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Protein

F-box only protein 33

Gene

Fbxo33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 33
Alternative name(s):
AIG30-12-1
Gene namesi
Name:Fbxo33
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1917861. Fbxo33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562F-box only protein 33PRO_0000314464Add
BLAST

Proteomic databases

EPDiQ8VE08.
MaxQBiQ8VE08.
PaxDbiQ8VE08.
PRIDEiQ8VE08.

Expressioni

Gene expression databases

BgeeiQ8VE08.
CleanExiMM_FBXO33.
ExpressionAtlasiQ8VE08. baseline and differential.
GenevisibleiQ8VE08. MM.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035948.

Structurei

3D structure databases

ProteinModelPortaliQ8VE08.
SMRiQ8VE08. Positions 70-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 11447F-boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 6151Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFZV. Eukaryota.
ENOG410YDCW. LUCA.
GeneTreeiENSGT00390000017718.
HOGENOMiHOG000072695.
HOVERGENiHBG051575.
InParanoidiQ8VE08.
KOiK10310.
OMAiQLRWLSC.
OrthoDBiEOG7QZG98.
TreeFamiTF321665.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VE08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFLSVPQP RPPGARTRAG AARLVRWRRR QRLRLLQLRR LRGLLRGLRR
60 70 80 90 100
RPGTGGRRPS RMALCGQAAG AASLPSELIV HIFSFLPAPD RLRASASCSH
110 120 130 140 150
WRECLFYPAL WPQLRICLRV SPAEQPRLEF LMRKCGWFVR ELRVEFAAEN
160 170 180 190 200
YLSGGGGPGD GGSGGGTDTG TGGEDGEALQ LSSRWLEVLR IYLELVLCVL
210 220 230 240 250
LSIRNNRNLQ KFSLFGDISV VHQQGSLSST YLSRVDPDGK KIKQIQQLFE
260 270 280 290 300
EILSNSRQLK WLSCGFMLEI VTPTSLSSLS NPIANTMEHL SLLDNNIPGN
310 320 330 340 350
STLITAVELE RFVNLRSLAL DFCDFTAEMA RVLTDSNHVP LQRLSLLVHN
360 370 380 390 400
ASVMLKSLDN MPNDEHWKAL SRKSSSLRVY LMVFDIKSED MLKILKPSIP
410 420 430 440 450
LERVHFDSYV TCVSGAIVDL ISRQYDKFLT HFILMNDMID TSGFPDLSDN
460 470 480 490 500
RNEDPLVLLA WRCTKLTLLA IHGYTVWAHN LIAIARLRGS DLKVLQVTEE
510 520 530 540 550
SIDFDQGELA DQDVDPVQNL IEQVSLGLGQ SWHAVLDIES LSVFTEPNRH
560
FYREMQSFSE DI
Length:562
Mass (Da):63,363
Last modified:July 27, 2011 - v3
Checksum:iD7D423279B015872
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti514 – 5141V → A in AC147101 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147101 Genomic DNA. No translation available.
BC006669 mRNA. Translation: AAH06669.1.
BC020022 mRNA. Translation: AAH20022.1.
CCDSiCCDS49072.1.
RefSeqiNP_001028328.2. NM_001033156.4.
UniGeneiMm.311026.

Genome annotation databases

EnsembliENSMUST00000043204; ENSMUSP00000035948; ENSMUSG00000035329.
GeneIDi70611.
KEGGimmu:70611.
UCSCiuc007nqj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147101 Genomic DNA. No translation available.
BC006669 mRNA. Translation: AAH06669.1.
BC020022 mRNA. Translation: AAH20022.1.
CCDSiCCDS49072.1.
RefSeqiNP_001028328.2. NM_001033156.4.
UniGeneiMm.311026.

3D structure databases

ProteinModelPortaliQ8VE08.
SMRiQ8VE08. Positions 70-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035948.

Proteomic databases

EPDiQ8VE08.
MaxQBiQ8VE08.
PaxDbiQ8VE08.
PRIDEiQ8VE08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043204; ENSMUSP00000035948; ENSMUSG00000035329.
GeneIDi70611.
KEGGimmu:70611.
UCSCiuc007nqj.2. mouse.

Organism-specific databases

CTDi254170.
MGIiMGI:1917861. Fbxo33.

Phylogenomic databases

eggNOGiENOG410IFZV. Eukaryota.
ENOG410YDCW. LUCA.
GeneTreeiENSGT00390000017718.
HOGENOMiHOG000072695.
HOVERGENiHBG051575.
InParanoidiQ8VE08.
KOiK10310.
OMAiQLRWLSC.
OrthoDBiEOG7QZG98.
TreeFamiTF321665.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8VE08.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VE08.
CleanExiMM_FBXO33.
ExpressionAtlasiQ8VE08. baseline and differential.
GenevisibleiQ8VE08. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-562.
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. "Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death."
    Lutz M., Wempe F., Bahr I., Zopf D., von Melchner H.
    FEBS Lett. 580:3921-3930(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YBX1, IDENTIFICATION IN THE SCF(FBXO33) COMPLEX WITH CUL1; SKP1 AND RBX1, FUNCTION IN UBIQUITINATION OF YBX1.

Entry informationi

Entry nameiFBX33_MOUSE
AccessioniPrimary (citable) accession number: Q8VE08
Secondary accession number(s): A0JLR4, E9QMJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.