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Q8VE11

- MTMR6_MOUSE

UniProt

Q8VE11 - MTMR6_MOUSE

Protein

Myotubularin-related protein 6

Gene

Mtmr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei336 – 3361Phosphocysteine intermediateBy similarityPROSITE-ProRule annotation
    Binding sitei382 – 3821SubstrateBy similarity

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: Ensembl
    2. protein tyrosine phosphatase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 6Imported (EC:3.1.3.-)
    Gene namesi
    Name:Mtmr6Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:2145637. Mtmr6.

    Subcellular locationi

    Nucleus envelope By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear envelope Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 617617Myotubularin-related protein 6PRO_0000367041Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei108 – 1081Phosphotyrosine1 Publication
    Modified residuei557 – 5571PhosphoserineBy similarity
    Modified residuei585 – 5851PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8VE11.
    PaxDbiQ8VE11.
    PRIDEiQ8VE11.

    PTM databases

    PhosphoSiteiQ8VE11.

    Expressioni

    Gene expression databases

    BgeeiQ8VE11.
    GenevestigatoriQ8VE11.

    Interactioni

    Subunit structurei

    Interacts with ALKBH4, KCNN4, MTMR7, MTMR8 and MTMR9.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022563.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VE11.
    SMRiQ8VE11. Positions 4-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 499376Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni248 – 2514Substrate bindingBy similarity
    Regioni273 – 2742Substrate bindingBy similarity
    Regioni336 – 3427Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322789.
    GeneTreeiENSGT00710000106694.
    HOGENOMiHOG000210599.
    HOVERGENiHBG000220.
    InParanoidiQ8VE11.
    KOiK18083.
    OMAiVFNIIMN.
    OrthoDBiEOG71RXJC.
    PhylomeDBiQ8VE11.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF06602. Myotub-related. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VE11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHIRTTKVE QVKLLDRFST NNKSLTGTLY LTATHLLFID AQQKETWILH    50
    HHIASVEKLA LTTSGCPLVI QCKNFRIVHF IVPRERDCHD IYNSLLQLSK 100
    QAKYEDLYAF SYNPKQNDTE RRNGWQLIDL AAEYERMGVP NANWQLSDAN 150
    REYKVCETYP RELYVPRTAS RPVIVGSSNF RSKGRLPVLS YCRQGTEAAI 200
    CRCSQPLSGF SARCLEDEHL LQAISKANPG NRYMYVVDTR PKLNAIANRA 250
    AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGS KGLSVNDFYS 300
    GLESSGWLRH IKAVLDAAIF LAKAIVVENA SVLVHCSDGW DRTSQVCSLG 350
    SLLLDSYYRT MKGFMVLIEK DWISFGHKFS ERCGHLDGDP REVSPVFTQF 400
    LECVWHLTQQ FPQAFEFNEA FLLQIHEHIH SCQFGNFLGN CQKEREELRL 450
    KEKTYSLWPF LLDDKKKYLN PLYSSKSQRL TVLEPNTASF NFKFWRNMYH 500
    QFDRTLHPRQ SVLSIIMNMN EQSKQLEEDI KDLEAKIKQC KNGILTKELL 550
    HAVHPESPAL KTSLCLKEPS LLPVKDTLRA IEGSSPADNR YCDYAEEFSK 600
    SEPTVVSLEY GVARMTC 617
    Length:617
    Mass (Da):70,933
    Last modified:March 1, 2002 - v1
    Checksum:iEE699C578602A013
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK076218 mRNA. Translation: BAC36259.1.
    AK154859 mRNA. Translation: BAE32884.1.
    CH466535 Genomic DNA. Translation: EDL36118.1.
    BC020019 mRNA. Translation: AAH20019.1.
    CCDSiCCDS27176.1.
    RefSeqiNP_659092.1. NM_144843.4.
    UniGeneiMm.247007.

    Genome annotation databases

    EnsembliENSMUST00000022563; ENSMUSP00000022563; ENSMUSG00000021987.
    GeneIDi219135.
    KEGGimmu:219135.
    UCSCiuc007ufa.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK076218 mRNA. Translation: BAC36259.1 .
    AK154859 mRNA. Translation: BAE32884.1 .
    CH466535 Genomic DNA. Translation: EDL36118.1 .
    BC020019 mRNA. Translation: AAH20019.1 .
    CCDSi CCDS27176.1.
    RefSeqi NP_659092.1. NM_144843.4.
    UniGenei Mm.247007.

    3D structure databases

    ProteinModelPortali Q8VE11.
    SMRi Q8VE11. Positions 4-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022563.

    PTM databases

    PhosphoSitei Q8VE11.

    Proteomic databases

    MaxQBi Q8VE11.
    PaxDbi Q8VE11.
    PRIDEi Q8VE11.

    Protocols and materials databases

    DNASUi 219135.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022563 ; ENSMUSP00000022563 ; ENSMUSG00000021987 .
    GeneIDi 219135.
    KEGGi mmu:219135.
    UCSCi uc007ufa.2. mouse.

    Organism-specific databases

    CTDi 9107.
    MGIi MGI:2145637. Mtmr6.

    Phylogenomic databases

    eggNOGi NOG322789.
    GeneTreei ENSGT00710000106694.
    HOGENOMi HOG000210599.
    HOVERGENi HBG000220.
    InParanoidi Q8VE11.
    KOi K18083.
    OMAi VFNIIMN.
    OrthoDBi EOG71RXJC.
    PhylomeDBi Q8VE11.
    TreeFami TF315197.

    Enzyme and pathway databases

    Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    ChiTaRSi MTMR6. mouse.
    NextBioi 376593.
    PROi Q8VE11.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VE11.
    Genevestigatori Q8VE11.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported and NODImported.
      Tissue: Dendritic cellImported and Embryonic headImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumorImported.
    4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell1 Publication.

    Entry informationi

    Entry nameiMTMR6_MOUSE
    AccessioniPrimary (citable) accession number: Q8VE11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3