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Q8VE01

- DUS18_MOUSE

UniProt

Q8VE01 - DUS18_MOUSE

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Protein
Dual specificity protein phosphatase 18
Gene
Dusp18
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 Publication
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. phosphatase activity Source: MGI
  3. protein tyrosine phosphatase activity Source: UniProtKB-EC
  4. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: RefGenome
  2. protein localization to organelle Source: MGI
  3. protein targeting to membrane Source: MGI
  4. protein targeting to mitochondrion Source: MGI
  5. response to antibiotic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 18 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:Dusp18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1922469. Dusp18.

Subcellular locationi

Cytoplasm. Nucleus By similarity. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
Note: Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extrinsic component of mitochondrial inner membrane Source: MGI
  3. intrinsic component of mitochondrial inner membrane Source: MGI
  4. mitochondrial inner membrane Source: MGI
  5. mitochondrial intermembrane space Source: MGI
  6. mitochondrion Source: MGI
  7. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Dual specificity protein phosphatase 18
PRO_0000094829Add
BLAST

Proteomic databases

PRIDEiQ8VE01.

PTM databases

PhosphoSiteiQ8VE01.

Expressioni

Gene expression databases

BgeeiQ8VE01.
CleanExiMM_DUSP18.
GenevestigatoriQ8VE01.

Structurei

3D structure databases

ProteinModelPortaliQ8VE01.
SMRiQ8VE01. Positions 19-179.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 14970Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 14147Sufficient for mitochondrial localization
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00750000117525.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ8VE01.
KOiK14165.
OMAiASPCAFP.
OrthoDBiEOG7PK90H.
PhylomeDBiQ8VE01.
TreeFamiTF316009.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020420. Atypical_DUSP_famB.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VE01-1 [UniParc]FASTAAdd to Basket

« Hide

MTSPWSAFPV QIPQPSIRGL SQITKSLFIS NGVAANNKLL LSSNQITTVI    50
NVSVEVANTF YEDIQYVQVP VVDAPVARLS NFFDSVADRI HSVEMQKGRT 100
LLHCAAGVSR SAALCLAYLM KYHAMSLVDA HTWTKSCRPI IRPNSGFWEQ 150
LIHYELQLFG KNTMQMMDSP MGRIPDIYEK ETRLMIPL 188
Length:188
Mass (Da):21,119
Last modified:March 1, 2002 - v1
Checksum:i86CB43E390DC7DE3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK015917 mRNA. Translation: BAC25470.1.
AK081916 mRNA. Translation: BAC38371.1.
AL731853 Genomic DNA. Translation: CAI51861.1.
BC020036 mRNA. Translation: AAH20036.1.
CCDSiCCDS24369.1.
RefSeqiNP_776106.1. NM_173745.5.
XP_006514936.1. XM_006514873.1.
UniGeneiMm.32588.

Genome annotation databases

EnsembliENSMUST00000055931; ENSMUSP00000057346; ENSMUSG00000047205.
ENSMUST00000109996; ENSMUSP00000105624; ENSMUSG00000047205.
GeneIDi75219.
KEGGimmu:75219.
UCSCiuc007htu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK015917 mRNA. Translation: BAC25470.1 .
AK081916 mRNA. Translation: BAC38371.1 .
AL731853 Genomic DNA. Translation: CAI51861.1 .
BC020036 mRNA. Translation: AAH20036.1 .
CCDSi CCDS24369.1.
RefSeqi NP_776106.1. NM_173745.5.
XP_006514936.1. XM_006514873.1.
UniGenei Mm.32588.

3D structure databases

ProteinModelPortali Q8VE01.
SMRi Q8VE01. Positions 19-179.
ModBasei Search...

PTM databases

PhosphoSitei Q8VE01.

Proteomic databases

PRIDEi Q8VE01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055931 ; ENSMUSP00000057346 ; ENSMUSG00000047205 .
ENSMUST00000109996 ; ENSMUSP00000105624 ; ENSMUSG00000047205 .
GeneIDi 75219.
KEGGi mmu:75219.
UCSCi uc007htu.2. mouse.

Organism-specific databases

CTDi 150290.
MGIi MGI:1922469. Dusp18.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00750000117525.
HOGENOMi HOG000233766.
HOVERGENi HBG051422.
InParanoidi Q8VE01.
KOi K14165.
OMAi ASPCAFP.
OrthoDBi EOG7PK90H.
PhylomeDBi Q8VE01.
TreeFami TF316009.

Miscellaneous databases

NextBioi 342484.
PROi Q8VE01.
SOURCEi Search...

Gene expression databases

Bgeei Q8VE01.
CleanExi MM_DUSP18.
Genevestigatori Q8VE01.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020420. Atypical_DUSP_famB.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. "Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane."
    Rardin M.J., Wiley S.E., Murphy A.N., Pagliarini D.J., Dixon J.E.
    J. Biol. Chem. 283:15440-15450(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDUS18_MOUSE
AccessioniPrimary (citable) accession number: Q8VE01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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