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Protein

Myotubularin-related protein 6

Gene

Mtmr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei336Phosphocysteine intermediatePROSITE-ProRule annotationBy similarity1
Binding sitei382SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 6Imported (EC:3.1.3.-)
Gene namesi
Name:Mtmr6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2145637 Mtmr6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003670411 – 617Myotubularin-related protein 6Add BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphotyrosineCombined sources1
Modified residuei557PhosphoserineBy similarity1
Modified residuei585PhosphoserineBy similarity1
Modified residuei607PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VE11
MaxQBiQ8VE11
PaxDbiQ8VE11
PRIDEiQ8VE11

PTM databases

iPTMnetiQ8VE11
PhosphoSitePlusiQ8VE11

Expressioni

Gene expression databases

BgeeiENSMUSG00000021987
ExpressionAtlasiQ8VE11 baseline and differential
GenevisibleiQ8VE11 MM

Interactioni

Subunit structurei

Interacts with ALKBH4, KCNN4, MTMR7, MTMR8 and MTMR9.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022563

Structurei

3D structure databases

ProteinModelPortaliQ8VE11
SMRiQ8VE11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 499Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST376

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 251Substrate bindingBy similarity4
Regioni273 – 274Substrate bindingBy similarity2
Regioni336 – 342Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000210599
HOVERGENiHBG000220
InParanoidiQ8VE11
KOiK18083
OMAiIMNMNEQ
OrthoDBiEOG091G02LA
PhylomeDBiQ8VE11
TreeFamiTF315197

Family and domain databases

CDDicd13343 PH-GRAM_MTMR6, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030581 MTMR6
IPR035998 MTMR6_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF34 PTHR10807:SF34, 1 hit
PfamiView protein in Pfam
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VE11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHIRTTKVE QVKLLDRFST NNKSLTGTLY LTATHLLFID AQQKETWILH
60 70 80 90 100
HHIASVEKLA LTTSGCPLVI QCKNFRIVHF IVPRERDCHD IYNSLLQLSK
110 120 130 140 150
QAKYEDLYAF SYNPKQNDTE RRNGWQLIDL AAEYERMGVP NANWQLSDAN
160 170 180 190 200
REYKVCETYP RELYVPRTAS RPVIVGSSNF RSKGRLPVLS YCRQGTEAAI
210 220 230 240 250
CRCSQPLSGF SARCLEDEHL LQAISKANPG NRYMYVVDTR PKLNAIANRA
260 270 280 290 300
AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGS KGLSVNDFYS
310 320 330 340 350
GLESSGWLRH IKAVLDAAIF LAKAIVVENA SVLVHCSDGW DRTSQVCSLG
360 370 380 390 400
SLLLDSYYRT MKGFMVLIEK DWISFGHKFS ERCGHLDGDP REVSPVFTQF
410 420 430 440 450
LECVWHLTQQ FPQAFEFNEA FLLQIHEHIH SCQFGNFLGN CQKEREELRL
460 470 480 490 500
KEKTYSLWPF LLDDKKKYLN PLYSSKSQRL TVLEPNTASF NFKFWRNMYH
510 520 530 540 550
QFDRTLHPRQ SVLSIIMNMN EQSKQLEEDI KDLEAKIKQC KNGILTKELL
560 570 580 590 600
HAVHPESPAL KTSLCLKEPS LLPVKDTLRA IEGSSPADNR YCDYAEEFSK
610
SEPTVVSLEY GVARMTC
Length:617
Mass (Da):70,933
Last modified:March 1, 2002 - v1
Checksum:iEE699C578602A013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076218 mRNA Translation: BAC36259.1
AK154859 mRNA Translation: BAE32884.1
CH466535 Genomic DNA Translation: EDL36118.1
BC020019 mRNA Translation: AAH20019.1
CCDSiCCDS27176.1
RefSeqiNP_659092.1, NM_144843.4
UniGeneiMm.247007

Genome annotation databases

EnsembliENSMUST00000022563; ENSMUSP00000022563; ENSMUSG00000021987
GeneIDi219135
KEGGimmu:219135
UCSCiuc007ufa.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMTMR6_MOUSE
AccessioniPrimary (citable) accession number: Q8VE11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health