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Protein

Transmembrane protein 5

Gene

Tmem5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 5
Gene namesi
Name:Tmem5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384919. Tmem5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini31 – 444414ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Transmembrane protein 5PRO_0000072588Add
BLAST

Proteomic databases

MaxQBiQ8VDX6.
PaxDbiQ8VDX6.
PeptideAtlasiQ8VDX6.
PRIDEiQ8VDX6.

PTM databases

iPTMnetiQ8VDX6.
PhosphoSiteiQ8VDX6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034620.
CleanExiMM_TMEM5.
ExpressionAtlasiQ8VDX6. baseline and differential.
GenevisibleiQ8VDX6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119308.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM5 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPG. Eukaryota.
ENOG410YH22. LUCA.
GeneTreeiENSGT00390000003526.
HOGENOMiHOG000007907.
HOVERGENiHBG061171.
InParanoidiQ8VDX6.
OMAiIFIKNWK.
OrthoDBiEOG091G0BR1.
TreeFamiTF328717.

Sequencei

Sequence statusi: Complete.

Q8VDX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTRTRLCS LLVALYCLFS IYAAYHVFFG RRRRPLGTTS RNSRKAAAAQ
60 70 80 90 100
AKERRGREQS ALESEEWNPW EGDEKNEQRH RVKTNLQILN KSTKEKIEHR
110 120 130 140 150
VQIWGKAAIG LYLWEHIFEG TLDPADVTAQ WREGQSVVGR THYSFITGPA
160 170 180 190 200
VVPGYFSIDV DNVVLVLNGR EKAKIFHATQ WLIYAQNLMK TQKLQHLAVV
210 220 230 240 250
LLGNEHCEND WIMQFLKRNG GFVDLLFITY DSPWINGADI LQWPLGVATY
260 270 280 290 300
RQFPVVEASW TMLHDERPYI CNFLGTAYEN SSRQALMNIL KQDGNDKLCW
310 320 330 340 350
VSAREQWQPQ ETNESLKNYQ DALLHSDLTL CPVGVNTECY RIYEACSFGS
360 370 380 390 400
IPVVEDVMTA GHCGNTTSQH SAPLQLLKAM GAPFIFIKNW KELPAILEKE
410 420 430 440
KTISLQEKIQ RRKVLLHWYQ HFKTELKWKF TKILESSFFI NNKV
Length:444
Mass (Da):51,386
Last modified:March 1, 2002 - v1
Checksum:i6A4F0548D91024FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020100 mRNA. Translation: AAH20100.1.
BC023194 mRNA. Translation: AAH23194.1.
CCDSiCCDS24214.1.
RefSeqiNP_694699.1. NM_153059.1.
UniGeneiMm.236764.

Genome annotation databases

EnsembliENSMUST00000140299; ENSMUSP00000119308; ENSMUSG00000034620.
GeneIDi216395.
KEGGimmu:216395.
UCSCiuc007hgd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020100 mRNA. Translation: AAH20100.1.
BC023194 mRNA. Translation: AAH23194.1.
CCDSiCCDS24214.1.
RefSeqiNP_694699.1. NM_153059.1.
UniGeneiMm.236764.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119308.

PTM databases

iPTMnetiQ8VDX6.
PhosphoSiteiQ8VDX6.

Proteomic databases

MaxQBiQ8VDX6.
PaxDbiQ8VDX6.
PeptideAtlasiQ8VDX6.
PRIDEiQ8VDX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000140299; ENSMUSP00000119308; ENSMUSG00000034620.
GeneIDi216395.
KEGGimmu:216395.
UCSCiuc007hgd.1. mouse.

Organism-specific databases

CTDi10329.
MGIiMGI:2384919. Tmem5.

Phylogenomic databases

eggNOGiENOG410IFPG. Eukaryota.
ENOG410YH22. LUCA.
GeneTreeiENSGT00390000003526.
HOGENOMiHOG000007907.
HOVERGENiHBG061171.
InParanoidiQ8VDX6.
OMAiIFIKNWK.
OrthoDBiEOG091G0BR1.
TreeFamiTF328717.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiQ8VDX6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034620.
CleanExiMM_TMEM5.
ExpressionAtlasiQ8VDX6. baseline and differential.
GenevisibleiQ8VDX6. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTMEM5_MOUSE
AccessioniPrimary (citable) accession number: Q8VDX6
Secondary accession number(s): Q8R566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.