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Protein

Regulator of chromosome condensation

Gene

Rcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Guanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of chromosome condensation
Alternative name(s):
Chromosome condensation protein 1
Gene namesi
Name:Rcc1
Synonyms:Chc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913989 Rcc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002066302 – 421Regulator of chromosome condensationAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N-dimethylproline; alternate1 Publication1
Modified residuei2N-methylproline; alternate1 Publication1
Modified residuei11PhosphoserineBy similarity1

Post-translational modificationi

N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Dimethylation produces a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8VE37
MaxQBiQ8VE37
PaxDbiQ8VE37
PRIDEiQ8VE37

PTM databases

iPTMnetiQ8VE37
PhosphoSitePlusiQ8VE37
SwissPalmiQ8VE37

Expressioni

Gene expression databases

BgeeiENSMUSG00000028896
CleanExiMM_RCC1
ExpressionAtlasiQ8VE37 baseline and differential
GenevisibleiQ8VE37 MM

Interactioni

Subunit structurei

Interacts with RAN. Interacts (via N-terminus and RCC1 repeats) with KPNA4. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221378, 64 interactors
IntActiQ8VE37, 64 interactors
MINTiQ8VE37
STRINGi10090.ENSMUSP00000030726

Structurei

3D structure databases

ProteinModelPortaliQ8VE37
SMRiQ8VE37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 84RCC1 1Add BLAST51
Repeati85 – 136RCC1 2Add BLAST52
Repeati138 – 189RCC1 3Add BLAST52
Repeati191 – 257RCC1 4Add BLAST67
Repeati258 – 311RCC1 5Add BLAST54
Repeati312 – 362RCC1 6Add BLAST51
Repeati363 – 416RCC1 7Add BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi4 – 24Bipartite nuclear localization signalBy similarityAdd BLAST21

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
GeneTreeiENSGT00910000144029
HOGENOMiHOG000234341
HOVERGENiHBG017712
InParanoidiQ8VE37
KOiK11493
PhylomeDBiQ8VE37
TreeFamiTF101139

Family and domain databases

Gene3Di2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00415 RCC1, 7 hits
PRINTSiPR00633 RCCNDNSATION
SUPFAMiSSF50985 SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS00625 RCC1_1, 1 hit
PS00626 RCC1_2, 4 hits
PS50012 RCC1_3, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VE37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKRIAKRR SPPEDAIPKS KKVKVSHRSH NTEPGLVLTL GQGDVGQLGL
60 70 80 90 100
GESVLERKKP ALVPLLQDVV QAEAGGMHTV CLSQSGQVYS FGCNDEGALG
110 120 130 140 150
RDTSVEGSEM VPGKVELQEK VVQVSAGDSH TAALTEDGRV FLWGSFRDNN
160 170 180 190 200
GVIGLLEPMK KSMVPVQVQL DAPVVKVASG NDHLVMLTND GDLYTLGCGE
210 220 230 240 250
QGQLGRVPEL FANRGGRQGL GRLLVPRCVL LKSRGTRGRV RFQDAFCGAY
260 270 280 290 300
FTFAISREGH VYGFGLSNYH QLGTPGTGSC FIPQNLTSFK NSTKSWVGFS
310 320 330 340 350
GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPVVSSV
360 370 380 390 400
ACGASVGYAV SKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MTGKQLENRV
410 420
VLTVSSGGQH TVLLVKDQAQ S
Length:421
Mass (Da):44,931
Last modified:March 1, 2002 - v1
Checksum:iACE5019E50E1E9DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45V → M in BAE29345 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150153 mRNA Translation: BAE29345.1
BC019807 mRNA Translation: AAH19807.1
CCDSiCCDS18723.1
RefSeqiNP_598639.1, NM_133878.3
UniGeneiMm.255045

Genome annotation databases

EnsembliENSMUST00000084250; ENSMUSP00000081271; ENSMUSG00000028896
ENSMUST00000105951; ENSMUSP00000101571; ENSMUSG00000028896
GeneIDi100088
KEGGimmu:100088
UCSCiuc008vbc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRCC1_MOUSE
AccessioniPrimary (citable) accession number: Q8VE37
Secondary accession number(s): Q3UDB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health