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Q8VE11

- MTMR6_MOUSE

UniProt

Q8VE11 - MTMR6_MOUSE

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Protein

Myotubularin-related protein 6

Gene

Mtmr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei336 – 3361Phosphocysteine intermediateBy similarityPROSITE-ProRule annotation
Binding sitei382 – 3821SubstrateBy similarity

GO - Molecular functioni

  1. calcium-activated potassium channel activity Source: Ensembl
  2. protein tyrosine phosphatase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 6Imported (EC:3.1.3.-)
Gene namesi
Name:Mtmr6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2145637. Mtmr6.

Subcellular locationi

Nucleus envelope By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Myotubularin-related protein 6PRO_0000367041Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081Phosphotyrosine1 Publication
Modified residuei557 – 5571PhosphoserineBy similarity
Modified residuei585 – 5851PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VE11.
PaxDbiQ8VE11.
PRIDEiQ8VE11.

PTM databases

PhosphoSiteiQ8VE11.

Expressioni

Gene expression databases

BgeeiQ8VE11.
GenevestigatoriQ8VE11.

Interactioni

Subunit structurei

Interacts with ALKBH4, KCNN4, MTMR7, MTMR8 and MTMR9.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022563.

Structurei

3D structure databases

ProteinModelPortaliQ8VE11.
SMRiQ8VE11. Positions 4-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 499376Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2514Substrate bindingBy similarity
Regioni273 – 2742Substrate bindingBy similarity
Regioni336 – 3427Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG322789.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210599.
HOVERGENiHBG000220.
InParanoidiQ8VE11.
KOiK18083.
OMAiVFNIIMN.
OrthoDBiEOG71RXJC.
PhylomeDBiQ8VE11.
TreeFamiTF315197.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VE11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHIRTTKVE QVKLLDRFST NNKSLTGTLY LTATHLLFID AQQKETWILH
60 70 80 90 100
HHIASVEKLA LTTSGCPLVI QCKNFRIVHF IVPRERDCHD IYNSLLQLSK
110 120 130 140 150
QAKYEDLYAF SYNPKQNDTE RRNGWQLIDL AAEYERMGVP NANWQLSDAN
160 170 180 190 200
REYKVCETYP RELYVPRTAS RPVIVGSSNF RSKGRLPVLS YCRQGTEAAI
210 220 230 240 250
CRCSQPLSGF SARCLEDEHL LQAISKANPG NRYMYVVDTR PKLNAIANRA
260 270 280 290 300
AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGS KGLSVNDFYS
310 320 330 340 350
GLESSGWLRH IKAVLDAAIF LAKAIVVENA SVLVHCSDGW DRTSQVCSLG
360 370 380 390 400
SLLLDSYYRT MKGFMVLIEK DWISFGHKFS ERCGHLDGDP REVSPVFTQF
410 420 430 440 450
LECVWHLTQQ FPQAFEFNEA FLLQIHEHIH SCQFGNFLGN CQKEREELRL
460 470 480 490 500
KEKTYSLWPF LLDDKKKYLN PLYSSKSQRL TVLEPNTASF NFKFWRNMYH
510 520 530 540 550
QFDRTLHPRQ SVLSIIMNMN EQSKQLEEDI KDLEAKIKQC KNGILTKELL
560 570 580 590 600
HAVHPESPAL KTSLCLKEPS LLPVKDTLRA IEGSSPADNR YCDYAEEFSK
610
SEPTVVSLEY GVARMTC
Length:617
Mass (Da):70,933
Last modified:March 1, 2002 - v1
Checksum:iEE699C578602A013
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK076218 mRNA. Translation: BAC36259.1.
AK154859 mRNA. Translation: BAE32884.1.
CH466535 Genomic DNA. Translation: EDL36118.1.
BC020019 mRNA. Translation: AAH20019.1.
CCDSiCCDS27176.1.
RefSeqiNP_659092.1. NM_144843.4.
UniGeneiMm.247007.

Genome annotation databases

EnsembliENSMUST00000022563; ENSMUSP00000022563; ENSMUSG00000021987.
GeneIDi219135.
KEGGimmu:219135.
UCSCiuc007ufa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK076218 mRNA. Translation: BAC36259.1 .
AK154859 mRNA. Translation: BAE32884.1 .
CH466535 Genomic DNA. Translation: EDL36118.1 .
BC020019 mRNA. Translation: AAH20019.1 .
CCDSi CCDS27176.1.
RefSeqi NP_659092.1. NM_144843.4.
UniGenei Mm.247007.

3D structure databases

ProteinModelPortali Q8VE11.
SMRi Q8VE11. Positions 4-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022563.

PTM databases

PhosphoSitei Q8VE11.

Proteomic databases

MaxQBi Q8VE11.
PaxDbi Q8VE11.
PRIDEi Q8VE11.

Protocols and materials databases

DNASUi 219135.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022563 ; ENSMUSP00000022563 ; ENSMUSG00000021987 .
GeneIDi 219135.
KEGGi mmu:219135.
UCSCi uc007ufa.2. mouse.

Organism-specific databases

CTDi 9107.
MGIi MGI:2145637. Mtmr6.

Phylogenomic databases

eggNOGi NOG322789.
GeneTreei ENSGT00760000118832.
HOGENOMi HOG000210599.
HOVERGENi HBG000220.
InParanoidi Q8VE11.
KOi K18083.
OMAi VFNIIMN.
OrthoDBi EOG71RXJC.
PhylomeDBi Q8VE11.
TreeFami TF315197.

Enzyme and pathway databases

Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

ChiTaRSi MTMR6. mouse.
NextBioi 376593.
PROi Q8VE11.
SOURCEi Search...

Gene expression databases

Bgeei Q8VE11.
Genevestigatori Q8VE11.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF06602. Myotub-related. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and NODImported.
    Tissue: Dendritic cellImported and Embryonic headImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumorImported.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell1 Publication.

Entry informationi

Entry nameiMTMR6_MOUSE
AccessioniPrimary (citable) accession number: Q8VE11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3