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Protein

Regulator of chromosome condensation

Gene

Rcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of chromosome condensation
Alternative name(s):
Chromosome condensation protein 1
Gene namesi
Name:Rcc1
Synonyms:Chc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913989. Rcc1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Becomes dispersed throughout the cytoplasm during mitosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002066302 – 421Regulator of chromosome condensationAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N-dimethylproline; alternate1 Publication1
Modified residuei2N-methylproline; alternate1 Publication1
Modified residuei11PhosphoserineBy similarity1

Post-translational modificationi

N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Dimethylation produces a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8VE37.
MaxQBiQ8VE37.
PaxDbiQ8VE37.
PRIDEiQ8VE37.

PTM databases

iPTMnetiQ8VE37.
PhosphoSitePlusiQ8VE37.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028896.
CleanExiMM_RCC1.
ExpressionAtlasiQ8VE37. baseline and differential.
GenevisibleiQ8VE37. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221378. 64 interactors.
IntActiQ8VE37. 64 interactors.
MINTiMINT-2568412.
STRINGi10090.ENSMUSP00000030726.

Structurei

3D structure databases

ProteinModelPortaliQ8VE37.
SMRiQ8VE37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 84RCC1 1Add BLAST51
Repeati85 – 136RCC1 2Add BLAST52
Repeati138 – 189RCC1 3Add BLAST52
Repeati191 – 257RCC1 4Add BLAST67
Repeati258 – 311RCC1 5Add BLAST54
Repeati312 – 362RCC1 6Add BLAST51
Repeati363 – 416RCC1 7Add BLAST54

Sequence similaritiesi

Contains 7 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00860000133726.
HOGENOMiHOG000234341.
HOVERGENiHBG017712.
InParanoidiQ8VE37.
KOiK11493.
PhylomeDBiQ8VE37.
TreeFamiTF101139.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 7 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00625. RCC1_1. 1 hit.
PS00626. RCC1_2. 4 hits.
PS50012. RCC1_3. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VE37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKRIAKRR SPPEDAIPKS KKVKVSHRSH NTEPGLVLTL GQGDVGQLGL
60 70 80 90 100
GESVLERKKP ALVPLLQDVV QAEAGGMHTV CLSQSGQVYS FGCNDEGALG
110 120 130 140 150
RDTSVEGSEM VPGKVELQEK VVQVSAGDSH TAALTEDGRV FLWGSFRDNN
160 170 180 190 200
GVIGLLEPMK KSMVPVQVQL DAPVVKVASG NDHLVMLTND GDLYTLGCGE
210 220 230 240 250
QGQLGRVPEL FANRGGRQGL GRLLVPRCVL LKSRGTRGRV RFQDAFCGAY
260 270 280 290 300
FTFAISREGH VYGFGLSNYH QLGTPGTGSC FIPQNLTSFK NSTKSWVGFS
310 320 330 340 350
GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPVVSSV
360 370 380 390 400
ACGASVGYAV SKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MTGKQLENRV
410 420
VLTVSSGGQH TVLLVKDQAQ S
Length:421
Mass (Da):44,931
Last modified:March 1, 2002 - v1
Checksum:iACE5019E50E1E9DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45V → M in BAE29345 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150153 mRNA. Translation: BAE29345.1.
BC019807 mRNA. Translation: AAH19807.1.
CCDSiCCDS18723.1.
RefSeqiNP_598639.1. NM_133878.3.
UniGeneiMm.255045.

Genome annotation databases

EnsembliENSMUST00000084250; ENSMUSP00000081271; ENSMUSG00000028896.
ENSMUST00000105951; ENSMUSP00000101571; ENSMUSG00000028896.
GeneIDi100088.
KEGGimmu:100088.
UCSCiuc008vbc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150153 mRNA. Translation: BAE29345.1.
BC019807 mRNA. Translation: AAH19807.1.
CCDSiCCDS18723.1.
RefSeqiNP_598639.1. NM_133878.3.
UniGeneiMm.255045.

3D structure databases

ProteinModelPortaliQ8VE37.
SMRiQ8VE37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221378. 64 interactors.
IntActiQ8VE37. 64 interactors.
MINTiMINT-2568412.
STRINGi10090.ENSMUSP00000030726.

PTM databases

iPTMnetiQ8VE37.
PhosphoSitePlusiQ8VE37.

Proteomic databases

EPDiQ8VE37.
MaxQBiQ8VE37.
PaxDbiQ8VE37.
PRIDEiQ8VE37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084250; ENSMUSP00000081271; ENSMUSG00000028896.
ENSMUST00000105951; ENSMUSP00000101571; ENSMUSG00000028896.
GeneIDi100088.
KEGGimmu:100088.
UCSCiuc008vbc.2. mouse.

Organism-specific databases

CTDi1104.
MGIiMGI:1913989. Rcc1.

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00860000133726.
HOGENOMiHOG000234341.
HOVERGENiHBG017712.
InParanoidiQ8VE37.
KOiK11493.
PhylomeDBiQ8VE37.
TreeFamiTF101139.

Miscellaneous databases

ChiTaRSiRcc1. mouse.
PROiQ8VE37.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028896.
CleanExiMM_RCC1.
ExpressionAtlasiQ8VE37. baseline and differential.
GenevisibleiQ8VE37. MM.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 7 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00625. RCC1_1. 1 hit.
PS00626. RCC1_2. 4 hits.
PS50012. RCC1_3. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCC1_MOUSE
AccessioniPrimary (citable) accession number: Q8VE37
Secondary accession number(s): Q3UDB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.