases

EnsembliENSMUST00000028653; ENSMUSP00000028653; ENSMUSG00000027224.
ENSMUST00000110537; ENSMUSP00000106166; ENSMUSG00000027224.
GeneIDi213696.
KEGGimmu:213696.
UCSCiuc008man.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844566 Genomic DNA. Translation: CAM16336.1.
BC019755 mRNA. Translation: AAH19755.1.
CCDSiCCDS16661.1.
RefSeqiNP_001292191.1. NM_001305262.1.
XP_006499154.1. XM_006499091.2.
XP_006499157.1. XM_006499094.2.
XP_006499158.1. XM_006499095.2.
UniGeneiMm.247121.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028653.

Proteomic databases

PaxDbiQ8VE49.
PRIDEiQ8VE49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028653; ENSMUSP00000028653; ENSMUSG00000027224.
ENSMUST00000110537; ENSMUSP00000106166; ENSMUSG00000027224.
GeneIDi213696.
KEGGimmu:213696.
UCSCiuc008man.1. mouse.

Organism-specific databases

CTDi90527.
MGIiMGI:2384861. Duoxa1.

Phylogenomic databases

eggNOGiKOG3921. Eukaryota.
ENOG410ZP7G. LUCA.
GeneTreeiENSGT00390000008240.
HOGENOMiHOG000231775.
HOVERGENiHBG080429.
InParanoidiQ8VE49.
KOiK17233.
OMAiKPTFPMD.
TreeFamiTF312996.

Miscellaneous databases

NextBioi374076.
PROiQ8VE49.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VE49.
CleanExiMM_DUOXA1.
ExpressionAtlasiQ8VE49. baseline and differential.
GenevisibleiQ8VE49. MM.

Family and domain databases

InterProiIPR018469. Dual_oxidase_maturation_fac.
[Graphical view]
PfamiPF10204. DuoxA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiDOXA1_MOUSE
AccessioniPrimary (citable) accession number: Q8VE49
Secondary accession number(s): A2AQ97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: November 11, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.