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Q8VE01

- DUS18_MOUSE

UniProt

Q8VE01 - DUS18_MOUSE

Protein

Dual specificity protein phosphatase 18

Gene

Dusp18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 PublicationPROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. phosphatase activity Source: MGI
    3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: RefGenome
    2. protein localization to organelle Source: MGI
    3. protein targeting to membrane Source: MGI
    4. protein targeting to mitochondrion Source: MGI
    5. response to antibiotic Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 18 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:Dusp18
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1922469. Dusp18.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus By similarity. Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Intermembrane side 1 Publication
    Note: Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extrinsic component of mitochondrial inner membrane Source: MGI
    3. intrinsic component of mitochondrial inner membrane Source: MGI
    4. mitochondrial inner membrane Source: MGI
    5. mitochondrial intermembrane space Source: MGI
    6. mitochondrion Source: MGI
    7. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Dual specificity protein phosphatase 18PRO_0000094829Add
    BLAST

    Proteomic databases

    PRIDEiQ8VE01.

    PTM databases

    PhosphoSiteiQ8VE01.

    Expressioni

    Gene expression databases

    BgeeiQ8VE01.
    CleanExiMM_DUSP18.
    GenevestigatoriQ8VE01.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VE01.
    SMRiQ8VE01. Positions 19-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 14970Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni95 – 14147Sufficient for mitochondrial localizationAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117525.
    HOGENOMiHOG000233766.
    HOVERGENiHBG051422.
    InParanoidiQ8VE01.
    KOiK14165.
    OMAiASPCAFP.
    OrthoDBiEOG7PK90H.
    PhylomeDBiQ8VE01.
    TreeFamiTF316009.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VE01-1 [UniParc]FASTAAdd to Basket

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    MTSPWSAFPV QIPQPSIRGL SQITKSLFIS NGVAANNKLL LSSNQITTVI    50
    NVSVEVANTF YEDIQYVQVP VVDAPVARLS NFFDSVADRI HSVEMQKGRT 100
    LLHCAAGVSR SAALCLAYLM KYHAMSLVDA HTWTKSCRPI IRPNSGFWEQ 150
    LIHYELQLFG KNTMQMMDSP MGRIPDIYEK ETRLMIPL 188
    Length:188
    Mass (Da):21,119
    Last modified:March 1, 2002 - v1
    Checksum:i86CB43E390DC7DE3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK015917 mRNA. Translation: BAC25470.1.
    AK081916 mRNA. Translation: BAC38371.1.
    AL731853 Genomic DNA. Translation: CAI51861.1.
    BC020036 mRNA. Translation: AAH20036.1.
    CCDSiCCDS24369.1.
    RefSeqiNP_776106.1. NM_173745.5.
    XP_006514936.1. XM_006514873.1.
    UniGeneiMm.32588.

    Genome annotation databases

    EnsembliENSMUST00000055931; ENSMUSP00000057346; ENSMUSG00000047205.
    ENSMUST00000109996; ENSMUSP00000105624; ENSMUSG00000047205.
    GeneIDi75219.
    KEGGimmu:75219.
    UCSCiuc007htu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK015917 mRNA. Translation: BAC25470.1 .
    AK081916 mRNA. Translation: BAC38371.1 .
    AL731853 Genomic DNA. Translation: CAI51861.1 .
    BC020036 mRNA. Translation: AAH20036.1 .
    CCDSi CCDS24369.1.
    RefSeqi NP_776106.1. NM_173745.5.
    XP_006514936.1. XM_006514873.1.
    UniGenei Mm.32588.

    3D structure databases

    ProteinModelPortali Q8VE01.
    SMRi Q8VE01. Positions 19-179.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8VE01.

    Proteomic databases

    PRIDEi Q8VE01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055931 ; ENSMUSP00000057346 ; ENSMUSG00000047205 .
    ENSMUST00000109996 ; ENSMUSP00000105624 ; ENSMUSG00000047205 .
    GeneIDi 75219.
    KEGGi mmu:75219.
    UCSCi uc007htu.2. mouse.

    Organism-specific databases

    CTDi 150290.
    MGIi MGI:1922469. Dusp18.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117525.
    HOGENOMi HOG000233766.
    HOVERGENi HBG051422.
    InParanoidi Q8VE01.
    KOi K14165.
    OMAi ASPCAFP.
    OrthoDBi EOG7PK90H.
    PhylomeDBi Q8VE01.
    TreeFami TF316009.

    Miscellaneous databases

    NextBioi 342484.
    PROi Q8VE01.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VE01.
    CleanExi MM_DUSP18.
    Genevestigatori Q8VE01.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    4. "Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane."
      Rardin M.J., Wiley S.E., Murphy A.N., Pagliarini D.J., Dixon J.E.
      J. Biol. Chem. 283:15440-15450(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDUS18_MOUSE
    AccessioniPrimary (citable) accession number: Q8VE01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3