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Protein

Ribitol-5-phosphate xylosyltransferase 1

Gene

Rxylt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Ribitol-5-phosphate xylosyltransferase 1By similarity (EC:2.4.2.-)
Alternative name(s):
Transmembrane protein 5Curated
UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferaseBy similarity
Gene namesi
Name:Rxylt1
Synonyms:Tmem5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384919 Tmem5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 444ExtracellularSequence analysisAdd BLAST414

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725881 – 444Ribitol-5-phosphate xylosyltransferase 1Add BLAST444

Proteomic databases

MaxQBiQ8VDX6
PaxDbiQ8VDX6
PeptideAtlasiQ8VDX6
PRIDEiQ8VDX6

PTM databases

iPTMnetiQ8VDX6
PhosphoSitePlusiQ8VDX6

Expressioni

Gene expression databases

BgeeiENSMUSG00000034620
CleanExiMM_TMEM5
ExpressionAtlasiQ8VDX6 baseline and differential
GenevisibleiQ8VDX6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119308

Family & Domainsi

Sequence similaritiesi

Belongs to the RXYLT1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPG Eukaryota
ENOG410YH22 LUCA
GeneTreeiENSGT00390000003526
HOGENOMiHOG000007907
HOVERGENiHBG061171
InParanoidiQ8VDX6
KOiK21052
OMAiCWVSARE
OrthoDBiEOG091G0BR1
TreeFamiTF328717

Sequencei

Sequence statusi: Complete.

Q8VDX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTRTRLCS LLVALYCLFS IYAAYHVFFG RRRRPLGTTS RNSRKAAAAQ
60 70 80 90 100
AKERRGREQS ALESEEWNPW EGDEKNEQRH RVKTNLQILN KSTKEKIEHR
110 120 130 140 150
VQIWGKAAIG LYLWEHIFEG TLDPADVTAQ WREGQSVVGR THYSFITGPA
160 170 180 190 200
VVPGYFSIDV DNVVLVLNGR EKAKIFHATQ WLIYAQNLMK TQKLQHLAVV
210 220 230 240 250
LLGNEHCEND WIMQFLKRNG GFVDLLFITY DSPWINGADI LQWPLGVATY
260 270 280 290 300
RQFPVVEASW TMLHDERPYI CNFLGTAYEN SSRQALMNIL KQDGNDKLCW
310 320 330 340 350
VSAREQWQPQ ETNESLKNYQ DALLHSDLTL CPVGVNTECY RIYEACSFGS
360 370 380 390 400
IPVVEDVMTA GHCGNTTSQH SAPLQLLKAM GAPFIFIKNW KELPAILEKE
410 420 430 440
KTISLQEKIQ RRKVLLHWYQ HFKTELKWKF TKILESSFFI NNKV
Length:444
Mass (Da):51,386
Last modified:March 1, 2002 - v1
Checksum:i6A4F0548D91024FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020100 mRNA Translation: AAH20100.1
BC023194 mRNA Translation: AAH23194.1
CCDSiCCDS24214.1
RefSeqiNP_694699.1, NM_153059.1
UniGeneiMm.236764

Genome annotation databases

EnsembliENSMUST00000140299; ENSMUSP00000119308; ENSMUSG00000034620
GeneIDi216395
KEGGimmu:216395
UCSCiuc007hgd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRXLT1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDX6
Secondary accession number(s): Q8R566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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